Microbiota and viral hepatitis:State of the art of a complex matter
Microbiota 和病毒的肝炎: 一件复杂的事的现状作者机构：Clinic for Infectious and Tropical DiseasesClinical Centre of Serbia Faculty of MedicineUniversity of BelgradeBelgrade 101801Serbia Department of Experimental and Clinical MedicineUniversity of FlorenceFirenze 50100Italy
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2021年第27卷第33期
页 面：5488-5501页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：Supported by The Italian Ministry of University and Research(MIUR) the Foundation‘Ente Cassa di Risparmio di Firenze’ No.FCR 2017
主 题：Gut microbiota Hepatitis B virus Hepatitis C virus Liver diseases,Fecal transplantation
摘 要：Changes in gut microbiota influence both the gut and liver,which are strictly connected by the so-called“gut-liver axis.The gut microbiota acts as a major determinant of this relationship in the onset and clinical course of liver *** to the results of several studies,gut dysbiosis is linked to viral hepatitis,mainly hepatitis C virus and hepatitis B virus *** bacteriaderived metabolites and cellular components are key molecules that affect liver function and modulate the pathology of viral *** studies showed that the gut microbiota produces various molecules,such as peptidoglycans,lipopolysaccharides,DNA,lipoteichoic acid,indole-derivatives,bile acids,and trimethylamine,which are translocated to the liver and interact with liver immune cells causing pathological ***,the existence of crosstalk between the gut microbiota and the liver and its implications on host health and pathologic status are essential factors impacting the etiology and therapeutic *** mechanisms behind the pathogenic role of gut-derived components on the pathogenesis of viral hepatitis remain unclear and not *** this review,we discuss the current findings of research on the bidirectional relationship of the components of gut microbiota and the progression of liver diseases and viral hepatitis and vice ***,this paper highlights the current therapeutic and preventive strategies,such as fecal transplantation,used to restore the gut microbiota composition and so improve host health.
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