Review of a new bone tumor therapy strategy based on bifunctional biomaterials

作     者：Jinfeng Liao Ruxia Han Yongzhi Wu Zhiyong Qian Jinfeng Liao;Ruxia Han;Yongzhi Wu;Zhiyong Qian

作者机构：State Key Laboratory of Oral DiseasesNational Clinical Research Centre for Oral DiseasesState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan UniversityChengduSichuanP.R.China 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2021年第9卷第2期

页      面：153-165页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(2017YFC1103500,2017YFC1103502) the National Natural Science Foundation(31972925,31771096,31930067,31525009) the 1·3·5 project for disciplines of excellence,West China Hospital,Sichuan University(ZYGD18002) the Sichuan Science and Technology Program(2020YJ0065) the Sichuan University Spark Project(2018SCUH0029) the State Key Laboratory of Oral Diseases Foundation(SKLOD202016) 

主　　题：biomaterials chemotherapy mortality 

摘      要：Bone tumors,especially those in osteosarcoma,usually occur in *** standard clinical treatment includes chemotherapy,surgical therapy,and radiation ***,surgical resection often fails to completely remove the tumor,which is the main cause of postoperative recurrence and metastasis,resulting in a high mortality ***,bone tumors often invade large areas of bone,which cannot repair itself,and causes a serious effect on the quality of life of ***,bone tumor therapy and bone regeneration are challenging in the ***,this review presents the recent developments in bifunctional biomaterials to achieve a new strategy for bone tumor *** selected bifunctional materials include 3D-printed scaffolds,nano/microparticle-containing scaffolds,hydrogels,and bone-targeting *** related studies on bifunctional biomaterials combining tumor photothermal therapy with enhanced bone regeneration were ***,a perspective on the future development of biomaterials for tumor therapy and bone tissue engineering is *** review will provide a useful reference for bone tumor-related disease and the field of complex diseases to combine tumor therapy and tissue engineering.