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Establishment of a humanized st6GAL1 mouse model for influenza research

Animal Models and Experimental Medicine 2024年第3期7卷 337-346页

作者： Lyu Chao Han Feng Gao Qian Lv Limin Lu Ziwei Lu Shuangshuang Li Xiaoyan Hu Yuechao Yang Mengjie Zhao Yingze Liu Jun Lu Xuancheng Duo Shuguang National Key laboratory of Intelligent Tracking and Forecasting for infectious diseases Chinese Center for Disease Control and PreventionBeijingChina Institute of Zoology Chinese Academy of SciencesBeijingChina NHC Key laboratory of Biosafety National Key Laboratory of Intelligent Tracking and Forecasting for Infectious DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Zhejiang Provincial Key laboratory of Medical genetics Key Laboratory of Laboratory MedicineMinistry of EducationSchool of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhouChina

Background:This study aimed to construct and characterize a humanized influenza mouse model expressing ***:humanized fragments,consisting of the endothelial cell-specific K18 promoter,human st6GAL1-encoding gene,and luciferase gene,were microinjected into the fertilized eggs of *** manipulated embryos were transferred into the oviducts of pseudopregnant female *** offspring were identified using *** exhibiting elevated expression of the hst6GAL1 gene were selectively bred for propagation,and in vivo analysis was performed for *** of the humanized gene was tested by performing immunohistochemical(IHC)*** and biochemical analyses using the whole blood and serum of humanized hst6GAL1 mice were ***:Successful integration of the human st6GAL1 gene into the mouse genome led to the overexpression of human SiaT *** mice were identified as carrying copies of the humanized gene,and the in vivo analysis indicated that hst6GAL1gene expression in positive mice mirrored influenza virus infection *** IHC results revealed that hst6GAL1 was expressed in the lungs of humanized ***,the hematologic and biochemical parameters of the positive mice were within the normal ***:A humanized influenza mouse model expressing the hst6GAL1 gene was successfully established and characterized.

关键词： hst6GAL1 humanized mice influenza animal model

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New Gene Variants Associated with the Risk of Chronic HBV Infection

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Virologica Sinica 2020年第4期35卷 378-387页

作者： Mengjie Fan Jing Wang Sa Wang Tengyan Li Hong Pan Hankui Liu Huifang Xu Daria V.Zhernakova stephen J.O’Brien Zhenru Feng Le Chang Erhei Dai Jianhua Lu Hongli Xi Yanyan Yu Jianguo Zhang Binbin Wang Zheng Zeng Department of infectious diseases Peking University First HospitalBeijing 100034China Department of Medical genetics and Development Biology School of Medical BasicCapital Medical UniversityBeijing 100069China Center for genetics National Research Institute for Family PlanningBeijing 100081China BGI-Shenzhen Shenzhen 518083China BGI Genomics BGI-ShenzhenShenzhen 518083China laboratory of Genomic Diversity Center for Computer TechnologiesITMO UniversitySt.PetersburgRussia 197101 Guy Harvey Oceanographic Center Halmos College of Natural Sciences and OceanographyNova Southeastern UniversityFt LauderdaleFL 33004USA Department of laboratory Medicine Peking University First HospitalBeijing 100034China The Fifth Hospital of Shijiazhuang Shijiazhuang 050024China

Some patients with chronic hepatitis B virus(HBV)infection failed to clear HBV,even persistently continue to produce antibodies to *** we performed a two stage genome wide association study in a cohort of Chinese patients designed to discover single nucleotide variants that associate with HBV infection and clearance of *** first stage involved genome wide exome sequencing of 101 cases(HBsAg plus anti-HBs positive)compared with 102 control patients(antiHBs positive,HBsAg negative).Over 80%of individual sequences displayed 209 sequence ***,uncertain bases[10%or low-quality base calls([50%)were filtered and compared to the human reference genome *** the second stage,579 chronic HBV infected cases and 439 HBV clearance controls were sequenced with selected genes from the first *** there were no significant associated gene variants in the first stage,two significant gene associations were discovered when the two stages were assessed in a combined *** association showed rs506121-“T”allele[within the dedicator of cytokinesis 8(DOCK8)gene]was higher in chronic HBV infection group than that in clearance group(P=0.002,OR=0.77,95%CI[0.65,0.91]).The second association involved rs2071676—A allele within the Carbonic anhydrase(CA9)gene that was significantly elevated in chronic HBV infection group compared to the clearance group(P=0.0003,OR=1.35,95%CI[1.15,1.58]).Upon replication these gene associations would suggest the influence of DOCK8 and CA9 as potential risk genetic factors in the persistence of HBV infection.

关键词： Whole exome sequencing HBV infection DOCK8 CA9 Variation

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Suppressing fatty acid synthase by type Ⅰ interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1624-1635页

作者： Saba R.Aliyari Amir Ali Ghaffari Olivier Pernet Kislay Parvatiyar Yao Wang Hoda Gerami Ann-Jay Tong Laurent Vergnes Armin Takallou Adel Zhang Xiaochao Wei Linda D.Chilin Yuntao Wu Clay F.Semenkovich Karen Reue stephen T.Smale Benhur Lee Genhong Cheng Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesCA 90095USA EnViro International Laboratories Los AngelesCA 90077USA Department of human genetics David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA Division of Endocrinology Metabolism and Lipid ResearchWashington University School of MedicineSt.LouisMO 63110USA Center for infectious Disease Research School of Systems BiologyGeorge Mason University ManassasVA 20110USA Diabetic Cardiovascular Disease Center WashingtonUniversity School of MedicineSt.LouisMO 63110USA

SARS-CoV-2 is an emerging viral pathogen and a major global public health challenge since December of 2019, with limited effective treatments throughout the *** part of the innate immune response to viral infection, type Ⅰ interferons(IFN-Ⅰ) trigger a signaling cascade that culminates in the activation of hundreds of genes, known as interferon stimulated genes(ISGs), that collectively foster an antiviral *** report here the identification of a group of type Ⅰ interferon suppressed genes,including fatty acid synthase(FASN), which are involved in lipid *** of FASN or the addition of its downstream product, palmitate, increased viral infection while knockout or knockdown of FASN reduced *** importantly, pharmacological inhibitors of FASN effectively blocked infections with a broad range of viruses, including SARS-CoV-2 and its variants of ***, our studies not only suggest that downregulation of metabolic genes may present an antiviral strategy by type Ⅰ interferon, but they also introduce the potential for FASN inhibitors to have a therapeutic application in combating emerging infectious diseases such as COVID-19.

关键词： Fatty acid synthase FASN IFN-I SARS-CoV-2 COVID-19 C75

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Development of human herpesvirus-6-specific regulatory T cells

Development of human herpesvirus-6-specific regulatory T cel...

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第九届全国免疫学学术大会

作者： Fang Wang Jing Chi Guangyong Peng Feng Zhou Jinfeng Wang Lingyun Li Dongju Feng Fangyi Xie Bin Gu Jian Qin Yun Chen Kun Yao Department of laboratory Medicine the First Affiliated Hospital of Nanjing Medical University Department of Microbiology and Immunology Nanjing Medical University Division of infectious diseases Allergy & Immunology and Department of Internal MedicineSaint Louis UniversitySt.LouisMissouri 63104 Department of Developmental genetics Nanjing Medical University College of Foreign Languages Hehai University

Background:human herpesvirus 6(HHV-6)is an important immunosuppressive and immunomodulatory *** mechanisms by which HHV-6 establishes latency and immunosuppression in its host are not well ***:HHV-6-specific

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Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study

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World Journal of Gastroenterology 2022年第21期28卷 2334-2349页

作者： Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler Department of General Internal Medicine and Psychosomatics University Hospital HeidelbergHeidelberg 69120Germany Department of human Molecular genetics Institute of Human GeneticsUniversity of HeidelbergHeidelberg 69120Germany Department of General Internal Medicine and Psychosomatics Internal Medicine IIUniversity Hospital HeidelbergHeidelberg 69120Germany Department of human Molecular genetics University of HeidelbergHeidelberg 69120Germany Gastrointestinal genetics Lab CIC bioGUNE-BRTADerio 48160Spain IKERBASQUE Basque Foundation for ScienceBilbao 48001Spain Unit of Clinical Epidemiology Department of Medicine SolnaKarolinska InstitutetStockholm 17177Sweden Institute of Medical Biometry and Informatics Heidelberg UniversityHeidelberg 69120Germany Lleida Institute for Biomedical Research Dr.PifarréFoundation(IRBLleida) Av.Alcalde Rovira RoureLleida 25198Spain Department of Clinical and Experimental Medicine Translational Research Center for Gastrointestinal DisordersKU LeuvenLeuven 3000Belgium Department of Gastroenterology Infectious Diseases and IntoxicationsUniversity of HeidelbergHeidelberg 69120Germany Department of General Internal Medicine and Psychosomatics Heidelberg UniversityHeidelberg 69120Germany Nottingham Digestive diseases Centre University of NottinghamNottingham NG72QLUnited Kingdom Helios Klinikum Rottweil Rottweil 78628Germany Department of Medicine Institute of Neurogastroenterology(H.M.)Martin-Luther-HospitalBelin 14193Germany Israelitisches Krankenhaus in Hamburg Hamburg 22297Germany Internal Medicine II Helios Klinikum KrefeldKrefeld 47805Germany Israelitisches Krankenhaus Hamburg Hamburg 22297Ghana Krankenhaus Vilsbiburg Vilsbiburg 84137Germany Division of Microbiome and Cancer German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Psychiatry and Neurobehavioral Science University College CorkCork T23Ireland Medicine in Digestive Disorders Department of MedicineLynda K.and David M.Underwood Center for Digestive DisordersHou

BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with *** In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United states,the United Kingdom,and ***,anxiety,and somatization symptoms and sociodemographic characteristics were *** functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive *** also performed separate analyses for sex and IBS *** scores were calculated as the number of minor alleles of the SNPs *** impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx *** Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in *** potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant *** We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with *** SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS.

关键词： Irritable bowel syndrome 5-HT3 receptor subunit gene polymorphisms Single-nucleotide polymorphism score Depression Anxiety Somatization

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An overview on biochar production, its implications, and mechanisms of biochar-induced amelioration of soil and plant characteristics

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Pedosphere 2022年第1期32卷 107-130页

作者： Fasih Ullah HAIDER Jeffrey ACOULTER Liqun CAI Saddam HUSSAIN Sardar Alam CHEEMA Jun WU Renzhi ZHANG College of Resources and Environmental Sciences Gansu Agricultural UniversityLanzhou 730070China Gansu Provincial Key Lab of Arid-land Crop Science Gansu Agricultural UniversityLanzhou 730070China Department of Agronomy and Plant genetics University of MinnesotaSt.PaulMN 55108USA Department of Agronomy University of Agriculture FaisalabadFaisalabad 38040Pakistan

The degradation of soil fertility and quality due to rapid industrialization and human activities has stimulated interest in the rehabilitation of low-fertility soils to sustainably improve crop yield. In this regard, biochar has emerged as an effective multi-beneficial additive that can be used as a medium for the amelioration of soil properties and plant growth. The current review highlights the methods and conditions for biochar production and the effects of pyrolysis temperature, feedstock type, and retention time on the physicochemical properties of biochar. We also discuss the impact of biochar as a soil amendment with respect to enhancing soil physical (e.g., surface area, porosity, ion exchange, and water-holding capacity) and chemical (e.g., pH, nutrient exchange,functional groups, and carbon sequestration) properties, improving the soil microbiome for increased plant nutrient uptake and growth, reducing greenhouse gas emissions, minimizing infectious diseases in plants, and facilitating the remediation of heavy metal-contaminated soils. The possible mechanisms for biochar-induced amelioration of soil and plant characteristics are also described, and we consider the challenges associated with biochar utilization. The findings discussed in this review support the feasibility of expending the application of biochar to improve degraded soils in industrial and saline-alkali regions, thereby increasing the usable amount of cultivated soil. Future research should include long-term field experiments and studies on biochar production and environmental risk management to optimize biochar performance for specific soil remediation purposes.

关键词： carbon sequestration crop yield pyrolysis soil amendment soil fertility soil remediation

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Evaluating chromosomal segregation in a family where both spouses carry an autosomal translocation

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Reproductive and Developmental Medicine 2023年第3期7卷 189-192页

作者： Irina L.Puppo Ziravard N.Tonyan Alsu F.Saifitdinova Julia A.Loginova Anna A.Kinunen Alisa N.Panina Julia R.Pastuhova Olga A.Leonteva Olga G.Chiryaeva Olga V.Malysheva Oleg S.Glotov Irina V.Poliakova Andrey V.Tikhonove Tatyana V.Vavilova Irina L.Menshikova Elvira V.Isakova Andrey S.Glotov Natalya K.Bichevaya International Centre for Reproductive Medicine Saint-Petersburg 197350Russia Department of laboratory Medicine and genetics Almazov National Medical Research CentreSaint-Petersburg197341Russia Department of Genomic Medicine D.O.Ott's Institute of ObstetricsGynecologyand ReproductologySaint-Petersburg 199034Russia Department of Biology.Herzen state Pedagogical University of Russia Saint-Petersburg 191186Russia DiaCarta Inc.2600 Hilltop DriveRichmondCA 94806 st.Petersburg Centre for Medical genetics Saint Petersburg194044Russia Department of ExperimentalMedical Virology MolecularGenetics and Biobankingof Pediatric Researchand Clinical Center for Infectious DiseasesSaint-Petersburg 197022Russia Medical institute of Surgut state University Surgut 628403 Russia CerbaLab Ltd. Saint-Petersburg 199106Russia

Autosomal reciprocal translocations represent exchanges of chromatin fragments between non-homologous *** are facilitated by the creation of quadrivalent structures during the first meiotic division,which are characterized by the length of the translocated and centric segments,asymmetry,and the presence of terminal breakpoints,all of which may impact segregation ***,we report a rare case of multiple reciprocal translocations within a single *** includes the evaluation of the translocations in each of the spouses and an analysis of their chromosome segregation patterns as determined by the constellation of universal characteristics in each of their *** obtained results will be of interest to fundamental biology,as they will expand the understanding of the factors affecting chromosome segregation during meiosis.

关键词： Embryo viability Genetic counseling Pre-implantation genetic testing Quadrivalent characteristics

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Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

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四川生理科学杂志 2022年第12期44卷 2223-2223页

作者： Danyel Lee st. giles laboratory of human genetics of infectious diseases Rockefeller Branch The Rockefeller University New York NY USA. laboratory of human genetics of infectious diseases Necker Branch INSERM U1163 Paris France. Paris City University Imagine Institute Paris France. laboratory of Virology and infectious Disease The Rockefeller University New York NY USA. Department of Cancer Biology Lerner Research Institute Cleveland Clinic Cleveland OH USA. human Evolutionary genetics Unit Institut Pasteur Paris City University CNRS UMR 2000 Paris France. Doctoral College Sorbonne University Paris France. laboratory of Immunology Lyon Sud Hospital Lyon France. Pediatric Intensive Care Department Hospital Sant Joan de Déu Barcelona Spain. Kids Corona Platform Barcelona Spain. Center for Biomedical Network Research on Epidemiology and Public Health (CIBERESP) Instituto de Salud Carlos III Madrid Spain. Department of Surgery and Surgical Specializations Faculty of Medicine and Health Sciences University of Barcelona Barcelona Spain. Respiratory and Immunological Dysfunction in Pediatric Critically Ill Patients Institute of Recerca Sant Joan de Déu Barcelona Spain. Bursa City Hospital Bursa Turkey. Ankara City Hospital Yildirim Beyazit University Ankara Turkey. Immunology and Rheumatology Division Department of Pediatrics University of Montreal CHU Sainte-Justine Montreal QC Canada. Center for Translational Research Institut Pasteur Paris City University Paris France. Department of Biochemistry and Center for RNA Science and Therapeutics Case Western Reserve University Cleveland OH USA. Department of Surgery Weill Cornell Medical College New York NY USA. Department of Pediatrics School of Medicine Emory University Atlanta GA USA. International Center of Infectiology Research (CIRI) University of Lyon INSERM U1111 Claude Bernard University Lyon 1 CNRS UMR5308 ENS of Lyon Lyon France. Departments of Neurosurgery and genetics and Yale Center for G

Multisystem inflammatory syndrome in children(MIS-C)is a rare and severe condition that follows benign *** report autosomal recessive deficiencies of OAS1,OAS2,or RNASEL in five unrelated children with *** cytosolic d... 详细信息

关键词： inflammatory children multisystem

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human genetic and immunological determinants of critical COVID-19 pneumonia

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四川生理科学杂志 2021年第11期43卷 1947-1947页

作者： Qian Zhang st giles laboratory of human genetics of infectious diseases Rockefeller Branch The Rockefeller University New York NY USA laboratory of human genetics of infectious diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France University of Paris Imagine Institute Paris France Howard Hughes Medical Institute Paris France The Rockefeller University & Howard Hughes Medical Institute New York NY USA Necker Hospital for Sick Children & INSERM Paris France Department of Pediatrics Necker Hospital for Sick Children Paris France Cemil Taşcıoglu City Hospital Istanbul Turkey laboratory of human genetics of infectious diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France Imagine Institute University of Paris Paris France Al Jalila Children’s Hospital Dubai United Arab Emirates San Raffaele Telethon Institute for Gene Therapy IRCCS Ospedale San Raffaele and Vita Salute San Raffaele University Milan Italy Hospices Civils de Lyon Lyon France Helix San Mateo CA USA Department of Intensive Care Medicine Critical Care Center CHU Lille Lille France Univ. Lille CNRS Inserm CHU Lille Institut Pasteur de Lille U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité deLille Lille France Shupyk National Medical Academy for Postgraduate Education Kiev Ukraine Department of Medical Microbiology University Medical Center Utrecht Utrecht The Netherlands Sidra Medicine Doha Qatar Primary Immunodeficiencies Group Department of Microbiology and Parasitology School of Medicine University of Antioquia Medellín Colombia School of Microbiology University of Antioquia Medellín Colombia IIBB-CSIC IDIBAPS Barcelona Spain Department of Immunology Second Faculty of Medicine Charles University University Hospital in Motol Prague Czech Republic Department of Immunology Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia Pulmonology Department Cliniques Universitaire

SARS-CoV-2 infection is benign in most individuals but,in-10%of cases,it triggers hypoxemic COVID-19 pneumonia,which becomes critical in-3%of *** ensuing risk of death(-1%)doubles every five years from childhood onward and is-1.5 times greater in men than in *** are the molecular and cellular determinants of critical COVID-19 pneumonia?Inborn errors of type I IFNs,including autosomal TLR3 and X-linked TLR7 deficiencies,are found in-1-5%of patients with critical pneumonia under 60 years old.

关键词： pneumonia critical cases

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Nat Genet:单基因突变导致过敏性皮炎的发生

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现代生物医学进展 2017年第27期17卷 I0004-I0004页

作者： Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D stone, Joshua D Milner Jeffrey R stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg laboratory of Allergic diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland USA Department of Pharmacology and Molecular Therapeutics Uniformed Services University of the Health Sciences Bethesda Maryland USA Immunodeficiency Diagnosis and Treatment Program Department of Pediatrics National Jewish Health Denver Colorado USA Department of Translational Medicine University of Piemonte Orientale Novara Italy Department of Immunobiology Yale University School of Medicine New Haven Connecticut USA Immunology Service Department of Laboratory Medicine NIH Clinical Center National Institutes of Health Bethesda Maryland USA human Immunological Disease Section National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland USA Merck Research Laboratories Merck and Co. Inc. Boston Massachusetts USA Clinical Research Directorate/Clinical Monitoring Research Program Leidos Biomedical Research Inc. NCI Campus at Frederick Frederick Maryland USA Servicio de Immunología y Reumatología Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan Buenos Aires Argentina Division of Dermatology Department of Medicine Washington University School of Medicine St. Louis Missouri USA Department of Pediatrics Division of Rheumatology and Department of Pathology and Immunology Washington University School of Medicine St. Louis Missouri USA Department of Pediatrics Children’s Hospital of Philadelphia Philadelphia Pennsylvania USA.

最近，研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变：CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析，发现了这一导致疾病产生的基因、

关键词：过敏性皮炎基因突变 Nat 神经性皮炎血缘关系研究所传染病 NIH

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