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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye Yan Sun Jing Cai Fubing Yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State key laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State key laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Designing a multi-epitope vaccine against Peptostreptococcus anaerobius based on an immunoinformatics approach

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Synthetic and Systems Biotechnology 2023年第4期8卷 757-770页

作者： Yudan Mao Xianzun Xiao Jie Zhang Xiangyu Mou Wenjing Zhao shenzhen key laboratory of Systems Medicine for inflammatory diseases School of MedicineShenzhen Campus of Sun Yat-Sen UniversityShenzhenGuangdong518107China

Peptostreptococcus anaerobius is an anaerobic bacterium,which has been found selectively en-riched in the fecal and mucosal microbiota of colorectal cancer(CRC)*** evidence suggest *** may contribute to the development of CRC in *** this study,we designed a multi-epitope chimeric vaccine against *** PCWBR2,a recently identified adhesin that interacts directly with colon cell lines by bindingα2/β1 integrin frequently overexpressed in human CRC tumors and cell *** tools predicted six cytotoxic T lymphocyte epitopes,five helper T lymphocyte epitopes,and six linear B lymphocyte *** predicted epitopes were joined with AAY or GPGPG linkers and a previously reported TLR4 agonist was added to the vaccine construct’s N terminal as an adjuvant using EAAAK linkers and the order of epitopes was *** in silico analysis revealed that the vaccine construct possesses satisfactory antigenicity,allergenicity,solubility,physicochemical properties,adjuvant-TLR4 molecular docking,and immune profile *** study provided a promising design for vaccines against ***.

关键词： Colorectal cancer Peptostreptococcus anaerobius PCWBR2 Immunoformatics Multi-epitope

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Did ZIKV evolve to be more dangerous? A new clue towards neurovirulence

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National Science Review 2018年第2期5卷 121-122页

作者： Gary Wong George F.Gao Guangdong key laboratory for Diagnosis and Treatment of Emerging Infectious diseases Shenzhen Key Laboratory of Pathogen and Immunity Shenzhen Third People's Hospital CAS key laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences

Before 2015,Zika virus(ZIKV)was a little-known flavivirus that caused sporadic symptomatic infections in humans(under 20 reported cases,but likely manymore unreported asymptomatic cases)in the decades following its di... 详细信息

关键词： ZIKA virus FLAVIVIRUSES EPIDEMICS

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Mechanisms and strategies to overcome immunotherapy resistance in hepatobiliary malignancies

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Hepatobiliary & Pancreatic diseases International 2022年第5期21卷 430-439页

作者： Jia Xiong Qing-Qing Wang Institute of Immunology Zhejiang University School of MedicineHangzhou 310058China The key laboratory for immunity and inflammatory diseases of Zhejiang Province Hangzhou 310058China

Unprecedented advances have been achieved in hepatobiliary cancer treatment with immune checkpoint blockade(ICB).However,the efflcacy of ICB in patients with hepatobiliary malignancies is still *** to immunotherapies is often orchestrated by complicated tumor-host-microenvironment interactions but could also occur after initial efflcacy,mostly when only partial responses are *** of cancer-resistance mechanisms will be beneficial to provide the rationale for the administration of personalized ***,we review the factors related to resistance to immune-targeted therapies in hepatobiliary malignancies and discuss the potential strategies for overcoming resistance and future directions of immunotherapy development.

关键词： Cancer immunotherapy Hepatobiliary malignancies Immune checkpoint blockade Drug resistance

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Circular RNAs:implications of signaling pathways and bioinformatics in human cancer

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Cancer Biology & Medicine 2023年第2期20卷 104-128页

作者： Fan Hu Yin Peng Xinmin Fan Xiaojing Zhang Zhe Jin Guangdong Provincial key laboratory of Genome Stability and Disease Prevention and Regional immunity and diseases Department of PathologySchool of Basic Medical SciencesMedical SchoolShenzhen UniversityShenzhen 518060China

Circular RNAs(circRNAs)form a class of endogenous single-stranded RNA transcripts that are widely expressed in eukaryotic *** RNAs mediate post-transcriptional control of gene expression and have multiple functions in biological processes,such as transcriptional regulation and *** serve predominantly as microRNA sponges,RNA-binding proteins,and templates for *** importantly,circRNAs are involved in cancer progression,and may serve as promising biomarkers for tumor diagnosis and *** traditional experimental methods are usually time-consuming and laborious,substantial progress has been made in exploring potential circRNA-disease associations by using computational models,summarized signaling pathway data,and other ***,we review the biological characteristics and functions of circRNAs,including their roles in ***,we focus on the signaling pathways associated with carcinogenesis,and the status of circRNA-associated bioinformatics ***,we explore the potential roles of circRNAs as prognostic biomarkers in cancer.

关键词： circRNA cancer signaling pathway database bioinformatics

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The immune landscape of esophageal cancer

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Cancer Communications 2019年第1期39卷 670-682页

作者： Tu-Xiong Huang Li Fu Guangdong Provincial key laboratory of Regional immunity and diseases Department of Pathology and Shenzhen International Cancer CenterShenzhen University Health Science CenterShenzhen 518060GuangdongP.R.China

Esophageal cancer(EC)seriously threatens human health,and a promising new avenue for EC treatment involves cancer *** improve the efficacy of EC immunotherapy and to develop novel strategies for EC prognosis prediction or clinical treatment,understanding the immune landscapes in EC is *** cells harbor abundant tumor antigens,including tumor-associated antigens and neoantigens,which have the ability to initiate dendritic cell-mediated tumor-killing cytotoxic T lymphocytes in the early stage of cancer *** EC cells battle the immune system,they obtain an ability to suppress antitumor immunity through immune checkpoints,secreted factors,and negative regulatory immune ***-associated fibroblasts also contribute to the immune evasion of EC *** factors of the immune landscape in EC tumor microenvironment are associated with cancer development,patient survival,or treatment *** on the immune landscape,peptide vaccines,adoptive T cell therapy,and immune checkpoint blockade can be used for EC *** strategies are required for better clinical outcome in *** review provides directions to design novel and effective strategies for prognosis prediction and immunotherapy in EC.

关键词： Esophageal cancer Immune landscape Prognosis Immunotherapy

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The role of myeloid-derived suppressor cells in gastrointestinal cancer

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Cancer Communications 2021年第6期41卷 442-471页

作者： Cheng Cui Penglin Lan Li Fu Guangdong Provincial key laboratory of Regional immunity and diseases Department of Pharmacology and International Cancer CentreShenzhen University School of MedicineShenzhenGuangdong 518055P.R.China

Gastrointestinal(GI)cancer encompasses a range ofmalignancies that originate in the digestive system,which together represent the most common form of cancer diagnosed ***,despite numerous advances in both diagnostics and treatment,the incidence and mortality rate of GI cancer are on the ***-derived suppressor cells(MDSCs)are a heterogeneous population of immature myeloid cells that increase in number under certain pathological conditions,such as infection and inflammation,and this expansion is of particular relevance to *** are heavily involved in the regulation of the immune system and act to dampen its response to tumors,favoring the escape of tumor cells from immunosurveillance and increasing both metastasis and *** recent studies have supported the use of MDSCs as a prognostic and predictive biomarker in patientswith cancer,and potentially as a novel treatment *** the present review,the mechanisms underlying the immunosuppressive functions of MDSCs are described,and recent researches concerning the involvement of MDSCs in the progression,prognosis,and therapies of GI cancer are *** aim of this work was to present the development of novel treatments targeting MDSCs in GI cancer in the hope of improving outcomes for patients with this condition.

关键词： gastrointestinal cancer tumor immunology myeloid-derived suppressor cells progression prognosis therapy

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Pluripotent Stem Cell-derived Strategies to Treat Acute Liver Failure: Current Status and Future Directions

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 692-699页

作者： Jingfeng Liu Zhiming Yuan Qingwen Wang Institute of Biomedicine and Biotechnology Shenzhen Institute of Advanced TechnologyChinese Academy of ScienceShenz-henGuangdongChina shenzhen key laboratory of immunity and inflammatory diseases Peking University Shenzhen Hospi-talShenzhenGuangdongChina Department of Rheumatism and Immunology Peking University Shenzhen HospitalShenz-henGuangdongChina Department of Gastroenterology Peking University Shenzhen HospitalShenzhenGuangdongChina

Liver disease has long been a heavy health and economic burden *** the disease is out of control and progresses to end-stage or acute organ failure,orthotopic liver transplantation(OLT)is the only therapeutic alternative,and it requires appropriate donors and aggressive administration of immunosuppressive ***,hepatocyte transplantation(HT)and bioartificial livers(BALs)have been proposed as effective treatments for acute liver failure(ALF)in *** human primary hepatocytes(PHs)are an ideal cell source to support these methods,the large demand and superior viability of PH is needed,which restrains its wide ***,a finding alternative to meet the quantity and quality of hepatocytes is *** this context,human pluripotent stem cells(PSC),which have unlimited proliferative and differential potential,derived hepatocytes are a promising renewable cell *** studies of the differentiation of PSC into hepatocytes has provided evidence that supports their clinical *** this review,we discuss the recent status and future directions of the potential use of PSC-derived hepatocytes in treating *** also discuss opportunities and challenges of how to promote such strategies in the common applications in clinical treatments.

关键词： Acute liver failure Hepatocyte transplantation Human pluripotent stem cells Bioartificial liver system

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Shikonin alleviates collagen-induced arthritis mice by inhibiting M1 macrophage polarization

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Journal of Traditional Chinese Medicine 2022年第6期42卷 932-939页

作者： HE Lianhua LUAN Huijie QIN Qingxia HE Juan CHEN Jian HU Yiping CAI Yueming SUN Desheng SHI Yu WANG Qingwen Department of Rheumatism and Immunology Peking University Shenzhen HospitalShenzhen 518036China shenzhen China Resources Sanjiu Pharmaceutical Trading Co. Ltd.Shenzhen 518029China The key laboratory of inflammatory and Immunology diseases Shenzhen 518036China Department of ultrasound Peking University Shenzhen HospitalShenzhen 518036China

OBJECTIVE: To investigate the effects of shikonin(SKN) on M1 and M2 polarization of macrophages both in vitro and in vivo. METHODS: Collagen-induced arthritis(CIA) in male DBA/1 mice were treated with a dose of 4 mg/kg/day of SKN for 23 d(n = 6/group). The histopathology of inflamed joints in CIA mice was evaluated to test the antiarthritic effect of SKN. M1/M2 polarization of macrophages induced by lipopolysaccharide(LPS) and interferon(IFN)-γ or interleukin(IL)-4 and IL-13, were used to assess the effect of SKN(0.05, 0.1, and 0.2 μM). The effect of SKN on the protein expression of nitric oxide synthase, arginase, CD68, and CD206 was evaluated using western blot analysis. RESULTS: The results of this study revealed that SKN delayed the arthritis feet symptom score, reduced the incidence rate of arthritis, and relieved the inflammation of joints in CIA mice. SKN inhibited M1 macrophage polarization but did not affect M2 macrophage polarization in the joints of CIA mice. Moreover, SKN inhibited M1 polarization induced by LPS and IFN-γ, but did not affect M2 polarization induced by IL-4 and IL-13. CONCLUSION: These findings suggest that SKN alleviated CIA through inhibiting M1 macrophage polarization and has great potential as a new drug for RA treatment.

关键词： Shikonin arthritis rheumatoid macrophages M1 polarization

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In situ immunomodulation of tumors with biosynthetic bacteria promote anti-tumor immunity

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Bioactive Materials 2024年第2期32卷 12-27页

作者： Zhongda Lin Fanqiang Meng Yumeng Ma Chi Zhang Zhirang Zhang Zhaoxin Yang Yuan Li Linlin Hou Yuzhong Xu Xin Liang Xudong Zhang shenzhen key laboratory for Systems Medicine in inflammatory diseases School of MedicineShenzhen Campus of Sun Yat-Sen UniversitySun Yat-Sen UniversityShenzhen518107GuangdongChina Guangdong Provincial key laboratory of Medical Molecular Diagnostics Key Laboratory of Stem Cell and Regenerative Tissue EngineeringSchool of Basic Medical SciencesGuangdong Medical UniversityDongguan523808China Department of Clinical laboratory Shenzhen Baoan HospitalThe Second Affiliated Hospital of Shenzhen UniversityShenzhen518101China

Immune checkpoint blockade(ICB)therapy potently revives T cell’s response to ***,patients suffered with tumors that had inadequate infiltrated immune cells only receive limited therapeutic benefits from ICB *** biology promotes the alternative strategy of harnessing tumor-targeting bacteria to synthesize therapeutics to modulate immunity in ***,we engineered attenuated Salmonella typhimurium VNP20009 with gene circuits to synthetize granulocyte-macrophage colony-stimulating factor(GM-CSF)and interleukin 7(IL-7)within tumors,which recruited dendritic cells(DCs)and enhanced T cell priming to elicit anti-tumor *** bacteria-produced GM-CSF stimulated the maturation of bone marrow-derived dendritic cells(BMDCs),while IL-7 promoted the proliferation of spleen isolated T cells and inhibited cytotoxicity T cell apoptosis in ***,engineered VNP20009 prefer to colonize in tumors,and inhibited tumor growth by enhancing DCs and T cell ***,the tumor-toxic GZMB^(+)CD8^(+)T cell and IFN-γ^(+)CD8^(+)T cell populations conspicuously increased with the treatment of engineered *** combination of GM-CSF-IL-7-VNP20009 with PD-1 antibody synergistically stunted the tumor progress and metastasis.

关键词： Salmonella GM-CSF IL-7 Synthetic biology Cancer immunotherapies

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