The immune landscape of esophageal cancer
作者机构：Guangdong Provincial Key Laboratory of Regional Immunity and DiseasesDepartment of Pathology and Shenzhen International Cancer CenterShenzhen University Health Science CenterShenzhen 518060GuangdongP.R.China
出 版 物：《Cancer Communications》 (癌症通讯（英文）)
年 卷 期：2019年第39卷第1期
页 面：670-682页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by grants from the National Key R&D Program of China(2017YFA0503900) the National Natural Science Foundation of China(81372583 and 81772957) the Science and Technology Program of Guangdong Province in China(2019B030301009) the Industry and Information Technology Foundation of Shenzhen(20180309100135860)
主 题：Esophageal cancer Immune landscape Prognosis Immunotherapy
摘 要：Esophageal cancer(EC)seriously threatens human health,and a promising new avenue for EC treatment involves cancer *** improve the efficacy of EC immunotherapy and to develop novel strategies for EC prognosis prediction or clinical treatment,understanding the immune landscapes in EC is *** cells harbor abundant tumor antigens,including tumor-associated antigens and neoantigens,which have the ability to initiate dendritic cell-mediated tumor-killing cytotoxic T lymphocytes in the early stage of cancer *** EC cells battle the immune system,they obtain an ability to suppress antitumor immunity through immune checkpoints,secreted factors,and negative regulatory immune ***-associated fibroblasts also contribute to the immune evasion of EC *** factors of the immune landscape in EC tumor microenvironment are associated with cancer development,patient survival,or treatment *** on the immune landscape,peptide vaccines,adoptive T cell therapy,and immune checkpoint blockade can be used for EC *** strategies are required for better clinical outcome in *** review provides directions to design novel and effective strategies for prognosis prediction and immunotherapy in EC.
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