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Multimorbidity and mortality among older patients with coronary heart disease in shenzhen,China

Journal of Geriatric Cardiology 2024年第1期21卷 81-89页

作者： Fu-Rong LI Shuang WANG Xia LI Zhi-Yuan CHENG Cheng JIN Chun-Bao MO Jing ZHENG Feng-Chao LIANG Dong-Feng GU shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine Southern University of Science and TechnologyShenzhenGuangdongChina School of Public Health and Emergency Management Southern University of Science and TechnologyShenzhenGuangdongChina shenzhen Health Development Research and Data Management Center ShenzhenChina School of Medicine Southern University of Science and TechnologyShenzhenGuangdongChina

BACKGROUND The current understanding of the magnitude and consequences of multimorbidity in Chinese older adults with coronary heart disease(CHD)is *** aimed to assess the association and population-attributable fractions(PAFs)between multimorbidity and mortality among hospitalized older patients who were diagnosed with CHD in shenzhen,*** We conducted a retrospective cohort study of older Chinese patients(aged≥65 years)who were diagnosed with *** proportional hazards models were used to estimate the associations between multimorbidity and all-cause and cardiovascular disease(CVD)*** also calculated the *** The study comprised 76,455 older hospitalized patients who were diagnosed with CHD between January 1,2016,and August 31,*** them,70,217(91.9%)had multimorbidity,defined as the presence of at least one of the predefined 14 chronic *** with cancer,hemorrhagic stroke and chronic liver disease had the worst overall death risk,with adjusted HRs(95%CIs)of 4.05(3.77,4.38),2.22(1.94,2.53),and 1.85(1.63,2.11),*** CVD mortality,the highest risk was observed for hemorrhagic stroke,ischemic stroke,and chronic kidney disease;the corresponding adjusted HRs(95%CIs)were 3.24(2.77,3.79),1.91(1.79,2.04),and 1.81(1.64,1.99),***-cause mortality was mostly attributable to cancer,heart failure and ischemic stroke,with PAFs of 11.8,10.2,and 9.1,*** for CVD mortality,the leading PAFs were heart failure,ischemic stroke and diabetes;the corresponding PAFs were 18.0,15.7,and 6.1,*** Multimorbidity was common and had a significant impact on mortality among older patients with CHD in shenzhen,***,heart failure,ischemic stroke and diabetes are the primary contributors to ***,prioritizing improved treatment and management of these comorbidities is essential for the survival prognosis of CHD patients from a holistic public health perspective.

关键词： patients morbidity mortality

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Isolation and characterization of mpox virus from the first mpox case in shenzhen,China

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Virologica Sinica 2024年第2期39卷 335-337页

作者： Lin Cheng Liuqing Yang Miao Wang Yabo Peng Haiyan Wang Xiaoxiang Yang Juanjuan Zhao Mingxia Zhang Fuxiang Wang Zheng Zhang Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalShenzhen518112China Department of Infectious Diseases Shenzhen Third People's HospitalShenzhen 518112China The Second Affiliated Hospital School of MedicineSouthern University of Science and TechnologyShenzhen 518112China

Dear Editor,Unlike previous outbreaks of the mpox(previously known as monkeypox),which were localized in Africa and resulted in small numbers of infections due to limited human-to-human transmission,the current outbreak beginning in May 2022,has spread rapidly primarily through human-to-human transmission in non-endemic countries(Gong et al.,2022).As of 27 Sep 2023,115 countries and regions have reported cases of mpox to the World Health Organization(WHO),bringing the total number of confirmed cases to 90,618 including 125 *** the number of new cases has decreased in most WHO regions in the second half of 2022,the curves reveal a long outbreak tail in different subregions of the *** worrying,106 mpox cases were reported in the mainland of China in June 2023.

关键词： mainland bringing

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Flashover Characteristics of Dry Band-water band on Hydrophobic Surfaces

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 392-400页

作者： Xiaohan Wu Fanghui Yin Bin Cao Daiming Yang Shichao Shao Liming Wang Tsinghua-Berkeley shenzhen Institute(TBSI) Shenzhen 518055China shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China shenzhen Polytechnic School Shenzhen 518055China

Due to their outstanding anti-flashover characteristics,composite insulators have been extensively applied in power systems.A lot of research has investigated flashover characteristics of hydrophobic specimens with artificial water ***,the phenomenon is not consistent with that of the contaminated composite *** the test specimens covered with water droplets,there is no obvious leakage current before the flashover and no obvious relationship between flashover voltage and the conductivity of water *** the contaminated composite insulator surface,there are short continuous arcs on the insulators before critical flashover,making insulators look like a luminous *** that under these two conditions,the proportion of water along the insulation distance is different,the flashover characteristic of“dry band-water band”on a hydrophobicity surface is analyzed in the present *** influence of the water band parameter(including length,width,and conductivity)as well as the length of dry band is *** this basis,the arc generation and development process of the surface covered with“dry band-water band”is *** research results improve the understanding of the flashover process on contaminated composite insulators.

关键词： Flashover characteristics hydrophobicity partial arc water band

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Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent ·CF_(2)H, CF_(2)H^(+), and :CF_(2) reactivities

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Science China Chemistry 2024年第3期67卷 953-962页

作者： Yuan-Qing Gu Hong-Xin Long Dan-Dan Zhang Mei-Feng Ruan Guo-Kai Liu School of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China

Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low ***,we report the design and synthesis of difluoromethyl phenoxathiinium tetrafluoroborate(PT-CF_(2)H^(+)BF_(4)^(-)) as a novel difluoromethylating reagent,which proves to be a bench-stable,general,powerful and versatile reagent with divergent·CF_(2)H,CF_(2)H^(+),and:CF_(2) *** use of this reagent,we demonstrated a vast array of difluoromethyl radical transfer reactions via diverse pathways involving photocatalyst-free visible-light induction,visible-light photoredox catalysis and visible-light mediation single electron transfer of EDA ***,the green and highly effective CF_(2)H^(+) and:CF_(2) transfer reactions were also readily accomplished.

关键词： difluoromethyl phenoxathiinium salt versatile difluoromethylating reagent difluoromethyl radical difluoromthyl cation difluorocarbene

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An overview of potential cardioprotective benefits of xanthophylls in atherosclerosis:an evidence-based review

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Food Science and Human Wellness 2024年第4期13卷 1739-1755页

作者： Yuting Su Feng Chen Jiehua Chen Mingfu Wang shenzhen Key Laboratory of Marine Microbiome Engineering Institute for Advanced StudyShenzhen UniversityShenzhen 518060China Institution for Innovative Development of Food Industry Shenzhen UniversityShenzhen 518060China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518060China shenzhen Key Laboratory of Food Nutrition and Health Shenzhen UniversityShenzhen 518060China

Atherosclerosis,as the most prevalent form of cardiovascular disease,is characterized by oxidized lowdensity lipoprotein(ox-LDL)accumulation in the vascular wall,increased inflammation of the large arteries,dysfunction of the endothelial cells(ECs)and vascular smooth muscle cells(VSMCs),which may eventually lead to the formation of ***,one of the main groups of carotenoids,have been proposed as preventive agents or adjunct therapies to prevent and slow the progression of atherosclerosis due to their cardioprotective ***,the underlying preventive mechanism of action of xanthophylls on the pathogenesis of atherosclerosis remains unclear,and clinical evidence of the effect of xanthophylls on atherosclerosis have not yet been summarized and critically *** this regard,we conducted a comprehensive literature search in four scientific databases(Pub Med,Google Scholar,Science Direct and Web of Science)and carefully analyzed the existing evidence to provide meaningful insights on the association between xanthophylls and atherosclerosis from various *** on the evidence from in vitro and in vivo studies,we explored several potential mechanisms,including antioxidant effect,anti-inflammatory effect,regulation of lipid metabolism,and modulation of ECs and VSMCs dysfunction,and we found that a clear picture of regulatory pathways of xanthophylls on atherosclerosis prevention and treatment is still *** addition,epidemiological studies suggested the possible relationship among high dietary intake of xanthophylls,high plasma/serum xanthophylls and a reduced risk of *** evidence from interventional studies investigating the effect of xanthophylls on atherosclerosis is very sparse,whilst indirect clinical evidence was only limited to astaxanthin and ***,well-designed long-term randomized controlled trials(RCTs)are highly recommended for future studies to investigate the effective dose of different

关键词： Atherosclerosis Xanthophylls Antioxidant Anti-inflammation Lipid metabolism

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Light-driven sextuple theranostics:nanomedicine involving second near-infrared AIE-active Ir(Ⅲ)complex for prominent cancer treatment

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Science China Chemistry 2024年第7期67卷 2314-2324页

作者： Xue Liu Jiangao Li Fei Zhang Dingyuan Yan Lei Wang Dong Wang Ben Zhong Tang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Material Science and EngineeringShenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Light-driven cancer theranostics has shown inexhaustible and vigorous vitality by virtue of its high efficacy,prominent controllability and *** of an all-round theranostic material simultaneously affording both multimodal diagnosis imaging and synergistic phototherapy would be an appealing yet significantly challenging ***,a novel nanomedicine Ir@PPEG-MeEPO was ingeniously constructed by integrating beforehand1O2-charged amphiphilic polymer and well-tailored Ir(Ⅲ)complex IrDPTP,which was featured by second near-infrared(NIR-Ⅱ)aggregation-induced emission(AIE)tendency,efficient reactive oxygen species(ROS)generation,good photothermal conversion efficiency and high-performance hydrogen gas *** the best of our knowledge,IrDPTP held the longest emission wavelength among all reported AIE Ir(Ⅲ)***,Ir@PPEG-MeEPO was capable of controllably releasing ROS via triggered photothermal effect upon NIR irradiation,making it well-adapted to hypoxic environment of *** distinctive characteristics of Ir@PPEG-MeEPO endowed it with unprecedented performance on sextuple theranostics comprised of NIR-Ⅱfluorescence-photoacoustic-photothermal trimodal imaging and photodynamic-photothermal-hydrogen trimodal therapy,witnessed by the precise tumor diagnosis and complete tumor *** study would open up new perspectives for the exploration of superior nanomedicine for practical cancer theranostics.

关键词： aggregation-induced emission NIR-II emission cancer theranostics multimodal diagnosis imaging multimodal therapy

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Experimental and numerical investigation of the flexural performance of channel steel-bolt joint for prefabricated subway stations

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 918-935页

作者： Lei WANG Shengyang ZHOU Xiangsheng CHEN Xian LIU Shuya LIU Dong SU Shouchao JIANG Qikai ZHU Haoyu YAO College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518060China Key Laboratory of Coastal Urban Resilient Infrastructures(MOE) Shenzhen UniversityShenzhen 518061China shenzhen Key Laboratory of Green Efficient and Intelligent Construction of Underground Metro StationShenzhen UniversityShenzhen 518061China College of Civil Engineering Tongji UniversityShanghai 200092China shenzhen Municipal Design&Research Co. Ltd.Shenzhen 518029China shenzhen Metro Group Co. Ltd.Shenzhen 518026China

Flexural performance of joints is critical for prefabricated *** study presents a novel channel steel-bolt(CB)joint for prefabricated subway ***-scale tests are carried out to investigate the flexural behavior of the CB joint under the design loads of the test-case *** addition,a three dimensional(3D)finite element(FE)model of the CB joint is established,incorporating viscous contact to simulate the bonding and detachment behaviors of the interface between channel steel and *** on the 3D FE model,the study examines the flexural bearing mechanism and influencing factors for the flexural performance of the CB *** results indicate that the flexural behavior of the CB joint exhibits significant nonlinear characteristics,which can be divided into four *** illustrate the piecewise linearity of the bending moment-rotational angle curve,a four-stage simplified model is proposed,which is easily applicable in engineering *** study reveals that axial force can enhance the flexural capacity of the CB joint,while the preload of the bolt has a negligible *** flexural capacity of the CB joint is approximate twice the value of the designed bending moment,demonstrating that the joint is suitable for the test-case station.

关键词： channel steel-bolt joint flexural performance full-scale test numerical simulation prefabricated subway station

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Ultrahigh thermoelectric properties of p-type BixSb2-xTe3 thin films with exceptional flexibility for wearable energy harvesting

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CARBON ENERGY 2024年第8期6卷 273-284页

作者： Zheng, Zhuang-Hao Zhong, Yi-Ming Li, Yi-Liu Nisar, Mohammad Mansoor, Adil Li, Fu Chen, Shuo Liang, Guang-Xing Fan, Ping Xu, Dongyan Wei, Meng Chen, Yue-Xing shenzhen univ Coll Phys & Optoelect Engn Shenzhen Key Lab Adv Thin Films & Applicat Key Lab Optoelect Devices & Syst Minist Educ & Gua Shenzhen Peoples R China shenzhen univ Coll Phys & Optoelect Engn Shenzhen Key Lab Adv Thin Films & Applicat Key Lab Optoelect Devices & Syst Minist Educ & Gua Shenzhen 518060 Peoples R China Chinese univ Hong Kong Dept Mech & Automat Engn Sha Tin Hong Kong Peoples R China

Use of a flexible thermoelectric source is a feasible approach to realizing self-powered wearable electronics and the Internet of Things. Inorganic thin films are promising candidates for fabricating flexible power supply, but obtaining high-thermoelectric-performance thin films remains a big challenge. In the present work, a p-type BixSb2-xTe3 thin film is designed with a high figure of merit of 1.11 at 393 K and exceptional flexibility (less than 5% increase in resistance after 1000 cycles of bending at a radius of similar to 5 mm). The favorable comprehensive performance of the BixSb2-xTe3 flexible thin film is due to its excellent crystallinity, optimized carrier concentration, and low elastic modulus, which have been verified by experiments and theoretical calculations. Further, a flexible device is fabricated using the prepared p-type BixSb2-xTe3 and n-type Ag2Se thin films. Consequently, an outstanding power density of similar to 1028 mu W cm(-2) is achieved at a temperature difference of 25 K. This work extends a novel concept to the fabrication of high-performance flexible thin films and devices for wearable energy harvesting.

关键词： BixSb2-xTe3 electrical transport properties flexibility thermoelectric THERMAL-CONDUCTIVITY BI2TE3 FILMS PERFORMANCE SB2TE3 FIGURE MERIT ENHANCEMENT FABRICATION TRANSITION COMPOSITE

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Constructing hierarchical arrays with core-shell metal oxides@metal coordination polymers for efficient and stable overall water splitting

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Nano Research 2024年第6期17卷 4882-4888页

作者： Shuai Qi Jinlian Liao Kunzhong Chen Senkai Li Jinwen Zhao Tianchi Huang Na Meng Hengpan Yang Qi Hu Chuanxin He College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

Developing non-precious metal-based bifunctional electrocatalysts capable for both hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)is essential to achieve efficient water electrolysis for mass hydrogen production,however it remains ***,we report the synthesis of hierarchical nanorod arrays comprising core-shell structured P-doped NiMoO4@NiFe-coordination polymer(denoted as P-NiMoO4@NiFeCP)as bifunctional electrocatalysts for water ***,we systematically investigate the influence of NiFeCP shell thickness on electrocatalytic activity,manifesting the presence of strong interfacial synergetic effect between P-NiMoO4 and NiFeCP for boosting both the HER and *** advantageous hierarchical architectures and unique core-shell structures,optimized P-NiMoO_(4)@NiFeCP-7.3(7.3 is the shell thickness in nm)requires overpotentials of merely 256 and 297 mV to yield a current density of 1000 mA·cm^(−2)for the HER and OER in 1 M KOH,*** importantly,it can serve as a bifunctional electrocatalyst for efficient and sustainable overall water electrolysis,delivering large current densities of 500 and 1000 mA·cm^(−2)at low cell voltages of 1.804 and 1.865 V,along with high stability of over 500 h at 1000 mA·cm−2,demonstrating the great potential of this electrocatalyst towards practical applications.

关键词： hydrogen evolution reaction oxygen evolution reaction overall water splitting non-precious metal-based electrocatalysts core-shell structures

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Toxicity mechanisms of photodegraded polyvinyl chloride nanoplastics on pea seedlings

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 111-124页

作者： Hao Wu Beibei He Bocheng Chen An Liu College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

Nanoplasctics(NPs),which are very small in particle size,exert toxic effect to ***,compared to original NPs,photodegraded NPs would pose higher *** is because their relatively higher specific surface areas and the presence of additives which can more easily *** original NPs and aged NPs affect plant growth has not been widely *** work chose polyvinyl chloride NPs(PVC-NPs)that were subjected to up to 1000 h UV light radiation to explore the impact of PVC-NPs on the growth of pea seedlings(Pisum Sativum L.).The results indicated the existence of PVC-NPs with longer UV light radiation time and higher concentrations had more negative influences on pea seedlings’growth such as germination rate(decreased by 10.6%–22.5%),stem length(decreased by 2.8%–8.1%),dry weight(decreased by 6.3%–7.1%)and fresh weight(decreased by 6.7%–14.8%).It was also noted that photodegraded PVC-NPs resulted in damage to leaf stomata and roots,hindering photosynthesis and absorption of nutrients and hence the decrease in chlorophyll and soluble sugar *** to transcriptomic investigation results,the presence of aged PVC-NPs primarily influenced protein processing in endoplasmic reticulum(upregulated metabolic pathway)and phenylpropanoid biosynthesis(downregulated metabolic pathway)of pea *** results provide an in-depth understanding of how NPs influence the growth of plants.

关键词： Nanoplasctics Polyvinyl chloride Toxicity mechanisms Plant growth

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