An overview of potential cardioprotective benefits of xanthophylls in atherosclerosis:an evidence-based review

作     者：Yuting Su Feng Chen Jiehua Chen Mingfu Wang Yuting Su;Feng Chen;Jiehua Chen;Mingfu Wang

作者机构：Shenzhen Key Laboratory of Marine Microbiome EngineeringInstitute for Advanced StudyShenzhen UniversityShenzhen 518060China Institution for Innovative Development of Food IndustryShenzhen UniversityShenzhen 518060China College of Civil and Transportation EngineeringShenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Food Nutrition and HealthShenzhen UniversityShenzhen 518060China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2024年第13卷第4期

页      面：1739-1755页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1002[医学-临床医学] 08[工学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 083201[工学-食品科学] 10[医学] 

基　　金：supported by the National Key R&D Program of China(YFD2100103) 

主　　题：Atherosclerosis Xanthophylls Antioxidant Anti-inflammation Lipid metabolism 

摘      要：Atherosclerosis,as the most prevalent form of cardiovascular disease,is characterized by oxidized lowdensity lipoprotein(ox-LDL)accumulation in the vascular wall,increased inflammation of the large arteries,dysfunction of the endothelial cells(ECs)and vascular smooth muscle cells(VSMCs),which may eventually lead to the formation of ***,one of the main groups of carotenoids,have been proposed as preventive agents or adjunct therapies to prevent and slow the progression of atherosclerosis due to their cardioprotective ***,the underlying preventive mechanism of action of xanthophylls on the pathogenesis of atherosclerosis remains unclear,and clinical evidence of the effect of xanthophylls on atherosclerosis have not yet been summarized and critically *** this regard,we conducted a comprehensive literature search in four scientific databases(Pub Med,Google Scholar,Science Direct and Web of Science)and carefully analyzed the existing evidence to provide meaningful insights on the association between xanthophylls and atherosclerosis from various *** on the evidence from in vitro and in vivo studies,we explored several potential mechanisms,including antioxidant effect,anti-inflammatory effect,regulation of lipid metabolism,and modulation of ECs and VSMCs dysfunction,and we found that a clear picture of regulatory pathways of xanthophylls on atherosclerosis prevention and treatment is still *** addition,epidemiological studies suggested the possible relationship among high dietary intake of xanthophylls,high plasma/serum xanthophylls and a reduced risk of *** evidence from interventional studies investigating the effect of xanthophylls on atherosclerosis is very sparse,whilst indirect clinical evidence was only limited to astaxanthin and ***,well-designed long-term randomized controlled trials(RCTs)are highly recommended for future studies to investigate the effective dose of different