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Engineering of Fe d-band center in Fe_(3)O_(4)/CeO_(2)hetero-nanoparticles via orbital coupling for high-efficiency oxygen reduction electrocatalysis

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Nano Research 2025年第1期18卷 129-139页

作者： Jiayi Liu Jingwen Yin Yingzi Lin Mingxin Pang Huan Pang Songtao Zhang Lin Xu Jun Yang Yawen Tang Jiangsu key laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023Chin a 2 State key laboratory of Multiphase Complex Systems Center of MesoscienceInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009China Testing Center Yangzhou UniversityYangzhou 225009China

The deliberate engineering of the d-band center of metal site represents an effective strategy to boost the intrinsic electrocatalytic performance toward the oxygen reduction reaction(ORR).Herein,following a heterointerfaceinduced orbital coupling rationale,we report a judicious design of an efficient ORR electrocatalyst consisting of Fe_(3)O_(4)/CeO_(2)hetero-nanoparticles in-situ encased into N-doped carbon nanofibers(abbreviated as Fe_(3)O_(4)/CeO_(2)@N-CNFs hereafter).The theoretic calculations uncover that the Fe_(3)O_(4)/CeO_(2)heterointerface-triggered orbital coupling can cause the down shift of the d-band center positions of Fe sites,which leads to the weakened chemisorption of oxygenated groups and lowered energy barrier for the potential-determining step,ultimately dramatically boosting the ORR intrinsic *** a consequence,the well-designed Fe_(3)O_(4)/CeO_(2)@N-CNFs display admirable ORR activity with a half-wave potential of 0.84 V and outstanding structural/electrochemical stability in an alkaline electrolyte,surpassing the commercial Pt/C benchmark and a majority of recently reported Fe_(3)O_(4)-based *** encouragingly,the Fe_(3)O_(4)/CeO_(2)@N-CNFsincorporated Zn-air battery outperforms the Pt/C-assembled counterpart with higher power density,larger energy density,and excellent cycling stability,serving as a competent candidate for ORR-involved renewable energy *** study offers an innovative approach for the rational manipulation of the d-band center and interfacial electron behavior of active sites toward the optimization of electrocatalytic performance.

关键词： hetero-nanoparticles electrospinning interfacial engineering orbital coupling oxygen reduction reaction

Regulation of graphdiyne-based nanozymes with enhanced oxidaselike activity by cobalt and nitrogen codoping

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Nano Research 2025年第1期18卷 21-29页

作者： Jiali Liu Xiaoli Wang Yongfu Lian Xue Wang Xiuxiu Wang Xingfa Gao Baoyun Sun Xihong Guo CAS key laboratory for biomedical Effects of Nanomaterial&Nanosafety Institute of High Energy PhysicsChinese Academy of ScienceBeijing 100049China key laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China laboratory of Theoretical and Computational Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The development of nanozymes with excellent intrinsic oxidase-like activity and specificity has received increasing ***(GDY)could be a promising choice for designing nanozymes with enhanced oxidase(OXD)-like activity due to its unique structure and ***,Co-N-GDY with high OXD activity but no peroxidase(POD)activity was synthesized by codoping of cobalt(Co)and nitrogen(N)into GDY and compared with other GDY-based nanozymes(including GDY,Co-GDY,and N-GDY).Upon analyzing the doping effect of Co and N on the OXD-like and POD-like activities,we found that the combination of Co and N in GDY played a significant role in enhancing the OXD-like activity,and even reversed the POD-like activity of N-GDY to OXD-like activity of *** electrochemical experiment and the theoretical calculations provided an explanation for the mechanism and showed that the activity was closely linked to the reduction ability of O_(2) or H_(2)O_(2) on the nanozyme substrates,which was determined by the ratedetermining step of the catalytic reaction.

关键词： nanozymes oxidase-like activity graphdiyne heteroatom doping regulation

Silicon-based metal-organic frameworks(SiMOFs)for immunogenic cell death in cancer therapy

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Nano Research 2025年第1期18卷 628-641页

作者： Min Han Zishan Chen Shiying Zhou Zunde Liao Xiangting Yi Yao He Yiling Zhong Kam W.Leong College of Pharmacy State Key Laboratory of Bioactive Molecules and Druggability AssessmentJinan UniversityGuangzhou 511443China Department of biomedical Engineering Columbia UniversityNew YorkNY 10027USA Institute of Functional Nano and Soft materials(FUNSOM) Soochow UniversitySuzhou 215123China

Silicon-based nanomaterials,known for their unique properties and favorable biocompatibility,significantly impact sectors like energy,electronics,and ***,metalorganic frameworks(MOFs)have emerged as promising candidates for biomedicine,characterized by adjustable chemical composition,high porosity,and ***,the combination of silicon with MOFs to create silicon-based MOF nanostructures(SiMOFs)remains ***,we establish a diverse library of SiMOFs with various nanostructures,including flower-like,capsule-like,hexagonal snowflake-like,and necklace-like morphologies via microwave-assisted *** SiMOFs,with their spacious interiors,are ideal for drug *** are used to load drugs and create drug-loaded SiMOFs(e.g.,SiFeO).SiFeO exhibits excellent photothermal effects and high reactive oxygen species(ROS)generation capacity,enabling synergistic treatments involving chemochemodynamic-photothermal *** approach efficiently triggers immunogenic cell death(ICD)and demonstrates excellent antitumor efficacy in *** staining reveals that the synergistic therapy can modulate the tumor microenvironment(TME)by reducing M2-phenotype macrophages,increasing the activation of antigen-presenting cells(APCs),enhancing the infiltration of CD4^(+)and CD8^(+)T cells,elevating Granzyme B production,and decreasing the presence of immunosuppressive regulatory T cells(Tregs).Consequently,drug-loaded SiMOFs-mediated combination therapy effectively reverses the immunosuppressive TME and activates robust antitumor immune responses by inducing ICD in tumor cells,ultimately achieving superior anticancer efficacy.

关键词： silicon-based nanomaterials nanocarriers immunogenic cell death antitumor immune responses

Preparation of TiO_(2) Nano-Flower Coating on Ti Substrates with Good Physical Sterilization Effect and Biocompatibility

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Acta metallurgica Sinica(English Letters) 2024年第9期37卷 1581-1589页

作者： Ruoyu Di Yonghua Sun Runhua Yao Sen Pei Xiaohong Yao Ruiqiang Hang shanxi key laboratory of biomedical metal materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan030024China College of Safety and Emergency Management Engineering Taiyuan University of TechnologyTaiyuan030024China

We report a facile solution method to form titanium oxide(TiO_(2))nano-flower structure on the titanium(Ti)substrates for realizing good physical sterilization and *** first prepare TiO_(2) nanotubes(NT)with a diameter of about 80-100 nm and a length of about 5μm on Ti substrates by anodization,which is utilized as ***,we employ immersion treatment in different concentrations of phosphoric acid solution at 75℃ for 5 h to realize the transformation from TiO_(2) NT to TiO_(2) nano-flower *** addition,we studied the effects of phosphoric acid concentration(1 wt%,2.5 wt%,5 wt% and 10 wt%)on the TiO_(2) nano-flower structure,and the antibacterial properties and biocompatibility of the TiO_(2) nano-flower *** results show that TiO_(2) nano-flower structure become larger and thicker with the increase in the phosphoric acid concentration,and the thickness of the coating can reach 6.88μ***,the TiO_(2) nano-flower structure shows good physical sterilization effect,especially for the TiO_(2) nano-flower structure formed in 10 wt%H^(3)PO_(4) solution,the antibacterial rate can reach 95%.In addition,the TiO_(2) nano-flower structure have no toxicity to the osteoblasts and support cell growth.

关键词： Anodization Biocompatibility Physical sterilization TiO_(2)nano-flower

Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS key laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

维普期刊数据库

Microstructure evolution and corresponding tensile properties of Ti–5Al–5Mo–5V–1Cr–1Fe alloy controlling by multi-heat treatments

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Progress in Natural Science:materials International 2021年第5期31卷 731-741页

作者： Zedong Liu Zhaoxin Du Hanyu Jiang Tianhao Gong Xiaoming Cui Jingwen Liu Jun Cheng School of materials Science and Engineering Inner Mongolia University of Technology Inner Mongolia key laboratory of Light metal materials Inner Mongolia University of Technology Northwest Institute for Non-ferrous metal Research Shaanxi Key Laboratory of Biomedical Metal Materials

The effects of microstructure morphology on corresponding tensile mechanical properties of Ti–5Al–5Mo–5V–1Cr–1Fe alloy controlling by three different heat treatment conditions (solution,single-step and two-step aging) were investigated in the present *** results show that the solution temperature exhibited an important impact on the precipitation behavior of secondary-αphase (αs) during aging,in which the content ofαsgradually increased with the increase of solution *** the alloy was single-step aged at500–600~°C,the needle-likeαsprecipitated from matrix,as well as the content ofαsdecreased and coarsened corresponding to the increase of aging *** with single-step aging,theαsslightly increased when the alloy was subjected to two-step aging heat *** tensile results show that theαsis the main strengthening phase in the ***,its content as well as the intensity of the precipitation mode directly affects the strength,whereas inevitably with an accompanying penalty on *** general,the higher solution temperature and the lower first-step aging temperature result in a more intensiveαsand then lead to the higher ***,{10■2}and{10■1}twins were found in two-step aged tensile samples,which may impart twinning-induced plasticity (TWIP).Overall,this study demonstrates that the alloy can be heat treated to achieve an excellent match between strength and ductility and to provide sufficient stress and optional ductility(ultimate strength of 978–1439 MPa and elongation of 8.25–18.9%).

关键词： Titanium alloy Heat treatment Two-step aging Microstructures Tensile properties Twins

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University key laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National key laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang key laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine key laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Biodegradable porous Zn-1Mg-3βTCP scaffold for bone defect repair:In vitro and in vivo evaluation

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Journal of materials Science & Technology 2023年第31期162卷 189-202页

作者： Runhua Yao Hui Wang Ruifeng Shan Lin Liu Yuyu Zhao Yonghua Sun Xiaohong Yao Di Huang Ruiqiang Hang shanxi key laboratory of biomedical metal materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China shanxi Xinhua Chemical Defense Equipment Research Institute Co. LtdTaiyuan 030008China Research Center for Nano-Biomaterials&Regenerative Medicine Department of Biomedical EngineeringCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China shanxi-Zheda Institute of Advanced materials and Chemical Engineering Taiyuan 030060China

Zn-based materials are promising as bone repair materials,but their poor mechanical property and bioactivity as well as low degradation rate render the potential *** structural and material design can address the *** this study,porous Zn-1 wt.%Mg-3 vol.%β-TCP scaffolds with 40%and 60%preset porosities were fabricated via heating-press sintering using NaCl particles as space holders,and their mechanical properties,in vitro degradation behavior,cytotoxicity and in vivo osteogenic activities were *** results showed that the actual porosities of the scaffolds were 22%and 50%.Mg exists in the form of Zn 2 Mg and Zn 11 Mg 2,whileβ-TCP evenly distributed in the *** compressive yield strength of scaffolds ranges from approximately 58.46 to 71.04 MPa,which is close to that of cancellous *** in vitro degradation tests showed that the corrosion rate of the scaffolds was in the range of about 2.73-4.28 mm y^(-1).Moreover,the scaffolds not only provided great space for osteoblasts adhesion and proliferation in vitro but also possessed favorable degradability and osteogenic activity in *** porous Zn-1 wt.%Mg-3 vol.%β-TCP scaffolds manifest reliable mechanical properties,desirable degradability,and osteogenic activity,which are promising as next-generation bone repair materials.

关键词： Biodegradation Zn-based composites Porous scaffolds Bone repair

Grain refinement and phase precipitation simultaneously improve the strength and ductility of ultra-high strength titanium alloy sheets

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Progress in Natural Science:materials International 2024年第5期34卷 1066-1075页

作者： Xudong Kang Zhaoxin Du Shaojun Wang Jun Cheng Zhiyong Yue Tianhao Gong Jingshun Liu Shuzhi Zhang School of materials Science and Engineering Inner Mongolia University of Technology Collaborative Innovation Center of Non-ferrous metal materials and Processing Technology Co-constructed by the Provience and Ministry Inner Mongolia Autonomous Region Inner Mongolia University of Technology Northwest Institute for Non-Ferrous metal Research Shanxi Key Laboratory of Biomedical Metal Materials College of Mechanical Engineering Inner Mongolia University of Technology State key laboratory of Metastable materials Science and Technology Yanshan University

The simultaneous high strength and high plasticity of metastable-β titanium alloy sheets remains a difficult challenge. In this work, a 1.2 mm thick sheet of Ti–15Mo–3Al-2.7Nb-0.25Si titanium alloy was obtained after rolling and annealing, and then subjected to a duplex-ageing treatment. The pre-ageing temperatures fell in the range of 300–390°C for 0.5–2h. The re-ageing temperatures were in the range of 500–600°C. After characterization, it was found that the alloy precipitates ω-phases during the pre-ageing process, and the distribution of such ω-phases evolves unevenly and increases in number with the increase of the pre-ageing ***, the strengthening mechanism of the alloy sheet is mainly α-phase nucleation assisted by ω-***, grain refinement appears as a mechanism to ensure the plasticity of the alloy. Finally the ω-phase evolution law is discussed in detail and the strengthening mechanism of the alloy sheet is also analyzed. At this work, a metastable-β titanium alloy sheet with strength of 1445.75 MPa and elongation of 6.55 % was *** study provides a new idea for the microstructure design and process improvement of the metastable-β titanium alloy sheet.

关键词： Metastable-β titanium Duplex-ageing treatment ω-phase Strengthening mechanism