Biodegradable porous Zn-1Mg-3βTCP scaffold for bone defect repair:In vitro and in vivo evaluation
作者机构：Shanxi Key Laboratory of Biomedical Metal MaterialsCollege of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanxi Xinhua Chemical Defense Equipment Research Institute Co.LtdTaiyuan 030008China Research Center for Nano-Biomaterials&Regenerative MedicineDepartment of Biomedical EngineeringCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical EngineeringTaiyuan 030060China
出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)
年 卷 期：2023年第162卷第31期
页 面：189-202页
核心收录：
学科分类：08[工学] 080501[工学-材料物理与化学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）]
基 金：supported by the Key Research and Development Program of Shanxi Province(No.202102130501007) the Central Leading Science and Technology Development Foundation of Shanxi Province(No.YDZJSX2021A019) the Natural Science Foundation of Shanxi Province(Nos.202103021223102 and 202203021211173) Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(Nos.2021SX-AT008 and 2021SX-AT009)
主 题：Biodegradation Zn-based composites Porous scaffolds Bone repair
摘 要：Zn-based materials are promising as bone repair materials,but their poor mechanical property and bioactivity as well as low degradation rate render the potential *** structural and material design can address the *** this study,porous Zn-1 wt.%Mg-3 vol.%β-TCP scaffolds with 40%and 60%preset porosities were fabricated via heating-press sintering using NaCl particles as space holders,and their mechanical properties,in vitro degradation behavior,cytotoxicity and in vivo osteogenic activities were *** results showed that the actual porosities of the scaffolds were 22%and 50%.Mg exists in the form of Zn 2 Mg and Zn 11 Mg 2,whileβ-TCP evenly distributed in the *** compressive yield strength of scaffolds ranges from approximately 58.46 to 71.04 MPa,which is close to that of cancellous *** in vitro degradation tests showed that the corrosion rate of the scaffolds was in the range of about 2.73-4.28 mm y^(-1).Moreover,the scaffolds not only provided great space for osteoblasts adhesion and proliferation in vitro but also possessed favorable degradability and osteogenic activity in *** porous Zn-1 wt.%Mg-3 vol.%β-TCP scaffolds manifest reliable mechanical properties,desirable degradability,and osteogenic activity,which are promising as next-generation bone repair materials.
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