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Relationship between state transition and photoinhibition of photosynthesis in wheat leaves

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Chinese Science Bulletin 1997年第21期42卷 1839-1843页

作者： Tan, XX Xu, DQ Shen, YG shanghai med univ Shanghai Inst Plant Physiol Shanghai 200032 Peoples R China

IT is well known that state transitions can keep even distribution of excitation energy betweenthe two photosystems (PS Ⅱ and PS Ⅰ), favoring efficient operation of the photosyntheticapparatus. However, state transitions are usually thought to be associated with low light con-ditions. Its physiological significance under high light conditions is still a controversial is-suc. Many people think that state transitions occur and take significant effect only under

关键词： state transition photoinhibition alleviation.

Effect of Helicobacter pylori infection on gastric epithelial cell proliferation

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World Journal of Gastroenterology 2000年第3期6卷 442-444页

作者： Gao H Wang JY Shen XZ Liu JJ shanghai med univ Zhongshan Hosp Dept Internal Med Shanghai 200032 Peoples R China

INTRODUCTION Helicobacter pylori(***)infection is one ofthe main pathogens of chronic gastritis and duodenalulcer(DU),and it may be considered as a riskfactor in the incidence of gastric *** infection may lead to the anomaly of gastricepithelial cell proliferation which is closely relatedto the development of gastric ***(VacA)is an important virulence andvacA subtype determines the toxic *** to its signal sequence,it can be groupedinto type sla,slb,slc and *** harboringvacAsla are more closely related with digestivediseases and may be the strains with high *** effect of *** infection on

关键词： Helicobacter pylori cell proliferation vacAsla strain gastric epithelial cell

Adhesion and immunomodulatory effects of Bifidobacterium lactis HN019 on intestinal epithelial cells INT-407

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World Journal of Gastroenterology 2010年第18期16卷 2283-2290页

作者： Liu, Chang Zhang, Zhuo-Yang Dong, Ke Guo, Xiao-Kui shanghai Jiao Tong univ Sch Med Inst Med Sci Dept Med Microbiol & Parasitol Shanghai 200025 Peoples R China

AIM:To elucidate the adherence and immunomodulatory properties of a probiotic strain Bifidobacterium lactis(***) ***:Adhesion assays of *** HN019 and Salmonella typhimurium(***) ATCC 14028 to INT-407 cells were carried out by detecting copies of species-specific genes with real-time polymerase chain *** study was further conducted by transmission electron ***-1β(IL-1β),interleukin-8,and tumor necrosis factor-α(TNF-α) gene expression were assessed while enzyme linked immunosorbent assay was used to detect IL-8 protein ***:The attachment of *** ATCC 14028 to INT407 intestinal epithelial cells was inhibited significantly by *** *** HN019 could be internalized into the INT-407 cells and attenuated IL-8 mRNA level at both baseline and *** pro-inflammatory ***-8 secretion was reduced while IL-1β and TNF-α mRNA expression level remained unchanged at baseline after treated with *** ***:*** HN019 does not up-regulate the intestinal epithelium expressed pro-inflammatory cytokine,it showed the potential to protect enterocytes from an acute inflammatory response induced by enteropathogen.

关键词： Probiotics Intestinal epithelium Enteropathogen Immunomodulation Adhesion

Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat liver

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World Journal of Gastroenterology 2000年第4期6卷 526-531页

作者： Yang, CQ Wang, JY He, BM Liu, JJ Guo, JS shanghai med univ Zhongshan Hosp Div Gastroenterol Shanghai 200032 Peoples R China

AIM To compare the effects of liposomes andglyco-poly-L-lysine on liver targeted uptake andexpression of plasmid in rat *** After binding with lipofectamine orgalactose-terminal glyco-poly-L-lysine,theplasmid could be expressed in eukaryotic cellswhen injected into Wistar rats by *** different time intervals after the injection,the distribution and expression of the plasmid inliver of rats were observed and compared using insitu hybridization and *** The expression of the plasmid bindingto liposomes or G-PLL could be markedly observed24 h later,and began to decrease one week later,but it still could be observed up to three *** liposomes and G-PLL could deliver theplasmid to the liver effectively,but the effect of thelatter was better than the former concerning thedistribution and expression of the plasmid targeteduptake in the *** G-PLL is better than liposome asthe targeted carrier for delivering exogenous genesto the liver.

关键词： liposomes glyco-poly-L-lysine targeted liver uptake exogenous gene

Induction of apoptosis by arsenic trioxide and hydroxycamptothecin in gastric cancer cells in vitro

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World Journal of Gastroenterology 2000年第4期6卷 532-539页

作者： Tu SP Zhong J Tan JH Jiang XH Qiao MM Wu YX Jiang SH shanghai Second med univ Ruijin Hosp Dept Gastroenterol Shanghai 200025 Peoples R China

AIM To study the effects of arsenic trioxide andHCPT on different degrees of differentiated gastriccancer cells（SGC-7901,MKN-45,MKN-28）withrespect to both cytotoxicity and induction ofapoptosis in *** The cytotoxicity of As2O3 and HCPTon gastric cancer cells was determined by *** changes of apoptosis ofgastric cancer cells were observed by lightmicroscopy and transmission electron *** and cell cycle changes of gastric cancercells induced by HCPT and As2O3 were investigatedby TUNEL method and flow *** As2O3 and HCPT had remarkablecytotoxic effects on different degrees ofdifferentiated gastric cancer *** IC50ofAs2O3 on well differentiated gastric cancer cellMKN-28,moderately differentiated gastric cancercell SGC-7901,and poorly differentiated gastriccancer cell MKN-28 were 8.91 μmol/L,10.57μmol/L,and 11.65 μmol/L,*** IC50of HCPT on MKN-28,SGC-7901,and MKN-45 were9.35 mg/L,10.21 mg/L,and 12.63 mg/Lrespectively after 48 h *** 12 h ofexposure to both drugs,gastric cancer cellsexhibited morphologic features of apoptosis,including cell shrinkage,nuclear condensation, and formation of apoptotic bodies.A typicalsubdiploid peak before G0/G1 phase was observedby flow *** apoptotic rates of SGC-7901,MKN-45,and MKN-28 were 13.84%,22.52%,and 9.68%,respectively after 48 hexposure to 10 μmol/L As2O3.The apoptotic ratesof SGC-7901,MKN-45,and MKN-28 were 21.88%,12.35%,and 30.26%,respectively after 48 hexposure to 10 mg/L *** apoptotic indicewere 7%-15% as assessed by TUNEL *** effect of As2O3 on SGC-7901 showedremarkable cell cycle specificity,which inducedcell death in G1 phase,and blocked G2/M *** also showed a remarkable cell cyclespecificity,by inducing cell death and a

关键词： gastric cancer apoptosis arsenic trioxide hydroxycamptothecin

Folate and fiber in the prevention of colorectal cancer:Between shadows and the light

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World Journal of Gastroenterology 2010年第8期16卷 921-926页

作者： Du, Wan Li, Wen-Ying Lu, Rong Fang, Jing-Yuan shanghai Jiao Tong univ Sch Med Renji Hosp Shanghai Inst Digest Dis Shanghai 200001 Peoples R China

Colorectal cancer (CRC) is one of the most common malignancies and causes of cancer deaths throughout the world. Endoscopy has its functional and finan-cial limitations; therefore,chemoprevention might be crucial in reducing the incidence of CRC. Although a number of studies have demonstrated the potential chemopreventive effects of folate (or folic acid),many challenges still remain. The relationship between fo-late intake and CRC risk is a complex association that might depend on many factors including gender,age,alcohol consumption,and smoking,all of which inter-fere with folate metabolism. The supplementary dose of fiber,the length of time required to observe the effects,and confounding factors exposed during the trial might also influence these findings. Therefore,more evidence from clinical studies is needed regarding the mechanisms that underlie the actions of bioactive food components in minimizing the risk of CRC.

关键词： Folate Fiber Butyrate Prevention Colorectal cancer

Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis

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World Journal of Gastroenterology 2010年第7期16卷 886-896页

作者： Qu, Xin-Hua Huang, Xiao-Lu Xiong, Ping Zhu, Cui-Ying Huang, You-Liang Lu, Lun-Gen Sun, Xu Rong, Lan Zhong, Liang Sun, Da-Yu Lin, Hai Cai, Ming-Ci Chen, Zhi-Wei Hu, Bing Wu, Lian-Ming Jiang, Yi-Bin Yan, Wei-Li shanghai Jiao Tong univ Sch Med Renji Hosp Shanghai 200127 Peoples R China shanghai Jiao Tong univ Sch Med Shanghai Peoples Hosp 9 Shanghai 200011 Peoples R China Indiana univ Sch Med Dept Cellular & Integrat Physiol Indianapolis IN 46202 USA shanghai Inst Digest Dis Shanghai 200001 Peoples R China Fudan univ Huashan Hosp Dept Gastroenterol Shanghai 200040 Peoples R China shanghai Hlth Dev Res Ctr Shanghai 200040 Peoples R China

AIM:To perform a meta-analysis of observational studies and randomized controlled trials(RCTs)on the association between Helicobacter pylori(***)and iron deficiency anemia(IDA).METHODS:A defined search strategy was used to search medline,Embase,the Cochrane Library,Clinical Trials,Cochrane Central Register of Controlled Trials,Premedline and *** ratio(OR)was used to evaluate observational epidemiology studies,and weighted mean difference(WMD)was used to demonstrate the difference between control and intervention ***:Fifteen observational studies and 5 RCTs were identified and used for *** pooled OR for observational studies was 2.22(95%CI:1.52-3.24,P<0.0001).The WMD for hemoglobin(HB) was 4.06 g/L(95%CI:-2.57-10.69,P=0.01),and the WMD for serum ferritin(SF)was 9.47μg/L(95%CI:-0.50-19.43,P<0.0001).Results were heterogeneous for all ***:This meta-analysis on observational studies suggests an association between *** and *** RCTs,eradication of *** can improve HB and SF levels but not significantly.

关键词： Helicobacter pylori Iron-deficiency anemia Meta-analysis Hemoglobins Odds ratio

Current status of radiology in China

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World Journal of Gastroenterology 2000年第2期6卷 193-197页

作者： Zeng SM Zhou KR Zhang ZY Peng WJ Yang FH Lin J Yang J Han XY shanghai med univ Zhongshan Hosp Dept Radiol Shanghai 200032 Peoples R China

INTRODUCTIONRadiology has been greatly advanced in China sinceits founding in 1949 and has been developed fasterand further more since China adopted the policy ofsocioeconomic reform in *** plays anincreasingly important role in the medical healthcare and treatment in the country and has reachedthe world’s advanced level in certain *** nowbriefly review the history of China’s radiology so asto give a clear picture of its development.

关键词： radiology/history radiology/leducation radiology/trends China

A comparison between intravenous and peritoneal route on liver targeted uptake and expression of plasmid delivered by Glyco-poly-L-lysine

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World Journal of Gastroenterology 2000年第4期6卷 508-512页

作者： Yang CQ Wang JY Fang GT Liu JJ Guo JS shanghai med univ Zhongshan Hosp Div Gastroenterol Shanghai 200032 Peoples R China

AIM To compare the effects of intravenous routeand peritoneal route on liver targeted uptake andexpression of plasmid delivered by galactose-terminal glyco-poly-L-lysine(G-PLL).METHODS The plasmid pTM/MMP-1 which couldbe expressed in eukaryotic cells was bound to G-PLL,and was then transferred into Wistar rats byintravenous and intraperitoneal *** and distribution of the plasmid wereobserved at different time periods by in situhybridization and *** The plasmid could be expressedsignificantly within 24 h after being transferred invivo by both intravenous and *** week later the expression began todecrease,and could still be observed three *** both the intravenous andintraperitoneal route could target-specificallydeliver the plasmid to the liver,the effect of theformer was better as compared to that of the *** Intravenous route is better for livertargeted uptake and expression of G-PLL-boundplasmids than the peritoneal route.

关键词： intraperitoneal injection intraperitoneal injection glyco-poly-L-lysine lwcr targeted uptake