Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat liver

作     者：Yang, CQ Wang, JY He, BM Liu, JJ Guo, JS 

作者机构：Shanghai Med Univ Zhongshan Hosp Div Gastroenterol Shanghai 200032 Peoples R China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2000年第6卷第4期

页      面：526-531页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the National Natural Science Foundation of China(№39570336) 

主　　题：liposomes glyco-poly-L-lysine targeted liver uptake exogenous gene 

摘      要：AIM To compare the effects of liposomes andglyco-poly-L-lysine on liver targeted uptake andexpression of plasmid in rat *** After binding with lipofectamine orgalactose-terminal glyco-poly-L-lysine,theplasmid could be expressed in eukaryotic cellswhen injected into Wistar rats by *** different time intervals after the injection,the distribution and expression of the plasmid inliver of rats were observed and compared using insitu hybridization and *** The expression of the plasmid bindingto liposomes or G-PLL could be markedly observed24 h later,and began to decrease one week later,but it still could be observed up to three *** liposomes and G-PLL could deliver theplasmid to the liver effectively,but the effect of thelatter was better than the former concerning thedistribution and expression of the plasmid targeteduptake in the *** G-PLL is better than liposome asthe targeted carrier for delivering exogenous genesto the liver.