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Microsurgical vasoepididymostomy for patients withinfectious obstructive azoospermia, cause, outcome,and associated factors

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Asian Journal of Andrology 2016年第5期18卷 759-762页

作者： Xiang-Feng Chen Bin Chen Wei Liu Yan-Ping Huang Hong-Xiang Wang Yi-Ran Huang Ping Ping center for Reproductive Medicine Shanghai Human Sperm Bank Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200135 China Department of Urology Shanghai Institute of Andrology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China shanghai KeyLaboratory for Assisted Reproduction and Reproductive genetics Shanghai 200135 China.

Azoospermia is of great importance to male infertility. Obstructive azoospermia （OA） due to infection is the most prevalent form of OA in China and has been less studied. We aim to observe the treatment outcome of microsurgical vasoepididymostomy （VE） and also to identify the factors relative to the result after reconstructive surgery. Two hundred and eight men presenting with OA due to infection during the study period from July 2010 to July 2013 were prospectively evaluated. Clinical examination, semen analysis, serum follicle stimulating hormone （FSH）, and scrotal ultrasound were done before surgical exploration. Among the 198 men who were selected for surgical procedures, 159 candidates underwent microsurgical VE with sperm detected in the epididymal fluid. As for the other 39 cases, reconstruction was not feasible. The average age was 28.5 ＋ 3.9 years （range 22-38）, with average follow-up being 16.5 ~ 5.9 months （range 4-28）. According to the 150 cases being followed after VE procedures, the total patency rate was 72% （108/150）. During follow-up, 38.7% （58/150） natural pregnancies occurred, with overall live birth rate being 32.7% （49/150）. Our data suggested that microsurgical VE is an effective therapy for postinfectious epididymal OA. Individualized counseling with prognosis based on etiology should be offered to patients to select optical therapy.

关键词： infection obstructive azoospermia vasoepididymostomy

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Epidemiological Survey and Risk Factor Analysis of Recurrent Spontaneous Miscarriages in Infertile Women at Large infertility centers

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Chinese Medical Journal 2017年第17期130卷 2056-2062页

作者： Hai-Yan Wang jie Qiao Xiao-Xi Sun Shu-Yu Wang Xiao-Yan Liang Yun Sun Feng-Hua Liu Reproductive Medical center Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China shanghai ji ai diagnosis and treatment center for genetics and infertility Shanghai 200011 China Reproductive Medical center Beijing Obstetrics and Gynecology Hospital Beijing 100006 China Reproductive Medical center The Sixth Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510665 China Reproductive Medical center Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital Shanghai 200011 China Reproductive Medical center Maternal and Child Health Hospital of Guangdong Province Guangzhou Guangdong 511400 China

Background：A higher frequency of spontaneous miscarriage has been observed in infertile couples,and there is a higher prevalence of infertility among patients with a history of recurrent spontaneous miscarriages （RSMs;〉2 miscarriages）.This study aimed to determine the proportion of infertile patients with RSM and examine risk factors associated in patients with RSM being treated with assisted reproductive ***：This cross-sectional observational study was conducted at six reproductive medicine centers in three cities of *** of 751 patients with at least one spontaneous miscarriage were *** data and etiological factors associated with infertility were compiled and compared between patients with a single spontaneous miscarriage （SSM） and those with ***：Two hundred （26.6%,95% confidence interval [CI]：23.50-29.95%） patients experienced RSMs and 551 （73.4%） had a single *** odds of RSM increased with increasing age （odds ratio [OR] =1.06）,uterine disorders （OR =2.09）,endocrine disorders （OR =2.48）,and immune disorders （OR =2.98）.Higher education level,masters or above,and a pelvic cavity disorder were associated with lower risk of RSM （OR =0.27 and 0.46,respectively）.Late spontaneous miscarriages were more frequent in patients with RSM than in those with a SSM （31.5% vs.14.2%,respectively,P 〈 0.001） and were associated with a history of uterine cavity procedures （OR =2.095） and cervical factors related to infertility （OR =4.136,95% CI：1.012-16.90）.Conclusions：Compared to patients with only a SSM,the conditions of patients with RSM are more *** increase the success rate of assisted reproductive technology,factors including uterus cavity adhesion,cervical relaxation,endocrine disorders,and immune disorders should be treated before assisted reproduction is *** data may provide treatment guidance for infertile patients with a history of RSM.

关键词： Assisted Reproductive Technology Epidemiological Survey infertility Recurrent Spontaneous Miscarriage Risk Factor

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Transcriptome research on spermatogenic molecular drive in mammals

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Asian Journal of Andrology 2015年第6期17卷 961-971,I0009页

作者： Zi-Jue Zhu Shi Yang Zheng Li Department of Urology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China Department of Andrology Urologic Medical CenterShanghai General Hospital Shanghai Jiao Tong University Shanghai 200080 China shanghai Key Laboratory of Reproductive Medicine Shanghai 200025 China.

It is known that spermatogenic disorders are associated with genetic deficiency, although the primary mechanism is still unclear. It is difficult to demonstrate the molecular events occurring in testis, which contains germ cells at different developmental stages. However, transcriptomic methods can help us reveal the molecular drive of male gamete generation. Many transcriptomic studies have been performed on rodents by utilizing the timing of the first wave of spermatogenesis, which is not a suitable strategy for research in fertile men. With the development of separation methods for male germ cells, transcriptome research on the molecular drive of spermatogenesis in fertile men has seen great progress, and the results could be ultimately applied to improve the diagnosis and treatment for male infertility.

关键词： GeneChip germ cell RNA-Seq sorting spermatogenesis transcriptome

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Decidualization and Related Pregnancy Complications

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Maternal-Fetal Medicine 2022年第1期4卷 24-35页

作者： jing Tong Shijian Lv jieqiong Yang Hongwanyu Li Weiya Li Cong Zhang center for Reproductive Medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200135China shanghai Key Laboratory for Assisted Reproduction and Reproductive genetics Shanghai200135China Shandong Provincial Key Laboratory of Animal Resistance Biology College of Life SciencesShandong Normal UniversityJinanShandong 250014China

Decidualization is the differentiation of endometrial stromal cells into secretory decidual stromal *** decidualization involves some amount of signaling molecules and pathways as well as genetic reprogramming,which is driven by the postovulatory rise in progesterone levels and local cyclic adenosine monophosphate *** extends from the primary decidual zone to the secondary decidual zone,and then exits through *** support that decidual fibroblasts function as the pool of decidual stromal cells during *** undergoes an acute inflammatory phase,an anti-inflammatory secretory phase to the final recession *** decidualization of the inner layer of endometrium,termed decidua,is the most critical determinant of pregnancy success,which can promote placenta formation,modulate immune tolerance,foster resistance to oxidative stress,sense embryo quality,and control *** to adequate decidualization in terms of hormones,biochemistry,and immunology leads to adverse pregnancy outcomes,including diseases such as preeclampsia,miscarriage,premature labor,repeated implantation failures,and some age-related decline in reproductive *** development of animal models and in vitro culture systems combined with emerging technologies provides a powerful system to explore the mechanism of ***,decidualization is a dynamic,multi-step process,and translating of current research progress into disease predictions and interventions for pregnancy complications remains to be *** study of periodic regeneration and spontaneous decidualization of the endometrium will be beneficial to the diagnosis and treatment of pregnancy diseases.

关键词： Decidua Decidualization Decidual stromal cells Endometrial stromal cells Pregnancy complications

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Transcriptomic analysis of granulosa cells in patients with endometriosis-related infertility:identification of potential molecular mechanisms

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Reproductive and Developmental Medicine 2023年第4期7卷 193-202页

作者： jian Zhang Yu Zhang jia-Li Luo Lin Yui Min-Zhi Gao Zhao-Gui Sun INHC Key Lab of Reproduction Regulation Shanghai Engineering Research Center of Reproductive Health Drug and DevicesShanghai Institute for Biomedical and Pharmaceutical TechnologiesSchool of Basic Medical SciencesFudan UniversityShanghai 200237China shanghai Key Laboratory for Assisted Reproduction and Reproductive genetics Center for Reproductive MedicineRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200135China.

Objective:To investigate the impact of endometriosis(EMS)on granulosa cell function and elucidate the molecular mechanisms ***:RNA sequencing,differential expression analysis,Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis,gene set enrichment analysis,protein–protein interaction analysis,and RT-qPCR were employed to assess the effects of EMS on granulosa cell ***:The results revealed significant differences in gene expression between the EMS and control groups,including genes related to immune regulatory functions and *** gene modules and hub genes were identified,including those related to cell cycle and immune and inflammatory ***-qPCR revealed significant upregulation of the hub genesCCL3 andIL1B in granulosa cells of patients with ***:The results of RNA sequencing demonstrated that EMS induces significant transcriptional alterations in granulosa cells of affected *** findings provide important insights into the diagnosis and treatment of EMS and highlight the importance of further investigation ofCCL3 andIL1B as potential biomarkers for EMS.

关键词： Endometriosis Female infertility Granulosa cells RNA sequencing

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