Transcriptome research on spermatogenic molecular drive in mammals
Transcriptome research on spermatogenic molecular drive in mammals作者机构：Department of Urology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China Department of Andrology Urologic Medical CenterShanghai General Hospital Shanghai Jiao Tong University Shanghai 200080 China Shanghai Key Laboratory of Reproductive Medicine Shanghai 200025 China.
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2015年第17卷第6期
页 面：961-971,I0009页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 071002[理学-动物学] 090102[农学-作物遗传育种]
基 金：supported by the key project of the National Natural Science Foundation of China the Science and Technology Development Fund of Shanghai Health and Family Planning Commission
主 题：GeneChip germ cell RNA-Seq sorting spermatogenesis transcriptome
摘 要：It is known that spermatogenic disorders are associated with genetic deficiency, although the primary mechanism is still unclear. It is difficult to demonstrate the molecular events occurring in testis, which contains germ cells at different developmental stages. However, transcriptomic methods can help us reveal the molecular drive of male gamete generation. Many transcriptomic studies have been performed on rodents by utilizing the timing of the first wave of spermatogenesis, which is not a suitable strategy for research in fertile men. With the development of separation methods for male germ cells, transcriptome research on the molecular drive of spermatogenesis in fertile men has seen great progress, and the results could be ultimately applied to improve the diagnosis and treatment for male infertility.
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