Epidemiological Survey and Risk Factor Analysis of Recurrent Spontaneous Miscarriages in Infertile Women at Large Infertility Centers
Epidemiological Survey and Risk Factor Analysis of Recurrent Spontaneous Miscarriages in Infertile Women at Large Infertility Centers作者机构：Reproductive Medical Center Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China Shanghai Ji Ai Diagnosis and Treatment Center for Genetics and Infertility Shanghai 200011 China Reproductive Medical Center Beijing Obstetrics and Gynecology Hospital Beijing 100006 China Reproductive Medical Center The Sixth Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510665 China Reproductive Medical Center Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital Shanghai 200011 China Reproductive Medical Center Maternal and Child Health Hospital of Guangdong Province Guangzhou Guangdong 511400 China
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2017年第130卷第17期
页 面：2056-2062页
核心收录：
学科分类：090603[农学-临床兽医学] 0710[理学-生物学] 07[理学] 09[农学] 0906[农学-兽医学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种]
基 金：sponsored by Abbott Established Pharmaceuticals Division in China
主 题：Assisted Reproductive Technology Epidemiological Survey Infertility Recurrent Spontaneous Miscarriage Risk Factor
摘 要：Background：A higher frequency of spontaneous miscarriage has been observed in infertile couples,and there is a higher prevalence of infertility among patients with a history of recurrent spontaneous miscarriages （RSMs;〉2 miscarriages）.This study aimed to determine the proportion of infertile patients with RSM and examine risk factors associated in patients with RSM being treated with assisted reproductive ***：This cross-sectional observational study was conducted at six reproductive medicine centers in three cities of *** of 751 patients with at least one spontaneous miscarriage were *** data and etiological factors associated with infertility were compiled and compared between patients with a single spontaneous miscarriage （SSM） and those with ***：Two hundred （26.6%,95% confidence interval [CI]：23.50-29.95%） patients experienced RSMs and 551 （73.4%） had a single *** odds of RSM increased with increasing age （odds ratio [OR] =1.06）,uterine disorders （OR =2.09）,endocrine disorders （OR =2.48）,and immune disorders （OR =2.98）.Higher education level,masters or above,and a pelvic cavity disorder were associated with lower risk of RSM （OR =0.27 and 0.46,respectively）.Late spontaneous miscarriages were more frequent in patients with RSM than in those with a SSM （31.5% vs.14.2%,respectively,P 〈 0.001） and were associated with a history of uterine cavity procedures （OR =2.095） and cervical factors related to infertility （OR =4.136,95% CI：1.012-16.90）.Conclusions：Compared to patients with only a SSM,the conditions of patients with RSM are more *** increase the success rate of assisted reproductive technology,factors including uterus cavity adhesion,cervical relaxation,endocrine disorders,and immune disorders should be treated before assisted reproduction is *** data may provide treatment guidance for infertile patients with a history of RSM.
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