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An update on the role of long non-coding RNAs in psoriasis

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Chinese Medical Journal 2021年第4期134卷 379-389页

作者： Jian-Kun Song Shuang-Yi Yin Wei Li Xiao-Dong Li Yue Luo Ying Luo Meng Xing Bin Li Le Kuai Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China lnstitute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai 201203China Center for Translational Medicine Huaihe Hospital of Henan UniversityKaifengHenan 475001China Department of Urology Surgery Huaihe Hospital of Henan UniversityKaifengHenan 475001China lnstitute of Evidence-Based Medicine and Knowledge Translation Henan UniversityKaifengHenan 475001China Department of Dermatology Shaanxi Traditional Chinese Medicine HospitalXianShaanxi 710004China

Increasing evidence suggests that long non-coding RNAs(lncRNAs)are of vital importance for various biological processes,and dysregulation of lncRNAs is frequently associated with various diseases such as *** modulate gene expression at the transcriptional,post-transcriptional,and translational levels;however,the specific regulatory mechanisms of lncRNAs in psoriasis remain largely *** review provides an overview of recent studies investigating mechanisms and functions of lncRNAs in psoriasis,especially focusing on the role of lncRNAs in keratinocytes,T cells,and dendritic cells.

关键词： Long non-coding RNAs(LncRNAs) Psoriasis Keratinocytes T cells Dendritic cells

Increased ratio of high sensitive C-reactive protein to interleukin-10 as a potential peripheral biomarker of schizophrenia and related with aggression

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Increased ratio of high sensitive C-reactive protein to inte...

Synthesis, Antimicrobial Activity, and Molecular Docking of Benzoic Hydrazide or Amide Derivatives Containing a 1,2,3-Triazole Group as Potential SDH Inhibitors

四川省医学会第十五次精神病学学术会议暨第三次心身医学学术会议

作者： Qinting Zhang Wu Hong Haozhe Li Fanglan Peng Fan Wang Ningning Li Hui Xiang Zongfeng,Zhang Yousong Su Yueqi Huang Shengyu Zhang Guoqin Zhao Rubai Zhou Ling Mao Zhiguang Lin Yiru Fang Bin Xie Min Zhao shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine shanghai Key Laboratory of Forensic Medicine Institute of Forensic Science Ministry of Justice Division of Mood Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Xu Hui District Mental Health Center of shanghai

Objective: Accumulating studies have indicated that immune dysfunction might be involved in the physiopathology of schizophrenia and aggression. This study aims to investigate the correlation between high sensitive C-reactive protein(hs CRP), interleukin(IL)-10 and clinical characters especially aggression, and also explore the potential role of hs CRP and IL-10 as plasma biomarkers of schizophrenia. Methods: Forty-one patients of schizophrenia and forty age and gender matched healthy individuals were enrolled. Psychopathological severity and aggression were assessed using Positive and Negative Symptom Scale(PANSS) and Modified Overt Aggression Scale(MOAS). The blood sampling and assessments were performed at the time of enrolment. Plasma concentrations of hs CRP and IL-10 were assessed by Enzyme-Linked Immunosorbent Assay(ELISA) according to the manufacturer protocol. Results:(1) Higher levels of hs CRP(p<0.001), lower levels of log IL-10(p<0.001)and higher ratios of hs CRP to IL-10(p<0.001) were observed in plasma of patients with schizophrenia compared to healthy controls;(2) ROC(Receiver Operating Characteristic) curve analysis revealed that ratio of hs CRP/IL-10(Predictive value: 0.783, p<0.01;Sensitivity: 85.4%;Specificity: 67.5%) was more applicable as a biomarker to distinguish schizophrenia from control group than hs CRP and IL-10 alone(Predictive value: 0.718, p<0.01;0.275, p<0.001, respectively);(2) There were significant negative correlations between hs CRP and score of thought disorder of PANSS(r=-0.355,p<0.05), between log IL-10 and the score of general symptoms and total score of PANSS(r=-0.397, p<0.05;r=-0.325, p<0.05), and positive correlation between hs CRP/IL-10 and the score of general symptoms of PANSS(r=0.393, p<0.05);(3) We also found positive correlations between hs CRP and the total score and verbal aggression score of MOAS(r=0.654, p<0.01;r=0.678, p<0.05), and between hs CRP/IL-10 and the total score of MOAS(r=0.636, p<0.01). Conclusions: O

关键词： Schizophrenia Aggression Biomarker C-reactive protein Interleukin-10(IL-10)

来源： cnki会议评论

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Chinese Journal of Chemistry 2021年第5期39卷 1319-1330页

作者： Yue Ding Ling Zhang Song Yang Zhong Li Pei-Yi Wang State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationCenter for R&D of Fine Chemicals of Guizhou UniversityGuiyongGuizhou 550025China College of Pharmacy East China University of Science&TechnologyShanghai 200237China

The present study was carried out in an attempt to synthesize a new class of antimicrobial agents containing a 1,2,3-triazole motif formed by classical copper catalyzed click *** bioassay results showed that five compounds 5a;5e,5h,5j,and 5k possessed a remarkable growth inhibitory activity against Botryosphaeria dothidea,Rhizoctonia solani and Gibberella zeae with EC_(50) values within 10.0-0.306μg/*** in vitro efficacy was better than those of the commercial agrochemicals Azoxystrobin,Boscalid,and *** vivo trials showed that compound 51 was effective for the control of rice sheath blight and wheat scab with the effects of 75% and 95%,*** mechanism studies suggested that target compounds were potential succinate dehydrogenase inhibitors(SDHIs),which were proposed by the agreeable molecular docking study and restrained SDH activity(IC_(50)=3.95 μg/mL,51).Interestingly,compounds 5r and 5s displayed good antibacterial activity against *** vivo screening of 5r and 5s against rice bacterial blight afforded a superior control effect(up to 51%)than those of commercial agents Bismerthiazol and Thiodiazole *** current studies could support some title compounds to be the lead compounds for exploring highly bioactive antimicrobial substrates,particularly the potential SDHIs.

关键词： Hydrazide Amide 1,2,3-Triazole Molecular docking SDH inhibitory activity

The function and regulation of TET2 in innate immunity and inflammation

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Protein & Cell 2021年第3期12卷 165-173页

作者： Boyi Cong Qian Zhang Xuetao Cao Laboratory of Immunity and Inflammation College of Life SciencesNankai UniversityTianjin 300071China National Key Laboratory of Medical Immunology Institute of ImmunologyNavy Military Medical UniversityShanghai 200433China Department of Immunology Center for ImmunotherapyInstitute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing 100005China

TET2,a member of ten-eleven translocation(TET)family as a-ketoglutarate-and Fe2+-dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine(5mC),has been widely recognized to be an important regulator for normal hematopoiesis especially *** and dysregulation of TET2 contribute to the development of multiple hematological *** studies reveal that TET2 also plays an important role in innate immune homeostasis by promoting DNA demethylation or independent of its enzymatic ***,we focus on the functions of TET2 in the initiation and resolution of inflammation through epigenetic regulation and signaling *** addition,we highlight regulation of TET2 at various molecular levels as well as the correlated inflammatory diseases,which will provide the insight to intervene in the pathological process caused by TET2 dysregulation.

关键词： TET2 innate immune response DNA demethylation inflammatory resolution inflammatory diseases

Ultrasound-guided microwave ablation for symptomatic adenomyosis:More areas of concern for more uniform and promising outcomes

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Journal of Interventional Medicine 2022年第3期5卷 122-126页

作者： Huili Zhang Songyuan Yu Huixiong Xu Department of Medical Ultrasound Shanghai Tenth People's HospitalUltrasound Researchand Education InstituteSchool of MedicineTongji UniversityShanghai200072China National Clinical Research Center of Interventional Medicine Shanghai 200072China Department of Ultrasound Zhongshan HospitalFudan UniversityShanghai200032PR China

Adenomyosis is a common gynecological disease in reproductive women,which causes serious dysmenorrhea,menorrhagia,anemia,and infertility,and has a serious impact on the physical and mental health of *** that the efficacy of the traditional medication and surgical treatment is not ideal,an increasing number of patients are searching for more effective and less invasive ***(US)-guided microwave ablation(MWA)has emerged as a new effective and minimally invasive alternative treatment for symptomatic adenomyosis,and it is widely being used in clinical *** studies have proven that it is an efficient and safe treatment modality for symptomatic adenomyosis,but a significant variance in clinical outcomes reported in previous studies was also ***,we have analyzed the potential causes of this problem from the aspects of the diagnosis of adenomyosis,symptom evaluation before ablation,steps of USguided ablation treatment,and outcome evaluation after ***,the clinical problems existing in the ablation treatment of adenomyosis are discussed,and the directions of future research are pointed out.

关键词： Ultrasound-guided microwave ablation Adenomyosis

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An Evolving Bloc

Beijing Review 2017年第18期60卷 20-21页

作者： Yu Lintao Chongyang Institute for Financial studies at Renmin university of China

The shanghai Cooperation Organization （SCO） held its 16th meeting of the Council of Heads of Government in the Russian re- sort city of Sochi from November 30 to December 1. It was the first meeting of its kind since the regional bloc expanded its membership in June to include India and Pakistan. The SCO now has China, Kazakhstan, Kyrgyzstan, Russia, Tajikistan, Uzbekistan. India and Pakistan as its full members.

关键词： An Evolving Bloc The shanghai Cooperation Organization (SCO)

Tropical cyclogenesis:Controlling factors and physical mechanisms

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Tropical Cyclone Research and Review 2023年第3期12卷 165-181页

作者： V.P.M.Rajasree Xi Cao Hamish Ramsay Kelly M.Nú~nez Ocasio Gerard Kilroy George R.Alvey III Minhee Chang Chaehyeon Chelsea Nam Hironori Fudeyasu Hsu-Feng Teng Hui Yu India Meteorological Department GoaIndia Chinese Academy of Sciences BeijingChina CSIRO EnvironmentAspendaleVictoriaAustralia National Center for Atmospheric Research ColoradoUSA Institut f¨ur Physik der Atmosph¨are Deutsches Zentrum f¨ur Luft-undBerlinGermany Cooperative Institute for Marine and Atmospheric studies University of MiamiMiamiFloridaUSA NOAA/Atlantic Oceanographic and Meteorological Laboratory/Hurricane Research Division MiamiFloridaUSA Korea Institute of Science and Technology SeoulRepublic of Korea Colorado State university ColoradoUSA Yokohama National university YokohamaJapan National Center for Atmospheric Research/Pacific Science Association ColoradoUSA shanghai Typhoon Institute/China Meteorological Administration ShanghaiChina

In this review,advances in the understanding of the controlling factors and physical mechanisms of tropical cyclogenesis(TCG)are summarized from recent(2018–2022)research on TCG,as presented in the Tenth International Workshop on Tropical Cyclones(IWTC-10).Observational,theoretical,and numerical modeling studies published in recent years have advanced our knowledge on the influence of large-scale environmental factors on ***,studies have shown clearly that appropriate convective coupling with tropical equatorial waves enhances the development chances of *** recently,illuminating research has been carried out on analyzing the mechanisms by which oscillations and teleconnections(El Ni˜no Southern Oscillation(ENSO)in particular)modulate TCG globally,in association with changes in the sea surface temperature(SST).In addition to this,recent research has diligently addressed different aspects of *** studies have reported the applicability of unified theories and physical mechanisms of TCG in different ocean ***,research has been carried out on TCG under different flow pattern regimes,dry air intrusion,importance of marsupial pouch,genesis of Medicanes,wind shear,convection and vertical ***,studies have discussed the possibility of near equatorial TCG provided that there is enough supply of background vertical vorticity and relatively low vertical wind *** has been made to understand the role of climate change on global and regional ***,there are still significant gaps which need to be addressed in order to better understand TCG prediction.

关键词： Tropical cyclogenesis AEW ENSO SST Marsupial pouch Dry air intrusion Moderate shear Convection Near equatorial TCG Climate change

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin Ling Qiao-Nan Shan Xu-Yong Wei Rui Wang Chang-Ku Jia Li Zhuang Tian Shen Li-Min Ding Zhi-Dan Xu Lai-Bang Luo Li-Bo Sun Guang-Ming Li Tai-Shi Fang Nan Jiang Kun Zhang Zhao-Jie Su Zhi-Hai Peng Ren Lang Tao Jiang Qiang He Lin-Sen Ye Yang Yang Yu-Ting He Wen-Zhi Guo Liu-Gen Lan Xu-Yong Sun Dong Chen Zhi-Shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi Bo Wang Jiang Liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen Wang Lin Zhong Jing-Sheng Ma Qi-Gen Li Sheng-Dong Wu Chang-Jiang Lu Cai-De Lu Dong-Hua Zhang Xuan Wang Zi-Qiang Li Mu-Jian Teng Jun-Jie Li Wen-Tao Jiang Jian-Hua Li Quan-Bao Zhang Ning-Qi Zhu Zheng-Xin Wang Kang He Qiang Xia Shao-Hua Song Zhi-Ren Fu Wei Qiu Guo-Yue Lv Rui-Peng Song Ji-Zhou Wang Zheng Wang Jian Zhou Gang Chen Ying-Peng Zhao Li Li Ze-Min Hu Qi-Jie Luo Zhong-Zhou Si Bin Xie Xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China Liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan university Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma Liver transplantation Conversion

风暴在长江三角洲侵蚀和沉积物向南输运中的控制作用

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Science Bulletin 2023年第6期68卷 553-556,M0003页

作者：杨世伦 Tjeerd J.Bouma Kehui Xu 史本伟杨海飞张文祥罗向欣李鹏黄远光田敏郭磊城戴志军 State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China Department of Estuarine and Delta Systems Royal Netherlands Institute for Sea Research Utrecht UniversityYerseke AC 4400the Netherlands Department of Oceanography and Coastal Sciences Louisiana State UniversityBaton Rouge LA 70803USA Coastal studies Institute Louisiana State UniversityBaton Rouge LA 70803USA School of Ocean Engineering and Technology Sun Yat-sen UniversityGuangzhou 510275China East China Sea Centre of Standard and Metrology State Oceanic Administration of ChinaShanghai 201306China

Densely populated coasts are vulnerable to storm damage. Episodic storm-induced redistribution of coastal sediment is known to have major geological and ecological implications [1,2], but little is known about storm-driven delta erosion and longshore sediment transport. The Yangtze (Changjiang) Delta and Zhejiang–Fujian coasts (Fig. S1 online) are among the world’s largest coastal depositional systems, and play an important role in supporting China’s socioeconomic development [3,4].

关键词： storm coastal depositional