Increased ratio of high sensitive C-reactive protein to interleukin-10 as a potential peripheral biomarker of schizophrenia and related with aggression
作者单位：Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Forensic Medicine Institute of Forensic Science Ministry of Justice Division of Mood Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Xu Hui District Mental Health Center of Shanghai
会议名称：《四川省医学会第十五次精神病学学术会议暨第三次心身医学学术会议》
会议日期：2016年
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
关 键 词：Schizophrenia Aggression Biomarker C-reactive protein Interleukin-10(IL-10)
摘 要：Objective: Accumulating studies have indicated that immune dysfunction might be involved in the physiopathology of schizophrenia and aggression. This study aims to investigate the correlation between high sensitive C-reactive protein(hs CRP), interleukin(IL)-10 and clinical characters especially aggression, and also explore the potential role of hs CRP and IL-10 as plasma biomarkers of schizophrenia. Methods: Forty-one patients of schizophrenia and forty age and gender matched healthy individuals were enrolled. Psychopathological severity and aggression were assessed using Positive and Negative Symptom Scale(PANSS) and Modified Overt Aggression Scale(MOAS). The blood sampling and assessments were performed at the time of enrolment. Plasma concentrations of hs CRP and IL-10 were assessed by Enzyme-Linked Immunosorbent Assay(ELISA) according to the manufacturer protocol. Results:(1) Higher levels of hs CRP(p0.001), lower levels of log IL-10(p0.001)and higher ratios of hs CRP to IL-10(p0.001) were observed in plasma of patients with schizophrenia compared to healthy controls;(2) ROC(Receiver Operating Characteristic) curve analysis revealed that ratio of hs CRP/IL-10(Predictive value: 0.783, p0.01;Sensitivity: 85.4%;Specificity: 67.5%) was more applicable as a biomarker to distinguish schizophrenia from control group than hs CRP and IL-10 alone(Predictive value: 0.718, p0.01;0.275, p0.001, respectively);(2) There were significant negative correlations between hs CRP and score of thought disorder of PANSS(r=-0.355,p0.05), between log IL-10 and the score of general symptoms and total score of PANSS(r=-0.397, p0.05;r=-0.325, p0.05), and positive correlation between hs CRP/IL-10 and the score of general symptoms of PANSS(r=0.393, p0.05);(3) We also found positive correlations between hs CRP and the total score and verbal aggression score of MOAS(r=0.654, p0.01;r=0.678, p0.05), and between hs CRP/IL-10 and the total score of MOAS(r=0.636, p0.01). Conclusions: O