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A Neural Circuit Controlling Virgin Female Aggression Induced by Mating-related Cues in Drosophila

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Neuroscience Bulletin 2023年第9期39卷 1396-1410页

作者： Xiaolu Wan Peng Shen Kai Shi Jing Li Fengming Wu Chuan Zhou State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China Institute of Molecular Physiology Shenzhen Bay LaboratoryShenzhen518132China

Females increase Aggression for mating opportunities and for acquiring reproductive resources.Although the close relationship between female Aggression and mating status is widely appreciated,whether and how female Aggression is regulated by mating-related cues remains poorly understood.Here we report an interesting observation that Drosophila virgin females initiate high-frequency attacks toward mated females.We identify 11-cis-vaccenyl acetate(cVA),a male-derived pheromone transferred to females during mating,which promotes virgin female Aggression.We subsequently reveal a cVA-responsive neural circuit consisting of four orders of neurons,including Or67d,DA1,aSP-g,and pC1 neurons,that mediate cVA-induced virgin female Aggression.We also determine that aSP-g neurons release acetylcholine(ACh)to excite pC1 neurons via the nicotinic ACh receptor nAChRα7.Together,beyond revealing cVA as a mating-related inducer of virgin female Aggression,our results identify a neural circuit linking the chemosensory perception of mating-related cues to aggressive behavior in Drosophila females.

关键词： Drosophila Aggression Pheromone 11-cis-vaccenyl acetate Acetylcholine Neural circuit

Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin

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Neuroscience Bulletin 2019年第5期35卷 841-852页

作者： Yiqiong Liu Yunong Sun Xiaoyan Zhao Ji-Young Kim Lu Luo Qian Wang Xiaolu Meng Yonghui Li Nan Sui Zhou-Feng Chen Chuxiong Pan Liang Li Yan Zhang State Key Laboratory of Membrane Biology College of Life Sciences Peking University Beijing 100871 China Department of Anesthesiology Beijing Tongren Hospital Capital Medical University Beijing 100005 China Department of Anesthesiology Department of Psychiatry Department of Developmental Biology Center for the Study of Itch Washington University School of Medicine Saint Louis MO 63110 USA School of Psychological and Cognitive Sciences Beijing Key Laboratory of Behavior and Mental Health Peking University Beijing 100871 China Beijing Institute for Brain Disorders Beijing 100069 China Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing 100101 China Hendrix College Conway AR 72032 USA PKU-IDG/McGovern Institute for Brain Research Beijing 100871 China

Isolation rearing(IR) enhances aggressive behavior, and the central serotonin(5-hydroxytryptamine,5-HT) system has been linked to IR-induced Aggression.However, whether the alteration of central serotonin is the cause or consequence of enhanced Aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2-/-and Lmx1 b-/-, we examined the association between central serotonin and Aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced Aggression after IR. 5-HT depletion in wild-type mice increased Aggression. On the other hand, application of 5-HT in Lmx1 b-/-mice inhibited the enhancement of Aggression under social isolation conditions. Dopamine was downregulated in Lmx1 b-/-mice. Similar to 5-HT, L-DOPA decreased Aggression in Lmx1 b-/-mice. Our results linkthe serotoninergic system directly to Aggression and this may have clinical implications for Aggression-related human conditions.

关键词： 5-HT Aggression Social isolation Dopamine Lmx1b

Association of problematic internet use with depression,impulsivity,anger,Aggression,and social anxiety:Results of a national study among Lebanese adolescents

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Pediatric Investigation 2021年第4期5卷 255-264页

作者： Chadia Haddad Diana Malaeb Hala Sacre Jad Bou Khalil Wael Khansa Roula Al Hajj Nelly Kheir Sylvia Saade Sahar Obeid Souheil Hallit Research Department Psychiatric Hospital of the CrossJal EddibLebanon INSERM Univ.LimogesCHU EsquirolIRDU1094 Tropical NeuroepidemiologyInstitute of Epidemiology and Tropical NeurologyGEISTLimogesFrance School of Pharmacy Lebanese International UniversityBeirutLebanon Life sciences and health department Paris-Est UniversityParisFrance INSPECT-LB:Institut National de SantéPublique Epidémiologie Clinique et ToxicologieBeirutLebanon Faculty of Medicine and Medical Sciences Holy Spirit University of Kaslik(USEK)JouniehLebanon Faculty of Arts and Sciences Holy Spirit University of Kaslik(USEK)JouniehLebanon

Importance:Several studies conducted worldwide(mostly in Western countries)highlighted the negative effects of problematic internet use,particularly among adolescents aged 12 to 17,including depression,impulsivity,Aggression,and social fear and avoidance.In Lebanon,literature on the prevalence and impact of problematic internet use among adolescents is limited.Objective:This study aim was to study the association between problematic internet use and depression,impulsivity,anger,Aggression and social phobia among Lebanese adolescents.Methods:A cross-sectional study was performed on 1103 young adolescents(14-17 years),recruited from October 2017 till April 2018.The Internet Addiction Test(IAT)was used to evaluate the level of problematic internet use.Data were analyzed using the MANCOVA analysis.The main independent variable of interest was the IAT,while the dependent variables included the psychological scales.Results:The multivariate analysis taking the psychological scales as the dependent variables and the problematic internet use(IAT score)as an independent variable,showed that problematic internet use was associated with higher depression,impulsivity,Aggression,anger,hostility and social anxiety.Interpretation:Problematic internet use has become an important health issue that should not be overlooked,particularly because of the increased use of the internet by adolescents.Educational programs on early exposure to the internet should be developed.

关键词： Problematic internet use Adolescents Depression Aggression Social phobia Hostility

Rethink Left-Behind Experience: New Categories and Its Relationship with Aggression

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International Journal of Mental Health Promotion 2021年第4期23卷 443-454页

作者： Chunyang Zhang Yijun Lin Yuyang Zhou Wei Xu Beijing Key Laboratory of Applied Experimental Psychology National Demonstration Center for Experimental Psychology Education(Beijing Normal University)Faculty of PsychologyBeijing Normal UniversityBeijing100875China College of Business Florida International UniversityMiami33199USA School of Psychology Nanjing Normal UniversityNanjing210097China

Left-behind experience refers to the experience of children staying behind in their hometown under the care of only one parent or their relatives while one or both of their parents leave to work in other places.College students with left-behind experience showed higher Aggression levels.To further explore the relationship between left-behind experience and Aggression,the current study categorized left-behind experience using latent class analysis and explored its relationship with Aggression.One thousand twenty-eight Chinese college students with left-behind experience were recruited,and their Aggression levels were assessed.The results showed that there were four categories of left-behind experience:“starting from preschool,frequent contact”(35.5%),“less than 10 years in duration,limited contact”(27.0%),“starting from preschool,over 10 years in duration,limited contact”(10.9%),and“starting from school age,frequent contact”(26.6%).Overall,college students who reported frequent contact with their parents during the left-behind period showed lower levels of Aggression than others did.Females were less aggressive than males in the“starting from preschool,frequent contact”left-behind situation,while males were less aggressive than females in the“starting from school age,frequent contact”situation.Thesefindings indicate that frequent contact with leaving parents contributes to decreasing Aggression of college students with left-behind experience.Meanwhile,gender is an important factor in this relationship.

关键词： Aggression left-behind experience college students gender differences latent class analysis

Advances in diagnosis and prediction for Aggression of pure solid T1 lung cancer

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Precision Clinical Medicine 2023年第3期6卷 141-147页

作者： Junhao Mu Jing Huang Min Ao Weiyi Li Li Jiang Li Yang Department of Respiratory and Critical Care Medicine the First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China

A growing number of early-stage lung cancers presenting as malignant pulmonary nodules have been diagnosed because of the increased adoption of low-dose spiral computed tomography.But pure solid T1 lung cancer with≤3 cm in the greatest dimension is not always at an early stage,despite its small size.This type of cancer can be highiy aggressive and is associated with pathological involvement,metastasis,postoperative relapse,and even death.However,it is easily misdiagnosed or delay diagnosed in clinics and thus poses a serious threat to human health.The percentage of nodal or extrathoracic metastases has been reported to be>20%in T1 lung cancer.As such,understanding and identifying the aggressive characteristics of pure solid T1 lung cancer is crucial for prevention,diagnosis,and therapeutic strategies,and beneficial to improving the prognosis.With the widespread of lung cancer screening,these highly invasive pure solid T1 lung cancer will become the main advanced lung cancer in future.However,there is limited information regarding precision medicine on how to identify these“early-stage”aggressive lung cancers.To provide clinicians with new insights into early recognition and intervention of the highly invasive pure solid T1 lung cancer,this review summarizes its clinical characteristics,imaging,pathology,gene alterations,immune microenvironment,multi-omics,and current techniques for diagnosis and prediction.

关键词： solid T1 lung cancer Aggression prediction

Traumatic Brain Injury in Prisoners: Relation to Risky Decision-Making, Aggression and Criminal Behavior

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Journal of Behavioral and Brain Science 2019年第7期9卷 289-299页

作者： Niki C. Kuin Erik J. A. Scherder Hanneke Gijsbers Erik D. M. Masthoff Penitentiary Institution Vught Vught The Netherlands VU University Department of Clinical Neuropsychology Amsterdam The Netherlands

The objective of this cross-sectional study was to investigate if Traumatic Brain Injury (TBI) is related to decision-making deficits as well as to heightened levels of (reactive) Aggression and criminal behavior in a group of Dutch male prisoners. Characteristics of Aggression were assessed using three self-report questionnaires as well as systematic staff observations, complemented with data from criminal records. A semi-structured interview was conducted to rate lifetime prevalence of TBI and the Iowa Gambling Task (IGT) was completed to assess risky decision-making. Out of the total of 133 participants, 74 (55.6%) reported having sustained one or more incidents with potential TBI. Statistical comparisons between offenders with and without TBI indicated that the offenders with TBI reported significantly higher levels of (reactive) Aggression on two out of three questionnaires than offenders without TBI (p-values ranging from 0.003 to 0.008), but no significant differences were found on staff observations of Aggression and on the IGT. The higher conviction rates in offenders with TBI compared to the non-TBI group showed a trend. The confirmed relationship between TBI and higher aggressive tendencies is especially relevant for forensic populations due to the high prevalence rates of TBI in offenders. How this relates to specific cognitive processes remains unclear. The lack of a statistical difference between offenders with and without TBI on the IGT is in contrast with literature in non-offender samples, but seems to be in line with other studies in forensic populations.

关键词： Aggression Prisoners Traumatic Brain Injury Decision-Making Iowa Gambling Task

Does Exposure to Noise Lead to Decreased Regulatory Abilities, and Increased Aggression?

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Journal of Behavioral and Brain Science 2016年第1期6卷 53-80页

作者： Farzaneh Pahlavan Melana Arouss Laboratory of Social Psychology: Threat & Society EA 4471 Institut de Psychologie Université Paris Descartes Paris France

Recent advances in the study of affective-cognitive regulation of aggressive behavior suggest positive correlations between poor executive capacities (ECF) and negative reactivity. If the global assumption is correct what are the likely implications of predicted relation? The central issue in present research is to verify this assumption and examine how situational characteristics can alter executive performance in adults experiencing Civil War (Syrians students living in their country or in a host country) and adults experiencing peaceful life (French students) to explore some of the consequences of those modifications for aggressive and anxious tendencies. Precisely, we expect the positive correlations between poor executive performances and high dispositional as well situational aggressive and anxious tendencies, specifically for adults exposed to warfare. In order to assess executive capacities and dispositional as well as situational aggressive and anxious tendencies, during one pilot and two comparative studies [pilot study: N = 60 female French students;first comparative study: N = 60 French and N = 60 Syrian students of both sexes (50%);second comparative study: N = 60 Syrian students of both sexes (50%) living in France] right-handed French/Arabic-speakers participants complete twice, before and after completion executive tasks (standard neuropsychological tests) under different experimental conditions (Aversive/Neutral condition), a series of Aggression and anxiety questionnaires. The results provide evidence of a dispositional relationship between poor executive functioning and negative reactivity, and extend it to situational level. For all participants, it shows that increases in impulsiveness (negative emotionality and aggressive choices) due to an aversive noise (80 db) are concomitant with an inability to focus individuals’ attention on ongoing tasks, specifically in those living directly or indirectly stressful life-event.

关键词： Aggression Self-Regulation ECF Experience of Civil War Aversive Noise Anxiety

Neonatal Exposure to the Dipeptidyl Peptidase-IV Inhibitors Diprotin A and Sitagliptin Induces Depression-Like Behavior, Anxiety, and Latent Aggression in Adolescent and Adult Rats

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Journal of Behavioral and Brain Science 2016年第4期6卷 167-183页

作者： Nataliya A. Krupina Nadezhda N. Khlebnikova Laboratory of the General Pathology of Nervous System Federal State Budgetary Scientific Institution “Institute of General Pathology and Pathophysiology” Moscow Russia

Emotional and motivational disorders in adults are often considered to be the result of altered neurodevelopment. Clinical and experimental data provide evidence that serine protease dipeptidyl peptidase-IV (DPP-IV, EC 3.***.14.5) is involved in the pathophysiology of psycho-emotional disorders. Recently, we have shown that adolescent and adult rats exhibit an increase in anxiety and depression-related behaviors after neonatal administration of a synthetic non-competitive inhibitor of DPP-IV, methionyl-2(S)-cyano-pyrrolidine. In the present study, we tested the effects of two competitive, selective DPP-IV inhibitors, sitagliptin (4 mg/kg) and diprotin A (2 mg/kg), administered at postnatal days 5 - 18 on the emotional and motivational behavior of adolescent and adult rats. We observed increased anxiety in one-month-old diprotin A- or sitagliptin-treated rats in the elevated plus maze;diprotin A also enhanced the animals’ anxiety score using a ranked scale for evaluating anxiety and phobias. In the sucrose consumption and preference test, depressive-like behavior was pronounced in both the diprotin A- and sitagliptin-treated one-month-old animals, while only the diprotin A-treated rats exhibited a decrease in sucrose consumption at the age of 2 months. The diprotin A-treated rats also demonstrated behavioral despair and decreased activity in the forced swimming test within 1 - 3 months of age. Increased Aggression was observed in 1 - 3-month-old diprotin A-treated rats and in two-month-old sitagliptin-treated rats. These findings support the hypothesis that DPP-IV is involved in the genesis of emotional and motivational disorders. Additionally, the results show that diprotin А impairs the adolescent and adult rats’ behavior more significantly than sitagliptin when the animals were treated with the DPP-IV inhibitors in the early postnatal period.

关键词： Dipeptidyl Peptidase IV Inhibitors Rat Depression Anxiety Aggression

Longitudinal Structural Equation Modeling of Internet Game and Aggression in Children

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Open Journal of Nursing 2015年第5期5卷 426-436页

作者： Joohyun Lee Kyung Sook Choi College of Nursing Eulji University Seongnam South Korea Red Cross College of Nursing Chung Ang University Seoul South Korea

This study aimed to identify the effects of Internet game on levels of Aggression in children in the context of individual, familial, and social environments. The subjects were 2844 fourth graders participated in the Korean Youth Panel Survey between 2004 and 2008. Internet game use, the levels of Aggression, self-esteem, self-control, stress, depression, attachment to parents, parental control, attachment to teachers, and attachment to peers were measured by 5-point Likert scales. The result showed that gender was the most effective factor influencing the initial level of, the rate of changes, an increase or decrease in the rate of changes in Internet game use and levels of Aggression. Boys showed higher levels of Internet game use and Aggression than girls. Children with higher self-esteem, self-control and lower stress and depression showed lower levels of Internet game use and Aggression. The levels of Internet game use at fourth grade was positively correlated with later increase in the levels of Aggression. Also, the faster increase in Internet game use caused faster increase in the levels of Aggression later. Based on the results, preventive measures such as limiting the opportunities to access Internet games might be worth to decrease the aggressive behaviors among children.

关键词： Internet Game Aggression Children