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Exercise attenuates angiotensinⅡ-induced muscle atrophy by targeting PPARγ/miR-29b

Journal of Sport and Health Science 2022年第6期11卷 696-707,F0003页

作者： Qi Liu Liyang Chen Xuchun Liang Yuqing Cao Xinyue Zhu Siqi Wang Jin Li Juan Gao Junjie Xiao Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesSchool of Life ScienceShanghai UniversityShanghai 200444China Shanghai Engineering Research Center of Organ Repair School of MedicineShanghai UniversityShanghai 200444China

Background:Exercise is beneficial for muscle atrophy.Peroxisome proliferator-activated receptor gamma(PPARγ) and microRNA-29 b(miR-29 b) have been reported to be responsible for angiotensinⅡ(AngⅡ)-induced muscle atrophy.However,it is unclear whether exercise can protect AngⅡ-induced muscle atrophy by targeting PPARγ/miR-29 b.Methods:Skeletal muscle atrophy in both the control group and the run group was established by AngⅡ infusion;after 1 week of exercise training,the mice were sacrificed,and muscle weight was determined.Myofiber size was measured by hematoxylin-eosin and wheat-germ agglutinin staining.Apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick end labeling staining.The expression level of muscle atrogenes,including F-box only protein 32(FBXO32,also called Atrogin-1) and muscle-specific RING-finger 1(MuRF-1),the phosphorylation level of protein kinase B(PKB,also called AKT)/forkhead box 03 A(FOX03 A)/mammalian target of rapamycin(mTOR) pathway proteins,the expression level of PPARγ and apoptosis-related proteins,including B-cell lymphoma-2(Bcl-2),Bcl-2-associated X(Bax),cysteine-aspartic acid protease 3(caspase-3),and cleaved-caspase-3,were determined by western blot.The expression level of miR-29 b was checked by reversetranscription quantitative polymerase chain reaction.A PPARγ inhibitor(T0070907) or adeno-associated virus serotype-8(AAV8)-mediated miR-29 b overexpression was used to demonstrate whether PPARγ activation or miR-29 b inhibition mediates the beneficial effects of exercise in AngⅡ-induced muscle atrophy.Results:Exercise can significantly attenuate AngⅡ-induced muscle atrophy,which is demonstrated by increased skeletal muscle weight,cross-sectional area of myofiber,and activation of AKT/mTOR signaling and by decreased atrogenes expressions and apoptosis.In AngⅡ-induced muscle atrophy mice models,PPARγ was elevated whereas miR-29 b was decreased by exercise.The protective effects of exercise in AngⅡ-induced muscle atrophy were inhibited by a PPARγ inhibitor(T0070907)

关键词： AngiotensinⅡ Exercise Muscle atrophy PPARg miR-29b

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Recent applications and chiral separation development based on stationary phases in open tubular capillary electrochromatography(2019–2022)

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Journal of Pharmaceutical Analysis 2023年第4期13卷 323-339页

作者： Xinyu Li Qianjie Ma Xiangtai Zheng Qin Chen Xiaodong Sun Shanghai Engineering Research Center of Organ Repair School of MedicineShanghai UniversityShanghai200444China shanghai Key Laboratory of Bio-Energy Crops School of Life SciencesShanghai UniversityShanghai200444China Institute of Translational Medicine Shanghai UniversityShanghai200444China

Capillary electrochromatography(CEC)plays a significant role in chiral separation via the double separation principle,partition coefficient difference between the two phases,and electroosmotic flow-driven separation.Given the distinct properties of the inner wall stationary phase(SP),the separation ability of each SP differs from one another.Particularly,it provides large room for promising applications of open tubular capillary electrochromatography(OT-CEC).We divided the OT-CEC SPs developed over the past four years into six types:ionic liquids,nanoparticle materials,microporous materials,biomaterials,non-nanopolymers,and others,to mainly introduce their characteristics in chiral drug separation.There also added a few classic SPs that occurred within ten years as supplements to enrich the features of each SP.Additionally,we discuss their applications in metabolomics,food,cosmetics,environment,and biology as analytes in addition to chiral drugs.OT-CEC plays an increasingly significant role in chiral separation and may promote the development of capillary electrophoresis(CE)combined with other instruments in recent years,such as CE with mass spectrometry(CE/MS)and CE with ultraviolet light detector(CE/UV).

关键词： Capillary electrochromatography Open tubular capillary Chiral separation Stationary phase Capillary electrophoresis with mass spectrometry(CE/MS)

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Oxidative cyclization of allyl compounds and isocyanide: A facile entry to polysubstituted 2-cyanopyrroles

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Chinese Chemical Letters 2024年第4期35卷 330-335页

作者： Yaping Zhang Wei Zhou Mingchun Gao Tianqi Liu Bingxin Liu Chang-Hua Ding Bin Xu Department of Chemistry Affiliated Nantong Hospital of Shanghai University(The Sixth People's Hospital of Nantong)Shanghai Engineering Research Center of Organ RepairInnovative Drug Research CenterSchool of MedicineShanghai UniversityShanghai 200444China State Key Laboratory of organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

A facile Tf OH-catalyzed oxidative cyclization of allyl compounds and isocyanide has been developed with the assistance of DDQ, where isocyanide is used as the crucial "N" and "CN" sources. Highly functionalized 2-cyanopyrroles are constructed efficiently through a new formal [3 + 2] mode, demonstrating diverse reactivity and synthetic utility in organic chemistry. 2-Cyanopyrrole is converted into a nucleobase analogue of Remdesivir and 5H-pyrrolo[2,1-a]isoindole through a three-step or a two-step sequence, respectively. This protocol features broad substrate scope, operational simplicity and good functional group tolerance.

关键词： Isocyanide Cyanopyrrole Insertion Allyl compound Bronsted acid catalysis

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Fromα-keto acids to nitrile oxides enabled by copper nitrate:a facile access to fused isoxazolines

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organic Chemistry Frontiers 2022年第3期9卷 676-681页

作者： Yuping Zhu Tianqi Liu Bingxin Liu Houguang Shi Qitao Tan Bin Xu Department of Chemistry Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai Engineering Research Center of Organ RepairInnovative Drug Research CenterSchool of MedicineShanghai UniversityShanghai 200444China State Key Laboratory of organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

α-Keto acids were unprecedentedly employed as novel precursors of nitrile oxides on treatment with copper nitrate,which reacted with maleimides via[3+2]dipolar cycloaddition leading to pharmacologically interesting fused isoxazolines.This approach offers a unique strategy and complementary method for the convenient generation of alkyl substituted nitrile oxides.

关键词： nitrate fused oxides

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A chiral metal-organic framework{(HQA)(ZnCl_(2))(2.5H_(2)O)}n for the enantioseparation of chiral amino acids and drugs

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Journal of Pharmaceutical Analysis 2023年第4期13卷 421-429页

作者： Xiangtai Zheng Qi Zhang Qianjie Ma Xinyu Li Liang Zhao Xiaodong Sun Shanghai Engineering Research Center of Organ Repair School of MedicineShanghai UniversityShanghai200444China School of Pharmacy Jiangsu UniversityZhenjiangJiangsu212013China Department of Pharmacy Shanghai Baoshan Luodian HospitalShanghai201908China Luodian Clinical Drug research center Institute for Translational Medicine ResearchShanghai UniversityShanghai200444China

Chiral metal-organic frameworks(CMOFs)with enantiomeric subunits have been employed in chiral chemistry.In this study,a CMOF formed from 6-methoxyl-(8S,9R)-cinchonan-9-ol-3-carboxylic acid(HQA)and ZnCl_(2),{(HQA)(ZnCl_(2))(2.5H_(2)O)}n,was constructed as a chiral stationary phase(CSP)via an in situ fabrication approach and used for chiral amino acid and drug analyses for the first time.The{(HQA)(ZnCl_(2))(2.5H_(2)O)}n nanocrystal and the corresponding chiral stationary phase were systematically characterised using a series of analytical techniques including scanning electron microscopy,X-ray diffraction,Fourier transform infrared spectroscopy,circular dichroism,X-ray photoelectron spectroscopy,thermogravimetric analysis,and Brunauer-Emmett-Teller surface area measurements.In opentubular capillary electrochromatography(CEC),the novel chiral column exhibited strong and broad enantioselectivity toward a variety of chiral analytes,including 19 racemic dansyl amino acids and several model chiral drugs(both acidic and basic).The chiral CEC conditions were optimised,and the enantioseparation mechanisms are discussed.This study not only introduces a new high-efficiency member of the MOF-type CSP family but also demonstrates the potential of improving the enantioselectivities of traditional chiral recognition reagents by fully using the inherent characteristics of porous organic frameworks.

关键词： Capillary electrochromatography Metal-organic framework Enantioseparation Chiral stationary phase Open-tubular column Dansyl amino acids

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Chemically revised conducting polymers with inflammation resistance for intimate bioelectronic electrocoupling

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Bioactive Materials 2023年第8期26卷 24-51页

作者： Sihao Qian Hsing-An Lin Qichao Pan Shuhua Zhang Yunhua Zhang Zhi Geng Qing Wu Yong He Bo Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China School of Materials Science and engineering&Shanghai Engineering Research Center of Organ Repair Shanghai UniversityShanghai200444China Innovation center for Textile Science and Technology Donghua UniversityShanghai201620China

Conducting polymers offer attractive mixed ionic-electronic conductivity,tunable interfacial barrier with metal,tissue matchable softness,and versatile chemical functionalization,making them robust to bridge the gap between brain tissue and electronic circuits.This review focuses on chemically revised conducting polymers,combined with their superior and controllable electrochemical performance,to fabricate long-term bioelectronic implants,addressing chronic immune responses,weak neuron attraction,and long-term electrocommunication instability challenges.Moreover,the promising progress of zwitterionic conducting polymers in bioelectronic implants(≥4 weeks stable implantation)is highlighted,followed by a comment on their current evolution toward selective neural coupling and reimplantable function.Finally,a critical forward look at the future of zwitterionic conducting polymers for in vivo bioelectronic devices is provided.

关键词： Bioelectronic Conducting polymer Zwitterion Antifouling Inflammation resistance

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Copper Nitrate-Mediated Selective Bond Cleavage of Alkynes:Diverse Synthesis of Isoxazoles

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Chinese Journal of Chemistry 2023年第23期41卷 3299-3304页

作者： Jianan Liu Kaijing Zhou Shaobo Sun Mingchun Gao Bin Xu Department of Chemistry Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong)Shanghai Engineering Research Center of Organ RepairInnovative Drug Research CenterSchool of MedicineShanghai UniversityShanghai200444 China Qianweichang College Shanghai UniversityShanghai200444 China State Key Laboratory of organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032 China

An unprecedented copper nitrate-mediated bond cleavage of alkynes was developed for the modular synthesis of isoxazoles,where either C—S bond or C≡C triple bond was cleaved selectively.Substituents attached to the C≡C triple bonds could differentiate the chemical bonds cleavage and reaction pathways disparately.Various transformations of products illustrate promising applications of the given protocols.

关键词： Alkynes Bond cleavage Copper nitrate Cyclization Isoxazoles Molecular diversity N-Heterocycles Substituent effects

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Lymphangiogenesis contributes to exercise-induced physiological cardiac growth

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Journal of Sport and Health Science 2022年第4期11卷 466-478页

作者： Yihua Bei Zhenzhen Huang Xing Feng Lin Li Meng Wei Yujiao Zhu Shuqin Liu Chen Chen Mingming Yin Huimin Jiang Junjie Xiao Cardiac Regeneration and Ageing Lab Institute of Geriatrics(Shanghai University)Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)School of MedicineShanghai UniversityNantong 226011China Shanghai Engineering Research Center of Organ Repair School of Life ScienceShanghai UniversityShanghai 200444China Clinical Laboratory center Beijing Hospital of Traditional Chinese MedicineBeijing 100010China

Background:Promoting cardiac lymphangiogenesis exerts beneficial effects for the heart.Exercise can induce physiological cardiac growth with cardiomyocyte hypertrophy and increased proliferation markers in cardiomyocytes.However,it remains unclear whether and how lymphangiogenesis contributes to exercise-induced physiological cardiac growth.We aimed to investigate the role and mechanism of lymphangiogenesis in exercise-induced physiological cardiac growth.Methods:Adult C57 BL6/J mice were subjected to 3 weeks of swimming exercise to induce physiological cardiac growth.Oral treatment with vascular endothelial growth factor receptor 3(VEGFR3) inhibitor SAR1 3 1 675 was used to investigate whether cardiac lymphangiogenesis was required for exercise-induced physiological cardiac growth by VEGFR3 activation.Furthermore,human dermal lymphatic endothelial cell(LEC)-conditioned medium was collected to culture isolated neonatal rat cardiomyocytes to determine whether and how LECs could influence cardiomyocyte proliferation and hypertrophy.Results:Swimming exercise induced physiological cardiac growth accompanied by a remarkable increase of cardiac lymphangiogenesis as evidenced by increased density of lymphatic vessel endothelial hyaluronic acid receptor 1-positive lymphatic vessels in the heart and upregulated LYVE-1 and Podoplanin expressions levels.VEGFR3 was upregulated in the exercised heart,while VEGFR3 inhibitor SAR131675 attenuated exercise-induced physiological cardiac growth as evidenced by blunted myocardial hypertrophy and reduced proliferation marker Ki67 in cardiomyocytes,which was correlated with reduced lymphatic vessel density and downregulated LYVE-1 and Podoplanin in the heart upon exercise.Furthermore,LEC-conditioned medium promoted both hypertrophy and proliferation of cardiomyocytes and contained higher levels of insulinlike growth factor-1 and the extracellular protein Reelin,while LEC-conditioned medium from LECs treated with SAR131675 blocked these effects.Functional rescue assays further demonstr

关键词： Cardiac lymphatics Exercise Physiological cardiac hypertrophy Proliferation VEGFR3

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Advanced nano drug delivery systems for neuroprotection against ischemic stroke

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Chinese Chemical Letters 2024年第2期35卷 151-162页

作者： Chenchen Xie Jun Liao Ning Zhang Yuhan Sun Yi Li Liyan Xiong Yingnan Zhang Xiaoyan Liu Wei Su Heming Chen Ping Zeng Xiaoqing Zhang Ying Lu Tingfang Wang Chuan Zhang Shanghai Engineering Research Center of Organ Repair School of MedicineShanghai UniversityShanghai 200444China Department of Pharmaceutical Science School of PharmacyNaval Medical UniversityShanghai 200433China Department of pharmacy the International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200030China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200040China

Ischemic stroke(IS)represents a significant threat to brain health due to its elevated mortality and disability rates.The efficacy of small-molecule neuroprotective agents has been impeded by challenges associated with traversing the blood-brain barrier(BBB)and limited bioavailability.Conversely,advanced nano drug delivery systems hold promise for overcoming these obstacles by facilitating efficient transportation across the BBB and maintaining optimal drug concentrations.This review aims to explore advanced neuroprotective nano drug delivery systems as a means of effectively administering neuroprotective agents to the brain using pharmaceutical approaches in the treatment of IS.By examining these systems,researchers and clinicians can gain valuable insights and innovative concepts,illuminating the potential of advanced neuroprotective nano drug delivery systems.Leveraging these advancements can drive the progress of pioneering and efficacious therapeutic interventions for IS.

关键词： Target Blood-brain barrier Ischemic stroke Nano drug delivery Neuroprotection

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Exercise training maintains cardiovascular health:signaling pathways involved and potential therapeutics

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3709-3726页

作者： Huihua Chen Chen Chen Michail Spanos Guoping Li Rong Lu Yihua Bei Junjie Xiao School of Basic Medical Science Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Engineering Research Center of Organ Repair School of MedicineShanghai UniversityShanghai 200444China Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesSchool of Life ScienceShanghai UniversityShanghai 200444China Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA

Exercise training has been widely recognized as a healthy lifestyle as well as an effective non-drug therapeutic strategy for cardiovascular diseases(CVD).Functional and mechanistic studies that employ animal exercise models as well as observational and interventional cohort studies with human participants,have contributed considerably in delineating the essential signaling pathways by which exercise promotes cardiovascular fitness and health.First,this review summarizes the beneficial impact of exercise on multiple aspects of cardiovascular health.We then discuss in detail the signaling pathways mediating exercise’s benefits for cardiovascular health.The exercise-regulated signaling cascades have been shown to confer myocardial protection and drive systemic adaptations.The signaling molecules that are necessary for exercise-induced physiological cardiac hypertrophy have the potential to attenuate myocardial injury and reverse cardiac remodeling.Exercise-regulated noncoding RNAs and their associated signaling pathways are also discussed in detail for their roles and mechanisms in exercise-induced cardioprotective effects.Moreover,we address the exercise-mediated signaling pathways and molecules that can serve as potential therapeutic targets ranging from pharmacological approaches to gene therapies in CVD.We also discuss multiple factors that influence exercise’s effect and highlight the importance and need for further investigations regarding the exercise-regulated molecules as therapeutic targets and biomarkers for CVD as well as the cross talk between the heart and other tissues or organs during exercise.We conclude that a deep understanding of the signaling pathways involved in exercise’s benefits for cardiovascular health will undoubtedly contribute to the identification and development of novel therapeutic targets and strategies for CVD.

关键词： cardiovascular protective organs

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