Exercise training maintains cardiovascular health:signaling pathways involved and potential therapeutics

作     者：Huihua Chen Chen Chen Michail Spanos Guoping Li Rong Lu Yihua Bei Junjie Xiao 

作者机构：School of Basic Medical ScienceShanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Engineering Research Center of Organ RepairSchool of MedicineShanghai UniversityShanghai 200444China Cardiac Regeneration and Ageing LabInstitute of Cardiovascular SciencesSchool of Life ScienceShanghai UniversityShanghai 200444China Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical SchoolBostonMA 02114USA 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第10期

页      面：3709-3726页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学] 

基　　金：supported by the grants from National Key Research and Development Project(2018YFE0113500 to J.X.) ational Natural Science Foundation of China(82020108002 and 81911540486 to J.X.,81970335 and 82170285 to Y.H.B.) the grant from Science and Technology Commission of Shanghai Municipality(21XD1421300 and 20DZ2255400 to J.X.) the“Dawn”Program of Shanghai Education Commission(19SG34 to J.X.) Shanghai Rising-Star Program(19QA1403900 to Y.H.B.) the grant from Science and Technology Commission of Shanghai Municipality(21SQBS00100 to Y.H.B.). 

主　　题：cardiovascular protective organs 

摘      要：Exercise training has been widely recognized as a healthy lifestyle as well as an effective non-drug therapeutic strategy for cardiovascular diseases(CVD).Functional and mechanistic studies that employ animal exercise models as well as observational and interventional cohort studies with human participants,have contributed considerably in delineating the essential signaling pathways by which exercise promotes cardiovascular fitness and health.First,this review summarizes the beneficial impact of exercise on multiple aspects of cardiovascular health.We then discuss in detail the signaling pathways mediating exercise’s benefits for cardiovascular health.The exercise-regulated signaling cascades have been shown to confer myocardial protection and drive systemic adaptations.The signaling molecules that are necessary for exercise-induced physiological cardiac hypertrophy have the potential to attenuate myocardial injury and reverse cardiac remodeling.Exercise-regulated noncoding RNAs and their associated signaling pathways are also discussed in detail for their roles and mechanisms in exercise-induced cardioprotective effects.Moreover,we address the exercise-mediated signaling pathways and molecules that can serve as potential therapeutic targets ranging from pharmacological approaches to gene therapies in CVD.We also discuss multiple factors that influence exercise’s effect and highlight the importance and need for further investigations regarding the exercise-regulated molecules as therapeutic targets and biomarkers for CVD as well as the cross talk between the heart and other tissues or organs during exercise.We conclude that a deep understanding of the signaling pathways involved in exercise’s benefits for cardiovascular health will undoubtedly contribute to the identification and development of novel therapeutic targets and strategies for CVD.