Recent applications and chiral separation development based on stationary phases in open tubular capillary electrochromatography(2019–2022)

作     者：Xinyu Li Qianjie Ma Xiangtai Zheng Qin Chen Xiaodong Sun Xinyu Li;Qianjie Ma;Xiangtai Zheng;Qin Chen;Xiaodong Sun

作者机构：Shanghai Engineering Research Center of Organ RepairSchool of MedicineShanghai UniversityShanghai200444China Shanghai Key Laboratory of Bio-Energy CropsSchool of Life SciencesShanghai UniversityShanghai200444China Institute of Translational MedicineShanghai UniversityShanghai200444China 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2023年第13卷第4期

页      面：323-339页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100704[医学-药物分析学] 07[理学] 070302[理学-分析化学] 0703[理学-化学] 10[医学] 

基　　金：This study was funded by the Project of National Natural Science Foundation of China(Grant No.:82003705) the Shanghai Science and Technology Innovation Foundation(Grant Nos.:23010500200 and 23ZR1422700). 

主　　题：Capillary electrochromatography Open tubular capillary Chiral separation Stationary phase Capillary electrophoresis with mass spectrometry(CE/MS) 

摘      要：Capillary electrochromatography(CEC)plays a significant role in chiral separation via the double separation principle,partition coefficient difference between the two phases,and electroosmotic flow-driven separation.Given the distinct properties of the inner wall stationary phase(SP),the separation ability of each SP differs from one another.Particularly,it provides large room for promising applications of open tubular capillary electrochromatography(OT-CEC).We divided the OT-CEC SPs developed over the past four years into six types:ionic liquids,nanoparticle materials,microporous materials,biomaterials,non-nanopolymers,and others,to mainly introduce their characteristics in chiral drug separation.There also added a few classic SPs that occurred within ten years as supplements to enrich the features of each SP.Additionally,we discuss their applications in metabolomics,food,cosmetics,environment,and biology as analytes in addition to chiral drugs.OT-CEC plays an increasingly significant role in chiral separation and may promote the development of capillary electrophoresis(CE)combined with other instruments in recent years,such as CE with mass spectrometry(CE/MS)and CE with ultraviolet light detector(CE/UV).