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Methacrylated gelatin and platelet-rich plasma based hydrogels promote regeneration of critical-sized bone defects

regenerative Biomaterials 2024年第4期3卷 66-81页

作者： Shichao Lian Zhiyu Mu Zhengchao Yuan Muhammad Shafiq Xiumei Mo Weidong Mu Department of Traumatic Orthopaedics Shandong Provincial HospitalShandong UniversityJinanShandong 250012China Zoucheng People’s Hospital ZouchengShandong 273500China Department of Medical Physics and Biomedical engineering University of LondonLondon WC1E 6BTUK State Key Laboratory for Modification of Chemical Fibers and Polymer materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620PR China Innovation center of Nanomedicine(iCONM) Kawasaki Institute of Industrial PromotionKawasaki-KuKawasaki 210-0821Japan

Physiological repair of large-sized bone defects requires instructive scaffolds with appropriate mechanical properties,biocompatibility,biodegradability,vasculogenic ability and *** objective of this study was to fabricate in situ injectable hydrogels using platelet-rich plasma(PRP)-loaded gelatin methacrylate(GM)and employ them for the regeneration of large-sized bone *** performed various biological assays as well as assessed the mechanical properties of GM@PRP hydrogels alongside evaluating the release kinetics of growth factors(GFs)from *** GM@PRP hydrogels manifested sufficient mechanical properties to support the filling of the tissue *** biofunction assay,the GM@PRP hydrogels significantly improved cell migration and ***,transcriptome RNA sequencing of human umbilical vein endothelial cells and bone marrow-derived stem cells were performed to delineate vascularization and biomineralization abilities of GM@PRP *** GM@PRP hydrogels were subcutaneously implanted in rats for up to 4 weeks for preliminary biocompatibility followed by their transplantation into a tibial defect model for up to 8 weeks in *** defects treated with GM@PRP hydrogels manifested significant bone regeneration as well as angiogenesis,biomineralization,and collagen *** on the biocompatibility and biological function of GM@PRP hydrogels,a new strategy is provided for the regenerative repair of large-size bone defects.

关键词： large-sized bone defect repair platelet-rich plasma hydrogel tissue scaffold gelatin methacrylate

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Long-Range Electronic Effect-Promoted Ring-Opening Polymerization of Thioctic Acid to Produce Biomimetic Ionic Elastomers for Bioelectronics

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CCS Chemistry 2024年第3期6卷 761-773页

作者： Hongfei Huang Huijing Wang Lijie Sun Ruohan Zhang Luzhi Zhang ZekaiWu Yaxuan Zheng Yang Wang Wei Fu Youwei Zhang Rasoul Esmaeely Neisiany Zhengwei You State Key Laboratory for Modification of Chemical Fibers and Polymer materials College of Materials Science and EngineeringInstitute of Functional MaterialsDonghua UniversityResearch Base of Textile Materials for Flexible Electronics and Biomedical Applications(China Textile Engineering Society)Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineShanghai 201620 Institute of Pediatric Translational medicine Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127 Department of materials and Polymer engineering Faculty of EngineeringHakim Sabzevari UniversitySabzevar ***

Poly(disulfide)s have been widely used in flexible wearable electronics,smart materials,and drug *** synthesis of poly(disulfide)s usually utilizes external stimuli or toxic initiators to promote the ***,we indicated that the long-range electronic effect can significantly alter the reactivity of the disulfide ***,we established deprotonation-promoted ring-opening polymerization of thioctic acid(TA)as a highly effective and simple method to synthesize poly(disulfide)s due to the long-range electronic effect and nucleophilic *** external stimuli and initiators,simple mixing of TA and deprotonation reagent,choline bicarbonate,in different ratios at room temperature rapidly produced a series of high molecular weight(up to 772 kDa)ionic liquid crystal poly(disulfide)s elastomers with room temperature self-healing ability,adjustable conductivity(2.39×10^(−2)∼0.28×10^(−2)S m^(−1)),degradability,biocompatibility,antibacterial property,and tissue-like softness(Young’s moduli ranging from 18.2±6.0 to 111.1±36.7 kPa).The experiments and density functional theory calculations also revealed the principle of long-range electronic effect to establish a new synthetic strategy of poly(disulfide)s with superior properties favorable for bioelectronics.

关键词： self-healing elastomers thioctic acid ionic liquid bioelectronics

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Chatter suppression techniques in milling processes:A state of the art review

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Chinese Journal of Aeronautics 2024年第7期37卷 1-23页

作者： Zhenmin LI Qinghua SONG Peijian JIN Zhanqiang LIU Bing WANG Haifeng MA Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of EducationSchool of Mechanical EngineeringShandong UniversityJinan 250061China National Demonstration center for Experimental Mechanical engineering Education Shandong UniversityJinan 250061China

Chatter in the machining system can result in a decrease in tool life,poor surface finish,conservative cutting parameters,*** many review papers promoting the understanding and research of this area,chatter suppression techniques are generally discussed within limited pages in the framework of comprehensive chatter-related *** recent years,the developments of smart materials,advanced sensing techniques,and more effective control strategies have led to some new progress in chatter ***,the widely used thin-walled parts present more and more severe machining challenges in their milling *** the above deficiencies,this paper summarizes the current state of the art in milling chatter *** classifications of chatter suppression techniques are proposed according to the working principle and control *** on the new classified framework,the mechanism and comparisons of different chatter suppression strategies are ***,the current challenges and potential tendencies of milling chatter suppression techniques are ***,integration,compactness,adaptability to workpiece geometry,and the collaboration of multiple control methods are predicted to be important trends in the future.

关键词： Active control Chatter suppression Damping Milling regenerative effect

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Expert consensus on pediatric orthodontic therapies of malocclusions in children

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International Journal of Oral Science 2024年第2期16卷 186-196页

作者： Chenchen Zhou Peipei Duan Hong He Jinlin Song Min Hu Yuehua Liu Yan Liu Jie Guo Fang Jin Yang Cao Lingyong Jiang Qingsong Ye Min Zhu Beizhan Jiang Wenhua Ruan Xiao Yuan Huang Li Rui Zou Yulou Tian Li Gao Rui Shu Jianwei Chen Renkai Liu Shujuan Zou Xiaobing Li State Key Laboratory of Oral Diseases&National center for Stomatology&National Clinical research center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National center for Stomatology&National Clinical research center for Oral Diseases&Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&Key Laboratory of Oral Biomedicine Ministry of Education&Hubei Key Laboratory of Stomatology&Department of Orthodontics&center for Dentofacial Development and Sleep medicine School and Hospital of StomatologyWuhan UniversityWuhanChina Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences&Chongqing Municipal Key Laboratory of Oral Biomedical engineering of Higher Education Stomatological Hospital of Chongqing Medical UniversityChongqing Medical University&College of StomatologyChongqing Medical UniversityChongqingChina Department of Orthodontics Hospital of StomatologyJilin UniversityChangchunChina Department of Orthodontic&Oral Biomedical engineering Laboratory Shanghai Stomatological HospitalFudan UniversityShanghaiChina Department of Orthodontics Central LaboratoryPeking University School and Hospital for Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina Department of Orthodontics School and Hospital of StomatologyCollege of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue

Malocclusion,identified by the World Health Organization(WHO)as one of three major oral diseases,profoundly impacts the dental-maxillofacial functions,facial esthetics,and long-term development of~260 million children in *** its physical manifestations,malocclusion also significantly influences the psycho-social well-being of these *** intervention in malocclusion can foster an environment conducive to dental-maxillofacial development and substantially decrease the incidence of malocclusion or reduce the severity and complexity of malocclusion in the permanent dentition,by mitigating the negative impact of abnormal environmental influences on the *** orthodontic treatment encompasses accurate identification and treatment of dental and maxillofacial morphological and functional abnormalities during various stages of dental-maxillofacial development,ranging from fetal stages to the early permanent dentition *** an economic and societal standpoint,the urgency for effective early orthodontic treatments for malocclusions in childhood cannot be overstated,underlining its profound practical and social *** consensus paper discusses the characteristics and the detrimental effects of malocclusion in children,emphasizing critical need for early *** elaborates on corresponding core principles and fundamental approaches in early orthodontics,proposing comprehensive guidance for preventive and interceptive orthodontic treatment,serving as a reference for clinicians engaged in early orthodontic treatment.

关键词： permanent stated children

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Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos M.Kanczler Stuart Lanham Andrew Rawlings Marta Roldo Gianluca Tozzi Jonathan I.Dawson Gianluca Cidonio Richard O.C.Oreffo Faculty of medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-ECM(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMSCs viability upon *** composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)*** inclusion of bone morphogenetic protein-2(BMP-2)with the HBMSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

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Synergetic burns treatment by self-adaption release system combined with cold atmospheric plasma

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Science China(Technological Sciences) 2023年第10期66卷 2808-2823页

作者： WANG XiaoXia LIU ZhiJun ZHAO LiPing YANG HuiJie QIN JiaMin ZHANG JingQi ZHAO JiaXuan GUAN XiuWen ZHANG WeiFen MA JinLong School of Pharmacy Weifang Medical UniversityWeifang 261053China Department of Microbiology School of Basic Medical SciencesWeifang Medical UniversityWeifang 261053China shandong engineering research center for smart materials and regenerative medicine Weifang Medical UniversityWeifang 261053China Collaborative Innovation center for Target Drug Delivery System Weifang Medical UniversityWeifang 261053China

In the tissue remodeling stage of burns,excessive medical therapy can cause scarring by promoting excessive fibroblast proliferation and collagen *** atmospheric plasma(CAP)has emerged in biomedicine for its excellent sterilization and wound-healing function,which is expected to reduce the use of drugs in burns ***,a novel therapy that could rapidly heal burns was developed using a combined self-adaption release system with *** self-adaption release system(Cur-ZIF8@HA)used curcumin(Cur)as the therapeutic drug and ZIF-8 modified with hyaluronic acid(HA)as the *** vitro study results showed that combined treatment methods can inactivate bacteria and enhance fibroblast cells'migration and *** vivo animal wound healing studies have demonstrated that the synergistic treatment of Cur-ZIF8@HA and CAP can help fibroblast proliferation and stimulate angiogenesis,indicating effective wound *** importantly,CAP can reduce collagen synthesis in granulation tissue recombination and further inhibit scar formation by combining with CurZIF8@*** the biomedical field,these findings underscore to a large extent that our research will open up new possibilities for the interaction of nanotechnology with new technologies of physical principles.

关键词： cold atmospheric plasma pH-sensitive release burns treatment nanoparticle

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A nanosystem of copper(II)-disulfiram for cancer treatment with high efficacy and few side effects

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Frontiers of materials Science 2021年第4期15卷 553-566页

作者： Liping ZHAO Xiaoxia WANG Mingxia JIANG Xinghan WU Mogen ZHANG Xiuwen GUAN Jinlong MA Weifen ZHANG College of Pharmacy Weifang Medical UniversityWeifang 261053China Department of Pathology Weifang Medical UniversityWeifang 261053China School of Clinical medicine Weifang Medical UniversityWeifang 261053China Collaborative Innovation center for Target Drug Delivery System Weifang Medical UniversityWeifang 261053China shandong engineering research center for smart materials and regenerative medicine Weifang Medical UniversityWeifang 261053China

Developing chemotherapy drugs with high efficacy and few side effects has been a bottleneck problem that requires an efficient *** active cancer treatment ingredient disulfiram(DSF),inspired by the copper(II)diethyldithiocarbamate complex(CuET),can be used in a one-pot synthesis method to construct a CuET delivery nanosystem(CuET-ZIFCu@HA).Due to the high biocompatibility,targeting of CD44 overexpressed cancer cells,and acid response of zeolitic imidazolate framework(ZIF)materials of hyaluronic acid(HA),we realized that CuET-ZIFCu@HA could become an effective and highly selective cancer *** in vivo and in vitro experiments have demonstrated that CuET-ZIFCu@HA has robust anti-tumor properties without evident side *** research provided a promising strategy for DSF nanosystems that involves simple preparation and high efficacy,both of which are key to reusing DSF in cancer treatment.

关键词： disulfiram copper(II)diethyldithiocarbamate complex zeolitic imidazolate framework targeted therapy

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Stem cell microencapsulation maintains stemness in inflammatory microenvironment

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International Journal of Oral Science 2022年第4期14卷 549-560页

作者： Yajun Zhao Yilin Shi Huiqi Yang Mengmeng Liu Lanbo Shen Shengben Zhang Yue Liu Jie Zhu Jing Lan Jianhua Li Shaohua Ge Department of Implantology&Periodontology School and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration&Shandong Provincial Clinical Research Center for Oral DiseasesJinanChina Key Laboratory of Shaanxi Province for Craniofacial Precision medicine research College of StomatologyXi'an Jiaotong UniversityXi'anChina Airong Plastic Surgery Hospital JinanChina

Maintaining the stemness of the transplanted stem cell spheroids in an inflammatory microenvironment is challenging but important in regenerative medicine. Direct delivery of stem cells to repair periodontal defects may yield suboptimal effects due to the complexity of the periodontal inflammatory environment. Herein, stem cell spheroid is encapsulated by interfacial assembly of metal-phenolic network(MPN) nanofilm to form a stem cell microsphere capsule. Specifically, periodontal ligament stem cells(PDLSCs) spheroid was coated with FeⅢ/tannic acid coordination network to obtain spheroid@[FeⅢ-TA] microcapsules. The formed biodegradable MPN biointerface acted as a cytoprotective barrier and exhibited antioxidative, antibacterial and anti-inflammatory activities, effectively remodeling the inflammatory microenvironment and maintaining the stemness of PDLSCs. The stem cell microencapsulation proposed in this study can be applied to multiple stem cells with various functional metal ion/polyphenol coordination, providing a simple yet efficient delivery strategy for stem cell stemness maintenance in an inflammatory environment toward a better therapeutic outcome.

关键词： inflammatory protective maintain

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Microorganism-derived biological macromolecules for tissue engineering

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Frontiers of medicine 2022年第3期16卷 358-377页

作者： Naser Amini Peiman Brouki Milan Vahid Hosseinpour Sarmadi Bahareh Derakhshanmehr Ahmad Hivechi Fateme Khodaei Masoud Hamidi Sara Ashraf Ghazaleh Larijani Alireza Rezapour Cellular and Molecular research center Iran University of Medical SciencesTehran ***Iran Institutes of regenerative medicine Faculty of Advanced Technologies in MedicineIran University of Medical SciencesTehran ***Iran Department of Tissue engineering and regenerative medicine Faculty of Advanced Technologies in MedicineIran University of Medical SciencesTehran ***Iran Department of Pharmaceutics University of MinnesotaMN 55455USA Burn research center Department of Plastic and Reconstructive SurgeryIran University of Medical SciencesTehran ***Iran Department of Medical Biotechnology Faculty of ParamedicineGuilan University of Medical SciencesRasht ***Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran ***Iran Cellular and Molecular research Centre Qom University of Medical SciencesQom ***Iran Department of Tissue engineering and regenerative medicine School of MedicineQom University of Medical SciencesQom ***Iran

According to literature,certain microorganism productions mediate biological ***,their beneficial characteristics remain ***,scientists concentrate on obtaining natural materials from live creatures as new sources to produce innovative smart biomaterials for increasing tissue reconstruction in tissue engineering and regenerative *** present review aims to introduce microorganism-derived biological macromolecules,such as pullulan,alginate,dextran,curdlan,and hyaluronic acid,and their available sources for tissue *** evidence indicates that these materials can be used as biological material in scaffolds to enhance regeneration in damaged tissues and contribute to cosmetic and dermatological *** natural-based materials are attractive in pharmaceutical,regenerative medicine,and biomedical *** study provides a detailed overview of natural-based biomaterials,their chemical and physical properties,and new directions for future research and therapeutic applications.

关键词： biological macromolecules regenerative medicine tissue engineering exopolysaccharide carbohydrate

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Multifunctional hydrophobic fabric-based strain sensor for human motion detection and personal thermal management

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Journal of materials Science & Technology 2023年第7期138卷 108-116页

作者： Tianxue Zhu Lexin Liu Jianying Huang Shuhui Li Yonggang Lei Weilong Cai Yuekun Lai Huaqiong Li College of Chemical engineering Fuzhou UniversityFuzhou 350116China Zhejiang engineering research center for Tissue Repair materials Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325000China Department of Chemistry University College LondonLondon WC1E 6BTUK Oujiang Laboratory(Zhejiang Lab for regenerative medicine Vision and Brain Health)Wenzhou 325000China

Multifunctional flexible devices for human motion detection and thermal management raised great at-tention as the problem of the aging population is becoming more and more ***,it is still a challenge to endow the devices with excellent stability and wide application *** we prepared a hydrophobic and conductive fabric-based strain sensor for smart fabric via successively coating with poly-dopamine(PDA),polyaniline(PANI),polypyrrole(PPy),and polydimethylsiloxane(PDMS)through in-situ polymerization and dip-coating,which could be used for strain sensor and wearable heater both in air and *** obtained sample exhibited a fast electrical response in 500 ms and could withstand 10,000 times stretching-releasing cycles,additionally,the sample exhibited satisfactory electro-thermal and photo-thermal *** a whole,the multifunctional fabric-based devices with excellent performances show great potential to be applied in medical monitoring and personal care,especially for aged and disabled persons.

关键词： Strain sensor Superhydrophobic Thermal management Photo-thermal device

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