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Protein-S-100-beta is increased in patients with decompensated cirrhosis admitted to ICU

Journal of Intensive Medicine 2024年第2期4卷 222-230页

作者： Nicolas Weiss Simona Tripon Maxime Mallet Françoise Imbert-Bismut Mehdi Sakka Dominique Bonnefont-Rousselot Philippe Sultanik Sarah Mouri Marika Rudler Dominique Thabut Sorbonne Université AP-HP.Sorbonne UniversitéHôpital de la Pitié-SalpêtrièreDépartement de NeurologieUnitéde Médecine Intensive RéanimationàOrientation NeurologiqueParisFrance Brain Liver Pitié-Salpêtrière(BLIPS)Study Group INSERM UMR_S 938Centre de recherche Saint-AntoineMaladies métaboliquesBiliaires et Fibro-Inflammatoire du FoieInstitute of Cardiometabolism and Nutrition(ICAN)ParisFrance Groupe de Recherche Clinique en REanimation et Soins intensifs du Patient en Insuffisance Respiratoire aiguE(GRC-RESPIRE)Sorbonne Université ParisFrance Assistance Publique-Hôpitaux de Paris AP-HP.Sorbonne UniversitéHôpital de la Pitié-SalpêtrièreService d'hépato-GastroentérologieUnitéde Soins Intensifs d'HépatologieParisFrance Assistance Publique-Hôpitaux de Paris AP-HP.Sorbonne UniversitéService de Biochimie MétaboliqueHôpitaux Universitaires Pitié-Salpêtrière-Charles FoixDMU BioGeMParis F-75013France UniversitéParis Cité UFR de PharmacieCNRSInsermUTCBSParisFrance

Background Hepatic encephalopathy(HE)is highly prevalent in patients with liver *** pathophysiology of HE is centered on the synergic role of hyperammonemia and systemic ***,some data suggest altered functioning of the blood–brain barrier(BBB).Assessing BBB function is challenging in clinical practice and at the ***-S-100 Beta(PS100-Beta)could be a useful peripheral marker of BBB permeability in *** study aimed to assess plasmatic PS100-Beta levels in a prospective cohort of patients admitted to the intensive care unit(ICU)with decompensated cirrhosis with and without overt *** We retrospectively evaluated a prospective cohort of cirrhotic patients admitted to the ICU from October 2013 to September 2015 that had an available plasmatic PS100-Beta *** with previous neurological impairment or limitation of intensive or resuscitative measures were *** HE was defined as West-Haven grades 2 to *** patients were compared to a control cohort of outpatient clinic cirrhotic and non-cirrhotic patients explored for isolated elevation of liver *** ICU discharge,the patients were followed for at least 3 months for the occurrence of overt *** outcomes(liver transplantation or death)were *** ability of PS100-Beta–in combination with other factors–to predict overt HE was evaluated in a multivariate analysis using logistic *** ratios were used to determine the effects and calculate odds ratios(OR).Survival analysis was performed by using the Kaplan–Meier method and survival between groups was compared using a Log-rank *** A total of 194 ICU patients and 207 outpatients were included in the *** levels of plasmatic PS100-Beta were detected in the ICU decompensated cirrhotic patients compared with the outpatients([0.15±0.01]mg/L vs.[0.08±0]mg/L,P1).ICU patients with overt HE had higher levels of PS100-Beta([0.19±0.03]mg/L)compared with the

关键词： Cirrhosis Hepatic encephalopathy Blood-brain barrier PS100-Beta Liver disease

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Distal Sensory Polyneuropathy among HIV Patients in Libreville in Gabon

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Neuroscience & Medicine 2015年第3期6卷 84-89页

作者： Kouna-Ndouongo Philomène Adoukonou Thierry Oura Landry Ibole James Assengone-Zeh Yvonne Moubeka Mounguengui Martine Mouangue Minso Gertrude service de neurologie Centre Hospitalier Universitaire de Libreville Libreville Gabon Unité d’Enseignement et de Recherche de neurologie Faculté de Médecine Université de Parakou Parakou Benin Hôpital d’Instruction des Armées Omar Bongo Ondimba Service de Neurologie Libreville Gabon

Distal sensory polyneuropathy (DSP) was more frequent among Human Immunodeficiency Virus (HIV) patients. The reliable tool for its diagnosis is not available everywhere in sub-Saharan Africa. We aimed to estimate the frequency of DSP among HIV patients in Libreville. We’ve conducted a cross-sectional study including all consecutives HIV-patients admitted to the HIV clinic in the University Teaching Hospital of Libreville (Gabon) between 1 May and 31 July 2014. All patients underwent a full neurological examination doing by two neurologists. The diagnosis of DSP was based on Brief Peripheral Neuropathy Screen (BPNS). We also collected the data concerning past medical history, the use of neurotoxic drug, history of disease and data of High Active Antiretroviral Therapy (HAART). The logistic regression was used to study the factors associated with DSP. They were 620 patients aged from 17 to 74 years with the mean age of 42.1 years ± 11.0 years and 570 (91.9%) were on HAART. The mean duration of disease was 57.6 ± 42.5 months. Among the 620 patients 170 fulfilled criteria for DSP, and the overall frequency of DSP was 27.4%. The associated factors in univariate analysis were the age, the occupation, the use of HAART, the HAART option, the stage of the disease, opportunistic disease, alcohol consumption, exposure to isoniazid, diabetes mellitus and the modes of contamination. But in multivariate analysis the associated factors were the stage of disease OR 2.7 [1.2 - 3.7], diabetes mellitus OR 2.4 [1.4 - 5.8] and the use of D4T in HAART OR 1.9 [1.1 - 4.9]. The main symptoms among the patients were burning feet (47.6%), the tingling (40.0%), numbness (27.6%), alteration of ankle reflex (87.6%) and alteration of vibration sensation (27.6%). The DSP was more frequent among HIV patients and could be explained by the duration of the disease, the association with metabolic disease and the use of D4T.

关键词： Distal Sensory Polyneuropathy HIV HAART Epidemiology Sub-Saharan Africa Frequency

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Intravenous immunoglobulin-mediated expansion of regulatory T cells in autoimmune patients is associated with increased prostaglandin E2 levels in the circulation

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Cellular & Molecular Immunology 2015年第5期12卷 650-652页

作者： Mohan S Maddur Jamma Trinath Magalie Rabin Francis Bolgert Moneger Guy Jean-Michel Vallat Laurent Magy Kithiganahalli N Balaji Srini V Kaveri Jagadeesh Bayry Institut National de la Sante et de la Recherche Medicale Paris France Centre de Recherche des Cordeliers Equipe - Immunopathology and Therapeutic Immunointervention Paris France Sorbonne Universites - UPMC Univ Paris 6 Paris France Universite Paris descartes Paris France department of Microbiology and Cell Biology Indian Institute of Science Bangalore India Centre de Reference 'Neuropathies Peripheriques Rares' et service de neurologie Hopital Universitaire Limoges Limoges France Reanimation Neurologique Neurologie 1 Hopital de la Pitie-Salpetriere Paris France International Associated Laboratory IMPACT (Institut National de la Sante et de la Recherche Medicale France -Indian Council of Medical Research India) National Institute of Immunohaematology Mumbai India

CD4＋FoxP3＋ regulatory T cells （Tregs） are immunosuppressive cells that are critical for immune tolerance. Several studies have demonstrated that one of the anti-inflammatory mechanisms of action of intravenous immunoglobulin （Wig） involves the expansion of Tregs. Recently, we demonstrated that IVIgmediated Treg expansion involves the cyclooxygenase-2 （COX-2）-dependent induction of prostaglandin E2 （PGE2） in human dendritic cells （DCs）. However, the validity of these findings in autoimmune patients is lacking.

关键词： associated increased prostaglandin

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Intracerebral Hemorrhage in Pointe a Pitre Hospital

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World Journal of Neuroscience 2018年第4期8卷 403-410页

作者： Mendinatou Agbetou Thierry Adoukonou Cosmin Alecu Anne Landais Annie Lannuzel service de neurologie du CHU Pointe-à-Pitre Université Antilles-Guyane Pointe-à-Pitre France Unité d’Enseignement et de Recherche de neurologie Université de Parakou Parakou Bénin

Background: In caribbean space stroke incidence is 50% higher than in Europe. This study aims to describe characteristics of intracerebral hemorrhage in Guadeloupe. Methods: This was a retrospective study of hospitalized patients with a no-traumatic intracerebral hemorrhage during one year from 2013 to 2014. Survivors were contacted by telephone at the end of the study and;if accept, vital status and Rankin scale were assessed. Results: In one year, 1418 patients were hospitalized for an acute stroke. 112 had no-traumatic intracerebral hemorrhage (7.9%). The sex ratio F/H was 0.72. Mean age of the population was at 63.0 ± 14.7 years. Hypertension and diabetes were the leading risk factors notice with respectively 62 and 25 patients. Intracerebral hemorrhage distribution was: deep 48.2%, lobar 30.4%, sub-tentorial 17.9%, meningeal 3.5%. Severity signs distribution were mass effect 79%, ventricular contamination 43% and cerebral herniation 37%. Mean during of in-hospital stay was 10.6 ± 10.3 days and in-hospital mortality was 22 patients (19.6%). A year and a half after emergency 5 additional death (4.5%) between 35 patients survivors was noticed with median Rankin scale 1.5. Conclusion: Intracerebral hemorrhage is less frequent in African American as compared to Caucasian;the epidemiological excess of strokes in this population is related to ischemic strokes.

关键词： Stroke Intracerebral Hemorrhage Guadeloupe

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Psychological Experience of Children and Adolescents with Homozygous Sickle Cell Disease in Brazzaville

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Open Journal of Pediatrics 2021年第1期11卷 35-49页

作者： Engoba Moyen Ghislain Armel Mpandzou Matimé Julianna Déborah Boukoulou Josué Euberma Diatewa Armel Landry Batchi-Bouyou Paul Macaire Ossou-Nguiét Georges Moyen Université Marien Ngouabi Brazzaville Congo service de Soins Intensifs Pédiatriques CHU de Brazzaville Brazzaville Congo service de neurologie CHU de Brazzaville Brazzaville Congo

Introduction: Sickle cell disease, the most frequent hemoglobinopathy, is one of many causes of psychological repercussions. Objectives: To determine the prevalence of psychological disorders in children/adolescents living with sickle cell disease and to identify the associated factors. Patients and Method: An analytical cross-sectional study was conducted from June to September 2019 at the national sickle cell center and at the mother-child consultation of the University Hospital of Brazzaville. Children/adolescents aged six to 19 years old followed for sickle cell disease were included. Psychological disorders were assessed using the Diagnostic and Statistical Manual of Mental Disorders “DSM-5” which assesses depression and anxiety disorders, the Rosenberg Self-Esteem Scale, and the Brief Illness Perception Questionnaire which assesses representations of chronic diseases. SPSS 20.0 software was used for statistical analysis.

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Frequency of Distal Sensory Polyneuropathy among Diabetics in Parakou in 2012

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Neuroscience & Medicine 2015年第3期6卷 90-97页

作者： Adoukonou Thierry Kouna-Ndouongo Philomène Sourokou Boni Justine Imorou Abdoulaye Houinato Dismand Unité d’Enseignement et de Recherche de neurologie Faculté de Médecine Université de Parakou Parakou Benin Unité de neurologie du service de Médecine du Centre Hospitalier Universitaire de Parakou Parakou Benin service de neurologie CHU Libreville Libreville Gabon Unité Diabète du Centre Hospitalier Universitaire de Parakou Parakou Benin Unité d’Enseignement et de Recherche de neurologie Faculté des Sciences de la Santé Université d’Abomey-Calavi Cotonou Benin

Background: The distal sensory polyneuropathy (DSP) was more frequent among diabetics, although its determinant was not well known among diabetics in Benin. Objective: We aimed to assess the frequency of DSP and its determinants among diabetics at Parakou. Methods: It was a cross-sectional study carried out from 1 March to 31 August 2012 and included 336 diabetics followed at the diabetes unit of Parakou hospital. The diagnosis of DSP was based on DNS (Diabetic Neuropathy Score) criteria and other criteria. All data concerning the diabetes mellitus were recorded. We used Epi-Info and SPSS 16.0 software to perform analysis. Results: They were 187 females (56.0%) with the mean age of 54.9 ± 10.9 years. 298 patients fulfilled criteria for DSP;the overall prevalence of DSP was 88.7%. The main associated factors in multivariate analysis were treatment duration of diabetes more than 4 years: OR = 36.7 [4.0 - 336.9];the elevated glycaemia: OR = 3.1 [1.4 - 7.1];the activity with high income: OR = 0.2 [0.0 - 0.8];the ethnicity: nagots/fon: OR: 3.7 [1.4 - 12.5]. Conclusion: Those results suggested the high frequency of DSP among diabetics at Parakou.

关键词： Distal Sensory Polyneuropathy Diabetes Neuropathy Frequency

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Unilateral Femoral Neck Fracture after Epileptic Seizure in Young Patient: A Case Report

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Open Journal of Orthopedics 2020年第8期10卷 166-171页

作者： J. C. Niyondiko P. Hakizimana P. Barasukana S. Manirakiza G. Ndayizeye C. P. Baramburiye S. Nimubona service de Chirurgie Orthopédique et Traumatologie Centre Hospitalo-Universitaire de Kamenge Bujumbura Burundi service de neurologie Centre Hospitalo-Universitaire de Kamenge Bujumbura Burundi service de Radiologie Centre Hospitalo-Universitaire de Kamenge Bujumbura Burundi

Femoral neck fracture occurring after an epileptic seizure is a rare and under-diagnosed injury. The majority of the reported cases in literature are old patients with osteoporosis. Younger patients present several risk factors of osteopenia and the treatment remains controversial. We present an outcome of a 23 years old patient with unilateral femoral neck fracture occurring during an epileptic seizure and we discuss the associated multiple risk factors of osteopenia and osteonecrosis of the hip. The patient was brought to the emergency department of Teaching Hospital of Kamenge (CHUK) complaining of pain in his left hip that had been progressing for one month after an epileptic seizure. There is a history of HIV infection since birth and epileptic seizures with ongoing treatments for both diseases. despite the high risk of avascular necrosis, the treatment choice has been influenced by the patient’s age and a conservative surgery by internal fixation with Dynamic Hip Screw has been made. Unfortunately, this treatment early resulted in osteonecrosis of the hip since HIV infection itself and the highly active anti-retroviral therapy increase its risk.

关键词： Femoral Neck Fracture Epileptic Seizure Osteopenia Internal Fixation

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Prevalence of migraine among university students at Parakou,Benin:A cross-sectional study

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World Journal of Neuroscience 2014年第1期4卷 18-24页

作者： Thierry Adoukonou Francis Tognon-Tchegnonsi Kouna Philomene Abdias Alabi Dismand Houinato Pierre-Marie Preux Unite d’Enseignement et de Recherche de neurologie Faculte de MedecineUniversite de ParakouParakouBenin Unite de neurologie du service de Medecine Hopital de Parakou ParakouBenin Faculte de Medecine Universite des Sciences de la Sante de LibrevilleLibrevilleGabon Unite d’Enseignement et de Recherche de neurologie Faculte des Sciences de la Sante de Universite d’Abomey-CalaviCotonouBenin Institut d’Epidemiologie Neurologique et de neurologie Tropicale LimogesFrance

Objective: To determine the prevalence of migraine and its associated factors in students at the University of Parakou. Methods: It was a cross-sectional study carried out from February 1st to April 30th 2011. It included all students registered during the academic year 2010-2011 and selected by systematic random sampling. Migraine was defined according to IHS 2004 criteria. To assess the link between migraine and body mass index we collected height and weight of each student. Multivariate analysis was used to study the factors associated with migraine, odds-ratio and their confidence interval were estimated. SPSS Soft-ware was used to perform statistical analysis. Results: During the study period 1200, students returned their questionnaires. They were 842 males and 358 females. 171 fulfilled migraine criteria, and the overall prevalence of migraine was 14.2% (CI 95%: 11.6% - 17.4%). The main associated factors were the sex with an OR: 2.3 (CI 95%: 1.6 - 3.2) and family history of headache with an OR: 1.6 (CI 95%: 1.1 - 2.4). Migraine with aura was the frequent form (59.1%) and visual aura the frequent form of aura. No association was found between migraine and body mass index but students with obesity had high risk of migraine with aura OR: 3.8 (CI 95%: 1.5 - 9.7) compared with those with normal weight. The main triggering factors were sleeplessness (90.1%) and mental fatigue (85.4%). Conclusion: The results suggest a high prevalence of migraine among students at Parakou University and no association between obesity and migraine.

关键词： Migraine Prevalence Epidemiology Students Obesity

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Neonatal Seizures: Epidemiological, Diagnostic Aspects and Short-Term Outcome at Issaka Gazoby Maternity Hospital of Niamey, Niger

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Open Journal of Pediatrics 2023年第5期13卷 689-696页

作者： Samaila Aboubacar Kamaye Moumouni Garba Moumouni Mamoudou Abdou Djafar Dan Jari Salissou Yahaya Haoua Gagara Adama Ali Hamani Amina Toudou Daouda Moussa Hassane Djibo Fatimata Soumana Alido service de Pédiatrie H&#244pital National Amirou Boubacar Diallo Niamey Niger Faculté des Sciences de la Santé Université Abdou Moumouni de Niamey Niamey Niger Maternité Issaka Gazoby de Niamey Niamey Niger service de neurologie Medicale H&#244pital National de Niamey Niamey Niger

Introduction: Neonatal seizures are one of the most challenging situations for paediatricians. The objective of this work was to study the epidemiological and diagnostic aspects and short-term outcomes of neonatal seizures at Issaka Gazoby Maternity Hospital in Niamey. Patients and Methods: This was a prospective study from November 2020 to April 2021 in the neonatology department of Issaka Gazoby Maternity Hospital. All newborns aged 0 to 28 days hospitalized for seizures and/or having convulsions during hospitalization were included. Neonatal characteristics, diagnostic aspects, and their outcomes were studied. Data were analyzed using SPSS version 20 software. Results: Of the 3.068 newborns admitted, 69 cases of neonatal seizures were recorded (2.24%). The sex ratio was 1.22, and 94.2% of neonates were born at term. Generalized crises were found in 50.7%. The main etiologies were perinatal asphyxia (46.4%) and early-onset neonatal infection (40.6%). The death rate was 20.3%. Neonates died between one (1) and three (3) days of age in 42.9%. The main death causes were perinatal asphyxia (50%) and early-onset neonatal infection (21.4%). Conclusion: Neonatal seizures are uncommon frequent, with a semiology dominated by generalized seizures. Mortality is high. The reinforcement of preventive measures is necessary.

关键词： Seizures Neonatal Perinatal Asphyxia Niger

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Identifying sex-specific differences in the carotid revascularisation literature:findings from a scoping review

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Stroke & Vascular Neurology 2021年第3期6卷 496-499,I0085-I0096页

作者： Vignan Yogendrakumar Michel Shamy Brian dewar dean A Fergusson Dar Dowlatshahi Candyce Hamel Sophia Gocan Mark Fedyk Jean-Louis Mas Peter Rothwell Virginia Howard Olena Bereznyakova On behalf of the WoW-CAD Investigators department of Medicine Division of Neurology and Ottawa Hospital Research InstituteUniversity of OttawaOttawaOntarioCanada Epidemiology Program Ottawa Hospital Research InstituteOttawaOntarioCanada Stroke Prevention Clinic Ottawa HospitalOttawaOntarioCanada Bioethics Program UC Davis Department of MedicineSacramentoCaliforniaUSA Universite Paris descartes Faculte de Medecine Site Cochin Parislle-de-FranceFrance service de neurologie Hôital Sainte-AnneParisFrance The University of Alabama at Birmingham School of Medicine BirminghamAlabamaUSA School of Public Health University of Alabama at BirminghamBirminghamAlabamaUSA 不详

Objective No systematic review of the literature has dedicated itself to looking at the management of symptomatic carotid stenosis in female *** this scoping review,we aimed to identify all randomised controlled trials(RCTs)that reported sex-specific outcomes for patients who underwent carotid revascularisation,and determine whether sufficient information is reported within these studies to assess short-term and long-term outcomes in female ***,setting and participants We systematically searched Medline,Embase,Pubmed and Cochrane libraries for RCTs published between 1991 and 2020 that included female patients and compared either endarterectomy with stenting,or any revascularisation(endarterectomy or stenting)with medical therapy in patients with symptomatic high-grade(>50%)carotid *** From 1537 references examined,27 eligible studies were ***-specific outcomes were reported in 13 *** patient characteristics of enrolled female patients were reported in 2 of those 13 *** outcomes reported included stroke and death,however,there was significant heterogeneity in the reporting of both periprocedural and long-term ***-specific differences relating to the degree of stenosis and time from index event to treatment are largely limited to studies comparing endarterectomy to medical *** events were not reported by *** Only half of the previously published RCTs and systematic reviews report sex-specific *** analyses on the results of carotid artery intervention for female patients with symptomatic stenosis are limited.

关键词： carotid stenosis finding

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