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Longitudinal quantitative electroencephalographic study in mono-hemispheric stroke patients

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Neural Regeneration Research 2019年第7期14卷 1237-1246页

作者： Filippo Zappasodi Franca Tecchio Laura Marzetti Vittorio Pizzella Vincenzo Di Lazzaro Giovanni Assenza Department of Neuroscience Imaging and Clinical Sciences and Institute for Advanced Biomedical Imaging"G.D'Annunzio" University Laboratory of electrophysiology for Translational NeuroScience(LET’S) ISTC-CNRand Fondazione Policlinico Gemelli IRCCS Unit of Neurology NeurophysiologyNeurobiologyDepartment of MedicineUniversità Campus Bio-Medico di Roma

The identification of individual factors modulating clinical recovery after a stroke is fundamental to personalize the therapeutic intervention to enhance the final clinical *** this framework,electrophysiological factors are promising since are more directly related to neuroplasticity,which supports recovery in stroke patients,than neurovascular *** this retrospective observational study,we investigated brain neuronal activity assessed via spectral features and Higuchi's fractal dimension(HFD) of electroencephalographic signals in acute phase(2–10 days from symptom onset,T0) and sub-acute phase(2.5 months,T1) in 24 patients affected by unilateral middle cerebral artery *** assessment of the clinical deficits was performed using the National Institutes of Health Stroke Scale(NIHSS),together with the effective recovery calculated as the ratio between difference of NIHSS at T0 and T1 over the NIHSS value at *** observed that delta and alpha band electroencephalographic signal power changed between the two phases in both the hemispheres ipsilateral(ILH) and contralateral(CHL) to the ***,at T0,bilateral higher delta band power correlated with worse clinical conditions(Spearman's rs = 0.460,P = 0.027 for ILH and rs = 0.508,P = 0.013 for CLH),whereas at T1 this occurred only for delta power in ILH(rs = 0.411,P = 0.046) and not for ***-hemispheric difference(ILH ***) of alpha power in patients was lower at T0 than at T1(P = 0.020).HFD at T0 was lower than at T1(P = 0.005),and at both phases,ILH HFD was lower than CLH HFD(P = 0.020).These data suggest that inter-hemispheric low band asymmetry and fractal dimension changes from the acute to the sub-acute phase are sensitive to neuroplasticity processes which subtend clinical *** study protocol was approved by the Bioethical Committee of Ospedale San Giovanni Calibita Fatebenefretelli(No.40/2011) on July 14,2011.

关键词： mono-hemispheric stroke delta band fractal dimension inter-hemispheric asymmetries EEG plasticity

Analysis of fMRI Single Subject Data in the Fourier Domain Acquired Using a Multiple Input Stimulus Experimental Design

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Journal of Signal and Information Processing 2012年第4期3卷 469-480页

作者： Daniel Rio Robert Rawlings Lawrence Woltz Jodi Gilman Daniel Hommer Laboratory of Neuroimaging and Genetics Martinos Center for Biomedical Imaging Massachusetts General Hospital Charlestown USA NIAAA Columbia USA 3Synergy Research Inc. Monrovia USA section of brain electrophysiology and imaging LCTS NIAAA National Institutes of Health Bethesda USA Synergy Research Inc. Monrovia USA

Analysis of functional MRI (fMRI) blood oxygenation level dependent (BOLD) data is typically carried out in the time domain where the data has a high temporal correlation. These analyses usually employ parametric models of the hemodynamic response function (HRF) where either pre-whitening of the data is attempted or autoregressive (AR) models are employed to model the noise. Statistical analysis then proceeds via regression of the convolution of the HRF with the input stimuli. This approach has limitations when considering that the time series collected are embedded in a brain image in which the AR model order may vary and pre-whitening techniques may be insufficient for handling faster sampling times. However fMRI data can be analyzed in the Fourier domain where the assumptions made as to the structure of the noise can be less restrictive and hypothesis tests are straightforward for single subject analysis, especially useful in a clinical setting. This allows for experiments that can have both fast temporal sampling and event-related designs where stimuli can be closely spaced in time. Equally important, statistical analysis in the Fourier domain focuses on hypothesis tests based on nonparametric estimates of the hemodynamic transfer function (HRF in the frequency domain). This is especially important for experimental designs involving multiple states (drug or stimulus induced) that may alter the form of the response function. In this context a univariate general linear model in the Fourier domain has been applied to analyze BOLD data sampled at a rate of 400 ms from an experiment that used a two-way ANOVA design for the deterministic stimulus inputs with inter-stimulus time intervals chosen from Poisson distributions of equal intensity.

关键词： fMRI (BOLD) Time Series Analysis Single Subject Analysis Fourier Domain Statistical Analysis Complex General Linear Model Alcoholism Research

The Subcutaneous Implantable Cardioverter-Defi brillator:A Practical Review and Real-World Use and Application

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Cardiovascular Innovations and Applications 2016年第B2期1卷 199-209页

作者： Mark E.Panna Jr,MD,FACC,FHRS William M.Miles,MD,FACC,FHRS Division of Cardiology Department of MedicineNorth Florida/South Georgia Veterans Affairs HospitalGainesvilleFLUSA section of electrophysiology Division of CardiologyDepartment of MedicineUniversity of FloridaFLUSA

The subcutaneous implantable cardioverter-defi brillator(ICD)is a novel technology using a subcutaneous(extrathoracic)system for treatment of potential lethal ventricular *** avoids many of the risks of transvenous ICD *** may be considered in patients having an ICD indication who do not have a pacing and/or cardiac resynchronization therapy indication,and who are unlikely to benefi t from antitachycardia pacing *** review patient selection,system components,the implantation technique,and screening considerations for subcutaneous ICD *** uses in specific patient populations,including children,patients with congenital heart disease,hypertrophic cardiomyopathy,or end-stage renal disease,and patients with preexisting pacemakers,are *** of future investigation are reviewed,including potential use with leadless pacing and magnetic resonance imaging.

关键词： subcutaneous implantable cardioverter-defi brillator sudden cardiac death

Differential modulation by orexin-A of AMPA receptors on ganglion cells and amacrine cells in rat retina

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Differential modulation by orexin-A of AMPA receptors on gan...

Dynamic Organization of Large-scale Functional brain Networks Supports Interactions Between Emotion and Executive Control

中国神经科学学会第十届全国学术会议

作者： Chao ZHENG Meng-Ya WANG Shi-Jun WENG Xiong-Li YANG Yong-Mei ZHONG Institute of Neurobiology Institutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan University Cell electrophysiology Laboratory Wannan Medical College

Objective Orexin-A and orexin-B exert their actions through two membrane-band receptors,which are known as orexin 1 and orexin 2 receptors(OXR and OXR).This neuropeptide system is involved in a variety of physiological processes in the central nervous ***,the function of orexins in the retina remains *** present study is to investigate whether and how orexin-A modulates AMPA receptors in retinal ganglion cells(GCs)and amacrine cells(ACs).Methods Immunocytochemical and retrograde labeling techniques were used to determine the identity of neurons,freshly dissociated from rat *** of orexin-A on AMPA receptor-mediated currents were investigated in freshly dissociated GCs and ACs by whole cell patch-clamp recording techniques combined with a rapid solution *** in intracellular calcium levels were measured by calcium imaging *** Orexin-A suppressed AMPA receptor(AMPAR)-mediated currents in GCs,but potentiated those in *** effects of orexin-A on the currents in GCs and ACs could be abolished by OXR and OXR selective antagonists,respectively,suggesting that these effects of orexin-A are respectively mediated by OXR and *** pathways mediating the two effects of orexin-A were further *** preincubation with the G inhibitor pertussis toxin or intracellular dialysis of the G activator mastoparan eliminated both the orexin-A effects on GCs and ACs,suggesting the involvement of G ***,cAMP,the PKA inhibitor Rp-cAMP,cGMP and the PKG blocker KT5823failed to block the orexin-A effects,but the two effects involved activation of PKC,as evidenced by the elimination of those by PKC antagonists bisindolylmaleimide Ⅳ and ***,the phosphatidylinositol(PI)-phospholipase C(PLC) inhibitor U73122 abolished the orexin-A effect on GCs,whereas the phosphatidylcholine(PC)-PLC inhibitor D609 eliminated that on ***,calcium was differentially involved in the orexin-A effects on GCs an

关键词： orexin-A orexin receptor AMPA receptor retina ganglion cells amacrine cells neuromodulation

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Neuroscience Bulletin 2024年第7期40卷 981-991页

作者： Haiyang Geng Pengfei Xu Andre Aleman Shaozheng Qin Yue-Jia Luo State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Tianqiao and Chrissy Chen Institute for Translational ResearchShanghai 200040China Beijing Key Laboratory of Applied Experimental Psychology National Demonstration Center for Experimental Psychology Education(BNU)Faculty of PsychologyBeijing Normal UniversityBeijing 100875China Center for Neuroimaging Shenzhen Institute of NeuroscienceShenzhen 518107China University of Groningen Department of Biomedical Sciences of Cells and SystemsSection Cognitive NeuroscienceUniversity Medical Center GroningenGroningenThe Netherlands Institute for Neuropsychological Rehabilitation University of Health and Rehabilitation SciencesQingdao 266113China Shenzhen Key Laboratory of Affective and Social Neuroscience Magnetic Resonance ImagingCenter for Brain Disorders and Cognitive SciencesShenzhen UniversityShenzhen 518060China Chinese Institute for brain Research Beijing 102206China

Emotion and executive control are often conceptualized as two distinct modes of human brain ***,however,is known about how the dynamic organization of large-scale functional brain networks that support flexible emotion processing and executive control,especially their *** amygdala and prefrontal systems have long been thought to play crucial roles in these *** advances in human neuroimaging studies have begun to delineate functional organization principles among the large-scale brain networks underlying emotion,executive control,and their ***,we propose a dynamic brain network model to account for interactive competition between emotion and executive control by reviewing recent resting-state and task-related neuroimaging studies using network-based *** this model,dynamic interactions among the executive control network,the salience network,the default mode network,and sensorimotor networks enable dynamic processes of emotion and support flexible executive control of multiple processes;neural oscillations across multiple frequency bands and the locus coeruleus−norepinephrine pathway serve as communicational mechanisms underlying dynamic synergy among large-scale functional brain *** model has important implications for understanding how the dynamic organization of complex brain systems and networks empowers flexible cognitive and affective functions.

关键词： Dynamic brain network Emotion Executive control Salience network Executive control network Default mode network

Relationship between event-related potential P300 and first episode schizophrenia

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Chinese Medical Journal 2007年第4期120卷 339-341页

作者： CHEN Xing-shi LU Ying-zhi WANG Ji-jun WANG Hong-xing ZHANG Ming-dao LOU Fei-yin CHEN Chong Department Of electrophysiology Shanghai Mental Health Center Shanghai 200030China Depantment of Psychiatry Fifth People＇s Hospital Zibo 255120Shandong Province China Department of Electronic EphalographySource imaging Shanghai Mental Health Center Shanghai 200030China

Although P300 abnormalities of event-related .potentials （ERPs） are consistently reported among schizophrenic patients as being the most compelling indices of their brain dysfunction, whether they are trait markers or state markers of schizophrenia remains in controversy. To shed a light on this point, we made a longitudinal study of P300 among first episode schizophrenic patients, from no medication until the patients had been medicated for 12 weeks.

关键词： schizophrenia event-relatedpotentials, P300 memory disorders

Cortical Representation of Pain and Touch:Evidence from Combined Functional Neuroimaging and electrophysiology in Non-human Primates

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Neuroscience Bulletin 2018年第1期34卷 165-177页

作者： Li Min Chen Departments of Radiology and Radiological Sciences and Psychology Institute of Imaging Science Vanderbilt University Medical Center

Human functional MRI studies in acute and various chronic pain conditions have revolutionized how we view pain, and have led to a new theory that complex multi-dimensional pain experience （sensory-discriminative, affective/motivational, and cognitive） is represented by concurrent activity in widely-distributed brain regions （termed a network or pain matrix）. Despite these break- through discoveries, the specific functions proposed for these regions remain elusive, because detailed electrophys- iological characterizations of these regions in the primate brain are lacking. To fill in this knowledge gap, we have studied the cortical areas around the central and lateral sulci of the non-human primate brain with combined submillimeter resolution functional imaging （optical imaging and fMRI） and intracranial electrophysiological recording. In this mini-review, I summarize and present data showing that the cortical circuitry engaged in nociceptive processing is much more complex than previously recognized. Electrophysiological evidence supports the engage- ment of a distinct nociceptive-processing network within SI （i.e., areas 3a, 3b, 1 and 2）, SII, and other areas along the lateral sulcus. Deafferentation caused by spinal cord injury profoundly alters the relationships between fMRI and electrophysiological signals. This finding has significant implications for using fMRI to study chronic pain conditions involving deafferentation in humans.

关键词： Nociception Non-human primate Cortex Functional MRI Functional connectivity

Fullerenol can improve the behavior of lead poisoning rats

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Fullerenol can improve the behavior of lead poisoning rats

Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson’s disease dementia

中国神经科学学会第十二届全国学术会议

作者： Ying-ying Zha Jin Ge Cell electrophysiology Laboratory Wannan Medical College

Objective Several reviews have been published about available applications of fullerenol, detailing the effects of fullerenol in manifold aspects,including drug delivery, reactive oxygen species quenching, targeted imaging, antiviral action, and antitumor therapy, even neuroprotection and *** primary purpose of this paper is to describe the effect of fullerenol on repairing brain damage caused by lead poisoning, showing how fullerenol might change the ability of learning and memory in lead-exposed animal models through cognitive and behavioral tests. Methods Transmission Electron Microscopy imaging, Open Field Test, Step-Down Test and Blood Analysis had been used to test some changes in lead poisoning rats. Results（1） In Anxiety Determination study, there were obvious differences in the trace distance between the control group and the two experimental groups.（2） In Passive Avoidance study, during the retention test,Latencies for rats receiving lead solution were remarkablely decreased compared with the control group, while fullerenol had not altered the step-down latencies *** analysis of the effect of fullerenol on lead-induced impairment reveal a significant difference compared with the lead-exposed group, p＜0.001.（3） In Hematology study, some parameters（WBC and PLT） obtained from the lead-treated group presented similar trends with those from non-treated control group, while other factors（RBC, HGB, HCT, MCV and MCHC）, as the important hematology markers of anemia, presented significantly different. Conclusion Our own experience provides direct evidence suggesting the repairing effect of fullerenol on brain damages caused by lead, through behavior test.

关键词： fullerenol lead poisoning rats behavior test

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Translational Neurodegeneration 2023年第1期12卷 872-888页

作者： Irene Frigerio Max A.Laansma Chen-Pei Lin Emma J.M.Hermans Maud M.A.Bouwman John G.J.M.Bol Yvon Galis-de Graaf Dagmar H.Hepp Annemieke J.M.Rozemuller Frederik Barkhof Wilma D.J.van de Berg Laura E.Jonkman section Clinical Neuroanatomy and Biobanking Department of Anatomy and NeurosciencesAmsterdam UMC Location Vrije Universiteit AmsterdamDe Boelelaan 1118AmsterdamThe Netherlands Amsterdam Neuroscience NeurodegenerationAmsterdamThe Netherlands Amsterdam Neurosci-ence Brain ImagingAmsterdamThe Netherlands Department of Neurology Amsterdam UMC Location Vrije Universiteit AmsterdamDe Boelelaan 1117AmsterdamThe Netherlands Department of Pathology Amsterdam UMC Location Vrije Universiteit AmsterdamDe Boelelaan 1117AmsterdamThe Netherlands Department of Radiology and Nuclear Medicine Amsterdam UMC Location Vrije Universiteit AmsterdamDe Boelelaan 1117AmsterdamThe Netherlands Institutes of Neurology and Healthcare Engineering University College LondonLondonUK.

Background Increased neurofilament levels in biofluids are commonly used as a proxy for neurodegeneration in several neurodegenerative *** this study,we aimed to investigate the distribution of neurofilaments in the cerebral cortex of Parkinson’s disease(PD),PD with dementia(PDD)and dementia with Lewy bodies(DLB)donors,and its association with pathology load and MRI measures of atrophy and *** Using a within-subject post-mortem MRI-pathology approach,we included 9 PD,12 PDD/DLB and 18 age-matched control *** thickness and mean diffusivity(MD)metrics were extracted respectively from 3DT1 and DTI at 3T in-situ *** autopsy,pathological hallmarks(pSer129-αSyn,p-tau and amyloid-βload)together with neurofilament light-chain(NfL)and phosphorylated-neurofilament medium-and heavy-chain(p-NfM/H)immunoreactivity were quantified in seven cortical regions,and studied in detail with confocal-laser scanning *** correlations between MRI and pathological measures were studied using linear mixed *** Compared to controls,p-NfM/H immunoreactivity was increased in all cortical regions in PD and PDD/DLB,whereas NfL immunoreactivity was increased in the parahippocampal and entorhinal cortex in PDD/***-positive neurons showed degenerative morphological features and axonal *** increased p-NfM/H correlated with p-tau load,and NfL correlated with pSer129-αSyn but more strongly with p-tau load in PDD/***,neuro-filament immunoreactivity correlated with cortical thinning in PD and with increased cortical MD in PDD/*** Taken together,increased neurofilament immunoreactivity suggests underlying axonal injury and neurofilament accumulation in morphologically altered neurons with increased pathological ***,we demonstrate that such neurofilament markers at least partly explain MRI measures that are associated with the neurodegenerative process.

关键词： Neurofilament NfL Axonal degeneration Parkinson’s disease Parkinson’s disease dementia Dementia with Lewy bodies Cortical thickness Cortical atrophy Mean diffusivity