Longitudinal quantitative electroencephalographic study in mono-hemispheric stroke patients

作     者：Filippo Zappasodi Franca Tecchio Laura Marzetti Vittorio Pizzella Vincenzo Di Lazzaro Giovanni Assenza 

作者机构：Department of NeuroscienceImaging and Clinical Sciences and Institute for Advanced Biomedical Imaging"G.D'Annunzio" University Laboratory of Electrophysiology for Translational NeuroScience(LET’S)ISTC-CNRand Fondazione Policlinico Gemelli IRCCS Unit of NeurologyNeurophysiologyNeurobiologyDepartment of MedicineUniversità Campus Bio-Medico di Roma 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2019年第14卷第7期

页      面：1237-1246页

核心收录：

学科分类：10[医学] 

基　　金：FZ and FT obtained financial support from the Italian Ministry of Health Cod.GR-2008-1138642 "Promoting recovery from Stroke:individually enriched therapeutic intervention in Acute phase" PNR-CNR Aging Program 

主　　题：mono-hemispheric stroke delta band fractal dimension inter-hemispheric asymmetries EEG plasticity 

摘      要：The identification of individual factors modulating clinical recovery after a stroke is fundamental to personalize the therapeutic intervention to enhance the final clinical *** this framework,electrophysiological factors are promising since are more directly related to neuroplasticity,which supports recovery in stroke patients,than neurovascular *** this retrospective observational study,we investigated brain neuronal activity assessed via spectral features and Higuchi s fractal dimension(HFD) of electroencephalographic signals in acute phase(2–10 days from symptom onset,T0) and sub-acute phase(2.5 months,T1) in 24 patients affected by unilateral middle cerebral artery *** assessment of the clinical deficits was performed using the National Institutes of Health Stroke Scale(NIHSS),together with the effective recovery calculated as the ratio between difference of NIHSS at T0 and T1 over the NIHSS value at *** observed that delta and alpha band electroencephalographic signal power changed between the two phases in both the hemispheres ipsilateral(ILH) and contralateral(CHL) to the ***,at T0,bilateral higher delta band power correlated with worse clinical conditions(Spearman s rs = 0.460,P = 0.027 for ILH and rs = 0.508,P = 0.013 for CLH),whereas at T1 this occurred only for delta power in ILH(rs = 0.411,P = 0.046) and not for ***-hemispheric difference(ILH ***) of alpha power in patients was lower at T0 than at T1(P = 0.020).HFD at T0 was lower than at T1(P = 0.005),and at both phases,ILH HFD was lower than CLH HFD(P = 0.020).These data suggest that inter-hemispheric low band asymmetry and fractal dimension changes from the acute to the sub-acute phase are sensitive to neuroplasticity processes which subtend clinical *** study protocol was approved by the Bioethical Committee of Ospedale San Giovanni Calibita Fatebenefretelli(No.40/2011) on July 14,2011.