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From talk to action:Developing a model to foster effective integration of traditional medicine into the Ghanaian healthcare system

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Journal of Integrative medicine 2023年第5期21卷 423-429页

作者： Irene G.Ampomah Bunmi S.Malau-Aduli Aduli E.O.Malau-Aduli Theophilus I.Emeto public health and tropical medicine James Cook UniversityTownsvilleQueensland 4811Australia department of Population and health University of Cape CoastCape Coast UC 182Ghana College of medicine and Dentistry James Cook UniversityTownvilleQueensland 4811Australia school of medicine and public health The University of NewcastleNewcastleNSW 2308Australia school of environmental and Life sciences The University of NewcastleNewcastleNSW 2308Australia World health Organization Collaborating Centre for Vector-Borne and Neglected tropical Diseases James Cook UniversityTownsvilleQueensland 4811Australia

This research assessed the experience of stakeholders and the efficacy of integrating traditional medicine into the Ghanaian health system using the Ashanti Region as the focal *** of an integrative healthcare delivery model including philosophies/values,structure,process and outcome were used to conduct a quality assessment of the integrated health system in *** element clearly showed that Ghana is currently not running a coordinated health practice model,thus making it a tolerant,rather than an inclusive,health ***,the primary purpose of this research is to discuss the development of a new and appropriately customised model that could enhance the practice of integrated healthcare in *** model we present has flexibility and far-reaching applicability in other African countries because such countries share similar socio-cultural and economic *** such,governments and health practitioners could adapt this model to improve the practice of integrated healthcare in their specific *** administrators and health system researchers could also adapt the model to investigate or to monitor the progress and efficacy of integrated healthcare practices within their *** might help to understand the relationships between the integration of traditional medicine and health outcomes for a given population.

关键词： Ghana healthcare health practice Integratedhealth Traditional medicine Model

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Co-Exposure to Multiple Pollutants and Its Cardiovascular Effects in a Subway System-Beijing Municipality,China,2017

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China CDC weekly 2021年第45期3卷 959-963页

作者： Wenlou Zhang Xuan Yang Xu Jia Wei Dong Hongyu Li Lu Pan Jiao Shan Shaowei Wu Xinbiao Guo Furong Deng department of Occupational and environmental health sciences School of Public HealthPeking UniversityBeijingChina Qingdao Municipal Center for Disease Control and Prevention Qingdao Institute of Preventive MedicineQingdaoShandongChina department of Occupational and environmental health sciences School of Public HealthXi'an Jiaotong University Health Science CenterXi'anShaanxiChina

Summary What is already known on this topic?With rapid urbanization,traffic-related air pollution has become a global ***,its association with cardiovascular health has not been fully *** is added by this report?This study provided novel evidence of the joint cardiovascular effect of multiple pollutants in subway cabins,further identified two pollutants that played dominant roles,and validated the effectiveness of targeted interventions.

关键词： pollution urbanization traffic

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Exosomes Derived from Hydroquinone-transformed Human Bronchial Epithelial Cells Inhibited Recipient Cell Apoptosis by transferring miR-221

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Biomedical and environmental sciences 2021年第7期34卷 520-527页

作者： XIAN Hong Yi CHEN Ying ZHANG Jia Ying TANG Mei Lin LIAN Zhen Wei JIANG Ran HU Zu Qing LI Yan Feng HU Da Lin department of environmental health Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou 510515GuangdongChina Grade 2017 Undergraduate Student Majoring in Preventive medicine School of Public HealthSouthern Medical UniversityGuangzhou 510515GuangdongChina Grade 2018 Undergraduate Student Majoring in Clinical medicine Department of Clinical MedicineJiamusi UniversityJiamusi 154007HeilongjiangChina

Objective Although benzene is a confirmed environmental carcinogen,the mechanism of its carcinogenicity remains largely *** suggested oncogene,miR-221,is elevated and plays important roles in various tumors,but its role in benzene-induced carcinogenesis remains *** In the present study,we constructed hydroquinone(HQ,a representative metabolite of benzene with biological activity)-transformed malignant cell line(16 HBE-t)and analyzed the level of miR-221 in it with *** from 16 HBE-t cells incubated with or without an miR-221 inhibitor were isolated by ultracentrifugation,characterized by transmission electron microscopy and laser scanning confocal microscope,and then transfected into 16 HBE *** effects of exosomal miR-221 on apoptosis induced by HQ in recipient cells were determined using flow *** The amount of miR-221 in 16 HBE-t was significantly increased compared with *** recipient cells ingested exosomes derived from 16 HBE-t,miR-221 was increased,and apoptosis induced by HQ was *** miR-221 in 16 HBE-t using an inhibitor did not significantly alter miR-221 or apoptosis in recipient *** Exosomal miR-221 secreted by 16 HBE-t inhibits apoptosis induced by HQ in normal recipient cells.

关键词： Benzene Toxic mechanism Apoptosis Exosomes miR-221 Intercellular communications

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Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)Contamination of High-touch Surfaces in Field Settings

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Biomedical and environmental sciences 2020年第12期33卷 925-929页

作者： Sahar Gholipour Mahnaz Nikaeen Reza Mohammadi Manesh Shima Aboutalebian Zahra Shamsizadeh Elahe Nasri Hossein Mirhendi department of environmental health Engineering School of HealthIsfahan University of Medical SciencesIsfahanIran department of environmental health Engineering Faculty of HealthKashan University of Medical SciencesKashanIran Environment Research Center Research Institute for Primordial Prevention of Non-communicable DiseaseUniversity of Medical SciencesIsfahanIran department of Medical Parasitology and Mycology School of MedicineIsfahan University of Medical SciencesIsfahanIran Infectious Diseases and tropical medicine Research Center Isfahan University of Medical SciencesIsfahanIran

The World health Organization declared Coronavirus disease 2019(COVID-19)a public health emergency of international concern(PHEIC)[1].Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the etiological agent of COVID-19,is an enveloped,single-stranded,positive-sense RNA *** severe acute respiratory syndrome coronavirus(SARS)and Middle East respiratory syndrome(MERS),the causative agent of COVID-19belongs to theβ-genus of the coronavirus family and has a genome sequence with an 82%similarity to that of SARS[1,2].Therefore,research on human coronaviruses,especially SARS-CoV and MERS-CoV,could be useful for predicting likely environmental fate and subsequent risks of SARS-CoV-2[1].

关键词： acute respiratory likely

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Replacement of leisure-time sedentary behavior with various physical activities and the risk of dementia incidence and mortality:A prospective cohort study

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Journal of Sport and health Science 2023年第3期12卷 287-294页

作者： Ying Sun Chi Chen Yuetian Yu Haojie Zhang Xiao Tan Jihui Zhang Lu Qi Yingli Lu Ningjian Wang Institute and department of Endocrinology and Metabolism Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China department of Medical sciences Uppsala UniversityUppsala 75185Sweden school of public health Zhejiang UniversityHangzhou 310058China Center for Sleep and Circadian medicine The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510180China department of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLA 70112USA department of Nutrition Harvard T.H.Chan School of Public HealthBostonMA 02115USA Channing Division of Network medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical SchoolBostonMA 02115USA

Background:Whether or not there is targeted pharmacotherapy for dementia,an active and healthy lifestyle that includes physical activity(PA)may be a better option than medication for preventing *** examined the association between leisure-time sedentary behavior(SB)and the risk of dementia incidence and *** further quantified the effect on dementia risk of replacing sedentary time with an equal amount of time spent on different physical ***:In the UK Biobank,484,169 participants(mean age=56.5 years;45.2%men)free of dementia were followed from baseline(2006-2010)through July 30,2021.A standard questionnaire measured individual leisure-time SB(watching TV,computer use,and driving)and PA(walking for pleasure,light and heavy do-it-yourself activity,strenuous sports,and other exercise)frequency and duration in the 4 weeks prior to *** E(APOE)genotype data were available for a subset of 397,519(82.1%)individuals.A Cox proportional hazard model and an isotemporal substitution model were used in this ***:During a median 12.4 years of follow-up,6904 all-cause dementia cases and 2115 deaths from dementia were *** comparison to participants with leisure-time SB8 h/day,and the HR of dementia mortality was 1.35(1.12-1.61)for>8 h/day.A 1 standard deviation increment of sedentary time(2.33 h/day)was strongly associated with a higher incidence of dementia and mortality(HR=1.06,95%CI:1.03-1.08 and HR=1.07,95%CI:1.03-1.12,respectively).The association between sedentary time and the risk of developing dementia was more profound in subjects60 years(HR=1.26,95%CI:1.00-1.58 ***=1.21,95%CI:1.08-1.35 in>8 h/day,p for interaction=0.013).Replacing 30 min/day of leisure sedentary time with an equal time spent in total PA was associated with a6%decreased risk a

关键词： Alzheimer's disease Apolipoprotein E Dementia Isotemporal substitution model Physical activity Sedentary behavior

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Sugar intake from sweetened beverages and diabetes:A narrative review

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World Journal of Diabetes 2021年第9期12卷 1530-1538页

作者： Tung-Sung Tseng Wei-Ting Lin Gabrielle V Gonzalez Yu-Hsiang Kao Lei-Shih Chen Hui-Yi Lin Behavioral and Community health sciences School of Public HealthLouisiana State University Health Sciences CenterNew OrleansLA 70112United States department of Global Community health and Behavioral sciences School of Public Health&Tropical MedicineTulane UniversityNew OrleansLA 70112United States department of health and Kinesiology Texas A&M UniversityCollege StationTX 77843United States Biostatistics Program School of Public HealthLouisiana State University Health Sciences CenterNew OrleansLA 70112United States

Type 2 diabetes mellitus(T2DM)is one of the fastest growing public health concerns around the ***-sweetened beverage(SSB)consumption has been proven to be associated with adverse health consequences in the diabetic *** SSB consumption,body weight control,healthy diets,and increased physical activity have been suggested as strategies to improve diabetes prevention and *** literature review provides an overview of:(1)The association between SSB consumption and the risk of T2DM;(2)Types of SSB consumption and T2DM;(3)The effect of obesity and inflammation on the association between SSB consum-ption and risk of T2DM;and(4)SSB consumption in T2DM *** is still work to be done to determine how SSB consumption is related to T2DM,but the current research on identifying the association between SSB consumption and T2DM is promising,with the most promising studies confirming the connection between SSBs,T2DM risk,and diabetes *** studies should explore more effective SSB related diabetes prevention and management interventions.

关键词： Sugar-sweetened beverages Type 2 diabetes mellitus Inflammation Obesity Diabetes management

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2-Hexyl-4-Pentylenic Acid(HPTA) Stimulates the Radiotherapy-induced Abscopal Effect on Distal Tumor through Polarization of Tumor-associated Macrophages

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Biomedical and environmental sciences 2021年第9期34卷 693-704页

作者： DUAN Wen Hua JIN Li Ya CAI Zu Chao LIM David FENG Zhi Hui department of Occupational health and Occupational medicine School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina school of health sciences Western Sydney UniversityCampbelltown 2560Australia

Objective The aim of this study was to explore the effects of 2-hexyl-4-pentylenic acid(HPTA)in combination with radiotherapy(RT)on distant unirradiated breast *** Using a rat model of chemical carcinogen(7,12-dimethylbenz[a]anthracene,DMBA)-induced breast cancer,tumor volume was monitored and treatment response was evaluated by performing HE staining,immunohistochemistry,immunofluorescence,q RT-PCR,and western blot *** The results demonstrated that HPTA in combination with RT significantly delayed the growth of distant,unirradiated breast *** mechanism of action included tumor-associated macrophage(TAM)infiltration into distant tumor tissues,M1 polarization,and inhibition of tumor angiogenesis by IFN-γ.Conclusion The results suggest that the combination of HPTA with RT has an abscopal effect on distant tumors via M1-polarized TAMs,and HPTA may be considered as a new therapeutic for amplifying the efficacy of local RT for non-targeted breast tumors.

关键词： Breast cancer Abscopal effect 2-hexyl-4-pentylenic acid(HPTA) Radiotherapy(RT) Tumor-associated macrophages(TAMs) Polarization Angiogenesis

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healthcare workers' knowledge towards Zika virus infection in Indonesia:A survey in Aceh

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Asian Pacific Journal of tropical medicine 2017年第2期10卷 182-186页

作者： Harapan Harapan Alma Aletta Samsul Anwar Abdul M.Setiawan Reza Maulana Nur Wahyuniati Muhammad R.Ramadana Sotianingsih Haryanto Alfonso J.Rodriguez-Morales Kurnia F.Jamil Medical Research Unit School of MedicineSyiah Kuala University tropical Disease Centre School of MedicineSyiah Kuala University department of Microbiology School of MedicineSyiah Kuala University department of Family medicine School of MedicineSyiah Kuala University department of Statistics Faculty of Mathematics and Natural SciencesSyiah Kuala University department of Microbiology Faculty of Medicine and Health SciencesState Islamic University of Maulana Malik Ibrahim department of Clinical Pathology Faculty of Medicine and Health SciencesJambi University public health and Infection Research Incubator and Group Faculty of Health SciencesUniversidad Tecnologica de Pereira department of Internal medicine School of MedicineSyiah Kuala University

Objective:To assess the knowledge on Zika virus(ZIKV) infection among healthcare providers(doctors) in Aceh province,***:A self-administered internet based survey was conducted from 3 May to 3 June 2016 among the members of doctor organizations in Aceh province.A set of validated,pre-tested questionnaire was used to measure knowledge regarding ZIKV infection and to collect a range of explanatory variables.A two-steps logistic regression analysis was employed to assess the association of participants' demographic,workplace characteristics and other explanatory variables with the ***:A total of 442 participants included in the final analysis and 35.9% of them(159) had a good knowledge on ZIKV *** model revealed that type of occupation,type of workplace,availability of access to medical journals and experience made Zika disease as differential diagnose were associated with knowledge on ZIKV *** addition,three significant source of information regarding ZIKV were online media(60%),medical article or medical news(16.2%) and television(13.2%).Conclusion:The knowledge of the doctors in Aceh regarding ZIKV infection is relatively *** who have a good knowledge on ZIKV infection are more confident to established ZIKV disease as differential diagnosis in their clinical ***,such program to increase healthcare providers' knowledge regarding ZIKV infection is needed to screen potential carriers of ZIKV infection.

关键词： Zika virus Zika fever Knowledge Attitude health care worker Indonesia

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Nicotine-induced upregulation of antioxidant protein Prx 1 in oral squamous cell carcinoma

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Chinese Science Bulletin 2013年第16期58卷 1912-1918页

作者： ZHAO YanHua ZHANG Min YAN Fei CASTO Bruce C TANG XiaoFei Division of Oral Pathology Beijing Institute of Dental Research School of Stomatology Capital Medical University Division of Medical Oncology Department of Internal Medicine Ohio State University College of Medicine and Comprehensive Cancer Center Division of environmental health sciences Ohio State University College of Public Health

Nicotine is a source of exogenous oxidative stress, which is associated with the pathogenesis of numerous diseases including oral squamous cell carcinoma (OSCC), whereas an antioxidant protein, peroxiredoxin 1 (Prx 1), plays an important role in the modulation of this condition. This study was to investigate the association between Prx 1 and tobacco-induced oxidative stress. The expression of Prx 1 and GST in OSCC Tca8113 cells, which were pre-treated with nicotine, was determined. In the present study, MTT assay, reactive oxygen species (ROS) assay, RT-PCR and Western blot analyses, respectively, were conducted to assess cell viability, ROS level, and expression level of Prx 1 and GST in nicotine-treated Tca8113 cells. Nuclear factor kappa B (NF- B) expression was detected by immuno-fluorescence. Our results showed the growth of Tca8113 cells was increased in a dose-dependent manner when cells were treated with nicotine at concentrations from 0.1 to 10 mol/L, but the proliferation of the cells decreased at 100 mol/L. ROS levels increased in all groups treated with nicotine at concentrations of 0.1, 1, 10, or 100 mol/L for 24h. Prx 1 and GST mRNA and protein expression were up-regulated in cells treated with nicotine for the same time at different concentrations or at the same concentration for different times (P<0.05). NF-B was translocated from cytoplasm to nucleus, the expression of NF- B was increased in nucleus. These results suggest that up-regulation of Prx1 expression appears to be associated with tobacco-induced oxidative stress, which may play an important role in the pathogenesis of OSCC.

关键词：鳞状细胞癌蛋白表达抗氧化剂尼古丁口腔诱导氧化应激 RT-PCR

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Estimation of Probability of Unprotected Heterosexual Vaginal Transmission of HIV-1 from Clients to Female Sex Workers in Kaiyuan,Yunnan Province, China

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Biomedical and environmental sciences 2010年第4期23卷 287-292页

作者： WEN-JUAN MA JUN-JIE WANG KATHLEEN-H. REILLY AI-MEI BI GUO-WEI DING KUMI SMITH NING WANG school of public health Peking Union Medical College Tsinghua University Beijing 100730 China National Center for AIDS/STD Control and Prevention Beijing 102206 China tulane university health sciences Center School of Public Health and Tropical Medicine New Orleans LA USA Kaiyuan Center for Disease Control and Prevention Kaiyuan 661600 Yunnan China university of North Carolina at Chapel Hill Chapel Hill NC USA

Objective To estimate the probability of unprotected heterosexual vaginal transmission of HIV-1 from clients to Female Sex Workers （FSWs） in Kaiyuan County, Yunnan province, China, and analyze factors which impact the transmission probability. Methods An open cohort research of FSWs in Kaiyuan was created from surveys conducted in April 2008, October 2008, and April 2009. Two cross-sectional surveys of local clients were also carried out in May 2008 and November 2008. A model was developed to estimate the probability of unprotected heterosexual vaginal transmission of HIV-1 from clients to FSWs. Results The transmission probability from clients to FSWs was estimated as 0.0023 [95% CI 0.0014-0.0032] per unprotected heterosexual act. Conclusion The transmission probability among this group engaging in commercial sex in Yunnan province differs from that found in studies from other countries, and future studies should estimate the influence factors of HIV-1 transmission probability, such as stage of HIV infection, co-morbid sexually transmitted infections （STIs）.

关键词： Transmission Probability HIV/AIDS Model FSW Clients

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