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Effect of high-frequency loading and parathyroid hormone administration on peri-implant bone healing and osseointegration

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International Journal of Oral Science 2018年第1期10卷 50-64页

作者： Aya Shibamoto Toru Ogawa Joke Duyck Katleen Vandamme Ignace Naert Keiichi Sasaki Division of Advanced Prosthetic Dentistry Tohoku University Graduate School of Dentistry Department of Oral Health Sciences Prosthetic DentistryBIOMAT-BiomaterialsKatholieke Universiteit Leuven

The objective of this study is to examine the effect of low-magnitude, high-frequency(LMHF) loading, and anti-osteoporosis medications such as parathyroid hormone(PTH) and bisphosphonates on peri-implant bone healing in an osteoporosis model, and to assess their combined effects on these processes. Thirteen-week-old ovariectomized rats(n = 44) were divided into three groups:PTH, alendronate, and saline. After 3 weeks of drug administration, titanium implants were inserted into the tibiae. Each group was subdivided into two groups: with or without LMHF loading via whole-body vibration(50 Hz at 0.5 g, 15 min per day, 5 days per week). Rats were killed 4 weeks following implantation. Removal torque test, micro-CT analyses(relative gray(RG) value, water = 0,and implant = 100), and histomorphometric analyses(bone-to-implant contact(BIC) and peri-implant bone formation(bone volume/tissue volume(BV/TV))) were performed. Removal torque values and BIC were significantly differed by loading and drug administration(ANOVA). Post hoc analysis showed that PTH-treated groups were significantly higher than the other drug-treated groups. BV/TV was significantly enhanced by PTH administration. In cortical bone, RG values were significantly increased by *** trabecular bone, however, RG values were significantly increased by PTH administration. These findings suggest that LMHF loading and PTH can act locally and additively on the bone healing process, improving the condition of implant osseointegration.

关键词： WHOLE-BODY VIBRATION ORAL BISPHOSPHONATES LOW-MAGNITUDE POSTMENOPAUSAL WOMEN MINERAL DENSITY MECHANICAL SIGNALS TITANIUM IMPLANTS DENTAL IMPLANTS TERIPARATIDE OSTEOPOROSIS

Total Saponin Fraction of Dioscorea Nipponica Makino Improves Gouty Arthritis Symptoms in Rats via M1/M2 Polarization of Monocytes and Macrophages Mediated by Arachidonic Acid Signaling

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Chinese Journal of Integrative Medicine 2023年第11期29卷 1007-1017页

作者： ZHOU Qi SUN Hui-juan ZHANG Xi-wu Research Institute of Chinese Medicine Heilongjiang University of Chinese MedicineHarbin(150040)China Graduate school Heilongjiang University of Chinese MedicineHarbin(150040)China

Objective:To explore the mechanism of effects of total saponin fraction from Dioscorea Nipponica Makino(TSDN)on M1/M2 polarization of monocytes/macrophages and arachidonic acid(AA)pathway in rats with gouty arthritis(GA).Methods:Seventy-two Sprague Dawley rats were randomly divided into 4 groups(n=18 in each):normal,model,TSDN at 160 mg/kg,and celecoxib at 43.3 mg/*** urate crystal(MSU)was injected into the rats’ankle joints to induce an experimental GA *** and tissue samples were collected on the 3rd,5th,and 8th days of drug *** changes in the synovium of joints were observed via hematoxylin and eosin(HE)*** expression levels of arachidonic acid(AA)signaling pathway were assessed via real-time polymerase chain reaction(q PCR)and Western *** cytometry was used to determine the proportion of M1 and M2 macrophages in the peripheral *** enzyme-linked immunosorbent assay(ELISA)was used to detect interleukine(IL)-1β,tumor necrosis factoralpha(TNF-α),IL-4,IL-10,prostaglandin E_(2)(PGE_(2)),and leukotriene B4(LTB4).Results:HE staining showed that TSDN improved the synovial tissue.q PCR and Western blot showed that on the 3rd,5th and 8th days of drug administration,TSDN reduced the m RNA and protein expressions of cyclooxygenase(COX)2,microsomal prostaglandin E synthase-1 derived eicosanoids(m PGES-1),5-lipoxygenase(5-LOX),recombinant human mothers against decapentaplegic homolog 3(Smad3),nucleotide-binding oligomerization domain-like receptor protein 3(NALP3),and inducible nitric oxide synthase(i NOS)in rats’ankle synovial tissues(Padministration and raised it on the 8th day(both Padministration,TSDN elevated the m RNA and protein expression of Arg1 and CD163(P<0.01).F

关键词： Smad3 Blood mother

Expansion and Management Implications of Invasive Alien Spartina alterniflora in Yancheng Salt Marshes, China

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Open Journal of Ecology 2016年第3期6卷 113-128页

作者： Chunyue Liu Hongxing Jiang Shuqing Zhang Chunrong Li Xin Pan Jun Lu Yunqiu Hou Northeast Institute of Geography and Agroecology Chinese Academy of Sciences Changchun China Research Institute of Forest Ecology Environment and Protection Key Laboratory of Forest Protection of State Forestry Administration Chinese Academy of Forestry Beijing China Yancheng National Nature Reserve Xinyanggang Sheyang County Jiangsu China school of Electrical & Information Technology Changchun Institute of Technology Changchun China

Improved understanding of the spatial dynamics of invasive plant species is critical for effective land management and control of future invasion. The Yancheng National Nature Reserve (YNNR), an internationally important wetland, has the largest distribution of alien Spartina alterniflora in China. This alien plant was intentionally introduced for erosion prevention and dike protection in China. However, it became an aggressive competitor with native salt marsh plants in the coastal regions in China. High resolution imagery, SPOT-5, was used to map plant communities including invasive species in the south core zone of YNNR with the natural ecosystem of salt marshes in 2003, 2005 and 2008. The fuzzy set assessment method significantly improved the classification accuracies over the conventional error matrix, i.e., from 73.8%, 73.5% and 81.4% to 91.5%, 91.6% and 93.4% in 2003, 2005 and 2008, respectively. It shows a great potential for mapping invasive plant species. Phragmites australis and S. alterniflora were the most accurately mapped classes, and sparse and dense Suaeda glauca were the least accurately mapped. From 2003 to 2008, S. alterniflora increased 28.8% from 1664.1 to 2142.6 ha in area size, and more than 2.5 times from 742 to 2608 patches. The highest increase in patch number occurred within the interval between 2001 and 3000 m from the eastern baseline. This increase was dominated by small patches with area less than 200 m2. During the study period, the mean spread width was 405 ± 80.7 m in the original large patch of area over 200 ha. The eastward/seaward spread was distinctively larger than the westward/landward. The results enhance the understanding of alien plant’s invasion patterns and help improve conservation efforts.

关键词： Spartina alterniflora SPOT-5 Remote Sensing Fuzzy Set Assessment Expansion Characteristics Management Implications

Research on Prediction of the Scale of OTC Drug Market in China Based on Quantitative Analysis

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Asian Journal of Social Pharmacy 2020年第3期15卷 145-152页

作者： Xu Yang Xu Lang Xue Aoming Hainan Bikai Pharmaceutical Co. LTD.Haikou 570311China Hainan Huiyuantang Pharmaceutical Co. LTD.Haikou 570311China school of business administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To analyze the scale of domestic OTC drug market and its influencing factors,so as to predict its future market and provide a scientific basis for pharmaceutical enterprises to grasp the opportunities in the *** The scale of OTC drug market from 1999 to 2018 in China and its influencing factors were analyzed by unit root test,Granger causality test and co-integration *** and Conclusion From the perspective of the global pharmaceutical market,OTC drug market has broad prospects and great development *** the influence of GDP and the number of elderly populations on the scale of OTC drug market is positive,the predicted growth rate of OTC market in the next three years is 5.82%,5.86%and 5.90%,respectively.

关键词： quantitative analysis OTC drugs prediction of the scale of market unit root test granger causality test co-integration test

Autonomous planning system based on temporal constraint satisfaction

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Journal of Harbin Institute of Technology(New Series) 2003年第3期10卷 304-307页

作者：徐瑞崔平远徐晓飞吴伟仁田玉龙 Deep Space Exploration Research Center Harbin Institute of Technology Harbin 150001 China School of Computer Science and Technology Harbin Institute of Technology Harbin 150001China Deep Space Exploration Research Center Harbin Institute of Technology Harbin 150001 China school of Computer Science and Technology Harbin Institute of Technology Harbin 150001China China National Space administration Beijing 100037 China China National Space administration Beijing 100037 Chinan order to realize spacecraft autonomy activity duration and complex temporal relations must be taken into consideration. In the space mission planning system the traditional planners are unable to describe this knowledge so an object-oriented temporal knowledge representation method is proposed to model every activity as an object to describe the activity's duration start-time end-time and the temporal relations with other activities. The layered planning agent architecture is then designed for spacecraft autonomous operation and the functions of every component are given. A planning algorithm based on the temporal constraint satisfaction is built in detail using this knowledge representation and system architecture. The prototype of Deep Space Mission Autonomous Planning System is implemented. The results show that with the object-oriented temporal knowledge description method the space mission planning system can be used to describe simultaneous activities resource and temporal constraints and produce a complete plan for exploration mission quickly under complex constraints.

In order to realize spacecraft autonomy activity duration and complex temporal relations must be taken into consideration. In the space mission planning system, the traditional planners are unable to describe this knowledge, so an object-oriented temporal knowledge representation method is proposed to model every activity as an object to describe the activity's duration, start-time, end-time and the temporal relations with other activities. The layered planning agent architecture is then designed for spacecraft autonomous operation, and the functions of every component are given. A planning algorithm based on the temporal constraint satisfaction is built in detail using this knowledge representation and system architecture. The prototype of Deep Space Mission Autonomous Planning System is implemented. The results show that with the object-oriented temporal knowledge description method, the space mission planning system can be used to describe simultaneous activities, resource and temporal constraints, and produce a complete plan for exploration mission quickly under complex constraints.

关键词： autonomous planning system object-oriented knowledge representation spacecraft temporal constraint satisfaction

Transcriptional Analysis of Normal Human Fibroblast Responses to Microgravity Stress

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Genomics, Proteomics & Bioinformatics 2008年第1期6卷 29-41页

作者： Yongqing Liu Eugenia Wang Department of Biochemistry and Molecular Biology University of Louisville School of Medicine Louisville KY 40202 USA. Current address. James Graham Brown Cancer Center Department of Ophthalmology and Visual SciencesUniversity of Louisville School of Medicine Louisville KY 40202 USA.

To understand the molecular mechanism（s） of how spaceflight affects cellular signaling pathways, quiescent normal human WI-38 fibroblasts were flown on the STS-93 space shuttle mission. Subsequently, RNA samples from the spaceflown and ground-control cells were used to construct two cDNA libraries, which were then processed for suppression subtractive hybridization （SSH） to identify spaceflight-specific gene expression. The SSH data show that key genes related to oxidative stress, DNA repair, and fatty acid oxidation are activated by spaceflight, suggesting the induction of cellular oxidative stress. This is further substantiated by the up-regulation of neuregulin 1 and the calcium-binding protein calmodulin 2. Another obvious stress sign is that spaceflight evokes the Ras/mitogen-activated protein kinase and phosphatidylinositol-3 kinase signaling pathways, along with up-regulating several Gl-phase cell cycle traverse genes. Other genes showing upregulation of expression are involved in protein synthesis and pro-apoptosis, as well as pro-survival. Interactome analysis of functionally related genes shows that c-Myc is the ＂hub＂ for those genes showing significant changes. Hence, our results suggest that microgravity travel may impact changes in gene expression mostly associated with cellular stress signaling, directing cells to either apoptotic death or premature senescence.

关键词： microgravity apoptosis premature senescence oxidative stress subtractive hybridization

Registration Method for CT-MR Image Based on Mutual Information

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Transactions of Tianjin University 2007年第3期13卷 226-230页

作者：张红颖张加万孙济洲 school of Computer Science and Technology Tianjin University College of Aeronautical Automation Civil Aviation University of China Tianjin 300300 China

Medical image registration is important in many medical applications. Registration method based on maximization of mutual information of voxel intensities is one of the most popular methods for 3-D multi-modality medical image registration. Generally, the optimization process is easily trapped in local maximum, resulting in wrong registration results. In order to find the correct optimum, a new multi-resolution approach for brain image registration based on normalized mutual information is proposed. In this method, to eliminate the effect of local optima, multi-scale wavelet transformation is adopted to extract the image edge features. Then the feature images are registered, and the result at this level is taken as the initial estimate for the registration of the original images. Three-dimensional volumes are used to test the algorithm. Experimental results show that the registration strategy proposed is a robust and efficient method which can reach sub-voxel accuracy and improve the optimization speed.

关键词： image registration edge detection mutual information wavelet transformation

Distribution and characteristic of PAHs in snow of Fildes Peninsula

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Journal of Environmental Sciences 2011年第9期23卷 1445-1451页

作者： Guangshui Na Chunyang Liu Zhen Wang Linke Ge Xindong Ma Ziwei Yao Key laboratory for Ecological Environment in Coastal Areas National Marine Environmental Monitoring Center Dalian 116023 China school of Bio- Technology Dalian Polytechnic University Dalian 116034 China

Polycyclic aromatic hydrocarbons （PAHs） investigation in different matrices has been reported largely,whereas reports on snow samples were ***,as the main matrix in the polar region,has an important study *** in snow samples were analyzed to investigate the distribution and contamination status of them in the Antarctic,as well as to provide some references for global migration of *** samples collected in Fildes Peninsula were enriched and separated by solid-phase membrane disks and eluted by methylene dichloride,then quantified by gas chromatography/mass *** types of PAHs were detected except for Benzo（a）*** component analysis method was applied to characterize *** factors （Naphthalene,Fluorene and Phenanthrene） accounted for 60.57%,21.61% and 9.80%,*** results showed that the major PAHs sources maybe the atmospheric transportation,and the combustion of fuel in Fildes *** comparison of concentration and types of PAHs between accumulated snow and fresh snow showed that the main compound concentrations in accumulated snow samples were higher than those in fresh *** risk assessment indicated that the amount of PAHs in the snow samples would not lead to ecological risk.

关键词： PAHs snow Antarctic principal component analysis risk assessment

Extracts of Portulaca oleracea promote wound healing by enhancing angiology regeneration and inhibiting iron accumulation in mice

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Chinese Herbal Medicines 2022年第2期14卷 263-272页

作者： Jinglin Guo Juan Peng Jing Han Ke Wang Ruijuan Si Hui Shan Xiaoying Wang Ju Zhang school of Nursing Qingdao UniversityQingdao 266071China Surgery of Traditional Chinese Medicine Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300150China school of Pharmacy Qingdao UniversityQingdao 266071China

Objective:To investigate the role of Portulaca oleracea(POL)in promoting revascularization and reepithelization as well as inhibiting iron aggregation and inflammation of deep tissue pressure injury(DTPI).Methods:The hydroalcoholic extract of POL(P)and aqueous phase fraction of POL(PD)were prepared based on maceration and liquid–liquid *** number of new blood vessels and VEGF-A expression level were assessed using H&E stain and Western blot on injured muscle to examine the role of POL different extracts in *** iron distribution and total elemental iron of injured muscle were detected using laser ablation inductively coupled plasma mass spectrometry(ICP-MS)and Perls’staining to determine whether POL extracts can inhibit the iron ***,the ability of POL extracts to promote wound healing by combining re-epithelization time,inflammation degree and collagen deposition area were comprehensively ***:In vitro,we observed a significant increase in HUVEC cell viability,migration rate and the number of the tube after P and PD treatment(Padministration of P and PD impacted vascularization and iron accumulation on injured tissue,evident from more new blood vessels,higher expression of VEGF-A and decreased muscle iron concentration of treatment groups compared with no-treatment groups(Padministration of P and PD(Padministration groups have high-quality wound healing,which is associated with increased new blood vessels,collagen deposition and re-epithelization,along with decreased iron accumulation and inflammatory *** results suggest that that POL extract is beneficial to repair injured muscle after ischemia–reperfusion,highlighting the potential of POL in the DTPI treatment.

关键词： deep tissue pressure injur ischemia-reperfusion Portulaca oleracea L. tissue repair wound healing