检索结果-南通市图书馆

Journal of Sport and Health Science 2021年第2期10卷 237-242页

作者： Sofie Blicher Eric Bartholomae Jochen Kressler Department of exercise and nutritional sciences San Diego State UniversitySan DiegoCA 92113USA

Background:Decaffeinated green tea extract(dGTE)can increase fat oxidation during leg exercise,but dGTE is unsuitable for many people(e.g.,those with injuries/disabilities),and its effects on arm exercise and women are ***:Eight adults(23-37 years old,4 women)performed an incremental arm cycle test to measure peak oxygen uptake(VO_(2_(peak))),followed by four 1-h trials at 50%VO_(2_(peak).Subjects were randomly assigned to 650 mg of dGTE or placebo(PLA)for 4 weeks followed by a 4-week washout and crossover *** samples were obtained pre-exercise and post-exercise for glycerol and free fatty acid *** gases were collected ***:VO_(2) showed no differences across trials((0.83-0.89)±(0.19-0.25)L/min,p=0.460),neither did energy expenditure((264-266)±(59-77)kcal,p=0.420)nor fat oxidation(dGTE=0.11 to 0.12 g/min ***=0.10 to 0.09 g/min,p=0.220).Fat oxidation as percentage of energy expenditure was not different for dGTE ***(23%±12%to 25%±11%vs.23%±10%to 21%±9%,p=0.532).Glycerol concentration increased post-exercise in all trials,independent of treatments(pre=(3.4-5.1)±(0.6-2.6)mg/dL ***=(7.9-9.8)±(2.6-3.7)mg/dL,p=0.867,η^(2)=0.005 for interaction),as did free fatty acid((3.5-4.8)±(1.4-2.2)mg/dL vs.(7.2-9.1)±(2.6-4.5)mg/dL,p=0.981,η^(2)=0.000).Conclusion:Chronic dGTE supplementation had no effect on lipolysis and fat oxidation during arm cycle exercise in men and women.

关键词： Arm exercise Cardiometabolic disease Fat oxidation Nutraceutical

exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Redistribution of nerve strain enables end-to-end repair under tension without inhibiting nerve regeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第7期14卷 1280-1288页

作者： Holly M.Howarth Turki Alaziz Brogan Nicolds Shawn O'Connor Sameer B.Shah Department of Bioengineering University of California Department of Orthopaedic Surgery University of California school of exercise and nutritional sciences San Diego State University Research Service VA San Diego Healthcare System

End-to-end repair under no or low tension leads to improved outcomes for transected nerves with short gaps,compared to repairs with a ***,grafts are typically used to enable a tension-free repair for moderate to large gaps,as excessive tension can cause repairs to fail and catastrophically impede *** this study,we tested the hypothesis that unloading the repair interface by redistributing tension away from the site of repair is a safe and feasible strategy for end-to-end repair of larger nerve ***,we tested the hypothesis that such an approach does not adversely affect structural and functional *** this study,we used a rat sciatic nerve injury model to compare the integrity of repair and several regenerative outcomes following end-to-end repairs of nerve gaps of increasing *** addition,we proposed the use of a novel implantable device to safely repair end-to-end repair of larger nerve gaps by redistributing tension away from the repair *** data suggest that redistriubution of tension away from the site of repair enables safe end-to-end repair of larger gap *** addition,structural and functional measures of regeneration were equal or enhanced in nerves repaired under tension – with or without a tension redistribution device – compared to tension-free *** that repair integrity is maintained,end-to-end repairs under tension should be considered as a reasonable surgical *** animal experiments were performed under the approval of the Institutional Animal Care and Use Committee of University of California,San Diego(Protocol S11274).

关键词： tension biomechanics strain end-to-end repair peripheral nerve nerve regeneration

Iron and liver fibrosis: Mechanistic and clinical aspects

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第5期25卷 521-538页

作者： Kosha J Mehta Sebastien Je Farnaud Paul A Sharp school of Population Health and Environmental sciences Faculty of Life Sciences and Medicine King’s College London Division of Human sciences School of Applied Sciences London South Bank University Faculty Research Centre for Sport Exercise and Life Sciences Coventry University Department of nutritional sciences School of Life Course Sciences Faculty of Life Sciences and Medicine King's College London

Liver fibrosis is characterised by excessive deposition of extracellular matrix that interrupts normal liver functionality. It is a pathological stage in several untreated chronic liver diseases such as the iron overload syndrome hereditary haemochromatosis, viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and diabetes. Interestingly, regardless of the aetiology, iron-loading is frequently observed in chronic liver diseases. Excess iron can feed the Fenton reaction to generate unquenchable amounts of free radicals that cause grave cellular and tissue damage and thereby contribute to fibrosis. Moreover, excess iron can induce fibrosis-promoting signals in the parenchymal and non-parenchymal cells, which accelerate disease progression and exacerbate liver pathology. Fibrosis regression is achievable following treatment, but if untreated or unsuccessful, it can progress to the irreversible cirrhotic stage leading to organ failure and hepatocellular carcinoma, where resection or transplantation remain the only curative options. Therefore,understanding the role of iron in liver fibrosis is extremely essential as it can help in formulating iron-related diagnostic, prognostic and treatment strategies. These can be implemented in isolation or in combination with the current approaches to prepone detection, and halt or decelerate fibrosis progression before it reaches the irreparable stage. Thus, this review narrates the role of iron in liver fibrosis. It examines the underlying mechanisms by which excess iron can facilitate fibrotic responses. It describes the role of iron in various clinical pathologies and lastly,highlights the significance and potential of iron-related proteins in the diagnosis and therapeutics of liver fibrosis.

关键词： Iron Liver pathologies Liver fibrosis Hepatic stellate cells Cirrhosis

Application of naturalβ-glucans as biocompatible functional nanomaterials

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2019年第4期8卷 315-319页

作者： Xiaojie Li Peter Chi Keung Cheung Food and nutritional sciences School of Life SciencesThe Chinese University of Hong KongHong KongChina

Naturally-occurringβ-glucans are mostly investigated for their antitumor activity and immunomodulatory *** have been widely regarded as a natural source for functional foods and ***,the physico-chemically stable and biocompatible properties ofβ-glucans are rarely explored as a coating material for nanomaterials to overcome the problems of aggregation and *** article reviews on the exploration ofβ-glucans,in particular those derived from mushrooms,as a natural coating material to modify the surface properties of bioactive substances as a relatively simple and cost-effective strategy to produce stable and biocompatible nanohybrids used for biopharmaceutical *** is envisaged that suchβ-glucan-based coating method will provide new opportunities to design biocompatible functional nanomaterials for wider clinical applications.

关键词： β-Glucans Biocompatibility Biopharmaceuticals Nanohybrids

Thyroid hormone action in metabolic regulation

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2011年第5期2卷 358-368页

作者： Yiyun Song Xuan Yao Hao Ying Key Laboratory of Nutrition and Metabolism Institute for Nutritional SciencesShanghai Institutes for Biological SciencesGraduate School of the Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

Thyroid hormone plays pivotal roles in growth,differentiation,development and metabolic homeostasis via thyroid hormone receptors(TRs)by controlling the expression of TR target *** transcriptional activity of TRs is modulated by multiple factors including various TR isoforms,diverse thyroid hormone response elements,different heterodimeric partners,coregulators,and the cellular location of *** the present review,we summarize recent advance in understanding the molecular mechanisms of thyroid hormone action obtained from human subject research,thyroid hormone mimetics application,TR isoform-specific knock-in mouse models,and mitochondrion study with highlights in metabolic ***,as future perspectives,we share our thoughts about current challenges and possible approaches to promote our knowledge of thyroid hormone action in metabolism.

关键词： thyroid hormone thyroid hormone receptor metabolic regulation central and peripheral effect thyroid diseases

Protein phase separation of plant nuclear pore complex

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2023年第6期16卷 973-974页

作者： Kentaro Tamura Masaya Koide school of Food and nutritional sciences Department of Environmental and Life SciencesUniversity of ShizuokaShizuoka 422-8526Japan

The nuclear pore complex(NPC)is an evolutionally conserved channel that controls the exchange of macromolecules between the nucleus and *** pores of the NPC form a permeability barrier that allows free permeability of small molecules(<40 kDa or~5 nm in diameter)(Schmidt and Gorlich,2016).However,larger molecules must interact with nuclear transport receptors(NTRs)to overcome the NPC permeability barrier.

关键词： separation overcome pores

Psycho-emotional content of illness narrative master plots for people with chronic illness:Implications for assessment

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2018年第3期8卷 79-82页

作者： Andy Soundy school of Sport Exercise and Rehabilitation SciencesUniversity of Birmingham

Illness narratives are stories of illness told by patients with chronic illness. One way of studying illness narratives is by considering illness narrative master *** examination of illness narrative master plots has revealed the importance of psycho-emotional information contained within the story that is told. There is a need for research to capture this information in order to better understand how common stories and experiences of illness can be understood and used to aid the mental well-being of individuals with chronic illness. The current editorial provides a suggestion of how this is possible. This editorial identifies that stories can be "mapped" graphically by combining emotional responses to the illness experience with psychological responses of the illness experience relating to hope and psychological adaptation. Clinicians and researchers should consider the evidence presented within this editorial as:(1) A possible solution for documenting the mental wellbeing of individuals with chronic illness; and(2) As a tool that can be used to consider changes in mental well-being following an intervention. Further research using this tool will likely provide insights into how illness narrative master plots are associated together and change across the course of a chronic illness. This is particularly important for illness narrative master plots that are difficult to tell or that are illustrative of a decline in mental well-being.

关键词： Illness narratives Assessment Emotions Psychological adaptation Hope

Autophagy as new emerging cellular effect of nanomaterials

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2013年第33期58卷 4031-4038页

作者： ZHONG WenYing Lü Min LIU LiYing SUN JinLi ZHONG ZengTao ZHAO Yun SONG HaiYun school of Life Science Sichuan University Institute for nutritional sciences Shanghai Institutes for Biological Sciences College of Life sciences Nanjing Agricultural University

The biosafety issue of nanoscale materials is getting more and more attention with their increasing manufacture and *** the research of cellular effects and underlying mechanisms related to toxicity of nanomaterials,most emphasis were placed on processes such as apoptosis,metabolic inhibition and oxidative *** evidence suggests that autophagy is part of the biological effects by nanomaterials and various kinds of nanomaterials are capable of disturbing the autophagic *** review will highlight the importance of autophagy as an emerging mechanism of nanomaterial toxicity and the implication in the therapy of autophagy-related *** summarize current research status of interaction between nanomaterials and autophagic *** is of note that nanomaterials can either induce or block autophagy,which result in similar phenotype but completely different biological *** is therefore important to perform comprehensive analysis of the whole autophagic flux in the future research.

关键词：纳米材料自噬作用细胞效应生物效应安全问题细胞凋亡氧化应激疾病治疗

Effect of plant-based functional foods for the protection against salt induced endothelial dysfunction

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2022年第5期11卷 1299-1305页

作者： Sheung Yin San JenniferMFWan Jimmy Chun Yu Louie Discipline of Food and nutritional sciences School of Biological SciencesFaculty of ScienceThe University of Hong KongPokfulam 999067Hong KongChina

This study aimed to compare the efficacy of four formulations of plant-based functional foods on the protection against salt-induced endothelial dysfunction.A randomized crossover design was *** healthy subjects were recruited,and on five separate occasions they received,in random sequence one of the following 5 treatments:250 mL of plain water(control)alone,and with beetroot powder,celery powder,green tea extract or beetroot powder with green tea extract prior to consuming 150 mL of high-salt chicken ***-mediated dilation(FMD),blood pressure(BP),heart rate(HR)and pulse-wave velocity(PWV)were measured at fasting and at 30,60,90 and 120 min *** with control,beetroot supplementation led to a significantly increased HR at 30,60 and 90 min postprandially(P=0.025,0.004,<0.001,respectively).No significant difference was observed for FMD,BP and PWV between control and any of the *** reduction may still be the most effective strategy to improve vascular health.

关键词： Endothelial dysfunction Salt intake Functional foods Nitrate Flavonoids Flow-mediated dilation