Autophagy as new emerging cellular effect of nanomaterials

作     者：ZHONG WenYing Lü Min LIU LiYing SUN JinLi ZHONG ZengTao ZHAO Yun SONG HaiYun 

作者机构：School of Life ScienceSichuan University Institute for Nutritional SciencesShanghai Institutes for Biological Sciences College of Life SciencesNanjing Agricultural University 

出 版 物：《Chinese Science Bulletin》 (中国科学通报)

年 卷 期：2013年第58卷第33期

页      面：4031-4038页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0702[理学-物理学] 

基　　金：supported by the National Basic Research Program of China(2011CB943900) the National Natural Science Foundation of China(31071145) 

主　　题：纳米材料 自噬作用 细胞效应 生物效应 安全问题 细胞凋亡 氧化应激 疾病治疗 

摘      要：The biosafety issue of nanoscale materials is getting more and more attention with their increasing manufacture and *** the research of cellular effects and underlying mechanisms related to toxicity of nanomaterials,most emphasis were placed on processes such as apoptosis,metabolic inhibition and oxidative *** evidence suggests that autophagy is part of the biological effects by nanomaterials and various kinds of nanomaterials are capable of disturbing the autophagic *** review will highlight the importance of autophagy as an emerging mechanism of nanomaterial toxicity and the implication in the therapy of autophagy-related *** summarize current research status of interaction between nanomaterials and autophagic *** is of note that nanomaterials can either induce or block autophagy,which result in similar phenotype but completely different biological *** is therefore important to perform comprehensive analysis of the whole autophagic flux in the future research.