Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

作     者：Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining Ou Meifeng Zheng;Borui Zhang;Sonata S Y Yau;Kwok-Fai So;Li Zhang;Haining Ou

作者机构：Department of Rehabilitation MedicineGuangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation MedicineThe Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation SciencesThe Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive ScienceLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain ScienceSchool of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation InstituteUniversity of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2025年第20卷第5期

页      面：1445-1454页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by STI2030-Major Projects,No.2022ZD0207600(to LZ) the National Natural Science Foundation of China,Nos.32070955(to LZ),U22A20301(to KFS) the Natural Science Foundation of Guangdong Province,No.2021A1515012197(to HO) Guangzhou Core Medical Disciplines Project,No.2021-2023(to HO) Key Research and Development Plan of Ningxia Hui Automomous Region,No.2022BEG01004(to KFS) Science and Technology Program of Guangzhou,China,No.202007030012(to KFS and LZ) 

主　　题：adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise 

摘      要：Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.