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Genomic Mosaicism of the Brain:Origin,Impact,and Utility

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Neuroscience Bulletin 2024年第6期40卷 759-776页

作者： Jared H.Graham Johannes C.M.Schlachetzki Xiaoxu Yang Martin W.Breuss Department of Pediatrics Section of Clinical Genetics and MetabolismUniversity of Colorado School of MedicineAurora80045-2581COUSA Department of Cellular and Molecular Medicine University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Department of Neurosciences University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Rady Children’s institute for Genomic Medicine San Diego92123CAUSA

Genomic mosaicism describes the phenomenon where some but not all cells within a tissue harbor unique genetic ***,research focused on the impact of genomic mosaicism on clinical phenotype—motivated by its involvement in cancers and overgrowth *** recently,we increasingly shifted towards the plethora of neutral mosaic variants that can act as recorders of cellular lineage and environmental ***,we summarize the current state of the field of genomic mosaicism research with a special emphasis on our current understanding of this phenomenon in brain development and *** the field of genomic mosaicism has a rich history,technological advances in the last decade have changed our approaches and greatly improved our *** will provide current definitions and an overview of contemporary detection approaches for genomic ***,we will discuss the impact and utility of genomic mosaicism.

关键词： Genomics Brain development Brain homeostasis Genomic mosaicism

Risk mapping of wildlife-vehicle collisions across thestate of Montana,USA:a machine-learning approach forimbalanced data along rural roads

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Transportation Safety and Environment 2024年第3期6卷 124-132页

作者： Matthew Bell Yiyi Wang Rob Ament Western Transportation institute Montana State University2327 University WayBozemanMT 59717USA School of Engineering San Francisco State University1600 Holloway AveSan FranciscoCA 94132USA

Wildlife-vehicle collisions(WVCs)with large animals are estimated to cost the USA over 8 billion USD in property damage,tens of thousands of human injuries and nearly 200 human fatalities each *** WVCs occur on rural roads and are not collected evenly among road segments,leading to imbalanced *** are a disproportionate number of analysis units that have zero WVC cases when investigating large geographic areas for collision *** units with zero WVCs can reduce prediction accuracy and weaken the coefficient estimates of statistical learning *** study demonstrates that the use of the synthetic minority over-sampling technique(SMOTE)to handle imbalanced WVC data in combination with statistical and machine-learning models improves the ability to determine seasonal WVC risk across the rural highway network in Montana,*** array of regularized variables describing landscape,road and traffic were used to develop negative binomial and random forest models to infer WVC rates per 100 million vehicle miles *** random forest model is found to work particularly well with SMOTE-augmented data to improve the prediction accuracy of seasonal WVC ***-augmented data are found to improve accuracy when predicting crash risk across fine-grained grids while retaining the characteristics of the original *** analyses suggest that SMOTE augmentation mitigates data imbalance that is encountered in seasonally divided WVC *** research provides the basis for future risk-mapping models and can potentially be used to address the low rates of WVCs and other crash types along rural roads.

关键词： wildlife-vehicle collisions machine learning SMOTE negative binomial risk mapping

Development,validation,and transportability of several machine-learned,non-exercise-based VO_(2max)prediction models for older adults

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Journal of Sport and Health Science 2024年第5期13卷 611-620页

作者： Benjamin T.Schumacher Michael J.LaMonte Andrea Z.LaCroix Eleanor M.Simonsick Steven P.Hooker Humberto Parada Jr. John Bellettiere Arun Kumar Herbert Wertheim School of Public Health and Human Longevity Science University of California San DiegoLa JollaCA 92093USA Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California san Diego Moores Cancer Center La JollaCA 92093USA Computer Science and Engineering and Halicioglu Data Science institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few maximal oxygen uptake(VO_(2max))non-exercise-based prediction equations,fewer using machine learning(ML),and none specifically for older *** direct measurement of VO_(2max)is infeasible in large epidemiologic cohort studies,we sought to develop,validate,compare,and assess the transportability of several ML VO_(2max)prediction ***:The Baltimore Longitudinal Study of Aging(BLSA)participants with valid VO2_(max)tests were included(n=1080).Least absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine(SVM)algorithms were trained to predict VO_(2max)*** developed these algorithms for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quantified the associations between measured and predicted VO_(2max)and ***:The age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine yielded root mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effect estimates but were not robust to ***:Measured VO_(2max)is a strong predictor of *** ML can improve the accuracy of prediction as compared to simpler approaches but estimates of association with mortality remain sensitive to *** studies should seek to reproduce these results so that VO_(2max),an important vital sign,can be more broadly studied as a modifiable target for promoting functional resiliency and healthy aging.

关键词： Cardiorespiratory fitness Prediction algorithms Epidemiology Mortality

Liquid biopsy for gastric cancer:Techniques,applications,and future directions

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World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina Díaz del Arco M Jesús Fernández Aceñero Luis Ortega Medina Department of Surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain Department of Legal Medicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tumor cells in blood through liquid biopsy(LB),this technique has evolved to encompass the analysis of multiple materials originating from the tumor,such as nucleic acids,extracellular vesicles,tumor-educated platelets,and other ***,research has extended to include the examination of samples other than blood or plasma,such as saliva,gastric juice,urine,or *** techniques are diverse,intricate,and *** must be highly sensitive,and pre-analytical,patient,and tumor-related factors significantly influence the detection threshold,diagnostic method selection,and potential ***,the implementation of LB in clinical practice still faces several *** potential applications of LB range from early cancer detection to guiding targeted therapy or immunotherapy in both early and advanced cancer cases,monitoring treatment response,early identification of relapses,or assessing patient *** the other hand,gastric cancer(GC)is a disease often diagnosed at advanced *** recent advances in molecular understanding,the currently available treatment options have not substantially improved the prognosis for many of these *** application of LB in GC could be highly valuable as a non-invasive method for early diagnosis and for enhancing the management and outcomes of these *** this comprehensive review,from a pathologist’s perspective,we provide an overview of the main options available in LB,delve into the fundamental principles of the most studied techniques,explore the potential utility of LB application in the context of GC,and address the obstacles that need to be overcome in the future to make this innovative technique a game-changer in cancer diagnosis and treatment within clinical practice.

关键词： Liquid biopsy Gastric cancer Circulating tumor cells Cell-free DNA Circulating tumor DNA Molecular

Trend of Developing Aqueous Liquid and Gel Electrolytes for Sustainable,Safe,and High‑Performance Li‑Ion Batteries

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Nano-Micro Letters 2024年第1期16卷 17-34页

作者： Donghwan Ji Jaeyun Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences&Technology(SAIHST)Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Biomedical institute for Convergence at SKKU(BICS) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea institute of Quantum Biophysics(IQB) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Present Address:Department of NanoEngineering University of California San DiegoLa JollaSan DiegoCA 92093USA

Current lithium-ion batteries(LIBs)rely on organic liquid electrolytes that pose significant risks due to their flammability and *** potential for environmental pollution and explosions resulting from battery damage or fracture is a critical ***-based(aqueous)electrolytes have been receiving attention as an alternative to organic ***,a narrow electrochemicalstability window,water decomposition,and the consequent low battery operating voltage and energy density hinder the practical use of aqueous ***,developing novel aqueous electrolytes for sustainable,safe,high-performance LIBs remains *** Review first commences by summarizing the roles and requirements of electrolytes–separators and then delineates the progression of aqueous electrolytes for LIBs,encompassing aqueous liquid and gel electrolyte development trends along with detailed principles of the *** aqueous electrolytes are progressed based on strategies using superconcentrated salts,concentrated diluents,polymer additives,polymer networks,and artificial passivation layers,which are used for suppressing water decomposition and widening the electrochemical stability window of water of the *** addition,this Review discusses potential strategies for the implementation of aqueous Li-metal batteries with improved electrolyte–electrode interfaces.A comprehensive understanding of each strategy in the aqueous system will assist in the design of an aqueous electrolyte and the development of sustainable and safe high-performance batteries.

关键词： Lithium-ion battery(LIB) Aqueous electrolyte Gel electrolyte Electrochemical stability window Li dendrite

Role of copper in central nervous system physiology and pathology

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Neural Regeneration Research 2025年第4期20卷 1058-1068页

作者： Martina Locatelli Cinthia Farina institute of Experimental Neurology Division of NeuroscienceIstituto di Ricovero e Cura a Carattere Scientifico(IRCCS)San Raffaele Scientific InstituteMilanItaly Vita-Salute san Raffaele University MilanItaly

Copper is a transition metal and an essential element for the organism,as alterations in its homeostasis leading to metal accumulation or deficiency have pathological effects in several organs,including the central nervous *** copper dysregulations have been evidenced in two genetic disorders characterized by mutations in the copper-ATPases ATP7A and ATP7B,Menkes disease and Wilson’s disease,respectively,and also in multifactorial neurological disorders such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,and multiple *** review summarizes current knowledge about the role of copper in central nervous system physiology and pathology,reports about unbalances in copper levels and/or distribution under disease,describes relevant animal models for human disorders where copper metabolism genes are dysregulated,and discusses relevant therapeutic approaches modulating copper ***,alterations in copper metabolism may contribute to the etiology of central nervous system disorders and represent relevant therapeutic targets to restore tissue homeostasis.

关键词： astrocytes central nervous system copper cuprizone multiple sclerosis myelin neurodegenerative disorders

Optical colorimetric LiTaO_(3)wafers for highprecision lithography on frequency control of SAW devices

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Photonics Research 2024年第2期12卷 341-349页

作者： MING HUI FANG YINONG XIE FANGQI XUE ZHILIN WU JUN SHI SHENG YU YANG YILIN LIU ZHIHUANG LIU HSIN CHI WANG FAJUN LI QING HUO LIU JINFENG ZHU School of Electronic Science and Engineering Xiamen UniversityXiamen 361005China Quanzhou san’an Integrated Circuit Co. Ltd.Quanzhou 362300China Eastern institute of Technology Ningbo 315200China

Surface acoustic wave(SAW)resonators based on lithium tantalate(LT,LiTaO_(3))wafers are crucial elements of mobile communication *** use of intrinsic LT wafers typically brings about low fabrication accuracy of SAW resonators due to strong UV reflection in the lithography *** hinders their resonance frequency control seriously in industrial *** doping and chemical reduction could be applied to decrease the UV reflection of LT wafers for high lithographic ***,conventional methods fail to provide a fast and nondestructive approach to identify the UV performance of standard single-side polished LT wafers for highprecision frequency ***,we propose a convenient on-line sensing scheme based on the colorimetry of reduced Fe-doped LT wafers and build up an automatic testing system for industrial *** levels of Fe doping and chemical reduction are evaluated by the lightness and color difference of LT-based *** correlation between the wafer visible colorimetry and UV reflection is established to refine the lithography process and specifically manipulate the frequency performance of SAW *** study provides a powerful tool for the fabrication control of SAW resonators and will inspire more applications on sophisticated devices of mobile communication.

关键词： lithography doping wafer

GraphFlow+:Exploiting Conversation Flow in Conversational Machine Comprehension with Graph Neural Networks

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Machine Intelligence Research 2024年第2期21卷 272-282页

作者： Jing Hu Lingfei Wu Yu Chen Po Hu Mohammed J.Zaki School of Computer Science Central China Normal UniversityWuhan 430079China Pinterest San Francisco 94016USA Meta Mountain View 94039USA Rensselaer Polytechnic institute Troy 12180USA

The conversation machine comprehension(MC)task aims to answer questions in the multi-turn conversation for a single ***,recent approaches don’t exploit information from historical conversations effectively,which results in some references and ellipsis in the current question cannot be *** addition,these methods do not consider the rich semantic relationships between words when reasoning about the passage *** this paper,we propose a novel model GraphFlow+,which constructs a context graph for each conversation turn and uses a unique recurrent graph neural network(GNN)to model the temporal dependencies between the context graphs of each ***,we exploit three different ways to construct text graphs,including the dynamic graph,static graph,and hybrid graph that combines the *** experiments on CoQA,QuAC and DoQA show that the GraphFlow+model can outperform the state-of-the-art approaches.

关键词： Conversational machine comprehension(MC) reading comprehension question answering graph neural networks(GNNs) natural language processing(NLP)

Survey on digital twins for Internet of Vehicles:Fundamentals,challenges,and opportunities

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Digital Communications and Networks 2024年第2期10卷 237-247页

作者： Jiajie Guo Muhammad Bilal Yuying Qiu Cheng Qian Xiaolong Xu Kim-Kwang Raymond Choo School of Computer and Software Nanjing University of Information Science and TechnologyNanjing210044China Department of Computer Engineering Hankuk University of Foreign StudiesGyeonggi-do17035South Korea Jiangsu Hydraulic Research institute Nanjing210044China Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78249-0631USA

As autonomous vehicles and the other supporting infrastructures(e.g.,smart cities and intelligent transportation systems)become more commonplace,the Internet of Vehicles(IoV)is getting increasingly *** have been attempts to utilize Digital Twins(DTs)to facilitate the design,evaluation,and deployment of IoV-based systems,for example by supporting high-fidelity modeling,real-time monitoring,and advanced predictive ***,the literature review undertaken in this paper suggests that integrating DTs into IoV-based system design and deployment remains an understudied *** addition,this paper explains how DTs can benefit IoV system designers and implementers,as well as describes several challenges and opportunities for future researchers.

关键词： Internet of vehicles Digital twin Simulation Traffic systems