Genomic Mosaicism of the Brain:Origin,Impact,and Utility

作     者：Jared H.Graham Johannes C.M.Schlachetzki Xiaoxu Yang Martin W.Breuss 

作者机构：Department of PediatricsSection of Clinical Genetics and MetabolismUniversity of Colorado School of MedicineAurora80045-2581COUSA Department of Cellular and Molecular MedicineUniversity of California San DiegoLa Jolla92093-0021San DiegoCAUSA Department of NeurosciencesUniversity of California San DiegoLa Jolla92093-0021San DiegoCAUSA Rady Children’s Institute for Genomic MedicineSan Diego92123CAUSA 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2024年第40卷第6期

页      面：759-776页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：support from the Boettcher Foundation and the National Institutes of Health(1K99HD111686) 

主　　题：Genomics Brain development Brain homeostasis Genomic mosaicism 

摘      要：Genomic mosaicism describes the phenomenon where some but not all cells within a tissue harbor unique genetic ***,research focused on the impact of genomic mosaicism on clinical phenotype—motivated by its involvement in cancers and overgrowth *** recently,we increasingly shifted towards the plethora of neutral mosaic variants that can act as recorders of cellular lineage and environmental ***,we summarize the current state of the field of genomic mosaicism research with a special emphasis on our current understanding of this phenomenon in brain development and *** the field of genomic mosaicism has a rich history,technological advances in the last decade have changed our approaches and greatly improved our *** will provide current definitions and an overview of contemporary detection approaches for genomic ***,we will discuss the impact and utility of genomic mosaicism.