The interplay of drug therapeutics and immune responses to SARS-CoV-2

作     者：Valeria Fumagalli Matteo Iannacone 

作者机构：Division of ImmunologyTransplantationand Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele UniversityMilanItaly Experimental Imaging CentreIRCCS San Raffaele Scientific InstituteMilanItaly 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2024年第21卷第2期

页      面：197-200页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by the European Research Council(ERC)Consolidator Grant 725038 the ERC Proof of Concept Grants 957502 and 101138728 the Italian Association for Cancer Research(AIRC)Grants 19891 and 22737 the Italian Ministry for University and Research Grants PE00000007(INF-ACT)and PRIN(2022FMESXL) a Funded Research Agreement from Asher Biotherapeutics and VIR Biotechnology 

主　　题：SARS-CoV-2 Nirmatrelvir Bisphosphonates Adaptive immunity Drug repurposing 

摘      要：The SARS-CoV-2 pandemic has necessitated rapid therapeutic and preventative *** vaccines form the frontline of defense,antiviral treatments such as nirmatrelvir have emerged as vital adjunctive measures,particularly for those unable or unwilling to be *** review delves into the potential influence of nirmatrelvir on enduring *** parallel,the potential of drug repurposing is explored,with bisphosphonates being examined for their possible effects against COVID-19 due to their immunomodulatory *** importance of rigorous clinical trials and careful interpretation of preliminary data is emphasized.