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Correlation between single nucleotide polymorphism of rs3811047 in IL-1 F7 gene and rheumatoid arthritis susceptibility among Han population in central plains of China

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Asian Pacific Journal of Tropical Medicine 2013年第1期6卷 73-75页

作者： Li-Pu Shi Ya He Zhi-Dui Liu Department of rheumatology People's Hospital of Zhengzhou

Objective:To discuss the association between single nucleotide polymorphism(SNP) of rs3811047 in IL-1 F7 gene and rheumatoid arthritis(RA) susceptibility among the Han population in central plains of ***:A total of 276 RA patients admitted to our hospital from December 2009 to December 2011 together with 276 healthy physical examinees in the same period were chosen as the *** typing for rs3811047 SNP in IL-1 F7 gene was carried out by using ligase detection reaction and polymerase chain reaction *** the frequency of each allele and genotypes distribution was calculated so as to evaluate the association between genotype distribution and RA ***:The frequency of A allele of rs3811047 in IL-1 F7 gene in RA group and control group was 16.27%and 17.68%,respectively,and that of G allele in two groups was 83.73%and 82.32%,*** difference between two groups wasn’t statistical significant(P >0.05).The frequency of genotype AA,AG and GG in RA group was 2.19%,27.84%and 69.97%,respectively,while that in control group was 2.94%,29.78%and 67.28%, *** difference of distribution of three genotypes was not statistically significant (P >0.05).RA patients with A allele were better than those without A allele in joint swelling index, rest pain,HAQ scoring and blood *** was significant difference between two groups in above indexes(P<0.05/P<0.01).Conclusions:No significant correlation between RA susceptibility among the Han population in central plains of China and rs3811047 SNP inIL-1 F7 gene is ***,A allele of rs3811047 has certain influence on the condition of RA patients.

关键词： Rheumatoid arthritis IL-1 F7 gene Single nucleotide polymorphism Susceptibility

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Aberrant TGF-β1 signaling contributes to the development of primary biliary cirrhosis in murine model

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World Journal of Gastroenterology 2013年第35期19卷 5828-5836页

作者： Bin Liu Xuan Zhang Feng-Chun Zhang Jin-Bao Zong Wen Zhang Yan Zhao Department of rheumatology theAffiliated Hospital of Qingdao University Medical College Department of rheumatology Peking Union Medical College Hospital Chinese Academy of Medical Science

AIM:To investigate whether transforming growth factor-β1(TGF-β1)signaling pathway is involved in the pathogenesis of primary biliary cirrhosis(PBC).METHODS:A murine model of PBC was developed by injection of polyinosinic polycytidylic acids(polyⅠ:C)in C57BL/6 mice,and the liver expressions of TGFβ1,TGF-βreceptorⅠ(TβRⅠ),TGF-βreceptorⅡ(TβRⅡ),p-Smad2/3,monoclonalα-smooth muscle actin antibody(α-SMA)andα1(Ⅰ)collagen in the mouse model and control mice were evaluated by immunohistochemistry,immunoblotting and real-time polymerase chain reaction(RT-PCR).Lymphocyte subsets in liver were analyzed using flow ***:The mouse model had several key phenotypic features of human PBC,including elevated levels of alkaline phosphatase,antimitochondrial antibodies,portal bile ducts inflammation,and progressive collagen *** with control mice,protein and mRNA levels of TGFβ1,TβRⅠ,TβRⅡ,p-Smad2/3,α-SMA andα1(Ⅰ)collagen in liver(1.7±0.4 vs 8.9±1.8,0.8±0.2 vs 5.1±1.5,0.6±0.01 vs5.1±0.1,0.6±0.3 vs 2.0±0.3,0.9±0.4 vs 3.4±0.6,0.8±0.4 vs 1.7±0.3,1.1±1.2 vs 11.8±0.6,P<0.05),and the total number and percentage of CD4+CD25+FOXP3+and CD8+lymphocytes(0.01±0.001vs 0.004±0.00,0.12±0.04 vs 0.52±0.23,P<0.01)were higher in the mouse ***:TGFβ1 might play a dual role in the development of PBC:it suppresses inflammatory response but operates to enhance *** aberrant activity of TGF-β1 signaling contributes to the development of PBC.

关键词： Primary biliary cirrhosis Transforming growth factor-β1 Regulatory T cell Liver

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Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis

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World Journal of Diabetes 2018年第2期9卷 53-58页

作者： Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan Denver Veterans Affairs Medical Center Division of Rheumatology University of Colorado Philadelphia Veterans Affairs Medical Center Division of Rheumatology University of Pennsylvania Omaha Veterans Affairs Medical Center Division of Rheumatology University of Nebraska Denver Health and Hospital Division of Rheumatology University of Colorado George Wahlen Veterans Affairs Medical Center Division of Rheumatology University of Utah

AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and *** Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not

关键词： Disease modifying anti-rheumatic drugs Drug toxicity Glucocorticoids Rheumatoid arthritis Tumor necrosis factor inhibitors

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Immunological pathogenesis and treatment of systemic lupus erythematosus

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World Journal of Pediatrics 2020年第1期16卷 19-30页

作者： Lu Pan Mei-Ping Lu Jing-Hua Wang Meng Xu Si-Rui Yang Department of Pediatric rheumatology and Allergy The First HospitalJilin UniversityChangchunChina Department of Allergy Immunology and rheumatology Children's HospitalZhejiang University School of MedicineHangzhouChina

Background Systemic lupus erythematosis(SLE)is a complex and clinically heterogeneous autoimmune disease.A variety of immunological defects contribute to SLE,including dysregulated innate and adaptive immune response.A clearer understanding of the mechanisms driving disease pathogenesis combined with recent advances in medical science is predicted to enable accelerated progress towards improved SLE-personalized approaches to *** aim of this review was to clarify the immunological pathogenesis and treatment of *** sources Literature reviews and original research articles were collected from database,including PubMed and *** articles about SLE were *** Breakdown of self-tolerance is the main pathogenesis of *** innate and adaptive immune networks are interlinked with each other through cytokines,complements,immune complexes and kinases of the intracellular *** targeted at possible targets of immunity have been assessed in clinical *** of them did not show better safety and efficacy than traditional ***,novel targeting treatments are still being *** Dysregulated immune response plays a critical role in SLE,including innate immunity and adaptive *** agents that aim to specifically target abnormal immune processes were assessing and may bring new hope to SLE patients.

关键词： Immunological pathogenesis Systemic lupus erythematosis Treatment

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Leptin in immuno-rheumatological diseases

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Cellular & Molecular Immunology 2011年第3期8卷 203-212页

作者： Marta Vadacca Domenico PE Margiotta Luca Navarini Antonella Afeltra Department of rheumatology and Clinical Medicine University Campus Bio-MedicoRomeItaly

Leptin is one of the most important hormones secreted by adipocytes,with a variety of physiological roles related to the control of metabolism and energy *** its discovery in 1994,leptin has attracted increasing interest in the scientific community for its pleiotropic *** of these functions is the relationship between nutritional status and immune *** structurally resembles proinflammatory cytokines,such as IL-6 and *** cytokine-like structural characteristic of leptin is implicative of its function in regulating immune *** role of leptin in regulating immune responses has been assessed in vitro as well as in clinical *** has been shown that disease conditions of reduced leptin production are associated with increased infection ***,immune-mediated disorders,such as autoimmune diseases,are associated with the increased secretion of leptin and the production of proinflammatory pathogenic *** this paper,we review the most recent advances of the role of leptin in immune-rheumatological diseases,and we discuss whether strategies aimed at modifying leptin levels could represent innovative and therapeutic tools for autoimmune disorders.

关键词： adipokines autoimmune diseases leptin rheumatic diseases

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IL-1β limits the extent of human 6-sulfo LacNAc dendritic cell (slanDC)-mediated NK cell activation and regulates CD95-induced apoptosis

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Cellular & Molecular Immunology 2017年第12期14卷 976-985页

作者： Dejene Milkessa Tufa Fareed Ahmad Debanjana Chatterjee Gerrit Ahrenstorf Reinhold Ernst Schmidt Roland Jacobs Department of Clinical Immunology and rheumatology Hannover Medical School30625 HannoverGermany

To function optimally,human blood natural killer(NK)cells need to communicate with other immune ***,it has been shown that NK cells communicate with 6-sulfo LacNAc dendritic cells(slanDCs),which are able to stimulate NK cells in *** this study,we investigated how slanDCs regulate the level of NK cell *** secretion of interleukin(IL)-1βby slanDCs during coculture with NK cells increased as a result of signaling via intercellular adhesion molecule-1 on slanDCs following its interaction with lymphocyte functionassociated antigen-1 on NK ***-1βinduced the expression of Fas receptor(CD95)on NK *** binding of Fas ligand(CD178)to CD95 induced the apoptosis of activated NK ***,IL-1βalso induced increased cyclooxygenase-2 expression in slanDCs,which in turn enabled the cells to secrete prostaglandin(PG)-***,PGE2 acted as a suppressing agent,tuning down the activation level of NK *** summary,IL-1βlimits the level of NK cell activation by inducing apoptosis and suppression as a homeostatic regulatory function.

关键词： COX-2 Fas-induced apoptosis immunosuppression NK cells slanDCs

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Psoriatic fasciitis in a pediatric patient: A case report

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World Journal of Clinical Cases 2019年第1期7卷 69-72页

作者： Gulcin Otar Yener Zahide Ekici Tekin Selcuk Yuksel Department of Pediatric rheumatology Pamukkale University School of Medicine

BACKGROUND Diffuse fasciitis with psoriatic arthritis on magnetic resonance imaging(MRI) has not been previously described in childhood. Here we present the first case report of a pediatric patient developing fasciitis, beyond plantar fasciitis, with psoriatic *** SUMMARY An 11-year-old female was admitted with the complaints of psoriatic rash on the body associated with severe pain in the lower extremities and arthritis in the right knee. Psoriasis was confirmed by skin biopsy, she diagnosed with juvenile psoriatic arthritis. Diagnostic tests did not indicate any pathology except *** of the femur and tibia revealed that high-signal inflammatory changes in the subdermal fascia. These findings led to a diagnosis of psoriatic *** was given for 3 mo but the patient showed no response to therapy;therefore, etanercept was added. However, there was no response to *** was switched to adalimumab at the sixth month of therapy. Clinical improvement started with therapy of adalimumab within one month. Fasciitis finding in MRI disappeared at seventh months on adalimumab therapy. She has no complaint for two years with *** The most effective imaging method is MRI and adalimumab may be the best choice of treatment for psoriatic fasciitis.

关键词： Case report Fasciitis Psoriasis Childhood Arthritis

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Multiple Myeloma Mimicking Spondyloarthritis: a Case Report

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Chinese Medical Sciences Journal 2014年第4期29卷 245-247页

作者： Ai-chun Liu Yan-ying Liu Yan Li Li Zhang Zhan-guo Li Department of rheumatology and Immunology Peking University People's Hospital Department of rheumatology and Immunology People's Hospital Xinyi

MULTIPLE myeloma （MM） is a hematologicmalignancy of differentiated plasma cells thataccumulate and proliferate in the bonemarrow. MM patients often develop bonedisease that results in severe bone pain, osteolytic lesions,and pathologic fractures,1 presenting with unexplainedbackache or bone pain in the long bones, ribs, skull, orpelvis.2 However, the low backache mimicking spondyloarthritisin MM is uncommon during clinical practice. Spondyloarthritis isa chronic systemic inflammatory disorder of the axialskeleton, mainly affecting the sacroiliac joint and spinecausing low backache.3 Here we report a patient with MMwhich was initially misdiagnosed and treated asspondyloarthritis.

关键词： multiple myeloma ankylosing spondylitis spondyloarthritis misdiagnosis

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Cellular signaling pathways of T cells in giant cell arteritis

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Journal of Geriatric Cardiology 2021年第9期18卷 768-778页

作者： Hai-Yan LI Jun-Nan XU Zong-Wen SHUAI Department of rheumatology and Immunology the First Affiliated Hospital of Anhui Medical UniversityHefeiChina

Giant cell arteritis(GCA)is a commonly occurring large vacuities characterized by angiopathy of medium and large-sized *** granulomatous formation plays an important role in the pathogenesis of *** of T cell lineages and signaling pathways in GCA have revealed the essential role of T cells in the pathology of GCA.T cells are the dominant population present in GCA ***4+T cell subtypes that are present include Th1,Th2,Th9,Th17,follicular helper T(Tfh)cells,and regulatory T(Treg)***8 T cells can primarily differentiate into cytotoxic CD8+T lymphocytes and Treg *** instrumental part of GCA is the interplay between dendritic cells,macrophages and endothelial cells,which can result in the vascular injury and the characteristics granulomatous infiltrates *** the inflammatory loop of GCA,several signaling pathways have been reported to play an essential role in recruiting,activating and differentiating T cells,including T-cell receptor(TCR)signaling,vascular endothelial growth factor(VEGF)-Jagged-Notch signaling and the Janus kinase and signal transducer and activator of transcription(STAT)pathway(JAK-STAT)*** this review,we have focused on the role of T cells and their potential signaling mechanism(s)that are involved in the pathogenesis of GCA.A better understanding of the role of T cells mediated complicated orchestration during the homeostasis and the changes could possibly favor developments of novel treatment strategies against immunological disorders associated with GCA.

关键词： GCA Cellular signaling pathways of T cells in giant cell arteritis

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Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro

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Current Medical Science 2021年第4期41卷 757-763页

作者： Wen-ze XIAO Li ZHAO Lin CAO Xiao-xia ZHU He-jian ZOU Department of rheumatology and Immunology Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Department of rheumatology and Immunology Fudan University Pudong Medical CenterShanghai 201300China

The aim of this study was to identify the effects of melatonin on acute gouty inflammation and to investigate the underlying *** found significantly lower serum melatonin levels in gout patients in the acute phase than in those in the remission phase or in normal *** mRNA expression of melatonin receptor 2(MT2)was also lower in gout patients than in normal *** verify the in-vivo role of melatonin,a gouty arthritis model was established by intraarticular injection of monosodium urate(MSU,1 mg)crystals into the paws of C57BL/6 *** inflammation in the mouse model was evaluated by measuring the thickness of the right paw/left paw,and the inflammation index was determined by examining infiltrating neutrophils with haematoxylin and eosin(H&E)*** was found to reduce both paw thickness and the inflammation index in the mouse model,and melatonin also reduced the mRNA levels of interleukin-1 beta(IL-1β),IL-6 and NLR family pyrin domain containing 3(NLRP3)*** mimic gouty inflammation in vitro,mouse peritoneal macrophages were stimulated with lipopolysaccharides(LPS)plus *** was revealed to reduce IL-1βsecretion by stimulated *** mRNA expression levels of IL-1βand IL-6 were also inhibited by *** blot analysis showed that the expression of NLRP3,caspase-1 and pro-IL-1βwas also inhibited by *** conclusion,our study demonstrated that melatonin alleviated gouty inflammation in vivo and in vitro,and the underlying mechanism may involve inhibiting the assembly of the NLRP3 inflammasome.

关键词： melatonin gout NLRP3 inflammasome monosodium urate

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