Leptin in immuno-rheumatological diseases
作者机构：Department of Rheumatology and Clinical MedicineUniversity Campus Bio-MedicoRomeItaly
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2011年第8卷第3期
页 面：203-212页
核心收录：
学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 0701[理学-数学] 070101[理学-基础数学]
主 题：adipokines autoimmune diseases leptin rheumatic diseases
摘 要：Leptin is one of the most important hormones secreted by adipocytes,with a variety of physiological roles related to the control of metabolism and energy *** its discovery in 1994,leptin has attracted increasing interest in the scientific community for its pleiotropic *** of these functions is the relationship between nutritional status and immune *** structurally resembles proinflammatory cytokines,such as IL-6 and *** cytokine-like structural characteristic of leptin is implicative of its function in regulating immune *** role of leptin in regulating immune responses has been assessed in vitro as well as in clinical *** has been shown that disease conditions of reduced leptin production are associated with increased infection ***,immune-mediated disorders,such as autoimmune diseases,are associated with the increased secretion of leptin and the production of proinflammatory pathogenic *** this paper,we review the most recent advances of the role of leptin in immune-rheumatological diseases,and we discuss whether strategies aimed at modifying leptin levels could represent innovative and therapeutic tools for autoimmune disorders.
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