Cellular signaling pathways of T cells in giant cell arteritis
Cellular signaling pathways of T cells in giant cell arteritis作者机构:Department of Rheumatology and Immunologythe First Affiliated Hospital of Anhui Medical UniversityHefeiChina
出 版 物:《Journal of Geriatric Cardiology》 (老年心脏病学杂志(英文版))
年 卷 期:2021年第18卷第9期
页 面:768-778页
核心收录:
学科分类:1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金:supported by National Natural Science Foundation of China(Number:8187061400)
主 题:GCA Cellular signaling pathways of T cells in giant cell arteritis
摘 要:Giant cell arteritis(GCA)is a commonly occurring large vacuities characterized by angiopathy of medium and large-sized *** granulomatous formation plays an important role in the pathogenesis of *** of T cell lineages and signaling pathways in GCA have revealed the essential role of T cells in the pathology of GCA.T cells are the dominant population present in GCA ***4+T cell subtypes that are present include Th1,Th2,Th9,Th17,follicular helper T(Tfh)cells,and regulatory T(Treg)***8 T cells can primarily differentiate into cytotoxic CD8+T lymphocytes and Treg *** instrumental part of GCA is the interplay between dendritic cells,macrophages and endothelial cells,which can result in the vascular injury and the characteristics granulomatous infiltrates *** the inflammatory loop of GCA,several signaling pathways have been reported to play an essential role in recruiting,activating and differentiating T cells,including T-cell receptor(TCR)signaling,vascular endothelial growth factor(VEGF)-Jagged-Notch signaling and the Janus kinase and signal transducer and activator of transcription(STAT)pathway(JAK-STAT)*** this review,we have focused on the role of T cells and their potential signaling mechanism(s)that are involved in the pathogenesis of GCA.A better understanding of the role of T cells mediated complicated orchestration during the homeostasis and the changes could possibly favor developments of novel treatment strategies against immunological disorders associated with GCA.