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Bone morphogenetic protein 7 mediates stem cells migration and angiogenesis:therapeutic potential for endogenous pulp regeneration

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International Journal of oral Science 2022年第3期14卷 381-395页

作者： Cheng Liang Qingqing Liang Xun Xu Xiaojing Liu Xin Gao Maojiao Li Jian Yang Xiaotao Xing haisen huang Qi Tang Li Liao Weidong Tian State Key laboratory of oral Diseases&National Clinical research Center for oral Diseases&Engineering research Center of oral Translational Medicine Ministry of Education&National Engineering Laboratory for Oral Regenerative MedicineWest China Hospital of StomatologySichuan UniversityChengduChina

Pulp loss is accompanied by the functional impairment of defense,sensory,and nutrition *** approach based on endogenous stem cells is a potential strategy for pulp ***,endogenous stem cell sources,exogenous regenerative signals,and neovascularization are major difficulties for pulp regeneration based on endogenous stem ***,the purpose of our research is to seek an effective cytokines delivery strategy and bioactive materials to reestablish an ideal regenerative microenvironment for pulp *** in vitro study,we investigated the effects of Wnt3a,transforming growth factor-beta 1,and bone morphogenetic protein 7(BMP7)on human dental pulp stem cells(h-DPSCs)and human umbilical vein endothelial cells.2D and 3D culture systems based on collagen gel,matrigel,and gelatin methacryloyl were fabricated to evaluate the morphology and viability of *** in vivo study,an ectopic nude mouse model and an in situ beagle dog model were established to investigate the possibility of pulp regeneration by implanting collagen gel loading *** concluded that BMP7promoted the migration and odontogenic differentiation of h-DPSCs and vessel *** gel maintained the cell adhesion,cell spreading,and cell viability of h-DPSCs in 2D or 3D *** transplantation of collagen gel loading BMP7 induced vascularized pulp-like tissue regeneration in *** injectable approach based on collagen gel loading BMP7 might exert promising therapeutic application in endogenous pulp regeneration.

关键词： therapeutic potential for endogenous pulp regeneration Bone morphogenetic protein 7 mediates stem cells migration and angiogenesis

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Amplifying protection against acute lung injury:Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair

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Chinese herbal Medicines 2024年第3期16卷 422-434页

作者： Junjie Li Ming Dong Qing Yao Xu Dong Yuanyuan Chen Jincai Wen Yingjie Xu Zhixin Wu Xiaomei Zhao Ye Xiu Xiaoyan Zhan Zhaofang Bai Xiaohe Xiao Chengde Medical University Chengde 067000China Department of hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China China Military Institute of Chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China National Key laboratory of Kidney Diseases The Fifth Medical Center of PLA General HospitalBeijing 100039China School of Stomatology Heilongjiang Key Lab of Oral Biomedicine Materials and Clinical Application&Experimental Center for Stomatology EngineeringJiamusi UniversityJiamusi 154007China Southern Medical University Guangzhou 510515China

Objective:Acute lung injury(ALI)is characterized by inflammation and currently lacks an efficacious pharmacological *** medicine combination of Lonicerae Japonicae Flos(LJF)and Forsythiae Fructus(FF)demonstrates combined properties in its anti-infective,anti-inflammatory,and therapeutic effects,particularly in alleviating respiratory *** previous studies,Chinese medicine has shown promising efficacy in lipopolysaccharides(LPS)-induced ***,there have been no reports of LJF and FF pairing for lung *** aim of this study is to compare the efficacy of herb pair Lonicerae Japonicae Flos-Forsythiae Fructus(LF)with LJF or FF alone in the treatment of ALI,and to explore whether LJF and FF have a combined effect in the treatment of lung injury,along with the underlying mechanism ***:A total of 36 mice were divided into six groups(control,model,LJF,FF,LF,dexamethasone)based on the treatments they received after undergoing sham-operation/LPS tracheal instillation.h&E staining and pulmonary edema indexes were used to evaluate lung injury *** exudate cells(AECs)were counted based on cell count in bronchoalveolar lavage fluid(BALF),and neutrophil percentage in BALF was measured using flow ***(MPO)activity in BALF was measured using enzyme-linked immunosorbent assay(ELISA),while the production of IL-1β,TNF-α,and IL-6 in the lung and secretion level of them in BALF were detected by quantitative polymerase chain reaction(qPCR)and *** effect of LJF,FF,and LF on the expression of Caspase-1 and IL-1βproteins in bone marrow derived macrophages(BMDMs)supernatant was assessed using Western blot method under various inflammasome activation *** addition,the concentration of IL-1βand changes in lactatedehydrogenase(LDh)release levels in BMDMs supernatant after LJF,FF,and LF administration,respectively,were measured using ***,the effects of LJF,FF and LF on STING and IRF3 phosphor

关键词： acute lung injury BMDMS inflammasomes Lonicerae Japonicae Flos-Forsythia Fructus drug pair STING

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Rational protein engineering of thermostable heparinase I from Bacteroides thetaiotaomicron for highly efficient heparin degradation

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Food Science and human Wellness 2024年

作者： Chuan Zhang Ruohan Zhao Leilei Yu Qixiao Zhai Jianxin Zhao hao Zhang Xuegang Luo Fengwei Tian Wei Chen State Key laboratory of Food Science and Technology， Jiangnan University School of Food Science and Technology， Jiangnan University Key laboratory of Industrial Fermentation Microbiology of the Ministry of Education & Tianjin Key lab of Industrial Microbiology， College of Biotechnology， Tianjin University of Science and Technology National Engineering research Center for Functional Food， Jiangnan University

heparin， a glycosaminoglycan， is a stable source of carbon that supports the growth of microorganisms in the human intestine. It is also a commonly used anticoagulant drug in clinical practice， with significant therapeutic effects. Low molecular weight heparin （LMWh） is a highly active low molecular weight fragment obtained via enzymatic reaction or the chemical degradation of heparin. LMWh has been applied globally in the prevention and treatment of venous thromboembolism in thrombosis patients. Simultaneously， as a potential prebiotic， because of its low molecular weight， LMWh can be well degraded by the gut microbiota to maintain intestinal balance. Enzymatic heparin degradation has recently emerged as a viable disposal method for LMWh preparation; however， only very few benchmark enzymes have been thoroughly described and subjected to protein engineering to improve their properties over the past few years. The commercialization of enzymes will require the development of robustly engineered enzymes that meet the demands of industrial processes. herein， we report a rational protein engineering strategy that includes molecular dynamic simulations of flexible amino acid mutations and disulfide bond screening. Several Bt-hepI mutants were obtained and screened for high thermal stability. We obtained the Bt-hepID204C/K208C/h189W/Q198Rvariant， which features a stabilized protein surface structure， with a 1.3-fold increase in kcat/Km， a 2.44-fold increase in thermal stability at 50℃， and a 1.8-fold decrease in the average molecular weight of LMWh produced at 40℃ compared with that seen with Bt-hepIWT. Our study establishes a strategy to engineer thermostable hepI to underpin its industrial applications.

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Lattice-distorted Pt wrinkled nanoparticles for highly effective hydrogen electrocatalysis

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Nano research 2024年第5期17卷 3819-3826页

作者： Xue Li Xiang han Zhenrui Yang Shun Wang Yun Yang Juan Wang Jiadong Chen Zhongwei Chen huile Jin Wenzhou Key lab of Advanced Energy Storage and Conversion Zhejiang Province Key Lab of Leather EngineeringCollege of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Institute of New Materials and Industry Technology College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Department of Chemical Engineering Waterloo Institute for NanotechnologyUniversity of WaterlooWaterlooOntario N2L 3G1Canada

Modulating Pt surfaces through the introduction of lattice distortion emerges as immensely effective strategy that enhances the kinetics of alkaline hydrogen evolution and oxidation *** this study,we fabricated lattice-distorted Pt wrinkled nanoparticles(LD-Pt WNPs)for efficient hydrogen *** LD-Pt WNPs not only outperform the Pt/C benchmark in hydrogen oxidation reaction,achieving an excellent mass-specific current of 968.5 mA·mg_(Pt)^(-1)(9 times that of Pt/C),but also demonstrate outstanding hydrogen evolution reaction activity with a small overpotential of 58.0 *** experiments and density functional theory calculations reveal that lattice defects introduce an abundance of unsaturated coordination atoms while modifying the d-band center of *** dual effect optimizes the binding strength of crucial h and Oh intermediates,leading to a significant reduction in the energy barrier of the reaction bottleneck,commonly known as the Volmer *** work unveils a fresh viewpoint on projecting and developing high efficiency electrocatalysts through defect engineering.

关键词： distortion nanoparticle hydrogen evolution reaction defect engineering hydrogen oxidation reaction

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Phase-stable wide-bandgap perovskites enabled by suppressed ion migration

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Journal of Energy Chemistry 2024年第9期96卷 120-128页

作者： Zhiyu Gao Yu Zhu Jingwei Zhu Cong Chen Zongjin Yi Yi Luo Yuliang Xu Kai Wu Tianshu Ma Fangfang Cao Zijun Chen Fang Yao Juncheng Wang Wenwu Wang Chuanxiao Xiao hao huang hongxiang Li Qianqian Lin Pei Cheng Changlei Wang Xia hao Guanggen Zeng Dewei Zhao College of Materials Science and Engineering&Institute of New Energy and Low-Carbon Technology&Engineering research Center of Alternative Energy Materials and Devices Ministry of EducationSichuan UniversityChengdu 610065SichuanChina School of Optoelectronic Science and Engineering&Collaborative Innovation Center of Suzhou Nano Science and Technology Key Lab of Advanced Optical Manufacturing Technologies of Jiangsu Province&Key Lab of Modern Optical Technologies of Education Ministry of ChinaSoochow UniversitySuzhou 215006JiangsuChina Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201ZhejiangChina Ningbo New Materials Testing and Evaluation Center Co.Ltd Ningbo 315201ZhejiangChina State Key laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structure&School of Resources Environment and MaterialsGuangxi UniversityNanning 530004GuangxiChina Key lab of Artificial Micro-and Nano-Structures of Ministry of Education of China School of Physics and TechnologyWuhan UniversityWuhan 430072HubeiChina College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065SichuanChina

Wide-bandgap(>1.7 eV)perovskites suffer from severe light-induced phase segregation due to high bromine content,causing irreversible damage to devices ***,the strategies of suppressing photoinduced phase segregation and related mechanisms have not been fully ***,we report a new passivation agent 4-aminotetrahydrothiopyran hydrochloride(4-ATphCl)with multifunctional groups for the interface treatment of a 1.77-eV wide-bandgap perovskite film.4-ATph^(+)impeded halogen ion migration by anchoring on the perovskite surface,leading to the inhibition of phase segregation and thus the passivation of defects,which is ascribed to the interaction of 4-ATph^(+)with perovskite and the formation of low-dimensional ***,the champion device achieved an efficiency of 19.32%with an open-circuit voltage(V_(OC))of 1.314 V and a fill factor of 83.32%.Moreover,4-ATphCl modified device exhibited significant improved stability as compared with control *** target device maintained 80%of its initial efficiency after 519 h of maximum power output(MPP)tracking under 1 sun illumination,however,the control device showed a rapid decrease in efficiency after 267 ***,an efficiency of 27.38%of the champion 4-terminal all-perovskite tandem solar cell was achieved by mechanically stacking this wide-bandgap top subcell with a 1.25-eV low-bandgap perovskite bottom subcell.

关键词： Wide-bandgap perovskite Phase segregation lon migration Interface post-treatment All-perovskite tandems

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Electrolyte-gated SrCoO_(x) FET sensor for highly sensitive detecting ph in extreme alkalinity solution

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Nano research 2024年第4期17卷 3079-3086页

作者： han Zhou Gaocan Qi Wenbin Li Yuhang Wang Zhihao Yuan School of Materials Science and Engineering Tianjin Key Lab of Photoelectric Materials&Devicesand Key Laboratory of Display Materials and Photoelectric Devices(Ministry of Education)Tianjin University of TechnologyTianjin 300384China

The ph monitoring is significantly important in chemical industry,biological process,and pollution ***,it remains a great challenge to measure ph in extreme alkalinity ***,we employ an electrolyte-gated field-effect-transistor(FET)strategy using non-stoichiometric SrCoO_(x) with rich oxygen-vacancy defects as channel materials for detecting extreme *** corresponding channel can provide effective oxygen-ion-migration sites for reversible transformation of Oh-↔O_(2)-+h^(+)driven by electric *** resultant electrolyte-gated FET sensor exhibits a sensitive linear response to high concentrations of alkaline solution,1–20 ***,the sensor has the ability to directly indicate the ph values ranging from 14.0 to 17.0 in consideration of ion-activity coefficient *** work offers a great possibility for directly detecting base concentration as well as ph values in extreme alkaline solutions.

关键词： field-effect-transistor(FET) ph sensor extreme alkaline solution SrCoO_(x) oxygen-ion migration

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Multi-site Passivation of ZnO Metal Oxides via Biomolecules for Efficient and highly Stable Organic Solar Cells

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Chinese Journal of Chemistry 2024年第14期42卷 1582-1592页

作者： Irfan Ismail Maria Khalil Xiaomei Gao Xingze Chen Muhammad Jawad Rong huang Zhiyun Li Emmanuel Acheampong Tsiwah Wei-shi Li Qun Luo Chang-Qi Ma i-lab&Printable Electronics research Center Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)SuzhouJiangsu215123 China University of Chinese Academy of Sciences(UCAS) Beijing100040 China School of Nano-Tech and Nano-Bionics University of Science and Technology of China(USTC)HefeiAnhui230027 China Shanghai Institute of Organic Chemistry(SIOC) Chinese Academy of Sciences(CAS)Shanghai200032 China Vacuum Interconnected Nanotech Workstation(Nano-X) SuzhouJiangsu215123 China

ZnO nanoparticles(nps)among metal oxide(MOs)are proven to be essential electron transporting layers(ETLs)applied in organic solar cells(OSCs).however,intrinsic defects,interfacial charge recombination,and catalytic behavior towards the active layer restrict the applications of ZnO nps for efficient and long-term stable *** commonly available biomolecule cytidine 5'-monophosphate(CMP-Oh)with phosphonic acid,its salt cytidine 5'-monophosphate disodium salt(CMP-ONa)with a phosphate group as an anchoring group and conjugated terminal functional in both analogous molecules provide carrier transfer bridge at bottom interface of the active *** theoretical investigations and characterizations have discovered the multi-site coordination of CMP-Oh towards acceptor molecules and ZnO *** dual-side alignment of CMP analogous molecules hinders interfacial charge recombination and enhances charge transfer potential at ***,PM6:L8-BO-based OSCs with modified ETL obtain 18.13%efficiency,12%higher than that of unmodified *** higher efficiency,CMP-Oh-based OSC devices illustrate remarkably improved thermal stability for 500 h at 85℃with 72%of initial PCE and operation stability for 2000 h with 90.1%of initial *** work reveals the passivation mechanism of multi-anchoring groups towards MOs and single-functional groups towards the active layer to optimize the interface for efficient and highly stable OSCs.

关键词： Organic solar cells Nanoparticles Nucleotides Interfacial interactions Surface chemistry Multi-site passivation

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Enhanced thermal constant B of diamond films for ultrahigh sensitivity negative temperature coefficient thermistors

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Science China Materials 2024年第10期67卷 3321-3329页

作者： Qiao Chen Yimeng Zhao Jiawei Li Xiyuan Liu Xinyue Wang Wenxi Zhang hongwei Zhu Gemmological Institute China University of GeosciencesWuhan 430074China Shenzhen research Institute China University of GeosciencesShenzhen 518057China State Key lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Southwest United Graduate School Kunming 650500China

Negative temperature coefficient(NTC)thermistor plays a crucial role in science research and engineering applications for precise temperature *** great progress has been achieved in NTC materials,enhancing sensitivity and maintaining this high sensitivity along with linearity across extensive temperature ranges remain a significant *** this study,we introduce a diamondbased thermistor(DT)characterized by its outstanding sensitivity,swift response time,and broad temperature monitoring *** temperature constant B for this DT,measured from 30 to 300°C(B30/300),achieves an exceptional value of 8012 K,which notably exceeds the temperature sensing capabilities of previously reported NTC thermistors within this extensive ***,diamond’s unique thermal conductivity and stability significantly boost the response speed and durability of the DT,offering substantial advantages over traditional ceramic *** enhanced temperature-sensitive properties of the DT are attributed to the presence of impurity elements in polycrystalline *** analysis indicates a hopping conduction mechanism,likely involving C-h or C-N dipoles at the diamond grain *** study marks a significant leap forward in diamond thermistor technology and sheds light on the mechanisms of thermal active conduction in diamond materials.

关键词： polycrystalline diamond thermistors negative temperature coefficient hopping conduction grain boundary

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Autophagy and mitophagy as potential therapeutic targets in diabetic heart condition:harnessing the power of nanotheranostics

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 79-101页

作者： Sagnik Nag Oishi Mitra Bhanu Maturi Simran Preet Kaur Ankita Saini Muskan Nama Soumik Roy Souvik Samanta Leena Chacko Rohan Dutta Suresh Babu Sayana Vetriselvan Subramaniyan Jasvinder Singh Bhatti Ramesh Kandimalla Jeffrey Cheah School of Medicine and health Sciences Monash University MalaysiaJalan Lagoon Selatan47500 Bandar SunwaySelangorMalaysia Department of Bio-Sciences School of Bio-Sciences&Technology(SBST)Vellore Institute of Technology(VIT)Tiruvalam RoadVellore 632014Tamil NaduIndia Department of Internal Medicine University of Alabama at BirminghamBirminghamALUSA Department of Microbiology University of Delhi(South Campus)Benito Juarez RoadNew Delhi 110021India Department of Biotechnology Indian Institute of TechnologyHyderabad(IIT-H)SangareddyTelangana 502284India BioAnalytical lab Meso Scale Discovery1601 Research BlvdRockvilleMDUSA Department of Pharmacology Government Medical CollegeSuryapetTelanganaIndia laboratory of Translational Medicine and Nanotherapeutics Department of Human Genetics and Molecular MedicineSchool of Health SciencesCentral University of PunjabBathindaIndia Department of Biochemistry Kakatiya Medical CollegeWarangal 506007India

Autophagy and mitophagy pose unresolved challenges in understanding the pathology of diabetic heart condition(DhC),which encompasses a complex range of cardiovascular issues linked to diabetes and associated *** significant progress in reducing mortality rates from cardiovascular diseases(CVDs),heart failure remains a major cause of increased morbidity among diabetic *** cellular processes are essential for maintaining cellular balance and removing damaged or dysfunctional components,and their involvement in the development of diabetic heart disease makes them attractive targets for diagnosis and *** a variety of conventional diagnostic and therapeutic strategies are available,DhC continues to present a significant ***-of-care diagnostics,supported by nanobiosensing techniques,offer a promising alternative for these complex *** conventional medications have been widely used in DhC patients,they raise several concerns regarding various physiological *** medicine places great emphasis on the application of nanotechnology to target autophagy and mitophagy in DhC,offering a promising approach to deliver drugs beyond the limitations of traditional *** article aims to explore the potential connections between autophagy,mitophagy and DhC,while also discussing the promise of nanotechnology-based theranostic interventions that specifically target these molecular pathways.

关键词： Autophagy Diabetes Diabetic heart condition Mitophagy Nanotheranostics Nanomedicine

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Derivative Spectroscopy and its Application at Detecting the Weak Emission/Absorption Lines

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research in Astronomy and Astrophysics 2024年第3期24卷 205-223页

作者： Lihuan Yu Jiangdan Li Jinliang Wang Jiajia Li Jiao Li Qiang Xi Zhanwen han Yunnan Observatories Chinese Academy of Sciences(CAS)Kunming 650011China Key lab of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

The development of spectroscopic survey telescopes like Large Sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST),Apache Point Observatory Galactic Evolution Experiment and Sloan Digital Sky Survey has opened up unprecedented opportunities for stellar *** types of stars,such as early-type emission-line stars and those with stellar winds,can be distinguished by the profiles of their spectral *** this paper,we introduce a method based on derivative spectroscopy(DS)designed to detect signals within complex backgrounds and provide a preliminary estimation of curve *** method exhibits a unique advantage in identifying weak signals and unusual spectral line profiles when compared to other popular line detection *** validated our approach using synthesis spectra,demonstrating that DS can detect emission signals three times fainter than Gaussian ***,we applied our method to 579,680 co-added spectra from LAMOST Medium-Resolution Spectroscopic Survey,identifying 16,629 spectra with emission peaks around the hαline from 10,963 *** spectra were classified into three distinct morphological groups,resulting in nine subclasses as follows.(1)Emission peak above the pseudo-continuum line(single peak,double peaks,emission peak situated within an absorption line,P Cygni profile,Inverse P Cygni profile);(2)Emission peak below the pseudo-continuum line(sharp emission peak,double absorption peaks,emission peak shifted to one side of the absorption line);(3)Emission peak between the pseudo-continuum line.

关键词： line identification-line profiles-methods data analysis-techniques spectroscopic-techniques radial velocities

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