Autophagy and mitophagy as potential therapeutic targets in diabetic heart condition:Harnessing the power of nanotheranostics

作     者：Sagnik Nag Oishi Mitra Bhanu Maturi Simran Preet Kaur Ankita Saini Muskan Nama Soumik Roy Souvik Samanta Leena Chacko Rohan Dutta Suresh Babu Sayana Vetriselvan Subramaniyan Jasvinder Singh Bhatti Ramesh Kandimalla Sagnik Nag;Oishi Mitra;Bhanu Maturi;Simran Preet Kaur;Ankita Saini;Muskan Nama;Soumik Roy;Souvik Samanta;Leena Chacko;Rohan Dutta;Suresh Babu Sayana;Vetriselvan Subramaniyan;Jasvinder Singh Bhatti;Ramesh Kandimalla

作者机构：Jeffrey Cheah School of Medicine and Health SciencesMonash University MalaysiaJalan Lagoon Selatan47500 Bandar SunwaySelangorMalaysia Department of Bio-SciencesSchool of Bio-Sciences&Technology(SBST)Vellore Institute of Technology(VIT)Tiruvalam RoadVellore 632014Tamil NaduIndia Department of Internal MedicineUniversity of Alabama at BirminghamBirminghamALUSA Department of MicrobiologyUniversity of Delhi(South Campus)Benito Juarez RoadNew Delhi 110021India Department of BiotechnologyIndian Institute of TechnologyHyderabad(IIT-H)SangareddyTelangana 502284India BioAnalytical LabMeso Scale Discovery1601 Research BlvdRockvilleMDUSA Department of PharmacologyGovernment Medical CollegeSuryapetTelanganaIndia Laboratory of Translational Medicine and NanotherapeuticsDepartment of Human Genetics and Molecular MedicineSchool of Health SciencesCentral University of PunjabBathindaIndia Department of BiochemistryKakatiya Medical CollegeWarangal 506007India 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2024年第19卷第3期

页      面：79-101页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Autophagy Diabetes Diabetic heart condition Mitophagy Nanotheranostics Nanomedicine 

摘      要：Autophagy and mitophagy pose unresolved challenges in understanding the pathology of diabetic heart condition(DHC),which encompasses a complex range of cardiovascular issues linked to diabetes and associated *** significant progress in reducing mortality rates from cardiovascular diseases(CVDs),heart failure remains a major cause of increased morbidity among diabetic *** cellular processes are essential for maintaining cellular balance and removing damaged or dysfunctional components,and their involvement in the development of diabetic heart disease makes them attractive targets for diagnosis and *** a variety of conventional diagnostic and therapeutic strategies are available,DHC continues to present a significant ***-of-care diagnostics,supported by nanobiosensing techniques,offer a promising alternative for these complex *** conventional medications have been widely used in DHC patients,they raise several concerns regarding various physiological *** medicine places great emphasis on the application of nanotechnology to target autophagy and mitophagy in DHC,offering a promising approach to deliver drugs beyond the limitations of traditional *** article aims to explore the potential connections between autophagy,mitophagy and DHC,while also discussing the promise of nanotechnology-based theranostic interventions that specifically target these molecular pathways.