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Long-term Consumption of Highland Barley Tea Promotes Healthy Aging of Skeletal Muscle

food Science and Human Wellness 2024年

作者： Li Yan Chenzhipeng Nie Qingwei Zheng Mingcong Fan Waleed AL-Ansi Haifeng Qian Li Wang State Key Laboratory of food Science and technology， School of food Science and technology， Jiangnan University

Highland barley tea (HBT) is made from roasted barley seeds and is abundant in β-glucan， amino acids， minerals， phenolics， and other natural active ingredients. These natural compounds found in whole grains have been shown to slow aging and positively affect skeletal muscle function. As a result， studying the effects of HBT on the skeletal muscle health of the elderly population is critical from a scientific and societal standpoint for improving their health status and reducing the medical burden on society. The antioxidant activity and the content of natural active substances were used as indicators to screen the optimal process of HBT brewing. The effects of long-term HBT consumption on aging in mice were investigated by using HBT as a substitute for drinking water in naturally aging mice for a 5-month intervention. Afterward， various factors were measured， such as basic physiological indices， inflammation， plasma metabolites， skeletal muscle function， and exercise capacity， to evaluate the effects of HBT on aging in mice. Long-term consumption of HBT reduced body and spleen weight， increased body weight percentage of skeletal muscle， and reduced plasma inflammation levels in aging mice. Metabolomic results showed increased plasma levels of the mitochondrial marker short-chain acylcarnitine and some amino acids. Additionally， there was a decrease in bile and long-chain acylcarnitine. The level of fibrosis in the gastrocnemius muscle of aging mice was suppressed， and the percentage of type I muscle fibers was increased， improving the endurance of the mice. Thus， long-term consumption of HBT may reduce body weight and increase skeletal muscle mitochondrial activity and exercise capacity in aging mice by reducing inflammation levels and alleviating mitochondrial damage.

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Distortion-aware beamforming design for multi-beam satellite communications with nonlinear power amplifiers

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Science China(Information Sciences) 2024年第6期67卷 359-369页

作者： Xiang XIAO Li YOU Kezhi WANG Xiqi GAO National Mobile Communications research Laboratory Southeast University Purple Mountain laboratories Department of Computer Science Brunel University London

Hardware components can cause different impairments, including power amplifier(PA) nonlinearities, which inevitably impact the system performance of satellite communications(SATCOM). In this work, we consider a multi-beam SATCOM downlink system and investigate the distortion-aware beamforming scheme with the characteristics of PA non-linearities. Notably, we aim to maximize the resource efficiency(RE), defined as the weighted sum of energy efficiency(EE) with spectral efficiency(SE), to obtain a flexible EE-SE tradeoff while accounting for the characteristics of PA distortion and the total power *** that the optimization objective is a sum of ratios and the high non-convexity involved in constraints,we propose an efficient approach that exploits the quadratic transformation, the Lagrange multiplier method,and the gradient ascent approach to handle this issue. Simulation results demonstrate the effectiveness of the distortion-aware beamforming approach in achieving the EE-SE tradeoff and exhibit a substantial RE performance gain over the conventional approach with ideal linear PAs assumed at the satellite transmitters.

关键词： multi-beam satellite communications nonlinear power amplifier energy and spectral efficiency tradeoff resource efficiency robust beamforming

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Unveiling the Role of Acetate in Probiotic-Mediated Promotion of Intestinal Serotonin Production Using Intestinal Organoids

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food Science and Human Wellness 2024年

作者： Peijun Tian Zheng Wang Xin Qian Jianxin Zhao Gang Wang Wei Chen State Key Laboratory of food Science and Resources， Jiangnan University School of food Science and technology， Jiangnan University National Engineering research Center for Functional food， Jiangnan University (Yangzhou) Institute of food Biotechnology， Jiangnan University

The neurotransmitter 5-hydroxytryptamine （5-HT）， primarily produced by intestinal enterochromaffin cells （EC）， relies on Tryptophan hydroxylase （TPH1） for synthesis. research suggested Bifidobacterium breve CCFM1025's potential in regulating Tph1 gene expression， maintaining 5-HT levels in stressed mice， but its precise mechanisms were unclear. This study used metabolomic techniques to assess probiotic fermentation products， revealing acetate as the crucial element in Bb-CCFM1025's regulation of gut 5-HT synthesis. Further exploration correlated acetate with Tph1 transcription in intestinal organoids. Transcriptomic methods and qRT-PCR validation demonstrated how acetate facilitated 5-HT synthesis and secretion. It unveiled that acetate orchestrates signaling pathways (PI3K-AKT， PLC-pERK， and PLC-IP3-Ca2+) within EC cells， enabling 5-HT production. These findings elucidate the biochemical mechanisms behind specific probiotics' effects， aiding in the targeted selection of similar beneficial strains. This study offers theoretical support for choosing probiotics with analogous functionalities based on their physiological impacts.

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The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes

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food Science and Human Wellness 2024年第1期13卷 370-380页

作者： Anjun Guo Xueying Li Lihua Pan Qiangming Li Jianping Luo Xueqiang Zha Engineering research Centre of Bioprocess of Ministry of Education Hefei University of TechnologyHefei 230009China School of food and Biological Engineering Hefei University of TechnologyHefei 230009China Key Laboratory of Metabolism and Regulation for Major Disease of Anhui Higher Education Institutes Hefei University of TechnologyHefei 230009China

In the present study,we investigated the intervention effects of a purified Polygonatum cyrtonema polysaccharide(PCP)on high-fat diet(HFD)-induced atherosclerosis in male and female LDLr-/-*** showed that HFD caused severe dyslipidemia,atherosclerotic lesions,oxidative damages and inflammation in male and female mice,and these effects seemed to be more pronounced in males than in ***,the above variations could be dose-dependently reversed by PCP treatment,and the intervention effects on males were greater than those on *** factor kappa-B(NF-κB),mitogen-activated protein kinase(MAPKs)and protein kinase B(Akt)are 3 pivotal signaling pathways mediating the development of ***,PCP was also found to significantly decrease the phosphorylation of p65,p38,extracellular-regulated kinase 1/2(ERK1/2)and Akt,and increase the protein expression of inhibitor of NF-κB(IκB)in the aortas of male and female mice induced by *** together,these findings indicated that PCP could be effective for the prevention of atherosclerosis,and the intervention effect of PCP on male mice was more obvious than that of female mice.

关键词： Polygonatum cyrtonema polysaccharide Anti-atherosclerosis Sex

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Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

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food Science and Human Wellness 2024年第2期13卷 982-992页

作者： Guangsu Zhu Min Guo Jianxin Zhao Hao Zhang Gang Wang Wei Chen State Key Laboratory of food Science and Resources Jiangnan UniversityWuxi 214122China School of food Science and technology Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of food Biotechnology Jiangnan UniversityYangzhou 225004China National Engineering Center of Functional food Jiangnan UniversityWuxi 214122China

The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive ***,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive ***,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)*** this study,we found that compared with EE or *** treatment alone,*** intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic ***,using microbiome and metabolome profiling,we found that the combination of *** and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite ***,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain ***,combined *** intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut *** findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.

关键词： Alzheimer’s disease Bifidobacterium breve Environmental enrichment Glutamine metabolism Microbiota-gut-brain axis

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Bifidobacterium adolescentis CCFM8630 Exerts Anti-Obesity Effects by Modulating Gut Microbiota-Related Tryptophan Metabolism

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food Science and Human Wellness 2024年

作者： Bo Zhang Linlin Wang Peijun Tian Xing Jin Ming Liang Zehua Chen Jianxin Zhao Hao Zhang Gang Wang State Key Laboratory of food Science and Resources， Jiangnan University School of food Science and technology， Jiangnan University National Engineering research Center for Functional food， Jiangnan University (Yangzhou) Institute of food Biotechnology， Jiangnan University Infinitus (China) Company Ltd. Wuxi Translational Medicine research Center and Jiangsu Translational Medicine research Institute Wuxi Branch

Obesity is a major focus of researchers due to its increasing prevalence and relationship with other diseases， such as cancer and cardiovascular diseases. Probiotics are active microorganisms and have been proven to alleviate obesity by modulating the microbiota. In this study， we found that oral administration of Bifidobacterium adolescentis CCFM8630 to obese mice inhibited high-fat-diet (HFD)-induced changes in body weight and adipose tissue and alleviated hepatic oxidative stress. Furthermore， B. adolescentis CCFM8630 treatment primarily affected the relative abundances of the phyla Proteobacteria and Actinobacteria， and thereby decreased the production of lipopolysaccharide (LPS) and the occurrence of LPS-related diseases. A high fiber intake increased the abundance of Lactobacillus and the concentrations of short-chain fatty acids in obese mice， but these changes were reversed by B. adolescentis CCFM8630 treatment. In addition， targeted metabolomic analysis and microbiota relationship analysis revealed that B. adolescentis CCFM8630 treatment modified the microbiota of obese mice by promoting the conversion of tryptophan (Trp) to xanthurenic acid， kynurenic acid， tryptamine， indole-3-acetic acid， and indole-3-carboxaldehyde; facilitated the expression of interleukin-17A and the aryl hydrocarbon receptor to generate interleukin-22 in the colon; and upregulated the expression of tight junction proteins， thereby strengthening intestinal barriers. In summary， our findings suggest that the intake of B. adolescentis CCFM8630 may alleviate obesity by modulating the gut microbiota and related Trp metabolism.

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Technological advancements in millet dehulling and polishing process: An insight into pretreatment methods, machineries and impact on nutritional quality

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Grain & Oil Science and technology 2024年第3期7卷 186-195页

作者： Shagolshem Mukta Singh Jayasree Joshi T P.Srinivasa Rao Agricultural and food Engineering Department Indian Institute of Technology KharagpurKharagpurWest Bengal 721302India

Millets are widely recognized for their nutritional significance;however, the methods employed for their processing are currently lacking. This article primarily focuses on the advanced technologies and progressions in millet dehulling and polishing. These technologies operate based on the fundamental principles of compression-shearing, abrasion-friction, and centrifugal-impact forces. Processing of millets can be challenging because of the physical characteristics and tight attachment of hull and bran to the endosperm. However, several dehullers have been designed to solve this problem for different kinds of millets. In addition, the nutritional and anti-nutritional characteristics undergo alterations due to both dehulling and polishing processes. These alterations are thoroughly examined and discussed in this article. Specifically, anti-nutrients such as tannins and phytate are predominantly found in the outer pericarp of the grain and experience a reduction after undergoing dehulling and polishing. The nutritional properties are also subjected to a reduction;however, this reduction can be mitigated by subjecting the grains to certain pretreatments before dehulling and polishing. These treatments serve to enhance dehulling efficiency and nutrient digestibility while simultaneously reducing the presence of anti-nutrients. Novel thermal and non-thermal methodologies such as microwave, hydrothermal, high-pressure processing, and ohmic heating can be employed for processing millets, thereby diminishing the loss of nutrients. Additional research can be carried out to investigate their impact on the dehulling and polishing of millets.

关键词： Millets Dehulling Polishing Pretreatment Novel thermal and non-thermal techniques

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A systematic review of global occurrence of emerging mycotoxins in crops and animal feeds,and their toxicity in livestock

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Emerging Contaminants 2024年第3期10卷 32-39页

作者： Oluwatobi Kolawole Wipada Siri-Anusornsak Awanwee Petchkongkaew Christopher Elliott Plant Sciences Group Wageningen University&ResearchDroevendaalsesteeg 46708 PB WageningenNetherlands Microarray Laboratory National Centre for Genetic Engineering and Biotechnology113 Thailand Science ParkPhahonyothin RoadPathum Thani12120Thailand The International Joint research Centre on food Security 113 Thailand Science ParkPhahonyothin RoadPathum Thani12120Thailand Department of food Science and technology Faculty of Agro-IndustryKasetsart UniversityBangkok10900Thailand Scientific Equipment and research Division Kasetsart University Research and Development Institute(KURDI)Kasetsart UniversityBangkok10900Thailand School of food Science and technology Faculty of Science and TechnologyThammasat UniversityPathum Thani12120Thailand

Mycotoxins are the most frequently occurring natural contaminant in food and *** occurrence in crops and animal feed represents an enormous challenge,particularly for livestock farmers in terms of increased production costs,reduced animal performance and *** study investigates the scale of emerging mycotoxins contamination of crops and animal feeds globally,and evaluates their impacts on the health and performance of livestock,especially when they co-occur alongside regulated *** mycotoxins including nivalenol,enniatins,beauvericin,diacetoxyscirpenol,fusaric acid,patulin,moniliformin and sterigmatocystin were found to be the most prevalent contaminants of cereals and other feed commodities *** pooled mean levels for beauvericin,nivalenol,enniatins,moniliformin,sterigmatocystin,diacetoxyscirpenol,fusaric acid,and patulin were 386,421,7,854,204,136,126,370 and 138 mg/kg,*** terms of toxicity,co-occurrence of emerging mycotoxins with each other and also with regulated mycotoxins profoundly impacts livestock performance,even at low ***,there is a need for cumulative risk assessments to evaluate the health risks associated with simultaneous exposure to emerging and regulated mycotoxins and also to develop effective mitigation strategies.

关键词： Emerging mycotoxins Animal feeds Contamination Livestock Systematic review Toxicity Crops Cereals

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Population genomic analysis unravels the evolutionary roadmap of pericarp color in rice

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Plant Communications 2024年第3期5卷 156-166页

作者： Lingjuan Xie Dongya Wu Yu Fang Chuyu Ye Qian-Hao Zhu Xinghua Wei Longjiang Fan Institute of Crop Sciences&Institute of Bioinformatics Zhejiang UniversityHangzhou 310058China Shandong(Linyi)Institute of Modern Agriculture Zhejiang UniversityLinyi 310014China Shanghai ZKW Molecular Breeding technology Co. Ltd.Shanghai 200234China CSIRO Agriculture and food Black Mountain LaboratoriesCanberraACT 2601Australia China National Rice research Institute Chinese Academy of Agricultural SciencesHangzhou 311401China

Pigmented rice stands out for its nutritional value and is gaining more and more *** rice,domes-ticated red rice,and weedy rice all have a red pericarp and a comprehensive genetic background in terms of the red-pericarp *** performed population genetic analyses using 5104 worldwide rice acces-sions,including 2794 accessions with red or black pericarps,85 of which were newly sequenced in this *** results suggested an evolutionary trajectory of red landraces originating from wild rice,and the split times of cultivated red and white rice populations were estimated to be within the past 3500 *** red rice was found to feralize to weedy rice,and weedy rice could be further re-domesticated to cultivated red rice.A genome-wide association study based on the 2794 accessions with pigmented peri-carps revealed several new candidate genes associated with the red-pericarp trait for further functional *** results provide genomic evidence for the origin of pigmented rice and a valuable genomic resource for genetic investigation and breeding of pigmented rice.

关键词： red rice population genomics pericarp color re-domestication divergence time

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Deficiency of circadian gene Per2 blocks luteolin-induced adipocyte browning in mice through weakening liver PPARα/RXRα/FGF21 pathway

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food Science and Human Wellness 2024年

作者： Shanshan Shui Juan Chen Yan Lin Jingjing Yuan Xin Wang Xian Zhang Jian Liu Lei Zheng Engineering research Center of Bio-process， Ministry of Education， Hefei University of technology Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province， College of food Science and Pharmacy， Zhejiang Ocean University School of food and Biological Engineering， Hefei University of technology

During the development of diet-induced obesity， the change of energy matebolism is closely related to the function of the circadian clock in mammals. Luteolin (LU)， one of the most common natural flavonoids riched in many edible plants， can ameliorate obesity by activating adipose tissue browning， but its effect on circadian clock in this process remains poorly understood. Here we found that dietary LU improved circadian misalignment of energy expenditure in high-fat diet (HFD)-fed wild-type (WT) mice. Moreover， dietary LU efficiently elevated UCP1 levels in adipose tissue during the dark period， which was similar to the LU-increased hepatic PER2 expressions. Hepatic PPARα/RXRα/FGF21 pathway was rhythmically elevated by dietary LU in HFD-fed WT mice， whereas the promotion was inhibited in Per2-/-mice. Meanwhile， Per2 deletion abolished the effects of dietary LU on adipose tissue browning in HFD-fed mice. Further， LU treatment directly activated PPARα/RXRα/FGF21 signaling in primary cultured hepatocytes from WT mice rather than Per2-/-mice. Taken together， the deletion of the core clock component Per2 impedes LU-induced adipose tissue browning through weakening PPARα/RXRα/FGF21 pathway in mice， providing a new insight into the interplay of energy metabolism and circadian clock for the anti-obesity activity of LU.

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