Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

作     者：Guangsu Zhu Min Guo Jianxin Zhao Hao Zhang Gang Wang Wei Chen Guangsu Zhu;Min Guo;Jianxin Zhao;Hao Zhang;Gang Wang;Wei Chen

作者机构：State Key Laboratory of Food Science and ResourcesJiangnan UniversityWuxi 214122China School of Food Science and TechnologyJiangnan UniversityWuxi 214122China (Yangzhou)Institute of Food BiotechnologyJiangnan UniversityYangzhou 225004China National Engineering Center of Functional FoodJiangnan UniversityWuxi 214122China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2024年第13卷第2期

页      面：982-992页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083201[工学-食品科学] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 

基　　金：supported by the National Natural Science Foundation of China(31972052,32021005,31820103010) the Fundamental Research Funds for the Central Universities(JUSRP22006,JUSRP51501) the Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province 

主　　题：Alzheimer’s disease Bifidobacterium breve Environmental enrichment Glutamine metabolism Microbiota-gut-brain axis 

摘      要：The gut microbiota-brain axis has emerged as a novel target for Alzheimer s disease(AD),a neurodegenerative disease characterised by behavioural and cognitive ***,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive ***,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)*** this study,we found that compared with EE or *** treatment alone,*** intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic ***,using microbiome and metabolome profiling,we found that the combination of *** and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite ***,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain ***,combined *** intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut *** findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.