The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes

作     者：Anjun Guo Xueying Li Lihua Pan Qiangming Li Jianping Luo Xueqiang Zha Anjun Guo;Xueying Li;Lihua Pan;Qiangming Li;Jianping Luo;Xueqiang Zha

作者机构：Engineering Research Centre of Bioprocess of Ministry of EducationHefei University of TechnologyHefei 230009China School of Food and Biological EngineeringHefei University of TechnologyHefei 230009China Key Laboratory of Metabolism and Regulation for Major Disease of Anhui Higher Education InstitutesHefei University of TechnologyHefei 230009China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2024年第13卷第1期

页      面：370-380页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：financially supported by the National Natural Science Foundation of China(32072176,31271814) the Outstanding Youth Funds of Anhui Province(2208085J31) the Fundamental Research Funds for the Central Universities(JZ2022HGQA0232,JZ2022HGTA0316) 

主　　题：Polygonatum cyrtonema polysaccharide Anti-atherosclerosis Sex 

摘      要：In the present study,we investigated the intervention effects of a purified Polygonatum cyrtonema polysaccharide(PCP)on high-fat diet(HFD)-induced atherosclerosis in male and female LDLr-/-*** showed that HFD caused severe dyslipidemia,atherosclerotic lesions,oxidative damages and inflammation in male and female mice,and these effects seemed to be more pronounced in males than in ***,the above variations could be dose-dependently reversed by PCP treatment,and the intervention effects on males were greater than those on *** factor kappa-B(NF-κB),mitogen-activated protein kinase(MAPKs)and protein kinase B(Akt)are 3 pivotal signaling pathways mediating the development of ***,PCP was also found to significantly decrease the phosphorylation of p65,p38,extracellular-regulated kinase 1/2(ERK1/2)and Akt,and increase the protein expression of inhibitor of NF-κB(IκB)in the aortas of male and female mice induced by *** together,these findings indicated that PCP could be effective for the prevention of atherosclerosis,and the intervention effect of PCP on male mice was more obvious than that of female mice.