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Intrahepatic cholestasis of pregnancy

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World Journal of Gastroenterology 2009年第17期15卷 2049-2066页

作者： Victoria Geenes Catherine Williamson Maternal and Fetal Disease group Institute of Reproductive and Developmental Biology Imperial College London London W12 0NN United Kingdom

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder characterized by maternal pruritus in the third trimester, raised serum bile acids and increased rates of adverse fetal outcomes. The etiology of ICP is complex and not fully understood, but it is likely to result from the cholestatic effects of reproductive hormones and their metabolites in genetically susceptible women. Equally unclear are the mechanisms by which the fetal complications occur. This article reviews the epidemiology, clinical features, diagnosis, etiology and management of ICP.

关键词： Cholestasis Pregnancy Pruritus Bile acid

Green spermatozoa illuminate a 30-year-old model： sperm-egg adhesion involves intra-acrosomal proteins

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Asian Journal of Andrology 2011年第5期13卷 665-666页

作者： Steve Tardif reproductive and developmental biology group Centrefor Oncology and Molecular Medicine Division ofMedical Sciences Ninewells Hospital University ofDundee Dundee Scotland DD1 9SY UK

Fertilisation in mammals involves many synchronized steps including spermegg adhesion. Prior to sperm-oolemma fusion, spermatozoa need to undergo the acrosome reaction （AR） or exocytosis. The universal belief, for many years, has been that the AR was initiated upon binding to the zona pellucida （ZP）. As such acrosomal proteins were not thought to be involved in the primary contact with the ZP. These proteins were only suggested to be biologically relevant once the sperm were attached to the ZP and during subsequent events. However,

关键词： Green reexamination

The second polar body contributes to the fate asymmetry in the mouse embryo

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National Science Review 2022年第7期9卷 32-42页

作者： Hongbin Jin Yang Han Huasong Wang J.Xiao He Li Weimin Shen Lin Zhang Luxi Chen Shunji Jia Ping Yuan Hui Chen Anming Meng Laboratory of Molecular developmental biology State Key Laboratory of Membrane BiologyTsinghua-Peking Center for Life Sciences School of Life SciencesTsinghua University Center for reproductive Genetics and reproductive Medicine Sun Yat-sen Memorial HospitalSun Yat-sen University Guangzhou Laboratory

The polar bodies(PBs) are extruded microcells during oocyte meiosis and generally regarded as inessentials for embryonic ***,PBs have been widelyused as important materials for pre-implantation genetic diagnosis in *** we report that the second PB(PB2) in the mouse zygote may play roles in cell-fate specification and post-implantation development.A subset of mRNAs encoding pluripotency-related factors are enriched in *** proteins maybe synthesized in PB2 after fertilization and transport from PB2 to the zygote before the two-cell *** PB2-attached blastomere(pbB) at the two-cell stage,compared to the other blastomere(npbB),likely contributes more descendants to the inner cell mass(ICM) lineage in the *** of PB2 from the zygote or transient blockage of material exchange between PB2 and the zygote by nocodazole treatment appears to cause a loss of the ICM fate bias of ***2 removal or nocodazole treatment also results in abnormal post-implantation *** of PB2 lysate into pbB of PB2-removed two-cell-stage embryos may reset the cell-fate preference and rescue post-implantation *** data collectively suggest that PB2 would demarcate the earliest cell-fate asymmetry of the mouse zygote and be required for post-implantation development.

关键词： mouse embryo polar body cell fate asymmetry

RLKs orchestrate the signaling in plant male-female interaction

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Science China(Life Sciences) 2016年第9期59卷 867-877页

作者： Hongju Li Wei-Cai Yang State Key Laboratory of Molecular developmental biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences

Different from animals, sessile plants are equipped with a large receptor-like kinase(RLK) superfamily. RLKs are a family of single trans-membrane proteins with divergent N-terminal extracellular domains capped by a signal peptide and C-terminal intracellular kinase. Researches in the last two decades have uncovered an increasing number of RLKs that regulate plant development, stress response and sexual reproduction, highlighting a dominant role of RLK signaling in cell-to-cell communications. Sexual reproduction in flowering plants is featured by interactions between the male gametophyte and the female tissues to facilitate sperm delivery and fertilization. Emerging evidences suggest that RLKs regulate almost every aspect of plant reproductive process, especially during pollination. Therefore, in this review we will focus mainly on the function and signaling of RLKs in plant male-female interaction and discuss the future prospects on these topics.

关键词： RLK signaling plant reproduction pollen tube female gametophyte male-female interaction pollen tube growth and guidance pollen tube reception

Late-onset hypogonadism： current concepts and controversies of pathogenesis, diagnosis and treatment

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Asian Journal of Andrology 2014年第2期16卷 192-202,I0007页

作者： Ilpo Huhtaniemi Institute of reproductive and developmental biology Imperial College London Hammersmth Campus London UK Department of Physiology University of Turku Kiinamyllynkatu Turku Finland.

Although suppressed serum testosterone （T） is common in ageing men, only a small proportion of them develop the genuine syndrome of low T associated with diffuse sexual （e.g., erectile dysfunction）, physical （e.g. loss of vigor and frailty） and psychological （e.g., depression） symptoms. This syndrome carries many names, including male menopause or climacterium, andropause and partial androgen deficiency of the ageing male （PADAM）. Late-onset hypogonadism （LOH） describes it best and is therefore generally preferred. The decrease of T in LOH is often marginal, and hypogonadism can be either due to primary testicular failure （low T, high luteinizing hormone （LH）） or secondary to a hypothalamic-pituitary failure （low T, low or inappropriately normal LH）. The latter form is more common and it is usually associated with overweight/obesity or chronic diseases （e.g., type 2 diabetes mellitus, the metabolic syndrome, cardiovascular and chronic obstructive pulmonary disease, and frailty）. A problem with the diagnosis of LOH is that often the symptoms （in 20%-40% of unselected men） and low circulating T （in 20% of men 〉70 years of age） do not coincide in the same individual. The European Male Ageing Study （EMAS） has recently defined the strict diagnostic criteria for LOH to include the simultaneous presence of reproducibly low serum T （total T 〈11 nmol 1-1 and free T 〈220 pmol 1-1） and three sexual symptoms （erectile dysfunction, and reduced frequency of sexual thoughts and morning erections）. By these criteria, only 2% of 40- to 80-year-old men have LOH. In particular obesity, but also impaired general health, are more common causes of low T than chronological age per se. Evidence-based information whether, and how, LOH should be treated is sparse. The most logical approach is lifestyle modification, weight reduction and good treatment of comorbid diseases. T replacement is widely used for the treatment, but evidence-based information about its real benefits and short- and lo

关键词： hypogonadism male ageing obesity testicular function testosterone

Mechanism of sperm-egg recognition during subzonal (perivitelline space) insemination

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Chinese Science Bulletin 1996年第18期41卷 1559-1563页

作者：陈大元杜淼邹贤刚宋祥芬孙青原段崇文庄大中刘辉 State Key Laboratory of reproductive biology Instutue of Zoology Chinese Academy of Sciences. Beijing 100080 China Institute of developmental biology Chinese Academy of Sciences. Beijing 100080 China

Three kinds of microinsemination techniques are prevailing all over the world in recent years, i.e. (ⅰ) partial zona dissection (PZD); (ⅱ) subzonal insemination (SUZI), and (ⅲ) intracytoplasmic sperm injection (ICSI). The common aim of the above techniques is to compensate for the failure or low success of in vitro fertilization and they are effectively used in the human clinics. The success rate of SUZI and ICSI is higher than that of PZD at present. As to the underlying mechanism, most studies were conducted to analyze the physiological effects and success rate or the importance of sperm acrosome reaction,

关键词： subzonal insemination spermatozoon sperm-egg recognition hamster. giant panda.

Emerging role of ER quality control in plant cell signal perception

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Protein & Cell 2012年第1期3卷 10-16页

作者： Hong-Ju Li Wei-Cai Yang State Key Laboratory of Molecular developmental biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

The endoplasmic reticulum quality control(ER-QC)is a conserved mechanism in surveillance of secreted signaling factors during cell-to-cell communication in *** data show that the ER-QC plays important roles in diverse cell-to-cell signaling processes during immune response,vegetative and reproductive development in *** tube guidance is a precisely guided cell-cell communication process between the male and female gametophytes during plant ***,the female signal has been identified as small secreted peptides,but how the pollen tube responds to this signal is still *** this review,we intend to summarize the role of ER-QC in plants and discuss the recent advances regarding our understanding of the mechanism of pollen tube response to the female signals.

关键词： cell-to-cell communication pollen tube guidance gametophyte ER quality control

Human embryonic stem cell-derived mesenchymal stem cells improved premature ovarian failure

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World Journal of Stem Cells 2020年第8期12卷 857-878页

作者： Khadijeh Bahrehbar Mojtaba Rezazadeh Valojerdi Fereshteh Esfandiari Rouhollah Fathi Seyedeh-NafisehHassani Hossein Baharvand Department of Stem Cells and developmental biology Cell Science Research CenterRoyan Institute for Stem Cell Biology and TechnologyTehran ***Iran Department of developmental biology University of Science and CultureTehran ***Iran Department of Embryology Reproductive Biomedicine Research CenterRoyan Institute for Reproductive BiomedicineTehran ***Iran Department of Anatomy Faculty of Medical ScienceTarbiat Modares UniversityTehran ***Iran

BACKGROUND Premature ovarian failure(POF)affects many adult women less than 40 years of age and leads to *** to previous reports,various tissue-specific stem cells can restore ovarian function and folliculogenesis in mice with chemotherapy-induced *** embryonic stem cells(ES)provide an alternative source for mesenchymal stem cells(MSCs)because of their similarities in phenotype and immunomodulatory and anti-inflammatory *** stem cell-derived mesenchymal stem cells(ES-MSCs)are attractive candidates for regenerative medicine because of their high proliferation and lack of barriers for harvesting tissue-specific ***,possible therapeutic effects and underlying mechanisms of transplanted ES-MSCs on cyclophosphamide and busulfan-induced mouse ovarian damage have not been *** To evaluate ES-MSCs vs bone marrow-derived mesenchymal stem cells(BMMSCs)in restoring ovarian function in a mouse model of chemotherapy-induced premature ovarian *** Female mice received intraperitoneal injections of different doses of cyclophosphamide and busulfan to induce *** human ES-MSCs or BMMSCs were transplanted into these *** days after the mice were injected with cyclophosphamide and busulfan and 4 wk after transplantation of the ESMSCs and/or BM-MSCs,we evaluated body weight,estrous cyclicity,folliclestimulating hormone and estradiol hormone concentrations and follicle count were used to evaluate the POF model and cell ***,terminal deoxynucleotidyl transferase mediated 2-deoxyuridine 5-triphosphate nick end labeling,real-time PCR,Western blot analysis and immunohistochemistry and mating was used to evaluate cell ***-linked immunosorbent assay was used to analyze vascular endothelial growth factor,insulin-like growth factor 2 and hepatocyte growth factor levels in ES-MSC condition medium in order to investigate the mechanisms that underlie their *** Th

关键词： Premature ovarian failure Human embryonic stem cells Chemotherapy drugs Mesenchymal stem cell Bone marrow Apoptosis

Zika virus infection—do they also endanger male fertility?

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Science China(Life Sciences) 2017年第3期60卷 324-325页

作者： Nafis A.Rahman Ilpo Huhtaniemi Institute of Biomedicine Department of Physiology University of Turku Department of Reproduction and Gynecological Endocrinology Medical University of Bialystok Institute of reproductive and developmental biology Imperial College London

Zika virus（ZIKV）is a mosquito-borne flavivirus,first discovered in the *** was originally limited to sporadic cases in Africa and Asia,until the Brazil ZIKV incidences in 2015,when it rapidly spread throughout the *... 详细信息

关键词：病毒感染生育能力男性发病率发热性