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Appearance of aseptic vascular grafts after endovascular aortic repair on[(18)F]fluorodeoxyglucose positron emission tomography/computed tomography

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世界放射学杂志:英文版(电子版) 2023年第8期15卷 241-249页

作者： Paige Bennett Maria Bernadette Tomas Christopher F Koch Kenneth J Nichols Christopher J Palestro Department of Radiology LIJMC Northwell HealthNew Hyde ParkNY 11040United States Department of Radiology Zucker School of Medicine at Hofstra/NorthwellHempsteadNY 11549United States Division of Nuclear Medicine and Molecular Imaging Department of RadiologyNorthwell HealthNew Hyde ParkNY 11040United States

BACKGROUND Diagnosis of prosthetic vascular graft infection with[(18)F]fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT)allows for early detection of functional changes associated with infection,based on increased glucose utilization by activated macrophages and *** vascular grafts,like all foreign bodies,can stimulate an inflammatory response,which can present as increased activity on 18F-FDG PET/***,distinguishing aseptic inflammation from graft infection,though important,can be *** the case of endovascular aneurysm repair(EVAR),a minimally invasive procedure involving the transfemoral insertion of an endoprosthetic stent graft,the normal postoperative appearance of these grafts on 18F-FDG PET/CT can vary over time,potentially confounding study *** To investigate the visual,semiquantitative,and temporal characteristics of aseptic vascular grafts in patients status post *** In this observational retrospective cohort study,patients with history of EVAR who underwent 18F-FDG PET/CT for indications other than infection were identified *** patients were asymptomatic for graft infection-no abdominal pain,fever of unknown origin,sepsis,or leukocytosis-at the time of imaging and for≥2 mo after each PET/*** studies such as CT for each patient were also reviewed,and any patients with suspected or confirmed vascular graft infection were *** hundred two scans performed on 43 patients(34 males;9 females;age=77±8 years at the time of the final PET/CT)were retrospectively *** 43 patients had an abdominal aortic(AA)vascular graft,40 patients had a right iliac(RI)limb graft,and 41 patients had a left iliac(LI)limb *** patients had 1 PET/CT and 21 patients had from 2 to 9 PET/*** were imaged between 2 mo to 168 mo(about 14 years)post *** grafts were imaged within 6 mo of placement,including three that were imaged wit

关键词： Aseptic vascular grafts Endovascular aortic repair [(18)F]fluorodeoxyglucose positron emission tomography/computed tomography

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Durable, superhydrophobic, antireflection, and low haze glass surfaces using scalable metal dewetting nanostructuring

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Nano Research 2013年第6期6卷 429-440页

作者： Daniel Infante Karl W. Koch Prantik Mazumder Lili Tian Albert Carrilero Domenico Tullit David Baker Valerio Pruneri ICFO-Institut de Ciencies Fotbniques Av. Carl Friedrich Gauss 3 08860 Castelldefels Barcelona Spain ICREA-Institucio Catalana de Recerca i Estudis Avan~ats Passeig Llu/s Companys 2308010 Barcelona Spain Coming Incorporated Sullivan Park Coming NY 14831 USA

In this paper we report a multifunctional nanostructured surface on glass that, for the first time, combines a wide range of optical, wetting and durability properties, including low omnidirectional reflectivity, low haze, high transmission, superhydrophobicity, oleophobicity, and high mechanical resistance. Nanostructures have been fabricated on a glass surface by reactive ion etching through a nanomask, which is formed by dewetting ultrathin metal films （〈 10 nm thickness） subjected to rapid thermal annealing （RTA）. The nanostructures strongly reduce the initial surface reflectivity （-4%）, to less than 0.4% in the 390--800 nm wavelength range while keeping the haze at low values （〈 0.9%）. The corresponding water contact angle （0c） is -24.5~, while that on a flat surface is -43.5~. The hydrophilic wetting nanostructure can be changed into a superhydrophobic and oleophobic surface by applying a fluorosilane coating, which achieves contact angles for water and oil of -156.3~ and -116.2~, respectively. The multicomponent composition of the substrate （Coming~ glass） enables ion exchange through the surface, so that the nanopillars＇ mechanical robustness increases, as is demonstrated by the negligible changes in surface morphology and optical performance after 5,000-run wipe test. The geometry of the nanoparticles forming the nanomask depends on the metal material, initial metal thickness and RTA parameters. In particular we show that by simply changing the initial thickness of continuous Cu films we can tailor the metal nanoparticles＇ surface density and size. The developed surface nanostructuring does not require expensive lithography, thus it can be controlled and implemented on an industrial scale, which is crucial for applications.

关键词： nanostructures surface modification antireflective superhydrophobic/philicsurfaces self-assembly dewetting

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采用并行处理的可编程滤波器

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电子设计技术 1997年第1期 58-58页

作者： Alex Belousov rego park ny

图1所表示的电路是一种直接采用一只低通滤波器,并通过其输入信号与滤波总输出信号相减的方法来构成一种稳定的高通滤波器的一种简易的方法。这种方法的数字基础是公式式中K(S)是指滤波器整个传输函数、1/(1+τS)和τS/(1+τs)分别是低... 详细信息

图1所表示的电路是一种直接采用一只低通滤波器,并通过其输入信号与滤波总输出信号相减的方法来构成一种稳定的高通滤波器的一种简易的方法。这种方法的数字基础是公式式中K(S)是指滤波器整个传输函数、1/(1+τS)和τS/(1+τs)分别是低通和高通滤波器的典型传输函数。这种方法有几个优点:第一,低通滤波器本身具有良

关键词：低通滤波器高通滤波器带通滤波器低截止滤波器电阻器传输函数

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为声频混合器供电的单电容器电源

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电子设计技术 1997年第10期 62-62页

作者： Aleksandr Belousov rego park ny

微功率、低电压运算放大器允许我们无需用电池或变压器就能构成高性能模拟信号处理器。而且采用一只电容器作为供电电源。图1所示电路是一个为联接电视拍摄器和录像机的音频编辑而设计的模拟混合器,它可以用如

关键词：电源电容器电器混合器声频

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为声频混合器供电的单电容器电源

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电子设计技术 1997年第9期 59-59页

作者： Aleksandr Belousov rego park ny

微功率、低电压运算放大器允许我们无需用电池或变压器就能构成高性能模拟信号处理器。而且采用一只电容器作为供电电源。图1所示电路是一个为联接电视拍摄器和录像机的音频编辑而设计的模拟混合器、它可以用如

关键词：电容器电池电器混合器声频电源

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Biomarkers in nonalcoholic fatty liver disease-the emperor has no clothes?

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World Journal of Gastroenterology 2015年第11期21卷 3223-3231页

作者： Madhusudana Girija Sanal Albert Einstein College of Medicine 1300 Morris Park AvenueBronxNY 10461United States

Fatty liver is present in over ten percentage of the world population and it is a growing public health *** fatty liver disease(NAFLD) is not a single disease,but encompasses a spectrum of diseases of different *** is difficult to find highly specific and sensitive diagnostic biomarkers when a disease is very ***,we should aim to find relevant prognostic markers rather than accurate diagnostic markers which will help to minimize the frequency of liver biopsies to evaluate disease *** are several biomarker panels commercially available,however,there is no clear evidence that more sophisticated panels are better compared to simple criteria such as,presence of diabetes over five years,metabolic syndrome,obesity,obstructive sleep apnea,aspartate transaminase/alanine transaminase(ALT) ratio > 0.8 or ferritin levels > 1.5 times normal in patients with over six month history of raised ALT and/or ultrasonological evidence of fat in the *** the biomarker panels are not a replacement for a liver *** the need and benefit of liver biopsy in NAFLD is questionable because there is no convincing evidence that biopsy and detailed staging of NAFLD improves the management of NAFLD and benefits the *** all there is no evidence based treatment for NAFLD other than management of lifestyle and components of "metabolic syndrome".

关键词： Nonalcoholic fatty liver disease Biomarkers Fibros

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具有12位分辨力的可编程阻抗

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电子设计技术 1996年第10期 56-56页

作者： Alex Belousov rego park ny

图1所示电路能将输入数字码变换成电阻抗,该图展示的等效电路可以对C;和R;数字编程,分辨力达到12位。这种电路的可能性应用场合包括可编程滤波器、信号发生器、数字测量电桥、阻抗标准,特别是在生物医学上用于动态皮肤阻抗模拟器。

关键词： MDAC 可编程分辨力

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The Effects of Bio-inspired Electromagnetic Fields on Normal and Cancer Cells

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Journal of Bionic Engineering 2019年第5期16卷 943-953页

作者： Xuelei Liu Zongming Liu Zhenning Liu Shujun Zhang Kamal Bechkoum Michael Clark Luquan Ren Key Laboratory of Bionic Engineering(Ministry of Educatiori) College of Biological and Agricultural Engineerings Jilin UniversityChangchun 130022China Department of Anesthesiology Jilin Cancer HospitalChangchun 130000China School of Computing and Technology University of GloucestershireThe ParkCheltenhamGL502RHUK Magnacare Health Groups 20-22 Pemberton Street Birmingham5186NYUK

The electromagnetic field(EMF)is one of many environmental factors,which earth creatures are exposed *** are many reports on the effects of EMF on living ***,since the mechanism has not yet been fiilly understood,the biological effects of EMF are still *** order to explore the effects of bio-inspired EMF(BIEMF)on normal and cancer cells,various cultured cells have been exposed to BIEMF of different directions,***,parallel and *** reduced ATP production in Hela and A549 cancer cells is found for the parallel and vertical *** careful examination on Hela cells has revealed a cell density dependent inhibition on colony *** morphological observation of BIEMF-exposed Hela cells has suggested that the retarded cell proli feration is probably caused by cell death via *** these results may afford new insights for cancer prevention and treatment.

关键词： electromagnetic fields(EMF) bio-inspired electromagnetic fields(BIEMF) directionality cancer cell proliferation

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Zwitterionic peptides:Tunable next-generation stealth nanoparticle modifications

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Bioactive Materials 2023年第9期27卷 113-124页

作者： Clyde Overby Soomin park Austin Summers Danielle S.W.Benoit Department of Biomedical Engineering University of Rochester RochesterNYUSA Center for Musculoskeletal Research University of RochesterRochesterNYUSA Department of Biology University of Rochester RochesterNYUSA Department of Biology Duquesne UniversityPAUSA Department of Chemical Engineering University of RochesterRochesterNYUSA Materials Science Program University of RochesterRochesterNYUSA Knight Campus for Accelerating Scientific Impact Department of BioengineeringUniversity of OregonEugeneORUSA

Adsorption of proteins to nanoparticles(NPs),a complex process that results in a protein corona,is controlled by NP surface properties that define NP interactions in *** to control adsorbed protein quantity through surface modification have led to improvements in circulation time or ***,current approaches have yet to be identified to control adsorbed protein identities within the ***,we report the development and characterization of diverse zwitterionic peptides(ZIPs)for NP anti-fouling surface functionalization with specific and controllable affinity for protein adsorption profiles defined by ZIP *** serum exposure of ZIP-conjugated NPs and proteomics analysis of the resulting corona,we determined that protein adsorption profiles depend not on the exact composition of the ZIPs but on the sequence and order of charges along the sequence(charge motif).These findings pave the way for developing tunable ZIPs to orchestrate specific ZIP-NP protein adsorption profiles as a function of ZIP charge motif to better control cell and tissue specificity and pharmacokinetics and provide new tools for investigating relationships between protein corona and biological ***,overall ZIP diversity enabled by the diversity of amino acids may ameliorate adaptive immune responses.

关键词： Nanoparticles Protein corona Surface functionalization Peptide design Cellular uptake

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The role of protein phosphorylation in the regulation of class switch recombination

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BIOCELL 2020年第4期44卷 545-558页

作者： KANO TANABE RYUTARO KAJIHARA Department of Medical Technology Faculty of Health ScienceKumamoto Health Science UniversityKumamoto861-5598Japan Department of Biomedical Laboratory Sciences Faculty of Life SciencesKumamoto UniversityKumamoto862-0976Japan Center for Immunotherapy Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA

Antibody is an important part of adaptive immune system and is produced only by B *** are five main classes(IgM,IgD,IgG,IgA,IgE)and some subclasses in *** and IgD are produced by mature naïve B *** the other hand,IgG,IgA and IgE are produced by activated antigen-specific B cells via class switch recombination(CSR).CSR is the irreversible DNA rearrangement from upstream to downstream classes in immunoglobulin heavy chain ***-stimulations of CD40 ligand(CD40L)and cytokines are required for induction of CSR by activating several transcription *** signal transduction pathways involve many protein *** or dephosphorylation of cellular protein is an important kind of post-translational protein modification in intracellular signal *** the fact,more than one third of the intracellular proteins are said to be transiently phosphorylated in human.A protein kinase is an enzyme that catalyzes the addition of phosphate to substrate ***,a protein phosphatase catalyzes the removal of phosphate from the *** review focuses on the mechanism of CSR controlled by protein phosphorylation and *** provide the role of protein kinase and phosphatase in the regulation of class switch recombination.

关键词： Antibody Kinase Phosphatase Signal Transduction

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