Zwitterionic peptides:Tunable next-generation stealth nanoparticle modifications

作     者：Clyde Overby Soomin Park Austin Summers Danielle S.W.Benoit 

作者机构：Department of Biomedical Engineering University of RochesterRochesterNYUSA Center for Musculoskeletal ResearchUniversity of RochesterRochesterNYUSA Department of Biology University of RochesterRochesterNYUSA Department of BiologyDuquesne UniversityPAUSA Department of Chemical EngineeringUniversity of RochesterRochesterNYUSA Materials Science ProgramUniversity of RochesterRochesterNYUSA Knight Campus for Accelerating Scientific ImpactDepartment of BioengineeringUniversity of OregonEugeneORUSA 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第27卷第9期

页      面：113-124页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：study was provided by the National Institute of Health(NIH)F31AR076874 R01DE018023 R01AR056696 and the National Science Foundation(NSF)CBET-1450897 and DMR-2103553 

主　　题：Nanoparticles Protein corona Surface functionalization Peptide design Cellular uptake 

摘      要：Adsorption of proteins to nanoparticles(NPs),a complex process that results in a protein corona,is controlled by NP surface properties that define NP interactions in *** to control adsorbed protein quantity through surface modification have led to improvements in circulation time or ***,current approaches have yet to be identified to control adsorbed protein identities within the ***,we report the development and characterization of diverse zwitterionic peptides(ZIPs)for NP anti-fouling surface functionalization with specific and controllable affinity for protein adsorption profiles defined by ZIP *** serum exposure of ZIP-conjugated NPs and proteomics analysis of the resulting corona,we determined that protein adsorption profiles depend not on the exact composition of the ZIPs but on the sequence and order of charges along the sequence(charge motif).These findings pave the way for developing tunable ZIPs to orchestrate specific ZIP-NP protein adsorption profiles as a function of ZIP charge motif to better control cell and tissue specificity and pharmacokinetics and provide new tools for investigating relationships between protein corona and biological ***,overall ZIP diversity enabled by the diversity of amino acids may ameliorate adaptive immune responses.