The role of protein phosphorylation in the regulation of class switch recombination

作     者：KANO TANABE RYUTARO KAJIHARA 

作者机构：Department of Medical TechnologyFaculty of Health ScienceKumamoto Health Science UniversityKumamoto861-5598Japan Department of Biomedical Laboratory SciencesFaculty of Life SciencesKumamoto UniversityKumamoto862-0976Japan Center for ImmunotherapyRoswell Park Comprehensive Cancer CenterBuffaloNY 14263USA 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2020年第44卷第4期

页      面：545-558页

核心收录：

学科分类：120202[管理学-企业管理（含：财务管理、市场营销、人力资源管理）] 12[管理学] 1202[管理学-工商管理] 

基　　金：JSPS KAKENHI Grant No.18K15369 JSPS KAKENHI Grant No.18K16165 

主　　题：Antibody Kinase Phosphatase Signal Transduction 

摘      要：Antibody is an important part of adaptive immune system and is produced only by B *** are five main classes(IgM,IgD,IgG,IgA,IgE)and some subclasses in *** and IgD are produced by mature naïve B *** the other hand,IgG,IgA and IgE are produced by activated antigen-specific B cells via class switch recombination(CSR).CSR is the irreversible DNA rearrangement from upstream to downstream classes in immunoglobulin heavy chain ***-stimulations of CD40 ligand(CD40L)and cytokines are required for induction of CSR by activating several transcription *** signal transduction pathways involve many protein *** or dephosphorylation of cellular protein is an important kind of post-translational protein modification in intracellular signal *** the fact,more than one third of the intracellular proteins are said to be transiently phosphorylated in human.A protein kinase is an enzyme that catalyzes the addition of phosphate to substrate ***,a protein phosphatase catalyzes the removal of phosphate from the *** review focuses on the mechanism of CSR controlled by protein phosphorylation and *** provide the role of protein kinase and phosphatase in the regulation of class switch recombination.