检索结果-南通市图书馆

Creating large EMS populations for functional genomics and breeding in wheat

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第2期23卷 484-493页

作者： Wenqiang Wang Xizhen Guan Yong Gan Guojun Liu Chunhao Zou Weikang Wang Jifa Zhang Huifei Zhang Qunqun Hao Fei Ni Jiajie Wu Lynn Epstein Daolin Fu Spring Valley Agriscience Co. Ltd.Jinan 250300China College of Life Sciences Zaozhuang UniversityZaozhuang 277160China National Key laboratory of Wheat Improvement College of AgronomyShandong Agricultural UniversityTai’an 271018China Department of Plant Pathology University of CaliforniaDavisCA 95616USA

Wheat germplasm is a fundamental resource for basic research,applied studies,and wheat breeding,which can be enriched normally by several paths,such as collecting natural lines,accumulating breeding lines,and introducing mutagenesis *** methane sulfonate(EMS)is an alkylating agent that can effectively introduce genetic variations in a wide variety of plant *** this study,we created a million-scale EMS population(MEP)that started with the Chinese wheat cultivars‘Luyan 128’,‘Jimai 38’,‘Jimai 44’,and‘Shannong 30’.In the M1 generation,the MEP had numerous phenotypical variations,such as>3,000 chlorophyll-deficient mutants,2,519 compact spikes,and 1,692 male sterile *** were also rare mutations,including 30 independent tillers each with double *** M1 variations of chlorophyll-deficiency and compact spikes were inheritable,appearing in the M2 or M3 *** advance the entire MEP to higher generations,we adopted a single-seed descendent(SSD)*** other seed composites of M2 were used to screen other agronomically important traits,such as the tolerance to herbicide *** MEP is available for collaborative projects,and provides a valuable toolbox for wheat genetics and breeding for sustainable agriculture.

关键词： wheat germplasm ethyl methane sulfonate genetics and breeding

NSUN2-mediated mRNA m^(5)C Modification Regulates the Progression of Hepatocellular Carcinoma

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2023年第4期21卷 823-833页

作者： Dan Song Ke An Wenlong Zhai Luyao Feng Yingjie Xu Ran Sun Yueqin Wang Yun-Gui Yang quancheng Kan Xin Tian Department of Pharmacy the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China CAS Key laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Henan Key laboratory of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhou 450052China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key laboratory of Digestive Organ Transplantation of Henan Province Zhengzhou UniversityZhengzhou 450052China

RNA modifications affect many biological processes and physiological *** 5-methylcytosine(m^(5)C)modification regulates the progression of multiple ***,its characteristics and functions in hepatocellular carcinoma(HCC)remain largely ***,we found that HCC tissues had a higher m^(5)C methylation level than the adjacent normal *** analysis revealed that the hypermethylated genes mainly participated in the phosphokinase signaling pathways,such as the Ras and PI3K-Akt *** m^(5)C methyltransferase NSUN2 was highly expressed in HCC ***,the expression of many genes was positively correlated with the expression of NSUN2,including GRB2,RNF115,AATF,ADAM15,RTN3,and ***-time PCR assays further revealed that the expression of the mRNAs of GRB2,RNF115,and AATF decreased significantly with the down-regulation of NSUN2 expression in HCC ***,NSUN2 could regulate the cellular sensitivity of HCC cells to sorafenib via modulating the Ras signaling ***,knocking down NSUN2 caused cell cycle *** together,our study demonstrates the vital role of NSUN2 in the progression of HCC.

关键词： 5-methylcytosine Hepatocellular carcinoma NSUN2 Ras pathway Sorafenib

RNA Structural Dynamics Modulate EGFR-TKI Resistance Through Controlling YRDC Translation in NSCLC Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2023年第4期21卷 850-865页

作者： Boyang Shi Ke An Yueqin Wang Yuhan Fei Caixia Guo Qiangfeng Cliff Zhang Yun-Gui Yang Xin Tian quancheng Kan Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Henan Key laboratory of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhou 450052China Key laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China MOE Key laboratory of Bioinformatics Center for Synthetic and Systems BiologyBeijing Advanced Innovation Center for Structural BiologyTsinghua-Peking Joint Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China

Epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs)positively affect the initial control of non-small cell lung cancer(NSCLC).Rapidly acquired resistance to EGFR-TKIs is a major hurdle in successful ***,the mechanisms that control the resistance of EGFR-TKIs remain largely *** structures have widespread and crucial functions in many biological regulations;however,the functions of RNA structures in regulating cancer drug resistance remain ***,the psoralen analysis of RNA interactions and structures(PARIS)method is used to establish the higher-order RNA structure maps of EGFRTKIs-resistant and-sensitive cells of *** results show that RNA structural regions are enriched in untranslated regions(UTRs)and correlate with translation efficiency(TE).Moreover,yrdC N6-threonylcarbamoyltransferase domain containing(YRDC)promotes resistance to *** structure formation in YRDC 30 UTR suppresses embryonic lethal abnormal vision-like 1(ELAVL1)binding,leading to EGFR-TKI sensitivity by impairing YRDC translation.A potential therapeutic strategy for cancer treatment is provided using antisense oligonucleotide(ASO)to perturb the interaction between RNA and *** study reveals an unprecedented mechanism through which the RNA structure switch modulates EGFR-TKI resistance by controlling YRDC mRNA translation in an ELAVL1-dependent manner.

关键词： RNA structure EGFR-TKI resistance Non-small cell lung cancer YRDC ELAVL1

Observation of flat-band and band transition in the synthetic space

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanced Photonics 2022年第3期4卷 114-121页

作者： Guangzhen Li Luojia Wang Rui Ye Shijie Liu Yuanlin Zheng Luqi Yuan Xianfeng Chen Shanghai Jiao Tong University School of Physics and AstronomyState Key Laboratory of Advanced Optical Communication Systems and NetworksShanghaiChina Shanghai Research Center for Quantum Sciences ShanghaiChina Shandong Normal University Collaborative Innovation Center of Light Manipulation and ApplicationsJinanChina

.Constructions of synthetic lattices in modulated ring resonators attract growing attention to interesting physics beyond the geometric dimensionality,where complicated connectivities between resonant frequency modes are explored in many theoretical *** implement experimental demonstration of generating a stub lattice along the frequency axis of light,in two coupled ring resonators of different lengths,with the longer one dynamically *** a synthetic photonic structure intrinsically exhibits the physics of flat *** show that the time-resolved band structure read-out from the drop-port output of the excited ring is the intensity projection of the band structure onto a specific resonant mode in the synthetic momentum space,where gapped flat band,mode localization effect,and flat-to-nonflat band transition are observed in experiments and verified by *** work provides evidence for constructing a synthetic stub lattice using two different rings,which,hence,makes a solid step toward experimentally constructing complicated lattices in multiple rings associated with synthetic frequency dimensions.

关键词： synthetic dimensions ring resonators dynamic modulation flat band.

Measurement-device-independent quantum key distribution protocol with phase post-selection

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2022年第7期10卷 1703-1711页

作者： CONG JIANG XIAO-LONG HU ZONG-WEN YU XIANG-BIN WANG Jinan Institute of Quantum Technology Jinan 250101China State Key laboratory of Low Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China School of Physics State Key Laboratory of Optoelectronic Materials and TechnologiesSun Yat-sen UniversityGuangzhou 510275China Data Communication Science and Technology Research Institute Beijing 100191China Shanghai Branch CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum PhysicsUniversity of Science and Technology of ChinaShanghai 201315China Shenzhen Institute for Quantum Science and Engineering and Physics DepartmentSouthern University of Science and TechnologyShenzhen 518055China Frontier Science Center for Quantum Information BeijingChina

Measurement-device-independent quantum key distribution(MDI-QKD)protocol can remove all the loopholes of the detection devices and,thus,has attracted much *** on the technique of single-photon interference,we propose a modified MDI-QKD protocol with phase *** prove the security of the announcement of the private phases in the X basis and show how to apply the phase post-selection method to the double-scanning four-intensity MDI-QKD *** numerical results show that the phase postselection method can significantly improve the key rates at all *** the double-scanning method,two parameters need to be scanned in the calculation of the final key rate,and the global parameter optimization is pretty *** propose an accelerated method that can greatly reduce the running time of the global parameter optimization *** makes the method practically useful in an unstable channel.

关键词： distribution phase quantum

Terahertz radiation enhancement in photoconductive antennas with embedded split-ring resonators

在线全文

学校读者我要写书评

暂无评论

Chinese Optics Letters 2020年第11期18卷 82-87页

作者：邓琥屈薇薇刘泉澄武志翔尚丽平 School of Information Engineering Southwest University of Science and TechnologyMianyang 621010China Joint laboratory for Extreme Conditions Matter Properties Southwest University of Science and TechnologyMianyang 621010China

This Letter proposes a novel method for enhancing terahertz(THz) radiation from microstructure photoconductive antennas(MSPCA). We present two types of MSPCA, which contain split-ring resonators(SRRs) and dipole photoconductive antennas(D-PCAs). The experimental results reveal that when the femtosecond laser is pumping onto the split position of the SRR, the maximum THz radiation power is enhanced by 92 times compared to pumping at the electrode edge of the D-PCA. Two π phase shifts occur as the pumping laser propagates from the negative electrode to the positive electrode. Analysis shows that photoinduced carrier charges move within the split position of the SRR.

关键词： terahertz microstructure photoconductive antenna split-ring resonators

Nonlinear Generation of Perfect Vector Beams in Ultraviolet Wavebands

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2022年第3期39卷 17-21页

作者：李慧刘海港杨洋飞飞陆瑞锋陈险峰 Institute of Ultrafast Optical Physics Department of Applied Physics&MIIT Key Laboratory of Semiconductor Microstructure and Quantum SensingNanjing University of Science and TechnologyNanjing 210094China State Key laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Research Center for Quantum Sciences Shanghai 201315China Jinan Institute of Quantum Technology Jinan 250101China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China

Perfect vector beams are a class of special vector beams with invariant radius and intensity profiles under changing topological ***,with the limitation of current devices,the generation of these vector beams is limited in the visible and infrared ***,we generate perfect vector beams in the ultraviolet region assisted by nonlinear frequency *** and simulation results show that the radius of the generated ultraviolet perfect vector beams remains invariant and is thus independent of the topological ***,we measure the power of the generated ultraviolet perfect vector beams with the change of their topological *** study provides an alternative approach to generating perfect vector beams for ultraviolet wavebands and may promote their application to optical trapping and optical communication.

关键词： bands ultraviolet topological

界面超分子交联提高柔性、可拉伸和磁性Fe_(3)O_(4)@Ti_(3)C_(2)Tx/弹性体的机械和电磁屏蔽性能

在线全文

学校读者我要写书评

暂无评论

Science China Materials 2021年第6期64卷 1437-1448页

作者：宋权乘陈彬霞周泽航卢灿辉 State Key laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China

电磁干扰和辐射无处不在,可能对电子设备的正常运行和人体健康造成危害.MXene具有出色的金属导电性和可调的表面化学,在屏蔽材料的制备中极具吸引力.本文通过结构设计和界面调控,制备了具有隔离网络结构的柔性Fe_(3)O_(4)@Ti_(3)C_(2)Tx... 详细信息

电磁干扰和辐射无处不在,可能对电子设备的正常运行和人体健康造成危害.MXene具有出色的金属导电性和可调的表面化学,在屏蔽材料的制备中极具吸引力.本文通过结构设计和界面调控,制备了具有隔离网络结构的柔性Fe_(3)O_(4)@Ti_(3)C_(2)Tx MXene/3,4-二羟基苯基乙酸(DOPAC)-环氧化天然橡胶(ENR)弹性体(FMDE).Fe_(3)O_(4)与DOPAC配体分子之间的金属-配体配位交联提供了强大的界面相互作用,从而显著增强复合材料的机械性能.与Ti_(3)C_(2)Tx/ENR弹性体相比,FMDE的最大拉伸强度和韧性分别提高了~306%和~475%.此外,借助ENR胶乳的体积排斥效应构建的3D隔离导电网络,以及引入的磁性Fe_(3)O_(4)纳米颗粒有效地改善了FMDE的电磁屏蔽性能,且证实了FMDE在反复弯曲拉伸后仍具有稳定的电磁屏蔽能力.

关键词： Ti_(3)C_(2)Tx epoxidized natural rubber Fe_(3)O_(4) metalligand coordination electromagnetic interference shielding

Involvement of long non-coding RNAs in the progression of esophageal cancer

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2021年第5期41卷 371-388页

作者： Wenhua Xue Yuanyuan Zheng Zhibo Shen Lifeng Li Zhirui Fan Wenbin Wang Zijia Zhu Yunkai Zhai Jie Zhao quancheng Kan Department of Pharmacy the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052P.R.China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052P.R.China Internet Medical and System Applications of National Engineering laboratory ZhengzhouHenan 450052P.R.China Henan Key laboratory of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhouHenan 450052P.R.China

Esophageal cancer(EC)is one of the most common malignant tumors of the digestive system with high incidence and mortality rate ***,exploring the pathogenesis of ECand searching for new targeted therapies are the current research hotspot for EC *** non-coding RNAs(lncRNAs)are endogenous RNAs with more than 200 nucleotides,but without proteincoding *** recent years,lncRNAs have gradually become the focuses in the field of non-coding *** lncRNAs have been proved to be closely related to the pathogenesis of *** lncRNAs are abnormally expressed in EC and participate in many biological processes including cell proliferation,apoptosis,and metastasis by inhibiting or promoting target gene *** can also regulate the progression of EC through epithelial-mesenchymal transformation(EMT),which is closely related to the occurrence,development,and prognosis of *** this article,we review and discuss the involvement of lncRNAs in the progression of EC.

关键词： apoptosis biomarker diagnosis drug resistance esophageal cancer long non-coding RNA metastasis prognosis proliferation