Involvement of long non-coding RNAs in the progression of esophageal cancer
作者机构：Department of Pharmacythe First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052P.R.China Department of Oncologythe First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052P.R.China Internet Medical and System Applications of National Engineering LaboratoryZhengzhouHenan 450052P.R.China Henan Key Laboratory of Precision Clinical PharmacyZhengzhou UniversityZhengzhouHenan 450052P.R.China
出 版 物：《Cancer Communications》 (癌症通讯（英文）)
年 卷 期：2021年第41卷第5期
页 面：371-388页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the Natural Science Foundation of Henan Province of China(202300410460) Henan Province Medical Science and Technology Research Project Joint Construction Project(Grant No.LHGJ20190003,LHGJ20190055) the National Natural Science Foundation of China(Grant No.31670895)
主 题：apoptosis biomarker diagnosis drug resistance esophageal cancer long non-coding RNA metastasis prognosis proliferation
摘 要：Esophageal cancer(EC)is one of the most common malignant tumors of the digestive system with high incidence and mortality rate ***,exploring the pathogenesis of ECand searching for new targeted therapies are the current research hotspot for EC *** non-coding RNAs(lncRNAs)are endogenous RNAs with more than 200 nucleotides,but without proteincoding *** recent years,lncRNAs have gradually become the focuses in the field of non-coding *** lncRNAs have been proved to be closely related to the pathogenesis of *** lncRNAs are abnormally expressed in EC and participate in many biological processes including cell proliferation,apoptosis,and metastasis by inhibiting or promoting target gene *** can also regulate the progression of EC through epithelial-mesenchymal transformation(EMT),which is closely related to the occurrence,development,and prognosis of *** this article,we review and discuss the involvement of lncRNAs in the progression of EC.
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