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Chinese Chemical Letters 2001年第4期12卷 293-296页

作者： Zhao Yang WANG Jia Ling CUI Bao Shan DU Qing Hua CHEN Department of Chemistry Beijing Normal UniversityBeijing 100875 Dept.of Chem. South China Nor.UnivGuangzhou 510631 present address:school of pharm. Beijing UnivBeijing 100033

1,4-Addition reaction of Grignard's reagent to 5-methoxy-2(5H)-furanone 1 was accomplished. which provided a new possible route for synthesizing beta -alkyl-Y-alkyloxy-Y-butyrolactone. A novel concise method of prepar... 详细信息

关键词： Michael addition Grignard reagent 1 3-dipolar cycloaddition silyl nitronates.

A review of research on coumarins from Radix Glehniae

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Asian Journal of Traditional Medicines 2020年第4期15卷 193-201页

作者： Lili Wang Zhong Yuan Medical and Nursing Branch Panjin Vocational and Technical CollegePanjin 124000PR China school of Traditional Chinese Materia Medica Shenyang Pharm aceutical UniversityShenyang 110016PR China

Radix Glehniae,with a wide range of chemical components of various pharm.cological effects,is widely used in the prevention and treatment of various diseases in clinical *** has a broad prospect of development and ***,as one of its major active components,also displays good biological activities for analgesia and sedation,antibacteria,antivirus,anti HIV,anti-inflammation,anti-tumor,anti mutation,tyrosinase inhibition,vasodilation and blood pressure *** aim of the present review is to discuss the studies on coumarin components,content determination,pharm.cological activities,processing methods and provide a guide for the further development and utilization of Radix Glehniae.

关键词： Radix Glehniae coumarin content determination pharm.cological activity processing method

Yak rumen microbiome elevates fiber degradation ability and alters rumen fermentation pattern to increase feed efficiency

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Animal Nutrition 2022年第4期11卷 201-214页

作者： Congcong Zhao Lamei Wang Shanlin Ke Xinhua Chen Akos Kenez Wei Xu Dangdang Wang Fan Zhang Yong Li Zhanhong Cui Yu Qiao Jing Wang Wenjuan Sun Jianhua Zhao Junhu Yao Zhongtang Yu Yangchun Cao College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxiChina Division of Gastroenterology Department of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical SchoolBostonMAUSA Department of Infectious Diseases and Public Health City University of Hong KongKowloonHong KongChina Qinghai Academy of Animal Husbandry and Veterinary Sciences Qinghai UniversityXiningQinghaiChina Department Animal Engineering Yangling Vocational&Technical CollegeYanglingShaanxiChina Shanghai Majorbio Bio-pharm.Technology Co. Ltd.ShanghaiChina Department of Animal Sciences The Ohio State UniversityColumbusOHUnited States

Rumen microbes play an important role in ruminant energy supply and animal *** studies showed that yak(Bos grunniens)rumen microbiome and fermentation differ from other ***,little is understood about the features of the rumen microbiome that make yak adapted to their unique environmental and dietary *** study was to investigate the rumen microbiome and metabolome to understand how yak adapt to the coarse forage and harsh environment in the Qinghai-Tibetan *** female Qaidam yellow cattle(Bos taurus),9 dzomo(hybrids of cattle and yak)and 9 female plateau yak(***),about 5 to 6 years old,were used in this *** fermentation parameters,fibrolytic enzyme activities,and rumen metataxonomic were *** 18(6 samples per group)were selected for rumen metagenomic and metabolome *** analysis revealed that the rumen microbiota was significantly different among plateau yak,Qaidam yellow cattle,and dzomo(Ppresent study showed that the rumen microbiome of plateau yak h

关键词： High plateau ruminant Rumen microbiome Metagenome Metabolome

Possible mechanism of benvitimod in atopic dermatitis and psoriasis

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Journal of Chinese pharm.ceutical Sciences 2022年第12期31卷 901-911页

作者： Jin Hu Jiajun Xue Juan Shen Beijing Wenfeng Tianji pharm Ltd.Changping 102200BeijingChina Zhonghao pharm.ceutical Zhongshan 538427GuangdongChina

Atopic dermatitis(AD)and psoriasis are common chronic and relapsing inflammatory skin diseases mainly mediated by T *** 2 and 17 inflammations are essential in the pathogenesis of AD and psoriasis,*** evidence suggests that benvitimod,a natural metabolite produced by bacterial symbionts,plays a therapeutic role in the development and progression of both AD and ***,the two most potent interactions with benvitimod are observed in the aryl hydrocarbon receptor(AhR)and nuclear factor-erythroid 2-related factor-2(Nrf2)***,it remains largely unknown how is the local interplay among benvitimod,AhR,and Nrf2,and how the epithelial microenvironment contributes to the complex inflammatory context that results in the treatment of AD and *** the present study,the modulatory effects of benvitimod on treating AD and psoriasis.

关键词： Benvitimod Atopic dermatitis Psoriasis Tapinarof AhR Nrf2

Testicular volume and clinical correlates of hypothalamic–pituitary–testicular function:A cross-sectional study in obese men

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Asian Journal of Andrology 2020年第4期22卷 354-359页

作者： Mark Ng Tang Fui Rudolf Hoermann Gary Wittert Mathis Grossmann Department of Medicine Austin Health University of MelbourneMelbourneVictoria 3084Australia Department of Endocrinology Austin HealthMelbourneVictoria 3084Australia school of Medicine University of AdelaideAdelaideSouth Australia 5005Australia

The aim of this study was to determine whether testicular volume is correlated with clinical and biochemical markers of hypothalamic–pituitary–testicular(HPT)axis *** was a cross-sectional substudy of a larger randomized controlled trial including obese men,body mass index(BMI)≥30 kg m−2,with a total testosterone levelpresent in a multivariable model,only BMI(-0.38 ml change in testicular volume per 1 kg m-2BMI;95%CI:−0.74,−0.02;P=0.04)and LH(-0.92 ml change in testicular volume per 1 IU l-1 LH;95%CI:−1.75,−0.095;P=0.03)remained independent significant predictors of testicular *** volume was positively correlated with IIEF-5(τ=0.2092,P=0.021),but not related to handgrip strength,physical function tests,or *** obese men,testicular volume is inversely and independently associated with measures of adiposity,but not with most clinical or biochemical markers of HPT axis *** a clinical perspective,this suggests that obesity might compromise the reliability of reduced testicular volume as a sign of androgen deficiency in men.

关键词： hypothalamic-pituitary-gonadal axis testicular volume testosterone

Melanoma: Surgery Subsequent to PDT—Is It Worth Doing? A 10-Year Pilot Trial Using Chlorin-Type Photosensitizer Bremachlorin<sup>&reg</sup>

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Journal of Cancer Therapy 2017年第10期8卷 902-912页

作者： Evgeniy I. Volkov Andrei V. Reshetnickov Harrie Vink State Budget Healthcare Facility “Sverdlovskiy Oblastnoy Oncologicheskiy Dispancer” Ekaterinburg Russia AREV pharm.LLC. Moscow Russia RADA-pharm. International B.V. Steenbergen The Netherlands

Bremachlorin®, also known as “Radachlorin®” and Photochlorin, a composition of 3 chlorophyll a derivatives in an aqueous solution [1], was initially introduced into the Russian and South Korean pharm.copoeias with the corresponding marketing authorizations received in 2006 and 2008, on the basal cell skin carcinoma PDT protocol. Phase I-II clinical trials led in 2002-2005 showed no side effects, a good tolerability by patients and a high clinical anti-tumor efficacy. Further studies described in the present paper were fulfilled in accordance with a skin melanoma PDT + surgery combined technique protocol in 2006-2016. Resulting from the present trial, up to the 100% complete responses were achieved after resection and plastic surgery following PDT, with no melanoma regrowth or metastases during 5 and 10-year observation periods. Conducting PDT one day prior to tumor dissection can guarantee to meet the ablastics principles at the subsequent surgery. At the same time, the PDT + surgery protocol can allow for dissecting the tumor with less distance from its edge, which seems to be important for the face localizations of tumors.

关键词： Melanoma Skin PDT Radahlorin Radachlorin Bremachlorin Photochlorin Laser Cancer

JTE-522-induced apoptosis in human gastric adenocarinoma cell line AGS cells by caspase activation accompanying cytochrome C release,membrane translocation of Bax and loss of mitochondrial membrane potential

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World Journal of Gastroenterology 2002年第2期8卷 217-223页

作者： Hong-Liang Li Xiao-Hong Li Jun-Hua Lü Xian-Da Ren,Department of pharm.cology,Jinan University pharm.cy College,Guangzhou 510632,Guangdong Province,China Dan-Dan Chen,Department of Cardiology,First Affiliated Hospital,Zhongshan University,Guangzhou 510089,Guangdong Province,China Hai-Wei Zhang,Department of Pathology,Jinan University Medical College,Guangzhou 510632,Guangdong Province,China Cun-Chuan Wang,Department of laparoscopic surgery,First Affiliated Hospital,Jinan University Medical College,Guangzhou 510632,Guangdong Province,China Jinan Univ Coll Pharm Dept Pharmacol Guangzhou 510632 Guangdong Prov Peoples R China Zhongshan Univ Affiliated Hosp 1 Dept Cardiol Guangzhou 510089 Guangdong Prov Peoples R China Jinan Univ Coll Med Dept Pathol Guangzhou 510632 Guangdong Prov Peoples R China Jinan Univ Coll Med Affiliated Hosp 1 Dept Iaparoscop Surg Guangzhou 510632 Guangdong Prov Peoples R China

AIM: To investigate the role of the mitochondrial pathway in JTE-522-induced apoptosis and to investigate the relationship between cytochrome C release, caspase activity and loss of mitochondrial membrane potential (Deltapsim). METHODS: Cell culture, cell counting, ELISA assay, TUNEL, flow cytometry, Western blot and fluorometric assay were employed to investigate the effect of JTE-522 on cell proliferation and apoptosis in AGS cells and related molecular mechanism. RESULTS: JTE-522 inhibited the growth of AGS cells and induced the apoptosis. Caspases 8 and 9 were activated during apoptosis as judged by the appearance of cleavage products from procaspase and the caspase activities to cleave specific fluorogenic substrates. To elucidate whether the activation of caspases 8 and 9 was required for the apoptosis induction, we examined the effect of caspase-specific inhibitors on apoptosis. The results showed that caspase inhibitors significantly inhibited the apoptosis induced by JTE-522. In addition, the membrane translocation of Bax and cytosolic release of cytochrome C accompanying with the decrease of the uptake of Rhodamin 123, were detected at an early stage of apoptosis. Furthermore, Bax translocation, cytochrome C release, and caspase 9 activation were blocked by *** and Z-IETD-CHO. CONCLUSION: The present data indicate a crucial association between activation of caspases 8, 9, cytochrome C release, membrane translocation of Bax, loss of Deltapsim and JTE-522-induced apoptosis in AGS cells.

关键词： Adenocarcinoma Stomach Neoplasms Amino Acid Chloromethyl Ketones Anti-Inflammatory Agents, Non-Steroidal Apoptosis Benzenesulfonates Caspases inhibitors Cyclooxygenase Inhibitors Cysteine Proteinase Inhibitors Cytochrome c Group Enzyme Activation Humans In Situ Nick-End Labeling Membrane Potentials Mitochondria Oxazoles Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Research Support, Non-U.S. Gov't Tumor Cells, Cultured bcl-2-Associated X Protein

J Clin pharm.Ther：外用聚维酮碘溶液能够导致血糖测量值高估

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现代生物医学进展 2016年第32期16卷 I0003-I0004页

作者： A. M. Lipshutz pharm. BCPS E. M. Hawes pharm. BCPS CPP Department of pharm.cy Mount Carmel West Hospital Columbus OH USA Department of pharm.cy UNC Medical Center Chapel Hill NC USA UNC Eshelman school of pharm.cy Chapel Hill NC USA Department of Family Medicine UNC School of Medicine Chapel Hill NC USA

血液中的糖分称为血糖，绝大多数情况下都是葡萄糖（英文简写Glu）。体内各组织细胞活动所需的能量大部分来自葡萄糖，所以血糖必须保持一定的水平才能维持体内各器官和组织的需要。根据一项病例报告，使用外用碘溶液能够导致血糖测量... 详细信息

血液中的糖分称为血糖，绝大多数情况下都是葡萄糖（英文简写Glu）。体内各组织细胞活动所需的能量大部分来自葡萄糖，所以血糖必须保持一定的水平才能维持体内各器官和组织的需要。根据一项病例报告，使用外用碘溶液能够导致血糖测量值高估。相关研究结果在线发表在Journal of Clinincal pharm.cy and Therapeutics期刊上。论文标题为＂Probable glucometer interference caused by topical iodine solution test site preparation＂。

关键词：测量值碘溶液血糖外用细胞活动病例报告 site 葡萄糖

Stigma and epilepsy in onchocerciasisendemic regions in Africa:a review and recommendations from the onchocerciasisassociated epilepsy working group

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Infectious Diseases of Poverty 2019年第3期8卷 21-31页

作者： Sarah O'Neill Julia Irani Joseph Nelson Siewe Fodjo Denis Nono Catherine Abbo Yasuaki Sato Augustine Mugarura Housseini Dolo Maya Ronse Alfred K.Njamnshi Robert Colebunders CRISS-school of Public Health Universite Libre de Bruxelles and LAMC Faculte de Philosophie et de Sciences Sociales Universite Libre de BruxellesBrusselsBelgium Department of Public health Institute o f Tropical MedicineAntwerpBelgium Global Health Institute University of AntwerpAntwerpBelgium Department of Mental Health Austrian Partnership Programme in Higher Education and Research for Developm ent(APPEAR)Project&AVSI FoundationGulu UniversityGuluUganda Department of Psychiatry Makerere UniversityKampalaUganda Department of Environmental Science and Technology Osaka Sangyo UniversityOsakaJapan Epilepsy Support Association of Uganda WakisoUganda Department of Neurology Yaounde Central Hospital/FMBSThe University of Yaounde IBrain Research Africa Initiative(BRAIN)YaoundeCameroon

Background:In onchocerciasis-endemic areas,particularly in those with a sub-optimal onchocerciasis control programme,a high prevalence of epilepsy is *** onchocerciasis and epilepsy are stigmatizing *** first international workshop on onchocerciasis-associated epilepsy(OAE)was held in Antwerp,Belgium(12-14 October 2017)and during this meeting,an OAE alliance was *** this paper,we review what is known about epilepsy-associated stigma in onchocerciasis-endemic regions,and present the recommendations of the OAE alliance working group on *** body:For this scoping review,literature searches were performed on the electronic databases PubMed,Scopus and Science Direct using the search terms"epilepsy AND onchocerciasis AND stigma".Hand searches were also undertaken using Google Scholar,and in total seven papers were identified that addressed epilepsy-related stigma in an onchocercisasis-endemic *** to the limited number of published research papers on epilepsyassociated stigma in onchocerciasis-endemic areas,other relevant literature that describes important aspects related to stigma is *** thematic presentation of this scoping review follows key insights on the barriers to alleviating the social consequences of stigma in highly affected onchocerciasis-endemic areas,which were established by experts during the working group on stigma and discrimination at the first international workshop on *** themes are:knowledge gaps,perceived disease aetiology,access to education,marriage restrictions,psycho-social well-being,burden on the care-giver and treatment seeking *** on the literature and expert discussions during the OAE working group on stigma,this paper describes important issues regarding epilepsy-related stigma in onchocerciasis-endemic regions and recommends interventions that are needed to reduce stigma and discrimination for the improvement of the psycho-social well-being of persons with ***

关键词： Epilepsy Onchocerciasis Stigma,Anti-epileptic treatment Nodding syndrome Discrimination Misconception,Africa

Corrigendum to“Nitrosamines crisis in pharm.ceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review”[***.14(2024)100919]

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Journal of pharm.ceutical Analysis 2024年第6期14卷 934-936页

作者： Hemanth P.R.Vikram Tegginamath Pramod Kumar Gunjan Kumar Narasimha M.Beeraka Rajashree Deka Sheik Mohammed Suhail Sandeep Jat Namitha Bannimath Gayatiri Padmanabhan Ravandur S.Chandan Pramod Kumar Bannimath Gurupadayya Department of pharm.ceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare Pvt.Ltd. New Delhi110076India Department of pharm.ceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of pharm.cology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells Center for Pediatric Research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal Physiology and Biochemistry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of pharm.cology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of pharm.ceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of pharm.cology University of GalwayGalwayH91 TK33Ireland

Original statement in the Section 2:*** search Our primary screening of 180 articles yielded the relevant data for this *** selection A total of 180 articles spanning from 1960 to the present day,including original research,reviews,case reports and studies reporting nitrosamine impurities above the no-observed-adverse-effect levels(NOAEL)established by regulatory agencies,were initially *** the primary screening,we considered factors such as relevance,publication date,access to the full article text,and content.

关键词： statement initially spanning