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Review of anticancer mechanisms of isoquercitin

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World Journal of Clinical Oncology 2016年第2期7卷 189-199页

作者： Guilherme di Camillo Orfali Ana Carolina Duarte Vivien Bonadio Natalia Peres Martinez Maria Elisa Melo Branco de Araújo Fernanda Bruschi Marinho Priviero Patricia Oliveira Carvalho Denise Gon?alves Priolli Scientific Initiation program Sao Francisco University Medical School postgraduate program in health science Sao Francisco University Medical School

This review was based on a literature search of PubM ed and Scielo databases using the keywords "quercetin,rutin,isoquercitrin,isoquercitin(IQ),quercetin-3-glucoside,bioavailability,flavonols and favonoids,and cancer" and combinations of all the *** collected relevant scientific publications from 1990 to 2015 about the absorption,bioavailability,chemoprevention activity,and treatment effects as well as the underlying anticancer mechanisms of *** are a group of polyphenolic compounds widely distributed throughout the plant *** subclass of flavonols receives special attention owing to their health *** main components of this class are quercetin,rutin,and IQ,which is a flavonoid and although mostly found as a glycoside,is an aglycone(lacks a glycoside side chain).This compound presents similar therapeutic profiles to quercetin but with superior bioavailability,resulting in increased efficacy compared to the aglycone *** has therapeutic applications owing to its wide range of pharmacological effects including antioxidant,antiproliferative,anti-inflammatory,anti-hypertensive,and *** protective effects of IQ in cancer may be due to actions on lipid *** addition,the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway,mixed-lineage protein kinase 3,mitogen-activated protein kinase,apoptotic pathways,as well proinflammatory protein *** review contributed to clarifying the mechanisms of absorption,metabolism,and actions of IQ and isoquercitrin in cancer.

关键词： Drug screening assays Antitumor Cancer Flavonoids Flavonols Antioxidants Neoplasms

Maytenus erythroxylon Reissek(Celastraceae) ethanol extract presents antidiarrheal activity via antimotility and antisecretory mechanisms

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World Journal of Gastroenterology 2017年第24期23卷 4381-4389页

作者： Rodrigo de Oliveira Formiga Zelma Glebya Maciel Quirino Margareth de Fátima Formiga Melo Diniz Alexsandro Fernandes Marinho Josean Fechine Tavares Leonia Maria Batista postgraduate program in Natural Products and Bioactive Synthetics Health Sciences CenterFederal University of Paraiba Applied science and Education Center Federal University of Paraiba

To investigate the acute toxicity, phytochemical profile, antidiarrheal activity and mechanisms of action of Maytenus erythroxylon (M. erythroxylon) ethanol extract. METHODSA castor oil-induced diarrhea model was used to evaluate antidiarrheal activity. Intestinal transit and gastric emptying protocols were used to evaluate a possible antimotility effect. KATP channels, nitric oxide, presynaptic α2-adrenergic and tissue adrenergic receptors were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory mechanisms. RESULTSAll tested doses of the extract (62.5, 125, 250 and 500 mg/kg) possessed antidiarrheal activity, with a significant decrease of the evacuation index. This activity is possibly related to a reduced gastric emptying (125, 250 and 500 mg/kg) and to a decreased percentage of intestinal transit for all tested doses. That last effect seems to be modulated by nitric oxide, KATP channels and tissue adrenergic receptors. Besides, the extract also presented antisecretory effect due to a decrease of intestinal fluid accumulation. CONCLUSIONThe antidiarrheal effect of M. erythroxylon found in this study involves antimotility and antisecretory mechanisms that may be attributed to the chemical compounds found in this species: saponins, flavonoids, tannins, triterpenes and steroids.

关键词： Medicinal plants Celastraceae Maytenus erythroxylon Diarrhea Antidiarrheal activity

Rapid and scalable preparation of highly quaternized polymer networks to achieve efficient simultaneous adsorption of iodide and pertechnetate

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science China Chemistry 2025年第01期 337-349页

作者： Meiyun Xu Song Gu Fulong Chen Zhe Zhao Peng Liu Daoben Hua State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University

The efficient separation of fission products,such as TcO4-and I-,holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis（bromomethyl）benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups （Cl@QPN）,exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/（mg min） for ReO4-（a nonradioactive surrogate of TcO4-） and 0.677 g/（mg min） for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO4-and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for99TcO4-.Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO4-,respectively.

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Relationship between PM_(10) and PM_(2.5) levels in high-traffic area determined using path analysis and linear regression

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Journal of Environmental sciences 2018年第7期30卷 105-114页

作者： Narut Sahanavin Tassanee Prueksasit Kraichat Tantrakarnapa interdisciplinary program of Environmental science Graduate School Chulalongkorn University Department of Environmental science Faculty of Science Chulalongkorn University Department of Social and Environmental Medicine Faculty of Tropical Medicine Mahidol University

The objective of this study was to determine the relationship between PM10 and PM2.5 levels as related to meteorological conditions and traffic flow using both a linear regression analysis and a path analysis. The Particulate matter（PM） samples were collected from Sukhumvit road, Bangkok, Thailand, at both open（104 samples） and covered（92 samples）areas along the road. Fifteen percent of all samples were separated before the statistical models were run and used for model validation. The results from the path analysis were more elaborate than those from the linear regression, thus indicating that meteorological conditions had a direct effect on the particulate levels and that the effects of traffic flow were more variable in open areas. The model also indicated that meteorological conditions had an indirect effect and that traffic flow had a direct effect on particulate levels in covered areas. The model validation results indicated that for open areas, the R^2 values were not very different between the path analysis and the linear regression model, but that the path analysis was more accurate than the linear regression model at very low PM concentrations. At high PM concentrations, the path analysis model also had a better fit than did the linear regression, so the predictions from the path analysis model were more accurate than those from the linear regression.

关键词： Path analysis PM10 PM2.5 Open roadside area Covered roadside area

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Clinical and environmental isolates of Burkholderia pseudomallei from Brazil: Genotyping and detection of virulence gene

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Asian Pacific Journal of Tropical Medicine 2017年第10期10卷 945-951页

作者： Tereza de Jesus Pinheiro Gomes Bandeira Debora de Souza Collares Maia Castelo-Branco Marcos Fabio Gadelha Rocha Rossana de Aguiar Cordeiro Crister Jose Ocadaque Manoel de Araújo Neto Paiva Raimunda Samia Nogueira Brilhante Jose Júlio Costa Sidrim Specialized Medical Mycology Center Postgraduate Program in Medical Microbiology Federal University of Ceará Christus School of Medicine postgraduate program in Veterinary sciences State University of Ceará Federal Institute of Education Science and Technology of Ceará

Objective: To evaluate the genetic diversity of clinical and environmental isolates of Burkholderia pseudomallei(***) recovered in Ceara, Brazil, and screen these isolates for the presence of type three secretion system virulence ***: Nineteen *** isolates(9 from clinical cases and 10 from soils)were *** amplified polymorphic DNA was performed with primers OPQ-2, OPQ-4 and OPQ-16 to evaluate the genetic diversity, and type three secretion system gene was detected through polymerase chain ***: Random amplified polymorphic DNA showed a genetic relatedness of approximately 50% among the tested *** isolates, which were grouped into two clades, of which the biggest ones comprised 18/19 isolates for primer OPQ-2, and 17/19 isolates for primer *** OPQ-4 grouped the isolates into three clades comprising 1/19, 3/19 and 15/19 ***, type three secretion system gene was detected in all tested ***: This is an effort to type *** strains from Ceara, which is important for better understanding this pathogen, contributing for the epidemiological surveillance of melioidosis in this endemic region.

关键词： Burkholderia pseudomallei Melioidosis RAPD TTSS gene

Effectiveness of BNT162b2 and CoronaVac vaccines against omicron in children aged 5 to 11 years

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World Journal of Pediatrics 2023年第10期19卷 949-960页

作者： Eduardo A.Oliveira Maria Christina L.Oliveira Ana Cristina Simões e Silva Enrico A.Colosimo Robert H.Mak Mariana A.Vasconcelos Ludmila R.Silva Daniella B.Martelli Clara C.Pinhati Hercílio Martelli-Júnior Department of Pediatrics Health Sciences Postgraduate ProgramSchool of MedicineFederal University of Minas Gerais(UFMG)R.Engenheiro Amaro Lanari 389/501Belo HorizonteMG30130-100Brazil Department of Statistics Federal University of Minas GeraisBelo HorizonteMGBrazil Department of Pediatrics Rady Children’s HospitalUniversity of CaliforniaLa JollaSan DiegoCAUSA health science/postgraduate program in Nursing.School of Nursing Federal University of Minas Gerais(UFMG)Belo HorizonteMG30130-100Brazil health science/Primary Care postgraduate program State University of Montes Claros(Unimontes)Montes ClarosMG39401-089Brazil

Background This study aimed to estimate vaccine effectiveness(VE)against omicron variant infection and severe corona virus disease 2019(COVID-19)in children aged 5–11 years hospitalized with acute respiratory *** A test-negative,case–control analysis was conducted from February 2022 to June *** enrolled 6950 eligible children,including 1102 cases and 5848 *** was calculated after immunization with one and two doses of BNT162b2 or *** outcomes were hospitalization with acute respiratory symptoms and detection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and severe *** adjusted odds ratio for the association of prior vaccination and outcomes was used to estimate *** For fully vaccinated children,the overall estimated VE against hospitalization with SARS-CoV-2 infection was 42%[95%confidence interval(CI)26 to 54].VE peaked at 29–42 days(67%,95%CI 40%to 82%)and then declined to 19%(95%CI,−20%to 45%)at 57–120 days after the second *** BNT162b2 vaccine had a similar VE against hospitalization with SARS-CoV-2 infection(45%,95%CI,20 to 61)compared to the CoronaVac vaccine(40%,95%CI,17%to 56%).Among cases,56(5%)children died;53(94.6%)were not fully *** cases,the two-dose schedule effectiveness against ICU admission,need for invasive ventilation,severe illness,and death were 10%(95%CI,−54%–45%),22%(95%CI−70%–68%),12%(95%CI,−62%–52%),and 16%(95%CI,−77%–75%),*** For hospitalized children aged 5–11 years during the omicron-predominant period in Brazil,two doses of both vaccines had moderate effectiveness against hospitalization with acute respiratory symptoms and SARS-CoV-2 infection and offered limited protection against endpoints of COVID-19 severity.

关键词： Children COVID-19 Effectiveness Omicron Vaccine

Baseball pitching kinematics,joint loads,and injury prevention

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Journal of Sport and health science 2012年第2期1卷 80-91页

作者： Sakiko Oyama interdisciplinary program of Human Movement science Department of Exercise and Sport ScienceUniversity of North Carolina at Chapel HillChapel HillNC 27599USA

There is a need for the prevention of upper extremity injuries that affect a large number of competitive baseball *** available evidence alludes to three possible ways to prevent these injuries:1) regulation of unsafe participation factors,2) implementation of exercise intervention to modify suboptimal physical characteristics,and 3) instructional intervention to correct improper pitching *** these three strategies,instruction of proper pitching technique is under-explored as a method of injury ***,the purpose of this review was to explore the utility of pitching technique instruction in prevention of pitching-related upper extremity injuries by presenting evidence linking pitching technique and pitching-related upper extremity injuries,as well as identifying considerations and potential barriers in pursuing this approach to prevent *** kinematic parameters measured using laboratory-based motion capture system have been linked to excessive joint loading,and thus pitching-related upper extremity *** we gain more knowledge about the influence of pitching kinematics on joint loading and injury risk,it is important to start exploring ways to modify pitching technique through instruction and feedback while considering the specific skill components to address,mode of instruction,target population,duration of program,and ways to effectively collaborate with coaches and parents.

关键词： Athletic training Baseball Instruction Intervention Pitching biomechanics Sport medicine

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Life cycle analysis of palm kernel shell gasification for supplying heat to an asphalt mixing plant

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Waste Disposal and Sustainable Energy 2020年第1期2卷 55-63页

作者： Sunu Herwi Pranolo Prabang Setyono Muhammad Akvis Fauzi Study program of Chemical Engineering Faculty of EngineeringUniversitas Sebelas MaretSurakartaIndonesia Magister Study program of Environmental science PostgraduateUniversitas Sebelas MaretSurakartaIndonesia

The Government of the Republic of Indonesia states that the thermal energy for hot-mixed asphalt production shall be supplied by the direct combustion of fossil fuels in the form of diesel oil,natural gas,or fuel gas from coal gasification which may generate GHG *** are able to substitute the fossil fuels through gasification *** converts the biomass using limited air into gaseous fuel containing mainly CO and H_(2) that are subsequently combusted to produce heat,carbon dioxide,and *** is obvious that the CO_(2) is then absorbed by the plants for photosynthesis,main-taining a balanced closed *** study examines the level of global warming potential of this system for supplying heat based on the openLCA v1.9 *** analysis used a gate-to-gate approach to evaluate scenarios of shell gasification to produce 1 metric tonne of hot-mixed *** scope covers raw material supply and transportation,palm kernel shell gasification,and *** evaluation concludes that gasification could potentially reduce CO_(2) *** impact analysis and interpretation of the results using the openLCA database of Traci 2.1 recommend that greater CO_(2) emis-sion reduction is possible using palm kernel shell gasification,not only for supplying heat but also for electricity generation to operate all electrical equipments.

关键词： Global warming Gasification Palm kernel shell Life cycle analysis Hot-mixed asphalt

Sequence of the main geochemical controls on the Cu and Zn fractions in the Yangtze River estuarine sediments

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Frontiers of Environmental science & Engineering 2016年第1期10卷 19-27页

作者： Shou ZHAO Dongxin WANG Chenghong FENG Ying WANG Zhenyao SHEN Key Laboratory for Water and Sediment science of Ministry of Education School of Environment Beijing Normal University Beijing 100875 China interdisciplinary Life science Graduate program Purdue University West Lafayette IN 47907 USA

Metal speciation can provide sufficient infor- mation for environmental and geochemical researches. In this study, based on the speciation determination of Cu and Zn in the Yangtze Estuary sediments, roles of eight geochemical controls （i.e., total organic carbon （TOC）, clay, Fe/Mn in five chemical fractions and salinity） are fully investigated and sequenced with correlation analysis （CA） and principal components analysis （PCA）. Results show that TOC, clay and Fe/Mn oxides are key geochemical factors affecting the chemical speciation distributions of Cu and Zn in sediments, while the role of salinity appears to be more indirect effect. The influencing sequence generally follows the order： TOC 〉 clay 〉 Mn oxides 〉 Fe oxides 〉 salinity. Among the different fractions of Fe/Mn oxides, residual and total Fe content, and exchangeable and carbonate Mn exert the greatest influences, while exchangeable Fe and residual Mn show the poorest influences.

关键词： chemical speciation geochemical factors,estuaries sediments correlation salinity

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