Review of anticancer mechanisms of isoquercitin
isoquercitin 的 anticancer 机制的评论作者机构：Scientific Initiation ProgramSao Francisco University Medical School Postgraduate Program in Health ScienceSao Francisco University Medical School
出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)
年 卷 期：2016年第7卷第2期
页 面：189-199页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：Supported by Sao Paulo Research Foundation-FAPESP No.2012-04634-1
主 题：Drug screening assays Antitumor Cancer Flavonoids Flavonols Antioxidants Neoplasms
摘 要：This review was based on a literature search of PubM ed and Scielo databases using the keywords quercetin,rutin,isoquercitrin,isoquercitin(IQ),quercetin-3-glucoside,bioavailability,flavonols and favonoids,and cancer and combinations of all the *** collected relevant scientific publications from 1990 to 2015 about the absorption,bioavailability,chemoprevention activity,and treatment effects as well as the underlying anticancer mechanisms of *** are a group of polyphenolic compounds widely distributed throughout the plant *** subclass of flavonols receives special attention owing to their health *** main components of this class are quercetin,rutin,and IQ,which is a flavonoid and although mostly found as a glycoside,is an aglycone(lacks a glycoside side chain).This compound presents similar therapeutic profiles to quercetin but with superior bioavailability,resulting in increased efficacy compared to the aglycone *** has therapeutic applications owing to its wide range of pharmacological effects including antioxidant,antiproliferative,anti-inflammatory,anti-hypertensive,and *** protective effects of IQ in cancer may be due to actions on lipid *** addition,the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway,mixed-lineage protein kinase 3,mitogen-activated protein kinase,apoptotic pathways,as well proinflammatory protein *** review contributed to clarifying the mechanisms of absorption,metabolism,and actions of IQ and isoquercitrin in cancer.
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