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Prognostic implications of overt congestion in heart failure with preserved ejection fraction and the interaction with spironolactone:Insights from TOPCAT

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Chinese Medical Journal 2024年第10期137卷 1249-1251页

作者： Yingwen Lin Hengli Zhao Dongtu Hu Jia Huang You Peng Juncong Li Dingli Xu Qingchun Zeng State Key Laboratory of Organ Failure Research Department of CardiologyNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Guangdong Provincial Key Laboratory of Clinical Pharmacology Medical Research InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510515China Department of Radiology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510150China Department of Obstetrics and Gynecology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

To the Editor:Heart failure with preserved ejection fraction(HFpEF)is a clinical entity characterized by impaired diastolic *** recently,there have been few studies directly evaluating how volume status impacts future cardiac events for patients with *** supporting the application of spironolactone in HFpEF is mainly derived from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist(TOPCAT)*** though primary analysis of the trial reached a neutral result,subgroup and subsequent post hoc analyses have confirmed its efficacy in selected groups of patients,suggesting that identifying the potential subgroups of patients who would benefit from spironolactone treatment is important.[1]Data regarding the impact of congestion status on the efficacy of spironolactone in HFpEF are lacking.

关键词： function. fraction impaired

Exercise for stroke prevention

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Stroke & Vascular Neurology 2018年第2期3卷 59-68页

作者： Peter L Prior Neville Suskin Lawson Health Research Institution LondonOntarioCanada St.Josephs Health Care Cardiac Rehabilitation and Secondary Prevention program LondonOntarioCanada Department of Medicine(cardiology) Schulich School of Medicine&DentistryWestern UniversityLondonOntarioCanada

We review evidence concerning exercise for stroke *** biological reasons suggest that exercise would be important in preventing *** definitive randomised controlled trials evaluating the impact of physical activity(PA)and exercise on preventing stroke and mortality are lacking,observational studies,small randomised controlled trials and meta-analyses have provided evidence that PA and exercise favourably modify stroke risk factors,including hypertension,dyslipidaemia,diabetes,sedentary lifestyle,obesity,excessive alcohol consumption and tobacco *** is,therefore,important to understand the factors associated with poststroke PA/exercise and cardiorespiratory *** associated factors include self-efficacy,social support and quality of patients’relationships with health *** associated factors include logistical barriers,medical comorbidities,stroke-related deficits,negative exercise beliefs,fear of falling,poststroke fatigue,arthropathy/pain and *** research is needed to specify efficacious behavioural approaches to increase poststroke *** techniques probably include physician endorsement of exercise programmesto patients,enhancement of patient-professional relationships,providing patients an exercise rationale,motivational interviewing,collaborative goal-setting with patients,addressing logistical concerns,social support in programsmes,structured exercise programming,individualised behavioural instruction,behavioural diary recording,reviewing behavioural consequences of exercise efforts,reinforcing successful exercise *** programming without counselling may increase short-term activity;simple advice or information-giving is probably *** patients or those with cognitive impairment may need increased structure,with emphasis on behaviour per se,versus self-regulation *** support the latest American Heart Association/American Stroke Associati

关键词： prevention behaviour programming

Thoracic aorta thickness and histological changes with aging: an experimental rat model

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Journal of Geriatric cardiology 2019年第7期16卷 580-584页

作者： Giulio Cesar Gequelim Djanira Aparecida da Luz Veronez Gustavo Lenci Marques Camila Harumi Tabushi Ronaldo da Rocha Loures Bueno Master’s Degree Student in postgraduate program of Internal Medicine Federal University of Paraná(UFPR)Medical Resident in Cardiology in Hospital de Clínicas UFPRCuritiba-PRBrazil Department of Anatomy School of MedicineUFPRCuritiba-PRBrazil Master’s Degree in Internal Medicine Adjunct ProfessorDepartment of Internal MedicineSchool of MedicineUFPRCuritiba-PRBrazil Medical Student Department of Internal MedicineSchool of MedicineUFPRCuritiba-PRBrazil Department of Internal Medicine School of MedicineUFPRCuritiba-PRBrazil

The three main components of the media layer of the aorta are elastic fibers,collagen fibers and smooth muscle cells(SMC).[1]This layer’s elastic properties are major determinants of its biomechanics in health and disease states.[2,3]Age-related changes in such elastic properties are associated with altered hemodynamic parameters,such as systolic hypertension,[4,5]and end-organ damage,[6,7]and are thought to result from changes of its main components.

关键词： Aging Collagen Elastic fibers Smooth muscle cells

Co-expression of HBZ,TAX and FOXp3 and HTLV-1-associated myelopathy/tropical spastic paraparesis development in HTLV-1-infected individuals:A systematic review

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Asian Pacific Journal of Tropical Medicine 2021年第8期14卷 333-340页

作者： Ana Carolina Marinho Monteiro Lima Greice Carolina Santos da Silva Fernanda Khouri Barreto Filipe Ferreira de Almeida Rego Luana Leandro Gois Luciane Amorim Santos Catholic University of Salvador SalvadorBahiaBrazil Multidisciplinary Institute in Health Federal University of BahiaVitoria da ConquistaBahiaBrazil Bahia School of Medicine and Public Health SalvadorBahiaBrazil postgraduate program in Health Sciences Faculty of Medicine of BahiaFederal University of BahiaSalvadorBahiaBrazil

Human T-cell lymphotropic virus type 1(HTLV-1)is associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP).It has been reported that the HTLV-1 proteins(specifically TAX and HBZ)can modulate FOXp3,resulting in an immune imbalance that can favor the progression of HAM/*** review aims to summarize the literature in order to clarify the relationship between the expression of HTLV-1 m RNAs and/or viral proteins(TAX and HBZ)with the expression of mRNA and/or protein FOXp3 and their correlation with HAM/TSP *** systematic review was conducted according to the recommendations of the Preferred Reporting Items for Systematic Reviews and *** search strategy was performed on the Medical Literature Analysis and Retrieval System Online and Latin American and Caribbean Literature in Health Sciences Platform using subject *** screening,six articles were included in this *** studies suggested that TAX and HBZ have a directly proportional correlation with FOXp3 in individuals with HAM/TSP,which also presented an increased expression of FOXp3 compared to asymptomatic controls and/or healthy *** systematic review indicates that TAX and HBZ can interact with FOXp3 and that interaction may influence HAM/TSP development.

关键词： HTLV-1 HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP) FOXp3 HBZ TAX

Metabolic landscape in cardiac aging:insights into molecular biology and therapeutic implications

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1610-1629页

作者： Saiyang Xie Si-Chi Xu Wei Deng Qizhu Tang Department of cardiology Renmin Hospital of Wuhan UniversityHubei Key Laboratory of Metabolic and Chronic DiseasesCardiovascular Research Institute of Wuhan UniversityWuhanPR China State Key Laboratory of Complex Severe and Rare Diseases Department of CardiologyPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingPR China Department of cardiology Renmin Hospital of Wuhan UniversityDepartment of CardiologyThe Fifth Affiliated Hospital of Xinjiang Medical UniversityÜrümqiPR China

Cardiac aging is evident by a reduction in function which subsequently contributes to heart *** metabolic microenvironment has been identified as a hallmark of malignancy,but recent studies have shed light on its role in cardiovascular diseases(CVDs).Various metabolic pathways in cardiomyocytes and noncardiomyocytes determine cellular senescence in the aging *** alteration is a common process throughout cardiac ***,the involvement of cellular senescence in cardiac injuries,including heart failure and myocardial ischemia and infarction,has been ***,metabolic complexity among human aging hearts hinders the development of strategies that targets metabolic *** over the past decade have linked cellular senescence and function with their metabolic reprogramming pathway in cardiac aging,including autophagy,oxidative stress,epigenetic modifications,chronic inflammation,and myocyte systolic phenotype *** addition,metabolic status is involved in crucial aspects of myocardial biology,from fibrosis to hypertrophy and chronic ***,further elucidation of the metabolism involvement in cardiac degeneration is still ***,deciphering the mechanisms underlying how metabolic reprogramming impacts cardiac aging is thought to contribute to the novel interventions to protect or even restore cardiac function in aging ***,we summarize emerging concepts about metabolic landscapes of cardiac aging,with specific focuses on why metabolic profile alters during cardiac degeneration and how we could utilize the current knowledge to improve the management of cardiac aging.

关键词： cardiac degeneration involvement

Ultrafast laser state active controlling based on anisotropic quasi-1D material

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Light(Science & Applications) 2024年第4期13卷 717-726页

作者： Zixin Yang Qiang Yu Jian Wu Haiqin Deng Yan Zhang Wenchao Wang Tianhao Xian Luyi Huang Junrong Zhang Shuai Yuan Jinyong Leng Li Zhan Zongfu Jiang Junyong Wang Kai Zhang Pu Zhou College of Advanced Interdisciplinary studies National University of Defense TechnologyChangsha 410073China. Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China. i-Lab&Key Laboratory of Nanodevices and Applications&Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China. School of Applied and Engineering Physics Cornell UniversityIthacaNY 14853USA. State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China. Shanghai Key Lab of Modern Optical System University of Shanghai for Science and TechnologyShanghai 200093China

Laser state active controlling is challenging under the influence of inherent loss and other nonlinear effects in ultrafast *** an extension of degree of freedom in optical devices based on low-dimensional materials may be a way ***,the anisotropic quasi-one-dimensional layered material Ta2PdS6 was utilized as a saturable absorber to modulate the nonlinear parameters effectively in an ultrafast system by polarization-dependent *** polarization-sensitive nonlinear optical response facilitates the Ta2PdS6-based mode-lock laser to sustain two types of laser states,i.e.,conventional soliton and noise-like *** laser state was switchable in the single fiber laser with a mechanism revealed by numerical *** coding was further demonstrated in this platform by employing the laser as a codable light *** work proposed an approach for ultrafast laser state active controlling with low-dimensional material,which offers a new avenue for constructing tunable on-fiber devices.

关键词： polarization fiber controlling

Presence of Severe Stenosis in Most Culprit Lesions of Patients with ST-segment Elevation Myocardial Infarction

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Chinese Medical Journal 2016年第17期129卷 2074-2078页

作者： Li Sheng Shuang Li Jian-Qiang Li Jing-Yi Xue Yan-Ming Sun Yong-Tai Gong Ling Jing Dang-Hui Sun Wei-Min Li Ding-Yu Wang Yue Li Department of cardiology The First Affiliated Hospital of Harbin Medical University Harbin Medical University Harbin Heilongjiang 150001 China postgraduate Institute Harbin Medical University Harbin Heilongjiang 150081 China

Background： Previous studies revealed that culprit vessels of ST-segment elevation myocardial infarction （STEMI） were often related to mild or moderate stenosis. However, recent studies suggested that severe stenosis was primarily found in culprit lesions. The objective of this study was to analyze the stenosis severity of culprit lesions in STEMI patients and to clarity the paradoxical results. Methods： A total of 489 consecutive STEMI patients who underwent primary percutaneous coronary intervention were retrospectively studied from January 2012 to December 2014. The patients were divided into three groups based on stenosis severity using quantitative coronary analysis： Group A, 314 cases, stenosis 〉70%： Group B, 127 cases, stenosis 50-70%： and Group C, 48 cases, stenosis 〈_50%,. The clinical, demographic, and angiographic data of all groups were analyzed. Results： Patients in Group A exhibited a significantly higher prevalence of history of angina pectoris （95.9% vs. 62.5%, P 〈 0.001 ）, inultivessel disease （73.2% vs. 54.2%, P = 0.007）, and lower cardiac ejection ITaction （53.3 ± 8.6 vs. 56.8 ± 8.4, P = 0.009） than those in Group C. Multivariable analysis revealed that history of angina pectoris （odds ratio [OR]： 13.89, 95% confidence interval [（7]： 6.21-31.11 ） and multivessel disease （OR： 2.32, 95%, CI： 1.25-4.31 ） were correlated with severe stenosis of the culprit lesion in Group A. Conclusions： Most culprit lesions in STEM[ patients were severe stenosis. These patients exhibited a higher prevalence of angina history and multivessel diseases.

关键词： Percutaneous Coronary Intervention Quantitative Coronary Angiography ST-segment Elevation Myocardial Infarction

Sanguinarine Attenuates Lipopolysaccharide-induced Inflammation and Apoptosis by Inhibiting the TLR4/NF-KB Pathway in H9c2 Cardiomyocytes

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Current Medical Science 2018年第2期38卷 204-211页

作者： Yan-yan MENG Yuan LIU Zhe-fu HU Yao ZHANG Jian NI Zhen-guo MA Hai-han LIAO Qing-qing WU Qi-zhu TANG Department of cardiology Renmin Hospital of Wuhan University Wuhan 430060 China Cardiovascular Research Institute Wuhan University Wuhan 430060 China Hubei Key Laboratory of cardiology Wuhan 430060 China

The inflammatory response is involved in the pathogenesis of the most common types of heart disease. Sanguinarine （SAN） has various pharmacological properties such as anti-inflammatory, antioxidant, antibacterial, antitumor, and immune-enhancing properties. However, few studies have investigated the effects of SAN on lipopolysaceharide （LPS）-induced inflammatory and apoptotic responses in H9c2 cardiomyocytes. Therefore, in this study, H9c2 cells were co-treated with SAN and LPS, and the mRNA levels of pro-inflammation markers and the apoptosis rate were measured to clarify the effect of SAN on cardiac inflammation. The underlying mechanism was further investigated by detecting the activation of Toll-like receptor （TLR）4/nuclear faetor-κB （NF-κB） signaling pathways. As a result, increased mRNA expression of interleukin （IL）-1β, IL-6, and TNFα induced by LPS was attenuated after SAN treatment; LPS-induced apoptosis ofHge2 cardiomyocytes and cleaved-caspase 8, 9, 3 were all significantly reduced by SAN. Further experiments showed that the beneficial effect of SAN on blocking the inflammation and apoptosis of H9c2 cardiomyocytes induced by LPS was associated with suppression of the TLR4/NF-κB signaling pathway. It was suggested that SAN suppressed the LPS-induced inflammation and apoptosis of H9c2 cardiomyocytes, which may be mediated by inhibition of the TLR4/NF-κB signaling pathway. Thus, SAN may be a feasible therapy to treat sepsis patients with cardiac dysfunction.

关键词： lipopolysaccharides sanguinarine inflammation H9c2 cardiac cells apoptosis

Pesticide Contamination in Land Reform Settlements in Brazil： Empirical Evidences from Caiaponia, Goias State

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Journal of Environmental Science and Engineering(A) 2013年第3期2卷 197-202页

作者： Alcido Elenor Wander Cleyzer Adrian da Cunha Agostinho Dirceu Didonet Brazilian Agricultural Research Corporation (Embrapa) Santo Antonio de Goias Goias 75375000 Brazil Department of postgraduate program in Agribusiness Federal University of Goias Goiania Goias 74001970 Brazil Department of postgraduate program in Regional Development Faculdades Alves Faria (ALFA) Goiania Goias 74445190Brazil

Brazil is the largest consumer of pesticides worldwide. Public health studies in Brazil show that inadequate use of pesticides increases the incidence of accidents and contamination of poor rural communities. This study sought to identify factors that determine the occurrence of problems with pesticides in a typical Brazilian land reform settlement. The study was carried out in Caiaponia, Goias state. In the empirical analysis, the econometric model pro bit was used. The dependent variable was the existence of health problems in the family setting that are caused by pesticides. The independent variables were the family size; the attendance to any church, whether Catholic or Protestant; if farmers received any technical assistance; the current health condition of the family, and if there are exacerbated erosion problems on the farm. Data from 28 farmers were collected through a structured questionnaire. Among the main findings, larger families have a higher probability of accidents involving pesticides. The current healthy conditions of family and the problems of soiled gradation in the farm imply are duction in the likelihood of contamination with pesticides. These two results indicate that rural households that have good health condition and have experienced environmental degradation on their farm have higher environmental awareness.

关键词： Pesticide use environmental awareness health issues.